Protein Alignment ash1 and ezh2

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: NP_001070747.1
• Gene: ezh2 / 768133
• ZFINID: ZDB-GENE-041111-259
• Length: 760
• Species: Danio rerio
• Alignment Length: 817
• Identity: 180/817 - (22%)
• Similarity: 278/817 - (34%)
• Gaps: 262/817 - (32%)

  Fly   855 LCSLKQQRRGGAAK-------QKVSAAKDL------------VQLQSPAGSYPPPGVFEPSVELE 900
            |..||:.||....|       ||:....|:            |.:.:|..|.  .|..|.:|:..
Zfish    26 LRQLKRFRRADEVKSMFSSNRQKILERTDILNQEWKLRRIQPVHIMTPVSSL--RGTRECTVDSG 88

  Fly   901 IQ------IPLSKLNESVITKAEVE---SPLLSALDIKEDTKKE----VGQRV-------VETLL 945
            ..      |||..||  .:....|.   |||.....::::|...    :|..:       :|.|:
Zfish    89 FSEFSRQVIPLKTLN--AVASVPVMYSWSPLQQNFMVEDETVLHNIPYMGDEILDQDGTFIEELI 151

  Fly   946 HKTGGNLLLKRKRKKINRTGFPTVRRKKRKVSVEQQTTAVIDEHEPEFDPDD-----EPLQSLRE 1005
            ....|.:...|:...||...|..:.....:.|..::.....|.|:.:|:..|     :..:..:|
Zfish   152 KNYDGKVHGDRECGFINDEIFVELVNALNQYSDNEEDDEEDDHHDYKFEKMDLCDGKDDAEDHKE 216

  Fly  1006 TRSSNNVNVQAAPNPPLD------CERVPQAG---EARETFVARTNQK---------APRLSVVA 1052
            ..||.:.|...:...|.|      ....|..|   |.:|.:...|.|:         .|.:....
Zfish   217 QLSSESHNNDGSKKFPSDKIFEAISSMFPDKGSTEELKEKYKELTEQQLPGALPPECTPNIDGPN 281

  Fly  1053 LERLQRPQT--------------------PARGRPRGRKPKNREQ-------------------- 1077
            .:.:||.|:                    |.:..|...|.||.|.
Zfish   282 AKSVQREQSLHSFHTLFCRRCFKYDCFLHPFQATPNTYKRKNMENLVDSKPCGIYCYMYMVQDGM 346

  Fly  1078 ---------AEAAPQPPPKSEPEIRPAKKRGRQPKQPVLEEPPPTPPPQQKKNKMEPNIRL--PD 1131
                     .|.|..|..:|     ..::|||.|.    ....|:.|....:.|...:.|.  .|
Zfish   347 VREYPAGVVPERAKTPSKRS-----TGRRRGRLPN----SNSRPSTPTVNSETKDTDSDREGGAD 402

  Fly  1132 GIDPNTNFSCKIRLKRRKNLEAGTQPKKEKPVQPVTVEEIPPEIPVSQEEID---AEAEAKRLDS 1193
            |.|.|.......:.:...:.||.:  :.:.||: :.:...||      |.:|   |||...|: .
Zfish   403 GNDSNDKDDDDKKDETTSSSEANS--RCQTPVK-LKLSSEPP------ENVDWSGAEASLFRV-L 457

  Fly  1194 IPTEHDPLPASESHNPGPQDYASCSESSEDKASTTSLRKL--SKVKKTYLVAGLFSNHYKQSLMP 1256
            |.|.:|..               |:.:.  ...|.:.|::  .:||::.::|
Zfish   458 IGTYYDNF---------------CAIAR--LIGTKTCRQVYEFRVKESSIIA------------- 492

  Fly  1257 PPAKVNKKPGLEEQVGPASLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSWNYR 1321
                  :.|.::|..        |...:|...|.           ||....|:..:....|
Zfish   493 ------RAPAVDENT--------PQRKKKRKHRL-----------WATHCRKIQLKKDGSS---- 528

  Fly  1322 KIRTNVYAESVRPNLAGFDHP------TCNC---KNQGEK--SCLDNCLNR-------------- 1361
               .:||      |....|||      :|.|   :|..||  .|...|.||
Zfish   529 ---NHVY------NYQPCDHPRQPCDSSCPCVTAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQ 584

  Fly  1362 ----MVYTECSPS---NCPAGE-------KCRNQKIQRHA-----VAPGVERFMTAD-KGWGVRT 1406
                :...||.|.   .|.|.|       .|:|..|||.|     :||       :| .|||:..
Zfish   585 CPCYLAVRECDPDLCLTCGAAEHWDSKNVSCKNCSIQRGAKKHLLLAP-------SDVAGWGIFI 642

  Fly  1407 KLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHSCE 1471
            |.|:.|..:|.||.||::::.| ..|...:|......:..:|:...|:|..|.|:..||.|||..
Zfish   643 KEPVQKNEFISEYCGEIISQDE-ADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVN 706

  Fly  1472 PNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFS 1508
            |||..:...|||..|:.:||||||:.||||.:||.:|
Zfish   707 PNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYS 743

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	57/336 (17%)
		AWS	1340..1388	CDD:197795	24/91 (26%)
		SET_ASH1L	1391..1531	CDD:380951	45/119 (38%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
ezh2	NP_001070747.1	EZH2_WD-Binding	39..68	CDD:463308	4/28 (14%)
		PRC2_HTH_1	159..262	CDD:436286	19/102 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	208..231		4/22 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	356..444		23/105 (22%)
		preSET_CXC	573..604	CDD:408079	4/30 (13%)
		SET_EZH2	623..742	CDD:380995	47/126 (37%)