DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ash1 and Setd5

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	XP_006506740.1	Gene:	Setd5 / 72895	MGIID:	1920145	Length:	1467	Species:	Mus musculus

Alignment Length:	1381	Identity:	250/1381 - (18%)
Similarity:	426/1381 - (30%)	Gaps:	481/1381 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1079 EAAPQPPPKSEPEIRPAK---KRGRQP--------KQPVLEE----------------------- 1109
            |....|..|:..|.:||:   .||..|        ..|.:.|
Mouse     2 EVLRDPIKKNSSESKPAQSGFSRGNSPLCCPESVEASPAVNEKSVYSTHNYGTTQRHGCRGLPYA 66

  Fly  1110 -------PPPTPP---------PQQKKNKMEPNIRLPDGIDPNTN------------------FS 1140
                   ||||||         |:...|.:...:....|..||:.                  .:
Mouse    67 DHNYGAPPPPTPPASPPVQTIIPRSDLNGLPSPVEERCGDSPNSEGETVPTWCPCGLSQDGFLLN 131

  Fly  1141 CK----------IRLKRRK--NLEAGTQPKKEKPVQPVTVEEIPPEIPVSQEEIDAEAEAKRLDS 1193
            |.          |||.|||  |:..|...                    :.|..|.|.....:..
Mouse   132 CDKCRGMSRGKVIRLHRRKQDNISGGDSS--------------------ATESWDEELSPSTVLY 176

  Fly  1194 IPTEHDPLPASESHNPGPQDYASCSESSEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQSLMPPP 1258
            ..|:|.|                        .|.|...:.:|.||..      .:..|....|..
Mouse   177 TATQHTP------------------------TSITLTVRRTKPKKRK------KSPEKGRAAPKT 211

  Fly  1259 AKVNKKP----GLEEQVGPASLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSW- 1318
            .|:...|    .|:|..                  ||         .|         .|.:..|
Mouse   212 KKIKNSPSEAQNLDENT------------------TE---------GW---------ENRIRLWT 240

  Fly  1319 -NYRKIRTNVYAESVRPNLAGFDHPTCNCKNQGEKSCLDNCLNRMVYTECSPSNCPAGEKCRNQ- 1381
             .|.:..||.|:..|:..|.  .|...|.:..|:.:.||. :|:   ||.:.:|...|.:.:.|
Mouse   241 DQYEEAFTNQYSADVQNALE--QHLHSNKEFVGKPAILDT-INK---TELACNNTVIGSQMQLQL 299

  Fly  1382 ----KIQRHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTH 1442
                ::|:|...              :|....:|..|.|:||.|:|:..::|:  :...:....:
Mouse   300 GRVTRVQKHRKI--------------LRAARDLALDTLIIEYRGKVMLRQQFE--VNGHFFKKPY 348

  Fly  1443 HYCL---HLDG-GLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELT- 1502
            .:.|   ..:| .:.:|.:..|:|.||:..||.||.|::....:|:..:.::|..||.:..|:|
Mouse   349 PFVLFYSKFNGVEMCVDARTFGNDARFIRRSCTPNAEVRHMIADGMIHLCIYAVSAITKDAEVTI 413

  Fly  1503 -YDYNFSLFNPSEGQPCRCNTPQCRGVIGGKSQRVKPLPAVEAKPSGEGLSGRNGRQRKQKAKKH 1566
             :||.:|..|......|......|.......:....|||...:.|:    .|...|:||.:.|:.
Mouse   414 AFDYEYSNCNYKVDCACHKGNRNCPIQKRNPNAAELPLPPPPSFPT----IGAETRRRKARRKEL 474

  Fly  1567 AQRQAG-----------KDISSAVAVA----------KLQPLSEKEKKLVRQFNT---------- 1600
            ...|..           :::...|.|:          :.....|||:....|.|:
Mouse   475 ELEQQNEVPEENPDPQPQEVPEKVTVSNEHEEVDNPEEKPEEEEKEEATDDQENSAHSRRTREDR 539

  Fly  1601 ---FLVRNFEKIRRCKAKRASDAAATASSPALGTTNGDI-PGRRPSTPSSPS-LAAQISALCSPR 1660
               .::..||.:.:.|.:|......::|...:.|::.:| .|....|.:..| :::.:|.:..|.
Mouse   540 KVEAIMHAFESLEKRKKRRDQPVEQSSSDIEITTSSSEIVVGEETKTAAPESEVSSPVSNVAIPS 604

  Fly  1661 NIKTRGLTQAVHDPELEKMAKMAVVLRDICSAMETLKMSDLLTTVSSKKKKP-IKTTLSGKLGST 1724
            ..::.|                 |..|....|.:......:.....:|..:| .|:.:|....|:
Mouse   605 TPQSTG-----------------VNTRRSSHAGDVAAEKPIPKPPPAKPSRPRPKSRISRYRTSS 652

  Fly  1725 AATSKVEFRSI-------QAQVEQG---HYKTPQEFDDHMQQLFVEAKQQHGDDEGKEKALQSLK 1779
            |...|.:.::|       ||.:|:|   :..||.|..:      .::..::....|.:..:.|:.
Mouse   653 AQRLKRQKQAIAQQAELSQAALEEGGSNNSVTPPEAGN------TDSSGENRQLTGSDPTVISVT 711

  Fly  1780 DSYEQQKIASYVQLVEILGDSESLQSFKPKEVLSSEEEPGKIAVKKSPGAKERDSPI-VPLKVTP 1843
            .|:..:..:.|.               |.|:.|.:|....|        |::::.|: .||::|.
Mouse   712 GSHVNRAASKYP---------------KTKKYLVTEWLNDK--------AEKQECPVECPLRITT 753

  Fly  1844 PP--------LLP-IEASPDEDVIRCICGLYK-------------------DEGLMIQCSKCMVW 1880
            .|        :|| :..||      .||...|                   .:|....|.|..:.
Mouse   754 DPTVLATTLNMLPGLIHSP------LICTTPKHYIRFGSPFMPERRRRPLLPDGTFSSCKKRWIK 812

  Fly  1881 QHTECTKADIDADNYQCERCEPREVDREIPLEEFTEEGHRYYLSLMRGDLQVRQGDAVYVLRDIP 1945
            |..|                |.......:|.|..|:  |.|..:.......:
Mouse   813 QALE----------------EGMTQTSSVPQETRTQ--HLYQSNETSNSSSI------------- 846

  Fly  1946 IKDESGKVLPTKKHTYETIGAIDYQECDIFRVEHLWKNELGKRFIFGHH---FLRPHETFHEP-- 2005
            .||.:..:.|.||                      ||:    |::...:   .|:|......|
Mouse   847 CKDNADLLSPLKK----------------------WKS----RYLMEQNITKLLQPLSPVTPPPP 885

  Fly  2006 --------------------------SRRFYPNEVVRVSLYEVVPIELVIGRCWVLDRTTF---- 2040
                                      |..|.|...:..:.....|::..:.....||.|..
Mouse   886 SSGSKSPQLTTPGQTHPGEEECRNGYSLMFSPITSLTTASRSNTPLQFELCHRKDLDLTKVGFPD 950

  Fly  2041 -----CKGRP--MECNDED---HCYICELRVDKTARFFSKAKANHPACTKSYAFRKFPEKIKISK 2095
                 |..||  :.||..|   |..:    |..:...|.....:.|......:.:.|..:..:..
Mouse   951 SSTHSCADRPSLLNCNHPDLASHPSV----VPTSEAGFPSRSGDGPQTLLRNSDQAFRTEFNLMY 1011

  Fly  2096 SYAPHDVDP--------SLLKTRKQKTELDVG-AGPTTMHKVSGRQEQHQAKMVGRKPRGISAPA 2151
            :|:|.:..|        |.|...::...||.| ..|     ..|...:::...:....||..:|.
Mouse  1012 AYSPLNAMPRADGLYRGSPLVGDRKPLHLDGGYCSP-----AEGFSSRYEHGFMKDLSRGSMSPG 1071

  Fly  2152 DATAVHVVTPVAPNKQMLKKRKSRLENVLITMKLKCLDAQTAQEQPIDLSYLLSGRG--ARQRKT 2214
            .......| |.||.....:|:.|.||    ..|.|    |.|:|.        ||.|  :.|.|:
Mouse  1072 GERTCEGV-PSAPQNPPQRKKVSLLE----YRKRK----QEAKEN--------SGGGNDSSQSKS 1119

  Fly  2215 Q-----QSSSSSTANS 2225
            :     |.||:|.:::
Mouse  1120 KSSGAGQGSSNSVSDT 1135

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795	13/52 (25%)
		SET	1392..1512	CDD:214614	30/125 (24%)
		Bromo_ASH1	1680..1787	CDD:99955	21/117 (18%)
		PHD_ASH1L	1858..1900	CDD:277023	8/60 (13%)
		BAH_polybromo	1929..2073	CDD:240068	27/188 (14%)
Setd5	XP_006506740.1	SET_SETD5	292..441	CDD:380958	37/164 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030