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Protein Alignment ash1 and Kmt2b

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	NP_001277502.1	Gene:	Kmt2b / 75410	MGIID:	109565	Length:	2722	Species:	Mus musculus

Alignment Length:	1122	Identity:	239/1122 - (21%)
Similarity:	354/1122 - (31%)	Gaps:	420/1122 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   639 RCRIQDDRLTGSSGKEKLLADANKLQATLAAPSPAQQL----------TLNGG-----GPASTLS 688
            ||||.:.|..|...:...|..|.:.|..:.:|:|:.:.          :|..|     .|...|.
Mouse  1783 RCRILEYRPWGPREEPVHLEAAEENQTIVHSPTPSSEPPNHDDLPDTDSLIPGDPVHHSPIQNLD 1847

  Fly   689 KPLK-----------RGLKKRKLSEPL----------VDFAMLSASASGT------PNGSGSSNG 726
            .||:           |.....::..|.          |.|..|.:..|.:      |....|...
Mouse  1848 PPLRTDSSNGPPPTPRSFSGARIKVPNYSPSRRPLGGVSFGPLPSPGSPSSLTHHIPTVGDSDFP 1912

  Fly   727 NTKRRHKKSQ--------SNDSSSP----DDHKLPLKKRHYLLTP--GERPPAEVA--------- 768
            ...||.::..        |..:|||    ...::||......|||  ||..|.::|
Mouse  1913 APPRRSRRPSPLATRPPPSRRTSSPLRTSPQLRVPLSTSVTALTPTSGELAPPDLAPSPLPPSED 1977

  Fly   769 --------------------FANGKLNAEAWAAAAAAAKSTASTKSQAQFNARSVKSALTPKKRH 813
                                ||...|..|.:.....||.:..|::.....::....|..|    |
Mouse  1978 LGPDFEDMEVVSGLSAADLDFAASLLGTEPFQEEIVAAGAVGSSQGGPGDSSEEEASPTT----H 2038

  Fly   814 LLEQP-TSVSG---AGSSASNSPLRIVVDNNSISGGKLLDISPSSLCSLKQQRRG---------- 864
            .:..| |.|||   |.||.:.:| ||    ..:.|   :|....|.....||.||
Mouse  2039 YVHFPVTVVSGPALAPSSLAGAP-RI----EQLDG---VDDGTDSEAEAVQQPRGQGTPPSGPGV 2095

  Fly   865 ------GAAKQKVSAAKDLVQ------LQSPAGSYPPPGVFEPSVE-LEIQIPLSKLNESVITKA 916
                  |||..:....:||..      |::..|  |..|...|..: |....||:  |.|...::
Mouse  2096 GRGGVLGAAGDRAQPPEDLPSEIVDFVLKNLGG--PGEGAAGPREDSLPSAPPLA--NGSQPPQS 2156

  Fly   917 EVESP-----------------LLSALDIKEDTKKEVGQRVVETLLHKTGGNLLLKRKRKKINRT 964
            ...||                 :||.....|..|....:.::                   :|:.
Mouse  2157 LSTSPADPTRTFAWLPGAPGVRVLSLGPAPEPPKPATSKIIL-------------------VNKL 2202

  Fly   965 GFPTVRRKKRKVSVEQQTTAVIDEHEPEFDPDDEPLQSLRETRSSNNVNVQAAPNPPLDCERVPQ 1029
            |              |....:..|.||...|..:|                  |.||:    :|.
Mouse  2203 G--------------QVFVKMAGEGEPVAPPVKQP------------------PLPPI----IPP 2231

  Fly  1030 AGEARETFVARTNQKAPRLSVVALERLQRPQTPARG----RPRGRKPKNREQAEAAPQPPP---- 1086
            ......|.     ...|.|||:          |..|    ||            |.|.|||
Mouse  2232 TAPTSWTL-----PPGPLLSVL----------PVVGVGVVRP------------APPPPPPPLTL 2269

  Fly  1087 --KSEPEIRPAK----KR-----GRQPKQPVLEEPPPTPPPQQKKNKMEPNIRLPD-----GIDP 1135
              .|.|...|.:    ||     ||.         ||.|||.:.....|....|.|     ||.
Mouse  2270 VFSSGPPSPPRQAIRVKRVSTFSGRS---------PPVPPPNKTPRLDEDGESLEDAHHVPGIS- 2324

  Fly  1136 NTNFSCKIRLKR---RKNLE---AGTQPKKEKPVQPVTVEEIPPEIPVSQEEIDAEAEAKRLDSI 1194
            .:.|| ::|:|.   |..|:   .|.||::|.|.:|   ::..|.:|:      |||.::.||.
Mouse  2325 GSGFS-RVRMKTPTVRGVLDLNNPGEQPEEESPGRP---QDRCPLLPL------AEAPSQALDG- 2378

  Fly  1195 PTEHDPLPASESHNPGPQDYASCSESSEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQSLMPPPA 1259
              ..|.|..|:.|:     |::...||.::                               .||:
Mouse  2379 --SSDLLFESQWHH-----YSAGEASSSEE-------------------------------EPPS 2405

  Fly  1260 KVNKKPGLEEQVGPASLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPT------RNVVPSW 1318
            ..:|:..:.::|||            :||     ||:..|..::.....|..      ..|..:.
Mouse  2406 PEDKENQVPKRVGP------------HLR-----FEISSDDGFSVEAESLEVAWRTLIEKVQEAR 2453

  Fly  1319 NYRKIRTNVYAESVRPNLAGFDHPTC-----------NCKN-------QGE-------------- 1351
            .:.::|...::......|.|..|...           .|::       |||
Mouse  2454 GHARLRHLSFSGMSGARLLGIHHDAVIFLAEQLPGAQRCQHYKFRYHQQGEGQEEPPLNPHGAAR 2518

  Fly  1352 -----KSCLDNCLNRMVYTECSPSNCPAGEKCRNQKIQ--------------------RH----- 1386
                 :.|..:..|   :........|.|..|..::.:                    ||
Mouse  2519 AEVYLRKCTFDMFN---FLASQHRVLPEGATCDEEEDEVQLRSTRRATSLELPMAMRFRHLKKTS 2580

  Fly  1387 AVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVV-------TEKEFKQRMASIYLNDTHHY 1444
            ..|.||.|  :|..|.|:..|..|..|..::||.|.|:       .||.:..:....|:
Mouse  2581 KEAVGVYR--SAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDGKGIGCYM------ 2637

  Fly  1445 CLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSL 1509
             ..:|...|:|....|:..||:||||||||..:...|.|...:|:||.|.|..||||||||.|.:
Mouse  2638 -FRMDDFDVVDATMHGNAARFINHSCEPNCFSRVIHVEGQKHIVIFALRRILRGEELTYDYKFPI 2701

  Fly  1510 FNPSEGQPCRCNTPQCR 1526
            .:.|...||.|...:||
Mouse  2702 EDASNKLPCNCGAKRCR 2718

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.