DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ash1 and Setdb1

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	XP_006232975.1	Gene:	Setdb1 / 689883	RGDID:	1308370	Length:	1322	Species:	Rattus norvegicus

Alignment Length:	1806	Identity:	319/1806 - (17%)
Similarity:	555/1806 - (30%)	Gaps:	670/1806 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   420 GSVRHQRSSHNHNSGYKSDASCKSRYSTKSCMSRRSRAKSCGYRSDCKESGKSGLRMRRKRRASM 484
            |..:.|.|:...|||       :|..|...||                               |:
  Rat     4 GVFKSQLSTGKQNSG-------ESMSSLPGCM-------------------------------SL 30

  Fly   485 LLKSSADDTVEDQDILQLAGLSLGQSSEESNEYISKPSLKSLPTTSASKKYGEINRYVTTGQYFG 549
            ....:|.|:.|..::.|.....||.|.||..::|.:...|........|:..|:..:|
  Rat    31 AAAPAAADSAEIAELQQAVVEELGISMEELRQFIDEELEKMDCIQQRKKQLAELETWV------- 88

  Fly   550 RGGSLSATNPDNFISKMMNQRKETPAPSKSSCKIKSRRSSAASMCSSYVSG-VSRMRRRHRRKSF 613
                |...:...::.::.:.                 .|...:.|.|.|.. .|::..::
  Rat    89 ----LQKESEVAYVDRLFDD-----------------ASREVTNCESLVKDFYSKLGLQY----- 127

  Fly   614 SHNKSLNIDSKLLTEIEIITSTFNSRCRIQDDRLTGSSGK--EKLLADANKLQATLAAPSPAQQL 676
             |:.|.:.::...|||..|...       .||.|:..||.  .:...|....:|..|....||.:
  Rat   128 -HDSSSDDEASQPTEIIEIPDE-------DDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDV 184

  Fly   677 TLNGGGPASTLSKPLKRGLKKRKLSEPLVDFAMLSASASGTPNGSGSSNGN------------TK 729
                        :.....:.|:..|:.      |.....|..:|..|.:|:            ||
  Rat   185 ------------QKFMDAVNKKSSSQD------LHKGTLGQVSGELSKDGDLIVSMRILGKKRTK 231

  Fly   730 RRHKKSQSNDSSSPDDHKLPLK---KRHYLLTPGE-----RPPAEVAFANGKLNA------EAWA 780
            ..||.:.....:.....|..:|   |...||:...     .|||:..|...::.|      :.|.
  Rat   232 TWHKGTLIAIQTVGLGKKYKVKFDNKGKSLLSGNHIAYDYHPPADKLFVGSRVVAKYKDGNQVWL 296

  Fly   781 AAAAAAKSTASTKSQAQF--------NARSVKSALTPKKRHLLEQPTSVSGAG---------SSA 828
            .|...|: |.:.|::.:|        .:...:|.|.|..|.|.:....:..:.         ::.
  Rat   297 YAGIVAE-TPNVKNKLRFLIFFDDGYASYVTQSELYPICRPLKKTWEDIEDSSCRDFIEEYITAY 360

  Fly   829 SNSPLRIVVDNNSISGGKLLDISPSSLCSLKQQRRGGAAKQKVSAAK-DLVQ---LQSPAGSYPP 889
            .|.|:.:      :..|:|          :|.:..|...|.:|.... .||:   |......:
  Rat   361 PNRPMVL------LKSGQL----------IKTEWEGTWWKSRVEEVDGSLVRILFLDDKRCEW-- 407

  Fly   890 PGVFEPSVELEIQIPLSKLNESVITKAEVESPLLSALDIKEDTKKEVGQRVVETLLHKTGGNLLL 954
              ::..|..||....:...:.|.:.|                               |.||.|.
  Rat   408 --IYRGSTRLEPMFSMKTSSASAMEK-------------------------------KQGGQLR- 438

  Fly   955 KRKRKKINRTGFPTVRRKKRKVSVEQQTTAVIDEHEPEFDPDDEPLQSLRETRSSNNVNVQAAPN 1019
                   .|.....||.|...|...|..|:...:.:|.     ||||.:          |..||.
  Rat   439 -------TRPNMGAVRSKGPVVQYTQDLTSTGIQFKPM-----EPLQPI----------VPPAPL 481

  Fly  1020 PPLDCERVPQAG--EARETFVARTNQKAPRLSVVALERLQRPQTPARGR------------PRGR 1070
            |.|...  ||||  |:.|:.:|::.::..:.|...     ||.:.:.|.            |.|:
  Rat   482 PMLPLS--PQAGDSESLESQLAQSRKQVAKKSTSF-----RPGSVSSGHSSPTSPTLSENVPPGK 539

  Fly  1071 KPKNR-----------EQAEAAPQPPPKSEPEIRPAKKRGRQPKQPVLEEPPPTPPP---QQKKN 1121
            ...|:           ..|.|||..||              .|..|:....||.||.   ..::.
  Rat   540 IGMNQTYRSPSASVTSTPAPAAPSGPP--------------APPGPLAPPGPPAPPAFHGMLERA 590

  Fly  1122 KMEPNIRLPDG----IDPNTNFSCKIRLKRRKNLEAGTQPKKEKPVQPVTVEEIPPEIPVSQE-- 1180
            ..||:.|.|..    :....:::|..|::..:|    .|.:.:.|:.          :|:..:
  Rat   591 PAEPSYRAPMEKLFYLPHVCSYTCLSRIRPMRN----EQYRGKNPLL----------VPLLYDFR 641

  Fly  1181 EIDAEAEAKRLDSIPTEHDPLPASESHNPGPQDYASCSESSEDKASTTSLRKLSKVKKTYLVAGL 1245
            .:.|.....|.......:.               ..|.         ..||.:.::::.....|.
  Rat   642 RMTARRRVNRKMGFHVIYK---------------TPCG---------LCLRTMQEIERYLFETGC 682

  Fly  1246 FSNHYKQSLMPPPAKVNK-----KP---------GLEEQ----VGPASLLPPPPYCEKYLRRTEM 1292
            ...:.:...:.|...|::     ||         |.|:.    |......|||..
  Rat   683 DFLYLEMFCLDPYVLVDRKFQPFKPFYYILDITYGKEDVPLSCVNEIDTTPPPQV---------- 737

  Fly  1293 DFELPYDIWWAYTNSKLPTRNVVPSWNYRKIRTNVYAESVRPN-LAGFDHPTC--NCKNQGEKSC 1354
                      ||:..::|.:.|.       |.|.       |. |.|.|   |  .|:::.:.:|
  Rat   738 ----------AYSKERIPGKGVF-------INTG-------PEFLVGCD---CKDGCRDKSKCAC 775

  Fly  1355 --------------------------LDNCLNRMVY-----TECSPSNCPAGEKCRNQKIQRHAV 1388
                                      |:.||...||     .:|.|:      .|.|:.:| |.:
  Rat   776 HQLTVQATACTPGGQINPSSGYQHKRLEECLPTGVYECNKRCKCDPN------MCTNRLVQ-HGL 833

  Fly  1389 APGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHHYCLHLDGGLV 1453
            ...::.|.|.:||||:|....||||:::..|.|:::|: :|..:
  Rat   834 QVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTD-DFADK--------------------- 876

  Fly  1454 IDGQRMGSDCRFVN--HSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQ 1516
             :|..|| |..|.|  |                          ||..|.....|...:.:.|:..
  Rat   877 -EGLEMG-DEYFANLDH--------------------------IESVENFKEGYESDVPSSSDSS 913

  Fly  1517 PCRCNTPQCRGVIGGKSQRVKPLPAVEAKPSGEGLSGRNGRQRKQKAKKHAQRQAGKDISSAVAV 1581
                                    .|:.|...:|.||..            ..:...|.||....
  Rat   914 ------------------------GVDMKDQEDGNSGSE------------DPEESNDDSSDDNF 942

  Fly  1582 AKLQPLSEKEKKLVRQFNTFLV-RNFEKIRRCKAKRASDAAATASSPALGTTNGDIPGRRPSTPS 1645
            .|.:           .|:|..| |::...|:.:.::.|:.:...|..:.....|  |...|.|||
  Rat   943 CKDE-----------DFSTSSVWRSYATRRQTRGQKESELSEVTSKDSRAPDRG--PPHVPITPS 994

  Fly  1646 SPSLAAQISALCSPRNIKTRGLTQAVHDPELEKMAKMAVVLRDICSAMETLKMSDLLTTVSSKKK 1710
            . |:..     |:|              |..|:..|..|.....|:::.....:|      |..:
  Rat   995 G-SVGG-----CNP--------------PSSEETPKNKVASWLSCNSVSEGGFAD------SDSR 1033

  Fly  1711 KPIKTTL--SGKLG------STAATSKVEFRSIQAQVEQGHYKTPQEFDDHMQQLFVEAKQQHGD 1767
            ...||:.  .|:.|      ..|:||.:.|:. :...:|...:.|:  |.:...:..|..|.||.
  Rat  1034 SSFKTSEGGDGRAGGGRGEAERASTSGLSFKD-EGDSKQSKKEDPE--DRNKMSVVTEGSQNHGH 1095

  Fly  1768 DEG-KEKALQSLKDSYEQQKIASYVQLVEILGDSESLQSFKPKEVL---SSEEEPGKIAVKKSPG 1828
            :.. |.:.|         ::.||.:.:::......|.|| .|.::|   ||.|..|:....:.|.
  Rat  1096 NPPMKSEGL---------RRPASKISMLQSQRVVTSTQS-NPDDILTLSSSTESEGESGTSRKPT 1150

  Fly  1829 AKERDSPIVPLKVTPPPLLPIEASPDEDVIRCICGLYKDEGLMIQCSKCMVWQHTECTKADIDAD 1893
            ..:..:..|                |.|.|:.|                         .:..|.|
  Rat  1151 TGQTSATAV----------------DSDDIQTI-------------------------SSGSDGD 1174

  Fly  1894 NYQCERCEPREVDREIPLEEFTEEGHRYYLSLMRGDLQVRQGDAVYVLRDIPIKD------ESGK 1952
            :::.::.......|::.::.                   .:|.|:.....|.||.      :.|:
  Rat  1175 DFEDKKNLSGPTKRQVAVKS-------------------TRGFALKSTHGIAIKSTNMASVDKGE 1220

  Fly  1953 VLPTKKHTYETIGAIDYQE-CDIFRVEHLWKNELGKRFIFGHHFLRPH--------ETFHE---P 2005
            ..|.:|:|.:   ..|.:| |.|  ::...:..||:   :.:|...|:        :| |:   |
  Rat  1221 SAPVRKNTRQ---FYDGEESCYI--IDAKLEGNLGR---YLNHSCSPNLFVQNVFVDT-HDLRFP 1276

  Fly  2006 SRRFYPNEVVRVSL-------YEVVPIELVIGR-----CWVLDRTTFCKGR 2044
            ...|:.::.:|...       |||..:|   |:     |..::    |:||
  Rat  1277 WVAFFASKRIRAGTELTWDYNYEVGSVE---GKELLCCCGAIE----CRGR 1320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795	15/80 (19%)
		SET	1392..1512	CDD:214614	26/121 (21%)
		Bromo_ASH1	1680..1787	CDD:99955	22/115 (19%)
		PHD_ASH1L	1858..1900	CDD:277023	4/41 (10%)
		BAH_polybromo	1929..2073	CDD:240068	31/146 (21%)
Setdb1	XP_006232975.1	YlqD	<44..118	CDD:287979	16/101 (16%)
		TUDOR	277..337	CDD:197660	12/60 (20%)
		TUDOR	368..420	CDD:197660	12/65 (18%)
		MBD	629..704	CDD:128673	10/108 (9%)
		Pre-SET	714..827	CDD:282838	27/155 (17%)
		SET	835..>898	CDD:214614	25/112 (22%)
		SET	<1237..1299	CDD:214614	11/67 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352005
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840