Protein Alignment ash1 and kmt2cb

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: XP_009296384.1
• Gene: kmt2cb / 568162
• ZFINID: ZDB-GENE-070705-340
• Length: 4892
• Species: Danio rerio
• Alignment Length: 2002
• Identity: 348/2002 - (17%)
• Similarity: 621/2002 - (31%)
• Gaps: 658/2002 - (32%)

  Fly     5 QNETAAAKVLETQRAQESGSENEETDSITDQSSQSK--SIKSATQFSVQRS-------------- 53
            |.:....:.:..||:.:|...|.:.|:|||...::|  ::|...:..||.:
Zfish  3065 QQQQKQMQAMIRQRSSDSFFPNIDFDAITDPIMKAKMVALKGINKMMVQNNMGMSPMVINNAQTG 3129

  Fly    54 ----DTDG------LRMRISAIRPTLGVVATKKPPKSRKMSTQDTESGCSEAKNRAVSKKVKVKR 108
                ||||      |..:.|.:.|.   :|...||........||:....|...|...:.:::::
Zfish  3130 QALPDTDGNITPMQLPGQDSKLAPH---IARPNPPNFGTGFAHDTQKAQYEDWLRETQQLLQMQQ 3191

  Fly   109 KKLASSSGISKSDKVSKSKKSQIS--AFSSDSEDD------------------------------ 141
            |.|....|..:..|.:.|.|.:.:  |.....|:|
Zfish  3192 KFLEEQIGAHRKSKKALSAKQRTAKKAGREFPEEDAEQLKHVTEQQGVVQKQLEQIRKQQKEHAE 3256

  Fly   142 --------------------------------------------LPLKVHQQ------------- 149
                                                        :|:::|..
Zfish  3257 LIEEYRVKQQQQGALQPPIMPGMQPPAGMMQVGPPINQSMVGPMMPIRLHSNQPDVTKMPNTAGW 3321

  Fly   150 ----------RAPRVLLSAIIQ---AAQSASKPTLDIGISSSDNELPNL---------------- 185
                      |.|.|:.:.::|   ...:|::||.    ..:..|.|::
Zfish  3322 HPGAPVPTGPRMPGVMPAQVVQPQPLQPAAARPTQ----VQAGGESPHVNFDDTNPFSEGFQERE 3382

  Fly   186 ------------VQAAIKRVE-------------SDTEDTTVEGSFRKAAKDKNLPQYQSTLLQD 225
                        ....||.||             |:.:|.|:.|.       ..:|.|...|.||
Zfish  3383 RKERLREQQERQRMQIIKEVERQHVKHCVEQQQVSNCQDGTMRGL-------SQMPFYNQELPQD 3440

  Fly   226 FMEKTQMLGQTVNAKLAEEKVAKAKEETLVQTAVPRKRRGRPKKVVPTVPAPGNSGPAI---NES 287
            ||:..::..|.......::   :..::..:        .|.|:.::...|.|...|...   |.:
Zfish  3441 FMQPPRLQQQIQGPTFPQQ---QGTQQGYI--------GGPPRPLLGNGPFPQEMGSGFAPQNLA 3494

  Fly   288 ADSGVISTTSTTQSTTPSPKMQNENAV---------PTGSLPIASSSKPKIDMAYLDKRMYATER 343
            .....:....|.......|.|..:|..         ||...|......|.:...|.:
Zfish  3495 VHGPNLIQAQTRPQRYSVPHMMAQNPPQGHPFPMEGPTPLPPNFPGPGPSLIQLYSN-------- 3551

  Fly   344 VLYPPPRSKRRQNNKKTACSSSNKEELQLDPLWREIDVNKKFRLRSMSVGAASGTGASTTICSKV 408
             :.|..:.|:::|.||       |::...:.|          |..|......|...|..|.|
Zfish  3552 -IIPEEKGKKKRNQKK-------KKDEDCESL----------RAPSTPHTPHSDMTAPLTPC--- 3595

  Fly   409 LAAKSGYVSDYGS--VRHQRSSHNH------NSGYKSDASCKSRYSTKSCMSRRSRAKSCGYRSD 465
                   |||..|  .|:.....:|      ..|..:..|..|:  ..|.:.|:....|||
Zfish  3596 -------VSDTSSTPTRNPMVFGDHEFCETSQPGSSTPGSMSSQ--PHSELERQLSEGSCG---- 3647

  Fly   466 CKESGKSGLRMRRKRRASMLLKSSADDTVEDQDI-----LQLAGLSLGQSSEESNEYISKPSLKS 525
                |.....|..:.....:|.:...:.||..|.     :.:. :.:|....|....:..||.:|
Zfish  3648 ----GGPESAMGHEEMHDRILSNIKLEKVEANDCHGHKPIDME-IRIGMVKVEREIMLHHPSSQS 3707

  Fly   526 LPTTSASKKYG-EINRYV---------------------------TTGQYFGRGGSLSAT----- 557
             |..|:.::.| |:.:::                           |..:.|.|..|:.:|
Zfish  3708 -PANSSKEEGGNELLKHLLKNKRTPPHALPHQRSEDSLRSEEEGSTESKAFFRQNSMDSTGTFSD 3771

  Fly   558 -NPDNF------ISKMMNQRKETP----APSKSSCKIKSRRSSAASMCSSYVSGVSRMRRRHRR- 610
             |..:|      ..|...:.|.||    .|:....|.|.....:.::.||....::.::::|..
Zfish  3772 SNHQDFPGPLILEDKKKQRNKRTPKSGDRPAPRCKKRKKEEDESQAVYSSTDPMITPLKQQHLSL 3836

  Fly   611 ---------KSFSH-----NKSLNIDSKLLTEIEIITSTFNSRCRIQDDRLTGSSG-------KE 654
                     .:|:|     ...|:.:::|       :.||.|.      .|.|.|.       |:
Zfish  3837 LPLMEPLVGVNFAHLMPYGGGQLDGENRL-------SGTFGSA------SLDGVSDYYSQLIYKQ 3888

  Fly   655 KLLADANKLQATLAAPSP---AQQLTLNGGGPASTLSK--------PLKRGLKKRKLSEPLVDFA 708
            ..|::.....|:| .|:|   |:|..|||......|::        .:.:||..|.|.....:..
Zfish  3889 NNLSNPPTPPASL-PPTPPPVARQKLLNGFATTEELARKGGLIAGHDVTKGLLARPLEFKAEEEL 3952

  Fly   709 MLSASASG--TPNGSGS----SNGNTKRRHKKSQSNDSSSPDDHKLPLKKRHYLLTPGERPPAEV 767
            :..|.|.|  |.|...|    .:.|.:....:....|.::||.           ..|...|.:.|
Zfish  3953 LAQALAQGPKTVNVPASLPTPPHNNQEELRGQEHCEDRNTPDS-----------FVPSSSPESVV 4006

  Fly   768 AFANGKLNAEAWAAAAAAAKSTASTKSQAQFNARSVKSALTP-------KKRHLLEQPTSVSGAG 825
            .....:.            ...:..|.:....|.|....:.|       |.:.:..:|:||....
Zfish  4007 GMEISRY------------PDLSLVKEEPPSPAMSPVIPMFPVFRDKDVKLQEVKTEPSSVFFDS 4059

  Fly   826 SSASNSPLRIVVDNNSISGGKLLDISPSSLCSLKQQRRGGAAK---QKVSAAKDLVQLQ------ 881
            |..|       |.|.|.:|          |.|:....:..||:   ..|:|..||::::
Zfish  4060 SFRS-------VQNGSNTG----------LVSIAIMLKPAAAENITDVVAAIADLIRVKIPSSYE 4107

  Fly   882 ---SPAGSYPPPGVFEPSVELEIQIPLSKLNESVITKAEVESPLLSALDIKEDTKKEVGQRVVET 943
               .|.||:   |..:.||:.:.                    |.|||.......::..|.::
Zfish  4108 VSSGPGGSF---GAIKTSVDPQC--------------------LASALPNGPRALRQAPQHLL-- 4147

  Fly   944 LLHKTGGNLLLKRKRKKINRTGFPTVRRKKRKVSVEQQTTAVIDEHEPEFDPDDEPLQS------ 1002
            |.|....|:..::.|....|.|......:..||.|..:....|.:.| |..|.:..|.|
Zfish  4148 LQHNHNKNIGGEQYRDGQVRPGSKQQWCQHCKVVVLGKGVRKITKDE-EVKPQESRLCSDGGLVF 4211

  Fly  1003 -------LRETRSSNNVNVQAAPNPPLDCERVPQAGEARETFVARTNQKAPRLS---VVALERLQ 1057
                   |..:.|.:|.|.....:.||..|     ...:::|....:|.:..:|   |..|.:||
Zfish  4212 CSHSCLILHSSSSQSNGNADNKASVPLLSE-----SALKQSFSKVQHQYSNNMSSLDVHCLAQLQ 4271

  Fly  1058 -RPQTPARGRPRGRKPKNREQAEAAPQP--------PPKSEPEIRP----------AKKRGRQPK 1103
             :|.:||........|....:.|:.|:.        ..|.:|.:..          .:.:|.:.:
Zfish  4272 PKPSSPAPYLHMAFAPAKAIKTESKPRSISEGHLKVTVKLKPRLHSHLEDKQWHHGKRWKGLRWR 4336

  Fly  1104 QPVLEEPPPTPPPQQKKNKMEPNIR---------------------------LPDG--------I 1133
            :..::...|...||..::::|..::                           :.||        :
Zfish  4337 KWTIDIAMPKVAPQSSESELEERLKQLTTSLRPCLTIRDQRRCCFCQQIGDGMTDGPARLLNLDL 4401

  Fly  1134 DPNTNFSC----------------KIRLKRRKN-------------------------------L 1151
            |...:.:|                .:.|.|::.                               |
Zfish  4402 DTWVHLNCALWSSEVYETQAGALINVGLARQRGQTVVCAFCQRLGATSGCHRLRCLNIYHFTCAL 4466

  Fly  1152 EAGTQPKKEKPV-----QP--------VTVE------EIPPEIPVSQEEIDAEAEAK-------- 1189
            :||....|:|.:     :|        :.||      .:...:.|.::|:...|.|.
Zfish  4467 QAGCTFFKDKTMLCHQHRPRGAGAAAGLHVEHQLRCFSVFRRVYVQRDELRQLAAAVQQPERGHT 4531

  Fly  1190 -RLDSI-------------PTEHDPL----PASES--------HNPGPQDYASCSESSEDKASTT 1228
             |:.|:             ||.|...    |..|:        |......|. ||....:..:..
Zfish  4532 FRVGSLLFHAMGQLPPALMPTFHSSTAIFPPGYEATRLYWSMRHGQKRCRYV-CSVEEHEGRAEF 4595

  Fly  1229 SLRKLSKVKKTYLVAGLFSNHYKQSLMPPPAKVNKKPGLEEQVGPASLLPPPPYCEKYLRRTEMD 1293
            |:|.:.:..:..::....:....:.::.|.|:...:.|:      ..|.|      .||:..::
Zfish  4596 SIRVIEQGYEDLVLTDTSAKGVWEKVLGPVAERRAETGM------LRLFP------IYLKGEDL- 4647

  Fly  1294 FELPYDIWWAYTN--SKLPTRNVVPSWNYRKIRTNVYAESVRPNLAGFDHPTCNCKNQGEKSCLD 1356
            |.|...   |.|.  ..||.......:.:|..|..:....:..|.:|..........|.|:..:.
Zfish  4648 FGLTIS---AVTRIAESLPGVEACSRYRFRYGRNPLLVLPLSMNSSGSARSELQTYPQHERVKIL 4709

  Fly  1357 NCLNRMVYTECSPSNCPAGEKCRNQKIQRHAVAPGVERFMTAD------------KGWGVRTKLP 1409
            :...|:  :.|..::..|.....:.|...|:.:....| :.:|            :|.|:.....
Zfish  4710 SSWPRI--SRCIQNSTVAASASSHSKHFVHSKSSQYRR-LASDWKSNVYLAHSRIQGLGLFAARA 4771

  Fly  1410 IAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNC 1474
            |.|.|.::||:|:::..:...:|.......:...|...:|...|||....||..|::||||.|||
Zfish  4772 IEKQTMVIEYMGDILRTEVAMRRELLYKAKNRPAYMFCIDSERVIDATNSGSPARYINHSCSPNC 4836

  Fly  1475 EMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCR 1526
            ..:..:.....::::.|...||.||||.|||..:..|.....||.|...:||
Zfish  4837 VAEVVTFERGYKIIISAACRIERGEELCYDYKLTPVNDQSKIPCHCGAAKCR 4888

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	59/419 (14%)
		AWS	1340..1388	CDD:197795	7/47 (15%)
		SET_ASH1L	1391..1531	CDD:380951	42/148 (28%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
kmt2cb	XP_009296384.1	PHD_SF	232..319	CDD:473978
		PHD1_KMT2C_like	332..377	CDD:276984
		PHD2_KMT2C	379..424	CDD:277069
		PHD3_KMT2C	459..507	CDD:276986
		PHD_SF	947..1003	CDD:473978
		PHD5_KMT2C_like	1004..1050	CDD:276988
		PHD_SF	1081..1131	CDD:473978
		HMG-box_KMT2C	1672..1752	CDD:438835
		PHA03247	<1871..2385	CDD:223021
		GBP_C	<3168..3268	CDD:460721	13/99 (13%)
		PHA03247	<3273..3602	CDD:223021	58/386 (15%)
		PHD_SF	4379..4483	CDD:473978	11/103 (11%)
		FYRN	4535..4586	CDD:461787	9/51 (18%)
		FYRC	4595..4676	CDD:461788	16/96 (17%)
		SET	4739..4891	CDD:394802	42/151 (28%)