Protein Alignment ash1 and Ehmt1

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: XP_006498485.1
• Gene: Ehmt1 / 77683
• MGIID: 1924933
• Length: 1312
• Species: Mus musculus
• Alignment Length: 1523
• Identity: 295/1523 - (19%)
• Similarity: 469/1523 - (30%)
• Gaps: 545/1523 - (35%)

  Fly   387 LRSMSVGAASGTGA-------STTICSKVLAAKSG----YVSDYGSVRHQRSSHNHNSGYKSDAS 440
            ||:.::.||....|       ....|.|....:.|    ..:|.||...|.......:..:::.|
Mouse    10 LRARAMAAADAEQAVLAKQETKQDCCMKTELLREGKDTPMAADEGSTEKQEGETPMAADGETNGS 74

  Fly   441 CK-----------------SRYSTKSCMSRRSRAKSCGYRSDCKESGKSGLRMRRKRRASMLLKS 488
            |:                 :|.|.:...:|.||....|......|.||..             ..
Mouse    75 CEKSGDPSHLNAPKHTQENTRASPQEGTNRVSRVAENGVSERDTEVGKQN-------------HV 126

  Fly   489 SADDTVEDQDILQLAGLSLGQSSEESNEY-ISKPSLKSLPTTSASKKYGEINRYVTTGQYFGR-- 550
            :|||.::...|             .||.| ::||:|:..|..:.:         :.|....|.
Mouse   127 TADDFMQTSVI-------------GSNGYFLNKPALQGQPLRTPN---------ILTSSLPGHAA 169

  Fly   551 ----GGSLSATNPDNFISKMMNQRKETP-----APSKSSCKIKSRRSSAASMCSSYVSGVSRMRR 606
                ||:...        :.::...:||     .|.:.|...:.|:.:|        ||......
Mouse   170 KTLPGGASKC--------RTLSALPQTPTTAPTVPGEGSADTEDRKPTA--------SGTDVRVH 218

  Fly   607 RHRRKSFSHNKSLNIDSKLLTEIEIITSTFNSRCRIQD--------DRLTGSSGKEKLLADANKL 663
            |.|:........|:..||             ....:||        :|.....|:::||.....|
Mouse   219 RARKTMPKSILGLHAASK-------------DHREVQDHKEPKEDINRNISECGRQQLLPTFPAL 270

  Fly   664 QATL------AAPSPAQQLTLNGGGP---ASTLSKPLKRGL--------KKRKLSEPLVDFAMLS 711
            ..:|      .|.:.:|...|    |   |:.:|:..||.:        ||.|:.:......|..
Mouse   271 HQSLPQNQCYMATTKSQTACL----PFVLAAAVSRKKKRRMGTYSLVPKKKTKVLKQRTVIEMFK 331

  Fly   712 ASASGTPNGSGSSNGNTKRRHKKSQSNDSSSPDDHKLPLKKRHYLLTPGERPPAEVAFANGKLNA 776
            :....|....|....:....|...:|.:..|.|:....|:                       :.
Mouse   332 SITHSTVGAKGEKALDDSALHVNGESLEMDSEDEDSDELE-----------------------DD 373

  Fly   777 EAWAAAAAAAKSTASTKSQAQFNARSVKSALTPKKRHLLEQPTSVSGAGSSASNSPLRIVVDNNS 841
            |...|..|||..|..:::..:..:.:.::|             .:.|.......||    .....
Mouse   374 EDHGAEQAAAFPTEDSRTSKESMSETDRAA-------------KMDGDSEEEQESP----DTGED 421

  Fly   842 ISGGKLLDISPSSLCSLKQ---QRRG--------GAAKQKVSAAKDLVQLQSPAGSYPPPGVFE- 894
            ..||...|:|..|  |:|:   :|||        .|.|::..:.|....:.........||..|
Mouse   422 EDGGDESDLSSES--SIKKKFLKRRGKTDSPWIKPARKRRRRSRKKPSSMLGSEACKSSPGSMEQ 484

  Fly   895 --------------PSVELEIQIPLSKL--NESVITKAEV-------ESPLLSALDIKEDTKKEV 936
                          .|::|.::..||..  ||.:.:..:|       |.||.|.   :.:|.|
Mouse   485 AALGDSAGYMEVSLDSLDLRVRGILSSQTENEGLASGPDVLGTDGLQEVPLCSC---RMETPK-- 544

  Fly   937 GQRVVETLLHKTGGNLLLKRKRKKINRTGFPTVRRKKRKVSVEQQ----TTAVIDEHEPEFDPDD 997
             .|.:.||    ..|..:..:                   ||:.:    |.:|: ::|.....:.
Mouse   545 -SREISTL----ANNQCMATE-------------------SVDHELGRCTNSVV-KYELMRPSNK 584

  Fly   998 EPLQSLRETRSSNNVNVQAAPNPP--------LDCE---------------RV------PQAGE- 1032
            .||..|.|......|..|..|...        ::|:               ||      |..||
Mouse   585 APLLVLCEDHRGRMVKHQCCPGCGYFCTAGNFMECQPESSISHRFHKDCASRVNNASYCPHCGEE 649

  Fly  1033 ---ARETFVARTNQKAPRLSVVALERLQRPQTPARGRPR------GRKPKNREQAEAAPQPPPKS 1088
               |:|..:|    ||...|.|.|...|.....|.||..      ...|::......|||.|...
Mouse   650 ASKAKEVTIA----KADTTSTVTLAPGQEKSLAAEGRADTTTGSIAGAPEDERSQSTAPQAPECF 710

  Fly  1089 EPE-----IRPAKKRGRQPKQPVLE--------EPPPTPPPQQKKNKMEPN-------------- 1126
            :|.     :||.....:.|.:..||        |.|       ||.:..|.
Mouse   711 DPAGPAGLVRPTSGLSQGPGKETLESALIALDSEKP-------KKLRFHPKQLYFSARQGELQKV 768

  Fly  1127 -IRLPDGIDPNTNFS-------------------CKIRLKRRKNLEAGTQPKKEKPVQPVTVEEI 1171
             :.|.||||||....                   |.:.::...|::..::.::
Mouse   769 LLMLVDGIDPNFKMEHQSKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQR------------ 821

  Fly  1172 PPEIPVSQEEIDAEAEAKRLDSIP------TEHDP----------LPASESH--------NPGPQ 1212
               .|:.:     .||...||::.      .:.||          |.|.:.|        :.|..
Mouse   822 ---TPLME-----AAENNHLDAVKYLIKAGAQVDPKDAEGSTCLHLAAKKGHYDVVQYLLSNGQM 878

  Fly  1213 DYASCSESSEDKASTTSLRKLSKVKKTYLVAGLFS------------------------------ 1247
            | .:|    :|....|.:...::.|...||..|.|
Mouse   879 D-VNC----QDDGGWTPMIWATEYKHVELVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEI 938

  Fly  1248 -----------NHYKQSLMPPPAKVNK------------------KPG--------LEEQVGPA- 1274
                       |.:..|.:...|:.|:                  |.|        |..||..|
Mouse   939 LLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLSSQVWSAL 1003

  Fly  1275 --------SLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPS----WNYRKIRTNV 1327
                    |....|...||.:.|         ||...|....:|..|.|.|    .||:.:..|.
Mouse  1004 QMSKALRDSAPDKPVAVEKTVSR---------DIARGYERIPIPCVNAVDSELCPTNYKYVSQNC 1059

  Fly  1328 YAE--SVRPNLAGFDH---------PTCNCKNQGEKSCLD---------NCLNRMVYTECSPSNC 1372
            ...  ::..|:....:         .||.|.....:...|         |.....:..||:.: |
Mouse  1060 VTSPMNIDRNITHLQYCVCVDDCSSSTCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHA-C 1123

  Fly  1373 PAGEKCRNQKIQRHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIY 1437
            .....|||:.:| :.:...::.:.|.|.|||||:...|..||::.|||||::::.|...|....|
Mouse  1124 SCWRNCRNRVVQ-NGLRARLQLYRTQDMGWGVRSLQDIPLGTFVCEYVGELISDSEADVREEDSY 1187

  Fly  1438 LNDTHH-----YCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVN----GLSRMVLFAKR 1493
            |.|..:     ||        ||.:..|:..||:||.||||....:..::    ...|:..|:.|
Mouse  1188 LFDLDNKDGEVYC--------IDARFYGNVSRFINHHCEPNLVPVRVFMSHQDLRFPRIAFFSTR 1244

  Fly  1494 AIEEGEELTYDYNFSLFNPSEGQ--PCRCNTPQCRGVIGGKSQRVKPLPAVEAKPSGEGLSGRNG 1556
            .|:.||:|.:||. ..|...:|:  .|||.:.:||                   .|...|:
Mouse  1245 LIQAGEQLGFDYG-ERFWDVKGKLFSCRCGSSKCR-------------------HSSAALA---- 1285

  Fly  1557 RQRKQKAKKHAQRQAGKDISSAVAVAKL 1584
             ||:..|.:..|.....|.|||.|...|
Mouse  1286 -QRQASAAQEPQENGLPDTSSAAAADPL 1312

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	75/448 (17%)
		AWS	1340..1388	CDD:197795	12/65 (18%)
		SET_ASH1L	1391..1531	CDD:380951	49/150 (33%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
Ehmt1	XP_006498485.1	EHMT_ZBD	530..660	CDD:411018	31/163 (19%)
		ANKYR	734..990	CDD:440430	42/287 (15%)
		ANK repeat	788..817	CDD:293786	2/28 (7%)
		ANK repeat	819..850	CDD:293786	7/50 (14%)
		ANK repeat	852..884	CDD:293786	6/36 (17%)
		ANK repeat	886..917	CDD:293786	6/30 (20%)
		ANK repeat	919..950	CDD:293786	0/30 (0%)
		ANK repeat	952..983	CDD:293786	3/30 (10%)
		SET_EHMT1	1050..1280	CDD:380933	65/259 (25%)