DRSC/TRiP Functional Genomics Resources

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Protein Alignment ash1 and setd1ba

DIOPT Version :10

Sequence 1:NP_524160.2 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster
Sequence 2:NP_001038599.2 Gene:setd1ba / 567970 ZFINID:ZDB-GENE-050309-289 Length:1844 Species:Danio rerio


Alignment Length:1775 Identity:343/1775 - (19%)
Similarity:549/1775 - (30%) Gaps:658/1775 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 ETQRAQESGSENEETDSITDQSSQSKSIKSATQ-----FSVQRSDTDG-LRM---RISAIRPTLG 70
            |||......|..|...|.| |.|:..|:.|..:     |..:|.|:|. :||   .||:....|.
Zfish   467 ETQPTTPPSSTPEPCPSPT-QESERNSLDSRIEMLLKPFLNERGDSDAEVRMDGSPISSSSSQLS 530

  Fly    71 VVATKKPPKSRKMSTQDTESGCSEAKNRAVSKKVKVKRKKLASSSGISKSDKVSKSKKSQISAFS 135
            .:..::|  ||..||...:...:...:....:.::.....||:|.|:|.::..|||...:     
Zfish   531 PIPPQRP--SRPSSTGLEDISPTPLPDSEDDEPIRGTASLLANSRGMSPTNMHSKSCVGE----- 588

  Fly   136 SDSEDDLPLKVHQQRAPRVLLSAIIQAAQSASKPTLDIGISSSDNELPN------------LVQA 188
                            ||..:..:....||:.:   |:.|  ||:|:|.            :|.:
Zfish   589 ----------------PRTAIDKMDTGHQSSGE---DMEI--SDDEMPGTPIASGDCDKNIVVNS 632

  Fly   189 AIKRVESD-----------------------TEDTTVE---------------GSFRKAAKD--K 213
            |:..:::.                       ...:||.               |.......|  .
Zfish   633 ALSLIQTIPMPPPGFPPLPHAAGFPLPPHHLPHHSTVSHLPSHHPMLHPLHSYGMMHFLPVDLLS 697

  Fly   214 NLPQYQSTLLQ-DFMEKTQMLGQTVNAKLAEEKVAKAKEETLVQTAVPRKRRGRPKKVVPTVPAP 277
            :|||    ||| .|..:||||          .::|:::.    ..|.|             .|||
Zfish   698 SLPQ----LLQMPFQMQTQML----------SRMAQSQH----PYAYP-------------YPAP 731

  Fly   278 GNSGPAINESADSGVISTTSTTQSTT-----PSPKMQNEN-AVPTGSLPIASSSKPKIDMAYLDK 336
            ..:..|:........:|..|....|.     |.|.|...| |||.   |.....|.....|.:|.
Zfish   732 SANPAAMPFGGPYPPLSVVSAPADTLHGQPWPLPSMPQFNPAVPP---PGYEPQKEDPHKATIDG 793

  Fly   337 RMYATERVLYPPPRSKRRQNNKKTACSSSNKEELQLDPLWREIDVNKKFRLRSMSVGAASGTGAS 401
            .:.|..:.|  ....|:..|.|.....:..|    .|..|.:.:::.|..|..:..|..      
Zfish   794 VLMAIVKEL--KAIMKKDLNRKMVEVVAFRK----FDEWWDKQELSAKATLTPVKTGEG------ 846

  Fly   402 TTICSKVLAAKSGYVSDYGSVRHQRSSHNHNSGYKSDASCKSRYSTKSCMSRR---SRAKSCGYR 463
                                              |.:.  |.|...|..||..   ::.:..|:.
Zfish   847 ----------------------------------KDEE--KERAKPKETMSSHLPWNKGEGLGFE 875

  Fly   464 SDCKESGKSGLRM-----RRKRRASMLLKSS---------ADDTVEDQDILQLAGLSLGQSSEES 514
            ......|..|:|:     :||:.......|.         .||.:||::                
Zfish   876 GMGLGIGLRGIRLPSFKVKRKQPPEPTSTSDNKRVRPSTPVDDELEDEE---------------- 924

  Fly   515 NEYISKPSLKSLPTTSASKKYGEINRYVTTGQYFGRGGSLSATNPDNFISKMMNQRKETPAPSKS 579
                             |::.|.     |.|......||.|...|...:.......:|.....|.
Zfish   925 -----------------SERMGR-----TDGSRVDPAGSSSKRRPARPLELDSEGEEEEETSGKE 967

  Fly   580 SCKIKSRRSSAASMCSSYVSGVSRMRRRHRRKSFSH-NKSLNIDSKLLTEIEIITSTFNSRCRIQ 643
            ...:...........|..:|....:.....:||.|| ::|.:.||                   .
Zfish   968 ESSLSDHEEEPVDDASERLSSGKDLEEEDEKKSESHSSESESSDS-------------------S 1013

  Fly   644 DDRLTGSSGKEKLLADANKLQATLAAPSPAQQLTLNGGGPASTLSKPLKRGLKKRKLSEPLVDFA 708
            ||.                                                              
Zfish  1014 DDE-------------------------------------------------------------- 1016

  Fly   709 MLSASASGTPNGSGSSNGNTKRRHKKSQSNDSSSPDDHKLPLKKRHYLLTPGERPPAEVAFANGK 773
              ::|:|.:.:||.||..      :.|...:|||.::               |....|.....|.
Zfish  1017 --ASSSSSSKSGSDSSGS------ESSSDYESSSEEE---------------EEEEEEEERIVGM 1058

  Fly   774 LNAEAWAAAAAAAKSTASTKSQAQFNARSVKSALTPKKRHLLEQPTSVSGAGSSASNSPLRI-VV 837
            .:.|...|..:.:.||.||.|..:.....||:..||......|:|..:.           |: .|
Zfish  1059 DDEEDVDARTSTSSSTTSTSSSDEEEVVEVKAPSTPTGPPPEEEPNELG-----------RLEAV 1112

  Fly   838 DNNSISGGKLLDISPSSLCSLKQQRRGGAAKQKVSAAKDLVQLQSPAGSYPPPGVFEPSVELEIQ 902
            |...|      |..||.:..:         |.||    :.|:..||.| .|..   |..|:||::
Zfish  1113 DEAEI------DHKPSMVSLI---------KTKV----EEVRPPSPKG-LPAD---ELDVDLEVK 1154

  Fly   903 IPLSKLNESVITKAEVE--------SPLLSALDIKEDTKKEVGQRVVETLLHKTGGNLLLKRKRK 959
            ||:.|      |:|.:|        :|..|..|..:||                         |.
Zfish  1155 IPVPK------TEASLEEVGNLRPPTPTGSFADSDQDT-------------------------RP 1188

  Fly   960 KINRTGFPTVRRKKRKVSVEQQTTA-----------------VIDEHE----PEFDPD------- 996
            ||....||.....:..|.:|.:||.                 |.|...    ||..||       
Zfish  1189 KIPTEDFPRTPGHEGPVPLESETTVPRSLPTPSMHLPLPPSHVPDPQSLLPPPETLPDMPVRGRL 1253

  Fly   997 ----DEP----------LQSLRETRSSNNVNVQAAPNPPLDCERV--PQAGEARETFVARTNQKA 1045
                |.|          .:.|.:.:|::.|.|....:.||....:  |....:..::.|    ::
Zfish  1254 PTEEDIPRTPGRDLMDRARGLGKLQSTDTVPVTPGSDTPLTGNSLSSPHILGSPFSYPA----QS 1314

  Fly  1046 PRLSVVALERLQRPQTPAR----------------GRPRGRKPKNR--EQAEAAPQPPPKSEPEI 1092
            |.||...      |:||.|                |.|..||..:.  |:.....:|...:.|:.
Zfish  1315 PVLSAGI------PRTPGRDLTFAPAFPDSAGLSAGLPIHRKASSEILEEKPLFKEPLLSASPQA 1373

  Fly  1093 ----RPAKKRGRQPKQPVLEEPPPTPPPQ-------------QKKNKMEPNIRLPDGIDPNTNFS 1140
                ..|......|..|....|.|..|||             ..|....|.|.:|..:|...:..
Zfish  1374 SLPNNAASSPFPGPPLPTASLPEPALPPQGSPPASIENSFPASPKELPVPMIDVPVPLDDTPSKK 1438

  Fly  1141 CKIRLKRRKNLEAGTQPKKEKPVQPVTVEEIP--PEIPVSQEEIDAEAEAKRLDSIPTEHDPLPA 1203
            ..:|.|.:|.::...:|:       ||:.|..  ||:||:.:..|..:|:.:      |.|..||
Zfish  1439 KLVRSKNKKGIQDSEEPQ-------VTLIEASSLPELPVNNQYPDLPSESIK------EEDGEPA 1490

  Fly  1204 SESHNPGPQDYASCSESSEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQSLMPPPAKVNK-KPGL 1267
                         .||..|.:..|.    :.||::|        :.|.:.   |..|..: :.|.
Zfish  1491 -------------FSEKEESQVPTI----IPKVEET--------SFYVEE---PIQKTRRQRRGW 1527

  Fly  1268 EEQVGPASLLPP--PPYCEKYLRRTEMDFE---LPYDIWWAYTNSKLPTRNVVPSWNYRKIRTNV 1327
            :|.:  .|:..|  .|....::.|:  |||   :.||||    |..:...::    .|.||   .
Zfish  1528 QELL--LSMHSPVASPRRPSFMPRS--DFEEMTILYDIW----NDGIDEEDI----RYLKI---T 1577

  Fly  1328 YAESVRPNLA--------GFDHPTCNC----------KNQGEKSCLDNCL-----------NRMV 1363
            |.:.::.:.|        ...||..|.          |..|.:..:..|.           ::|.
Zfish  1578 YDKMLQQDNAHDWLNDTLWVHHPPTNMGSATGVKKKRKEDGIRDHVTGCARSEGYYKIDKKDKMK 1642

  Fly  1364 YTECS----------------PS----NCPAGEKCRNQ--------------------KIQRHAV 1388
            |...|                |:    :..||.:.|::                    |.::..:
Zfish  1643 YLNSSRLQSEEPDVDTQGKSIPAQPQVSTRAGSERRSEQRRLLSSFSCDSDLLKFNQLKFRKKKI 1707

  Fly  1389 APGVERFMTAD-KGWGVRTKLPIAKGTYILEYVGEVV-------TEKEFK-QRMASIYLNDTHHY 1444
                 ||..:. ..||:....|||....::||||:.:       .||.:: :.:.|.|:      
Zfish  1708 -----RFCRSHIHDWGLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYEDEGIGSSYM------ 1761

  Fly  1445 CLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSL 1509
             ..:|...:||..:.|:..||:||||.|||..:..:|....::|:::::.|...||:||||.|.:
Zfish  1762 -FRVDHDTIIDATKCGNFARFINHSCNPNCYAKVITVESQKKIVIYSRQPINVNEEITYDYKFPI 1825

  Fly  1510 FNPSEGQPCRCNTPQCRGVI 1529
              ..|..||.|....|||.:
Zfish  1826 --EDEKIPCLCGAENCRGTL 1843

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ash1NP_524160.2 PHA03247 <1018..1281 CDD:223021 62/304 (20%)
AWS 1340..1388 CDD:197795 14/108 (13%)
SET_ASH1L 1391..1531 CDD:380951 45/148 (30%)
Bromo_ASH1 1680..1787 CDD:99955
PHD_ASH1L 1858..1900 CDD:277023
BAH_polybromo 1929..2073 CDD:240068
setd1baNP_001038599.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 18..58
RRM_Set1B 136..228 CDD:409965
PABP-1234 <145..333 CDD:130689
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 269..288
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 295..562 25/97 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 838..871 8/74 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 890..1108 54/370 (15%)
PHA03247 <1136..1500 CDD:223021 91/434 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1160..1341 40/215 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1367..1499 34/157 (22%)
N-SET 1556..1699 CDD:463344 23/153 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1647..1678 4/30 (13%)
RxxxRR motif. /evidence=ECO:0000250|UniProtKB:P38827 1678..1683 1/4 (25%)
SET_SETD1 1693..1840 CDD:380946 43/160 (27%)
Blue background indicates that the domain is not in the aligned region.

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