DRSC/TRiP Functional Genomics Resources

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Protein Alignment ash1 and KMT2C

DIOPT Version :9

Sequence 1:NP_001246834.1 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster
Sequence 2:XP_005250082.1 Gene:KMT2C / 58508 HGNCID:13726 Length:4983 Species:Homo sapiens


Alignment Length:1904 Identity:335/1904 - (17%)
Similarity:564/1904 - (29%) Gaps:734/1904 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    59 RMRISAIRPTLGVVATKKP--------------PKSRKMSTQDTESGCSEA-------------K 96
            ::.|....|..|.|:...|              |.|.....::.:....|.             :
Human  3374 QLPIKTCTPAPGTVSNANPQSGPPPRVEFDDNNPFSESFQERERKERLREQQERQRIQLMQEVDR 3438

  Fly    97 NRAVSKKVKVKRKKLASSSGISKSDKVSKSKKSQISAFSSDSEDDL-----PLK---VHQQRAPR 153
            .||:.:::::::..:..|. ||.    |::..|||..:|||...|.     ||:   .|||:..:
Human  3439 QRALQQRMEMEQHGMVGSE-ISS----SRTSVSQIPFYSSDLPCDFMQPLGPLQQSPQHQQQMGQ 3498

  Fly   154 VLLSAIIQAAQSAS-----------------------KPTLDIGISSSDNELPNLVQAAIKRVES 195
            ||....||.....|                       .|::.:|       .||.  :::|:...
Human  3499 VLQQQNIQQGSINSPSTQTFMQTNERRQVGPPSFVPDSPSIPVG-------SPNF--SSVKQGHG 3554

  Fly   196 DTEDTT-----VEGSFRKA------AKDKNLPQYQSTLL---QDFMEKTQMLGQTVNAKLAEEKV 246
            :...|:     |..||..|      ..:.:||..|.:.:   ..:...||.|.|..:..:.||| 
Human  3555 NLSGTSFQQSPVRPSFTPALPAAPPVANSSLPCGQDSTITHGHSYPGSTQSLIQLYSDIIPEEK- 3618

  Fly   247 AKAKEETLVQTAVPRKRRGRPKK---VVPTVPAPGNSGPAINESADSGVISTTSTTQSTTPS--P 306
                         .:|:|.|.||   ...:..||......|......|:..||||...:|||  |
Human  3619 -------------GKKKRTRKKKRDDDAESTKAPSTPHSDITAPPTPGISETTSTPAVSTPSELP 3670

  Fly   307 KMQNENAV-PTGSLPIASSSKPKIDMAYLDKRMYATERVLYPPPRSKRRQNNKKTACSSSNKEEL 370
            :..::.:| |.|      .|.|.:....|...:   |..|.....|:...|.:..|.|..:|..:
Human  3671 QQADQESVEPVG------PSTPNMAAGQLCTEL---ENKLPNSDFSQATPNQQTYANSEVDKLSM 3726

  Fly   371 QLDPLWREIDVNKKFRLRSMSVGAASGTGASTTICSKVLAAKSGYVSDYGSVRHQRSSHNHNSGY 435
            :......||.:.|                |.|..|.             |....:....|.:...
Human  3727 ETPAKTEEIKLEK----------------AETESCP-------------GQEEPKLEEQNGSKVE 3762

  Fly   436 KSDASCKSRYSTKSCMSRRSRAKSCGYRSDCKESGKSGLR-MRRKRRASMLLKSSADDTVEDQDI 499
            .:..:|       ...|.:|...|.|..:...:||...|: :.:.:::|.||....:.::..:| 
Human  3763 GNAVAC-------PVSSAQSPPHSAGAPAAKGDSGNELLKHLLKNKKSSSLLNQKPEGSICSED- 3819

  Fly   500 LQLAGLSLGQSSEESNEYISKPS-LKSLPTTSASKKYGEINRYVTTGQYFGRGGSLSATNPDNFI 563
                      ...:.|:.:.|.: .:.|.|..|..:.|           ||.|..|..|:..:..
Human  3820 ----------DCTKDNKLVEKQNPAEGLQTLGAQMQGG-----------FGCGNQLPKTDGGSET 3863

  Fly   564 SKMMNQRKETPAPSKSSCKIKSRRSSAASMCSSYVSGVSRMRRRHRRKSFSHNKSLNIDSKLLTE 628
            .|..::|.:... .|::.:.|.|:.......:.|.|          ..:|:|.|           
Human  3864 KKQRSKRTQRTG-EKAAPRSKKRKKDEEEKQAMYSS----------TDTFTHLK----------- 3906

  Fly   629 IEIITSTFNSRCRIQDDRLTGSSGKEKLLADANKLQATLAAPSPAQQLTLNGGGPASTLSKPLKR 693
                                                         |||:|               
Human  3907 ---------------------------------------------QQLSL--------------- 3911

  Fly   694 GLKKRKLSEPL--VDFAMLSASASGTPNGSGSSNGNTKRRHKKSQSNDSSSPDDHKLPLKKRHYL 756
                ..|.||:  |:||..      .|.|||..|...:.......:......|.:...:.|::.|
Human  3912 ----LPLMEPIIGVNFAHF------LPYGSGQFNSGNRLLGTFGSATLEGVSDYYSQLIYKQNNL 3966

  Fly   757 LTPGERPPAEV----------AFANGKLNAEAWAAAAAAAKSTASTKSQAQFNARSVKSALTPKK 811
            ..| ..|||.:          ..|||....|..|..|....|...||:            |.||.
Human  3967 SNP-PTPPASLPPTPPPMACQKMANGFATTEELAGKAGVLVSHEVTKT------------LGPKP 4018

  Fly   812 RHLLEQPTSVSGAGSSASNSPLRIVVDNNSISGGKLLDISPSSLCSLKQQRRGGAAKQKVSAAKD 876
            ..|..:|.....|.:.|              .|.|.:|: |:||.:.....            ::
Human  4019 FQLPFRPQDDLLARALA--------------QGPKTVDV-PASLPTPPHNN------------QE 4056

  Fly   877 LVQLQSPAGSYPPPGVFEPSVELE--IQIPLSKLNESVITKAE----VESPLL---------SAL 926
            .:::|...|....|..|.||...|  :.:.:|:..:..:.|.|    |.||::         |:.
Human  4057 ELRIQDHCGDRDTPDSFVPSSSPESVVGVEVSRYPDLSLVKEEPPEPVPSPIIPILPSTAGKSSE 4121

  Fly   927 DIKEDTKKEVGQRVVETLLHKTGGNLLLKRKRKKINRTGFPTVRRKKRKVSVEQQTTAVIDEHEP 991
            ..:.|.|.|.|.....:....:...          .|:|..:|.......:.|..::.|      
Human  4122 SRRNDIKTEPGTLYFASPFGPSPNG----------PRSGLISVAITLHPTAAENISSVV------ 4170

  Fly   992 EFDPDDEPLQSLRETRSSNNVNVQAAPNPP----LDCERVPQAGEARETFVAR----TNQKAPRL 1048
                  .....|...|..|:..|.:||:.|    :...|:....|.|:..:.|    .:...|||
Human  4171 ------AAFSDLLHVRIPNSYEVSSAPDVPSMGLVSSHRINPGLEYRQHLLLRGPPPGSANPPRL 4229

  Fly  1049 SVVALERLQRPQTP---------------------ARGRP------------------------- 1067
              |:..||::|..|                     |..||                         
Human  4230 --VSSYRLKQPNVPFPPTSNGLSGYKDSSHGIAESAALRPQWCCHCKVVILGSGVRKSFKDLTLL 4292

  Fly  1068 ------------------------------RGRKPKNREQAEAAPQPPPKSEPEIRPAKKRGRQ- 1101
                                          :.:..:|:|...:.||.|.:..|     .|...| 
Human  4293 NKDSRESTKRVEKDIVFCSNNCFILYSSTAQAKNSENKESIPSLPQSPMRETP-----SKAFHQY 4352

  Fly  1102 ------------PKQPVLEEPPPTPP---------------PQQKK--NKMEPNIRLPDGIDPNT 1137
                        |:.|....||.:||               |.:.|  .|::|.:|...|     
Human  4353 SNNISTLDVHCLPQLPEKASPPASPPIAFPPAFEAAQVEAKPDELKVTVKLKPRLRAVHG----- 4412

  Fly  1138 NF-SCKIRLKRRKNLEAGTQPKKEKPVQPVTVEEIPPE---IPVSQEEIDAEAEAKRLDSIPTEH 1198
            .| .|:...|:.:    |.:.||      .::..:.|:   .|..::|||     :.|..:.|..
Human  4413 GFEDCRPLNKKWR----GMKWKK------WSIHIVIPKGTFKPPCEDEID-----EFLKKLGTSL 4462

  Fly  1199 DPLPASESHNPGPQDYASCSESSEDKASTT----------------------------------- 1228
            .|       :|.|:||..|....|:....|                                   
Human  4463 KP-------DPVPKDYRKCCFCHEEGDGLTDGPARLLNLDLDLWVHLNCALWSTEVYETQAGALI 4520

  Fly  1229 ----SLRKLSKVK-----KTYLVAGLF----SNHY---------------KQSLMPPPAKVNKKP 1265
                :||:..::|     ||...:|..    :|.|               |..|.|    ::|..
Human  4521 NVELALRRGLQMKCVFCHKTGATSGCHRFRCTNIYHFTCAIKAQCMFFKDKTMLCP----MHKPK 4581

  Fly  1266 GLEEQVGPASLLPPPPYCEK--------YLRRTEMD----------------------------- 1293
            |:.||......:....|.::        .::|.|.|                             
Human  4582 GIHEQELSYFAVFRRVYVQRDEVRQIASIVQRGERDHTFRVGSLIFHTIGQLLPQQMQAFHSPKA 4646

  Fly  1294 -FELPYD---IWWA--YTNSK---------------------------LPTRNVVPSWNYRKIRT 1325
             |.:.|:   ::|:  |.|.:                           |...::.|...:.||..
Human  4647 LFPVGYEASRLYWSTRYANRRCRYLCSIEEKDGRPVFVIRIVEQGHEDLVLSDISPKGVWDKILE 4711

  Fly  1326 NV---------------YAES-------------VRPNLAGFDHPTCNCKN----QGEKSCLDNC 1358
            .|               |.:.             :..:|.|.:    .|:|    .|....::..
Human  4712 PVACVRKKSEMLQLFPAYLKGEDLFGLTVSAVARIAESLPGVE----ACENYTFRYGRNPLMELP 4772

  Fly  1359 LNRMVYTECSPSNCPAGEKCRNQKIQRHAV-----------------------APGVERFMTAD- 1399
            |      ..:|:.|...|...:..::|..:                       ||..::|:.:. 
Human  4773 L------AVNPTGCARSEPKMSAHVKRFVLRPHTLNSTSTSKSFQSTVTGELNAPYSKQFVHSKS 4831

  Fly  1400 ---------------------KGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHH 1443
                                 :|.|:.....|.|.|.::||:|.:: ..|...|...:|.:....
Human  4832 SQYRKMKTEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGTII-RNEVANRKEKLYESQNRG 4895

  Fly  1444 -YCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNF 1507
             |...:|...|||....|...|::||||.|||..:..:.....::::.:.|.|::||||.|||.|
Human  4896 VYMFRMDNDHVIDATLTGGPARYINHSCAPNCVAEVVTFERGHKIIISSSRRIQKGEELCYDYKF 4960

  Fly  1508 SLFNPSEGQPCRCNTPQCR 1526
            ...:.....||.|....||
Human  4961 DFEDDQHKIPCHCGAVNCR 4979

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ash1NP_001246834.1 AWS 1340..1388 CDD:197795 8/51 (16%)
SET 1392..1512 CDD:214614 36/142 (25%)
Bromo_ASH1 1680..1787 CDD:99955
PHD_ASH1L 1858..1900 CDD:277023
BAH_polybromo 1929..2073 CDD:240068
KMT2CXP_005250082.1 ePHD1_KMT2C 248..331 CDD:277166
PHD1_KMT2C_like 344..389 CDD:276984
PHD2_KMT2C 391..436 CDD:277069
PHD3_KMT2C 467..518 CDD:276986
PHD4_KMT2C 953..1009 CDD:277071
PHD5_KMT2C_like 1010..1056 CDD:276988
RanBP2-type Zn finger 1085..1107 CDD:275375
PHD6_KMT2C 1087..1137 CDD:277073
HMG-box 1671..1722 CDD:294061
DUF2962 1709..>1792 CDD:288077
SYCE1 <3198..3287 CDD:291886
ePHD2_KMT2C 4474..4578 CDD:277167 14/107 (13%)
FYRN 4624..4674 CDD:283589 5/49 (10%)
FYRC 4680..4761 CDD:283590 10/84 (12%)
SET <4797..4983 CDD:225491 43/184 (23%)
SET 4844..4965 CDD:214614 35/121 (29%)
PostSET 4967..4983 CDD:214703 5/13 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158057
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.870

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