Protein Alignment ash1 and ezh1

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: NP_001035072.2
• Gene: ezh1 / 664754
• ZFINID: ZDB-GENE-050114-1
• Length: 756
• Species: Danio rerio
• Alignment Length: 757
• Identity: 164/757 - (21%)
• Similarity: 263/757 - (34%)
• Gaps: 234/757 - (30%)

  Fly   915 KAEVESPLLSALDIKEDTKKEVGQRVVETLLHKTGGNLLLKRKRKKINRTGFPTVRRKKRKV--- 976
            |.||.:.||:     |:..|   .|:....|..:.|:  |..|:..:...|||:...:...:
Zfish    54 KIEVGTELLN-----EEWSK---LRIQSIPLSTSSGS--LPSKKLCMVEFGFPSFPNQAVAMRPL 108

  Fly   977 ------------SVEQQTTAVIDE---H------EPEFDPDDEPLQSLRETRSSNNVNVQAAPNP 1020
                        |..||...|.||   |      :...:.|:..|:.|.:       |.......
Zfish   109 TTVAGIPFMYSWSPLQQNFMVEDETFLHNIPYMGDEVLEQDEAFLEELID-------NYDGVHGD 166

  Fly  1021 PLDCERVPQAGEARETFVARTNQKAPRLSVVALERLQRPQTPARGR-----PRGRKPKNREQAEA 1080
            .:.|..:.:.|     |:   |.:..:..|.||.:...|:.....:     ...::.:.:|..::
Zfish   167 RVSCTFLIEGG-----FI---NDEIFKELVEALSQYSDPEEEEEEKEPTDAAENKQEEEKEMQKS 223

  Fly  1081 APQPPPKSEPEIRPAKKR----GRQ----PKQP-------VLEEPPPTPPPQQKKNK----MEP- 1125
            |.:.|.:|:......|.|    ||:    .|.|       :....|.....|:.|:|    :||
Zfish   224 AAEAPEESKTAFFKRKWRNTAEGRELSANKKIPHDKIFTAIASMFPYKGTMQELKDKYLDLLEPS 288

  Fly  1126 -NIRLPDGIDPNTNFSCKIRLKRRKNLEA-----------------------GTQPKKEKPVQPV 1166
             :::||....||.:......::|.::|.:                       ....:|.|.:...
Zfish   289 NHVKLPPLCTPNMDGPFAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHSSPNVYKRKSKEIHME 353

  Fly  1167 TVEEIPPEIPVSQEEIDAEAEAKRLDSIPT---EHDPLPASESHNPGPQDYASCSESSEDKASTT 1228
            | |....:..:.|:.....|:...:.|..|   ...|.|:|...:..|.......|...|..:|:
Zfish   354 T-EPCGLDCFLLQKGAKEFADQNMMRSQRTRRRRRQPRPSSSCGHTPPDSSEKGKEGGSDHETTS 417

  Fly  1229 SLRKLSKVKKTYLVAGLFSNHYKQSLMPPPAKVNKKPGLEEQVGPASLLPPPPY--CEKYLRRTE 1291
            |....|:.                     |:.:..|||.||.....|   ||.:  .|:.|.|.
Zfish   418 SSEGNSRC---------------------PSPIKMKPGEEESKESKS---PPQWSGAEESLFRV- 457

  Fly  1292 MDFELPYDIWWAYTNS---------------------------KLPTRN--VVPSWNYRKIR--- 1324
                    :...|.|:                           ::|..:  :.|....||.|
Zfish   458 --------LHGTYYNNFCSIARLIGTKTCREVYEFAVKEVLIDRMPLEDSGISPQKKKRKHRLWA 514

  Fly  1325 ----------TNVYAESVRPNLAGFDHP------TCNC---KNQGEK--SCLDNCLNRM----VY 1364
                      ..||      |....|||      :|.|   :|..||  .|...|.||.    ..
Zfish   515 KIQLKKDNSSNQVY------NYQPCDHPEHPCDSSCPCVITQNFCEKFCQCDRECQNRFPGCRCK 573

  Fly  1365 TECSPSNCP-----------------AGE-------KCRNQKIQRHAVAPGVERFM---TAD-KG 1401
            |:|:...||                 |.:       .|:|..|||     |:::.:   .:| .|
Zfish   574 TQCNTKQCPCYLAVRECDPDLCMTCGAADHWDSKQVSCKNCSIQR-----GLKKHLLLAPSDVAG 633

  Fly  1402 WGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHHYCLHLDGGLVIDGQRMGSDCRFV 1466
            ||...|.|:.|..:|.||.||::::.| ..|...||......:..:|:...|:|..|.|:..||.
Zfish   634 WGTFIKEPVQKNEFISEYCGELISQDE-ADRRGRIYDKYMSSFLFNLNNDFVVDATRKGNKIRFA 697

  Fly  1467 NHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFS 1508
            |||..|||..:...|||..|:.:||||||::||||.:||.:|
Zfish   698 NHSVNPNCYAKVVMVNGDHRIGIFAKRAIQQGEELFFDYRYS 739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	55/314 (18%)
		AWS	1340..1388	CDD:197795	22/86 (26%)
		SET_ASH1L	1391..1531	CDD:380951	47/122 (39%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
ezh1	NP_001035072.2	EZH2_WD-Binding	45..74	CDD:463308	8/27 (30%)
		PRC2_HTH_1	164..286	CDD:436286	22/129 (17%)
		SANT	447..489	CDD:238096	5/50 (10%)
		preSET_CXC	569..600	CDD:408079	4/30 (13%)
		SET_EZH1	617..752	CDD:380994	49/129 (38%)