DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ash1 and Spocd1

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	XP_017175994.1	Gene:	Spocd1 / 622480	MGIID:	3652045	Length:	1015	Species:	Mus musculus

Alignment Length:	1070	Identity:	201/1070 - (18%)
Similarity:	305/1070 - (28%)	Gaps:	443/1070 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   592 SMCSSYVSGVSRMRRRHRRKSFSHNKSLNIDSKLLTEIEIITSTFNSRCRIQDDRLTGSSGKEKL 656
            |:|....:|.||.         ....||:...::|...|                  |.:|.|:
Mouse    22 SLCDFLATGSSRS---------LCGTSLDFPDRVLVCTE------------------GPAGMEE- 58

  Fly   657 LADANKLQATLAAPSPAQQLTLNG-----------------GGPASTLSKPLKR----------- 693
                      .::||..|..|:.|                 |.|.|.:..|.:|
Mouse    59 ----------ASSPSFRQATTVEGMVSPEDPTLSKEGLSAKGPPPSPVLPPFRRKCRKCGICPQE 113

  Fly   694 ----GLKKRKLSEPLVD---------FA----MLSA--SASGTPNGSGSSNGNTKRRHKKSQSND 739
                |...|....|..|         ||    :||:  :..|.|.||...............|.|
Mouse   114 EEKSGFSLRFGQRPDGDPPECASPEAFAGPPRLLSSKDTEPGEPGGSWVECAVETEVENMLFSKD 178

  Fly   740 SSSPD--DH-----------KLPLKKRHYLLTPGERPPAEVAFANGKLNAEAWAAAAAAAKST-- 789
            ..:||  ||           .|.|..:..|.:|...|  ||...:.....|...|....:..|
Mouse   179 GVAPDSLDHLFEFPGLFGGEPLSLVTQEPLQSPALYP--EVLTEDSTDQQEVQPAFVVGSPGTPP 241

  Fly   790 --ASTKSQAQFNARSVKSALTPKKRHLLEQPTSVSGAGSSASNSPLRIVVDNNSISGGKLLDISP 852
              ...:.:||..:|..           |||..|......::|..||          ||  ||.:|
Mouse   242 DPVGPEDKAQSGSRME-----------LEQGLSAPANSCASSPEPL----------GG--LDGAP 283

  Fly   853 SSLCSLKQQRRGGAAKQKV--------------SAAKDLVQLQS--PAG---------------- 885
                  .:|||....|::.              ::.||..:|::  |.|
Mouse   284 ------LEQRRPTHVKKRPWTSPDDSSQDHAEGASKKDFPRLEARVPRGVKTVYYVYTGSGIRLV 342

  Fly   886 ---SYPPPGVFEPSVELEI-----------------------------------------QIPLS 906
               |...||..||..||:.                                         ..||.
Mouse   343 GAASSSQPGQIEPLEELDTNSARRKRRPTTAHPTPCQSDPSETENAEPHQQRAEDPGEQGMTPLD 407

  Fly   907 KLNESVITKAEVE-----SPLLSALDIKEDTKKEVGQRVVETLLHKT-GGNLLLKRKRKKI---- 961
            ....|.:.:|..|     :..|..|.::||..:.:.:.:.|.|.|.| ..||..|.|.:.:
Mouse   408 AGVRSTVVRAMQEVLWTRAQELPDLALREDEVEAIAEGIEEALFHLTQDTNLRYKNKYRSLLFNL 472

  Fly   962 --------------------NRTGFPTVRRKKRKVS-------------VEQQ--------TTAV 985
                                |.....:::...:::|             :|||        .:.:
Mouse   473 RDPRNVDLFLKVAHCDVTPNNLVQMSSIQLAPKELSRWRDQEERKGLDIIEQQQKELYRLPASKL 537

  Fly   986 IDEHEPEFDPDDEPLQSLRETRSSNNVNVQAAPNPPLDCERVPQAGEARETFVARTN-------- 1042
            ..:.|.|...|.:.:.:|.:...         |..|.:|...|.:....:|    ||
Mouse   538 THKGEVEIPRDLDQMLTLEDLME---------PIVPRECSLQPLSTPLEDT----TNWHQHHQCD 589

  Fly  1043 ------------QKA-----PRLSV---VALERLQRPQTPARGRPRGRKPKNREQ--AEAAPQPP 1085
                        :||     |.|.|   ..::|....:.||    ......|||:  .:.||.|.
Mouse   590 SNCQICTGGEEGRKADDGSQPELQVDISYNVDRKSSTKLPA----FSGVIMNREENAIQKAPGPA 650

  Fly  1086 PKSEPEIRPAKKRGRQPKQPV--------LEEPPPTPPPQQKKNKMEPNIRLPDGIDPNTNFSCK 1142
            |.|.||:  .|.....||:|.        |:..||:|||.:....|               ||.|
Mouse   651 PASSPEV--LKVGETPPKEPQDRLQMPAGLKNAPPSPPPWEGSLDM---------------FSIK 698

  Fly  1143 IRLKRRKNLEAGTQPKKEKPVQPVTVEEIPPEIPVSQEEIDAEAEAKRLDSIPTEH--DPLPASE 1205
             ..:.:..|.:|...:        .|:.:|          |....|.||   |..|  |.|.:.
Mouse   699 -HFRAKAQLISGHSCQ--------LVQALP----------DVIRSAGRL---PPSHVWDLLDSM- 740

  Fly  1206 SHNPGPQDYAS------CSESSEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQSLMPPPA----- 1259
                ||.....      |...|.|..:...|......|:.:.:|.:  ...|..|:|.||
Mouse   741 ----GPSKAKDICVIRLCPHGSRDIQNYRLLYSYLNNKQCHCLATV--QQVKMVLLPLPAFEPLP 799

  Fly  1260 ---KVNKKPGLE--------EQVGPASLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRN 1313
               :....||||        ..:.|...||.                         |.:.:|..|
Mouse   800 ARLRPLGGPGLEITHTSLLLAVLFPKDALPD-------------------------TATSIPVSN 839

  Fly  1314 VVP---SWNYRKIRTNVYAESVRPNLAGFDHPTCNCKNQGEKSCL--DNCLNRMVYTECSPSNCP 1373
            .||   |:: :::...:|:...|.:.|     |.:...:..|..|  .:...|.|   |:|.:.|
Mouse   840 KVPKTVSFS-KRVERILYSPEDRRSEA-----TSSPLEEDPKQSLARGSLAPRSV---CAPQSFP 895

  Fly  1374 AGEKCRNQKIQRHAVAPGVERFMTADKGWG 1403
            .|         |....|          |||
Mouse   896 RG---------RGRQGP----------GWG 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795	10/49 (20%)
		SET	1392..1512	CDD:214614	3/12 (25%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
Spocd1	XP_017175994.1	TFIIS_M	410..520	CDD:400056	17/109 (16%)
Spocd1	XP_017175994.1	SPOC	681..825	CDD:400205	38/187 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030