DRSC/TRiP Functional Genomics Resources

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Protein Alignment ash1 and Kmt2e

DIOPT Version :9

Sequence 1:NP_001246834.1 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster
Sequence 2:NP_081260.1 Gene:Kmt2e / 69188 MGIID:1924825 Length:1868 Species:Mus musculus


Alignment Length:1473 Identity:272/1473 - (18%)
Similarity:483/1473 - (32%) Gaps:440/1473 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SCSQNETAAAKVLETQRAQESGSENEETDSITDQSSQSKSIKSATQFSVQRS-DTDGLRMRISAI 65
            ||:.|       .|.:...|.|:.:....||       :||...|:.::... |....:.::.. 
Mouse   410 SCTPN-------AEVRHEIEEGTIHLYIYSI-------QSIPKGTEITIAFDFDYGNCKYKVDC- 459

  Fly    66 RPTLGVVATKKPPKS--RKMSTQDTESGCSEAKNRAVSKKVKVKRKKLASSSGISKSDK-VSKSK 127
                  ...|:.|:.  .|.|::.||:         ::...:.:|||       .|.:| .||.|
Mouse   460 ------ACLKENPECPVLKRSSESTEN---------INSGYETRRKK-------GKKEKDTSKEK 502

  Fly   128 KSQISAFSSDSEDDLPLKVHQQRAPRVLLSAIIQAAQSASKPTLDIGISSSDNELPNLVQAAIKR 192
            ..|....:.|.|.               .:..|::.::..:....:.:|.|:|:.|:.:....::
Mouse   503 DIQNQNMTLDCEG---------------TNNKIRSPETKQRKLSPLRLSVSNNQEPDFIDDMEEK 552

  Fly   193 ------VESDTEDTTVEGSFRKAAKDKNLPQYQSTLLQDF--MEK-----TQMLGQTVNAK---- 240
                  ||.::|:...|...:...:::.:    ..:||.|  :||     .|.|.:...||    
Mouse   553 TPISNEVEMESEEQIAERKRKMTREERKM----EAILQAFARLEKREKRREQALERISTAKTEVK 613

  Fly   241 --------LAEEKVA--KAKEETLVQTAVPRKRR--------------GRPKKVVPTVPAPGNSG 281
                    :|:.:|.  :.||||.::.|..:..|              |:.::...||....:..
Mouse   614 PECKESQVIADAEVVQEQVKEETAIKPAAAKVNRTKQRKSFSRSRTHIGQQRRRHRTVSMCSDIP 678

  Fly   282 PAINESADSGVISTTSTTQSTTPSPKMQNENAV----PTGSLPIASSSKPKIDMAYLDKRMYATE 342
            |:   |.|..|:|..:..::|..:.:.:.|.||    |...:|..:....|.             
Mouse   679 PS---SPDIEVLSQQNEIENTVLAIEPETETAVAEIIPEAEVPALNKCPTKY------------- 727

  Fly   343 RVLYPPPRSKRR-------QNNKKTACSSSNKEELQLDPLWREIDVNKKFRLRSMSVGAASGTGA 400
                  |::|:.       :.|:||...|.:..|       |.:.:.....:.:..:.:..|   
Mouse   728 ------PKTKKHLVNEWLSEKNEKTGKPSDSLSE-------RPLRITTDPEVLATQLNSLPG--- 776

  Fly   401 STTICSKVLAAKSGYV---SDYGSVRHQRSSHNHN-SGYKSDASCKSRYSTKSCMSRRSRAKSCG 461
             .|....|.:....|:   |.:.|.:.:|.....| ||     |||.|: .|..:...:......
Mouse   777 -LTYSPHVYSTPKHYIRFTSPFLSEKKRRKETTENISG-----SCKKRW-LKQALEEENSTILHR 834

  Fly   462 YRSDCKESGKSGLRMRRKRRASMLLKSSAD-----DTVEDQDILQLAGLSLGQSSEESNE----- 516
            |.|.|:|..:|. .:..:.::.:||..|..     ..::.:.:.||...:..:||..:..     
Mouse   835 YHSPCQERSRSP-TVNGENKSPLLLSDSCSLPDLTTPLKKRRLYQLLDTAYSESSTPTPSPYATP 898

  Fly   517 -----------YISKPSLKS----------------LPTT-------------SASKKYGEINRY 541
                       :.:.|.:||                .|.|             |:.:...||.|.
Mouse   899 THTDITPTDPAFATPPRIKSDDETYRNGYKPIYSPVTPVTPGTPGNTMHFENISSPESSPEIKRC 963

  Fly   542 VTTGQYFGRGGSLSATNP----------------------------------------------D 560
            ....:.:.|..::....|                                              |
Mouse   964 TYNQEGYDRPSNMLTLGPFRNSNLTELGLQEIKTIGYTSPRSRTEVNRPCPGEKESVSDLQLGLD 1028

  Fly   561 NFISKMMNQRKETPAPSKS--SCKIKSRRSSAASMCSSYVSGVSRMRRRHRRKSFSHNKSLNIDS 623
            ......:.:..||||..::  |.::.|..|...:|.||:|....|.         ..|.|:|.:.
Mouse  1029 AVEPAALQKSMETPAHDRTEPSNQLDSTHSGRGTMYSSWVKSPDRT---------GVNFSVNSNL 1084

  Fly   624 KLLTEIEIITS-----TFNSRCRIQDDRLTG---------------SSGKEKLLADANKLQATLA 668
            :.||....:.:     ...|:|.||.|...|               :||..:.:.| |.:..:..
Mouse  1085 RDLTPSHQLETGGGFRVSESKCLIQQDDTRGMFLGAAVFCTSEDGLASGFGRTVND-NLIDGSCT 1148

  Fly   669 APSPAQQLTLNGGGPASTLSKPLKRGLKKRKLSEPLVDFAMLSASASGTPNGSGSSNGNTKRRHK 733
            ..:|.|:..:       :|.:..||..:.||......:||::|.|..  |:||.||:|:   ...
Mouse  1149 PQNPPQKKKV-------SLLEYRKRQREARKSGSKPENFALISVSPH--PSGSLSSSGD---GCV 1201

  Fly   734 KSQSNDSSSPDDHKLPLKKRHYLLTPGERPPAEVAFANGKLNAEAWAAAAAAAKSTASTKSQAQF 798
            .|..|...:.:...|||.           |||..|           ||.||||.|.:|.:..:..
Mouse  1202 HSSENGEQAENQASLPLP-----------PPAAAA-----------AATAAAAYSASSEEGSSNC 1244

  Fly   799 NARSVKSALTPKKRHLLEQPTSVSGAGSSASNSPLRIVV----DNNSISGGKLLDISPSSLCSLK 859
               .||.|.:.:|:....|.|:.:........|..|.::    ..:..|||:    ||...||..
Mouse  1245 ---PVKDANSSEKKDPEVQWTASTSVEQVRERSYQRALLLSDHRKDKDSGGE----SPCVSCSPS 1302

  Fly   860 QQRRGGAAKQKVSAAKDLVQLQSPAGSYPPPGVFEPSVELEIQIP-LSKLNESVITKAEVESPLL 923
                               .:|||..|:   ....|.|..:...| ||:|      .|:.::...
Mouse  1303 -------------------HVQSPPSSH---SNHIPQVHAQSLAPSLSEL------MADPDAEGT 1339

  Fly   924 SALDIKEDTKKEVGQRVVETLLHKTGGNLLLKRKRKKINRTGFPTVRRKKRKVSVEQQTTAVIDE 988
            .|....|....:..|...:|....:.|.:...:...||           ..|.....:.||.:.|
Mouse  1340 EATSTSECPSPDTSQSPSKTSKPGSPGPINPAQSHGKI-----------LTKPDSHWEATATVSE 1393

  Fly   989 HEPEFDPDDEPLQSLRETRSSNNVNVQAAPNPPLDCERVPQAGEARETFVARTNQKAPRLSVVAL 1053
            .:.....:.||    :..:.|:|       .|.|.....|||      .....|.:.|:....|.
Mouse  1394 ADNSVHQNPEP----QHRQLSSN-------TPALSQNHAPQA------HALSANDQLPQKLPSAP 1441

  Fly  1054 ERLQRPQTPARGRPRGRKPKNREQAEAAPQPPPKSEPEIRPAKKRGRQPKQPVLEEPPPTPPPQQ 1118
            .:|..|.:|                  ..:.||||.....|.:.....||.|......|..|   
Mouse  1442 TKLHCPPSP------------------HTENPPKSSTPHTPVQHGYLSPKPPSQHLGSPFRP--- 1485

  Fly  1119 KKNKMEPNIRLPDGIDPNTNFSCKIRLKRRKNLEAGTQPKKEKPVQPVTVEEIPPEIPVSQEEID 1183
             .:...|.:..|             :.:.::|..|..|..:..| |..|...:..:.|..|....
Mouse  1486 -HHSQSPQVGTP-------------QRETQRNFYAAAQNLQANP-QQATSGALFTQTPSGQSSAT 1535

  Fly  1184 -AEAEAKRLDSIPTEHDPLPASESHNPGPQDYASCSESSEDKASTTSLRKLSKVKKTYLVAG--- 1244
             ::...:.|:|......|.|...|:....|..|:....::.|.|.:        ::|...:|   
Mouse  1536 YSQFNQQSLNSTAPPPPPPPPPSSYYQNQQPSANFQNYNQLKGSLS--------QQTVFTSGPNQ 1592

  Fly  1245 -LFSNHYKQS-----LMPPPAKVNKKPGLEEQVGPASLLPPPP 1281
             |..:..:||     :.|.....::.|.:..|...|:::||||
Mouse  1593 ALPGSTSQQSVPGHHVTPGHFLPSQNPTIHHQPAAAAVVPPPP 1635

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ash1NP_001246834.1 AWS 1340..1388 CDD:197795
SET 1392..1512 CDD:214614
Bromo_ASH1 1680..1787 CDD:99955
PHD_ASH1L 1858..1900 CDD:277023
BAH_polybromo 1929..2073 CDD:240068
Kmt2eNP_081260.1 HCFC1-binding motif (HBM). /evidence=ECO:0000250|UniProtKB:Q8IZD2 63..66
PHD_MLL5 120..163 CDD:277025
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 178..197
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 217..268
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 308..329
SET_KMT2E 323..451 CDD:380959 12/54 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 472..504 12/47 (26%)
Smc 483..>716 CDD:224117 50/261 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 646..682 5/38 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 884..924 5/39 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1038..1068 10/29 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1165..1222 20/72 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1236..1315 20/107 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1334..1565 51/294 (17%)
Herpes_BLLF1 <1350..1609 CDD:282904 58/330 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1585..1842 12/51 (24%)
PRK03427 <1749..>1857 CDD:235124
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.030

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