DRSC/TRiP Functional Genomics Resources

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Protein Alignment ash1 and nsd1b

DIOPT Version :9

Sequence 1:NP_001246834.1 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster
Sequence 2:XP_005173940.1 Gene:nsd1b / 564592 ZFINID:ZDB-GENE-080519-2 Length:1873 Species:Danio rerio


Alignment Length:1666 Identity:348/1666 - (20%)
Similarity:555/1666 - (33%) Gaps:473/1666 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   129 SQISAFSSDSED-------------DLPLKVHQQRAPRVLLSAIIQ-----------AAQSASKP 169
            |..|||.:.||:             |||      .:..::..|:||           .:::..||
Zfish   252 SPSSAFKTISEETINNTEIKVSVPVDLP------NSSFLINGAVIQNNHLNSLPHNRKSKNKKKP 310

  Fly   170 TLD-IGISSSDNELPNLVQAAIKRVESDTEDTTVEGSFRKAAKDKNLPQYQSTLLQDFMEKTQML 233
            |:. ..||...|....::..|:....||.:               ::||     ::.|.:.    
Zfish   311 TISHCRISEELNCEKGMIMDALDSPYSDID---------------SVPQ-----IRRFPKS---- 351

  Fly   234 GQTVNAKLAEEKVAKAKEETLVQTAVPRKRRGRPKKVVPTVPAPGNSG---------PAINESAD 289
                |.:::...|...|:.:...|.:|.......||.|.      |.|         ..:|..:.
Zfish   352 ----NEQISNHYVINYKQSSATPTVLPSTNDKDVKKNVE------NQGGLWFSKTGKGQVNGISR 406

  Fly   290 SGVISTTST----------TQSTTPSPKMQNENAVPTGSLPIASSSKPKIDMAYLDKRMYATERV 344
            :|:.|...:          ..|.:..|| .|.|   ||...:::.:|..:|...  |.:.|:.|:
Zfish   407 AGIKSVNCSFGKVSCKIKMPDSASMKPK-DNHN---TGLEHLSTEAKKALDRRV--KCLPASSRL 465

  Fly   345 LYPPPRS-KRRQNNKKTACSSSNKEELQL-----DPLWREIDVNKKFRLRSMSVGAA------SG 397
            :   .|: |..::.:.|..|||:.|....     .|.....||:....|:.|...|.      |.
Zfish   466 M---TRALKAMEDAEWTKESSSDLETKNCVSSFDSPSLETSDVHNSILLQKMPTAAIHDLKEDSK 527

  Fly   398 TGASTTICSKVLAAKSGYVSDYGSVRHQRSSHNHNSGYKSDASCKSRYSTKSCMSRRSRAKSCGY 462
            ......:.|::|..|    .|..||:.:     ..|...|.|.|....||:         |...:
Zfish   528 ISTHAKLSSELLCCK----DDEHSVKSE-----DESSLVSQAPCAFHSSTR---------KQNSH 574

  Fly   463 RSDCKESGKSGLRMRRKRRAS--------------------------------MLLKSSADDTVE 495
            .:|...|....|.:..|...:                                |:||...|...:
Zfish   575 VNDLSSSPTPSLHLNLKDMDNMNEISFKSLANEHSGQPLSFHPDSNYKFSTFLMMLKDMHDSREK 639

  Fly   496 DQDILQLAGLSLGQSSEESNEYISKPSLKSLPTTSASKKYGEINRYVTTGQYFGRGGSLSATNPD 560
            |.::|.:..|...:...|....||  .:|....||..||.......::...       |::|   
Zfish   640 DGNVLVVEPLPTTELINEEPLLIS--DVKDEKATSKQKKVKPKTNVMSENH-------LAST--- 692

  Fly   561 NFISKMMNQRKETPAPSKSSCKIKSRRSSAASMCSSYVSGVSRMRRRHR--RKSFSHNKSLNIDS 623
              |||         ...:||.||..::.:.....:.......::...||  .|....|.|.|:..
Zfish   693 --ISK---------TAQRSSKKISLKKKTTDIKANIDYKSFDKLISAHRLTSKEAETNFSANVPK 746

  Fly   624 KLLTEIEIITS----TFNSRCRIQDDRLTGSSGKEKLLADANKLQATLAAPSPAQQLTLNGGGPA 684
            |...:.:.::.    .....|..:.:|:  ||....:..|...........:.:..|..|.|...
Zfish   747 KRWQKFDQVSEKTVHIVEGNCIHKTERV--SSENCDVSMDGTNKSCFFGPETTSNALECNQGNCQ 809

  Fly   685 ST--------LSKPLKR--------------------------GLKKRKLSEPLVDFAMLSASAS 715
            :|        :.||.||                          .::.:|.|||:   |.......
Zfish   810 NTEAPTECKRIRKPSKRLIEWTEEYDQLFSAKKKAKKKPDSVTKIENQKCSEPV---AKTYDEVK 871

  Fly   716 GTPNGSGSSNGNTKRRHKKSQS-----NDSSSPDDHKLPLKKRHYLLTPGERPPAEVAFANGKLN 775
            ..|.   .:..:..||..:.|:     ...|:|..:.||.::...|......||.|:        
Zfish   872 QKPQ---VTEQDVSRRLPELQTPPPEDQSQSTPLINTLPCQESQVLSAETLTPPPEI-------- 925

  Fly   776 AEAWAAAAAAAKSTASTKSQAQFNARSVKSALTPKKRHLLEQPTSVSGA---GSSASNSPLRIVV 837
                   ..:.....|.:.|.|                 .:.|.:|..:   .|.....|.:.::
Zfish   926 -------IPSPCDNISNRDQLQ-----------------RQNPVAVGDSVCLNSKRQRKPTKKIL 966

  Fly   838 DNNSISGGKLL----DISPSSLCSLKQQRRGGAAKQKVSAAKDLVQLQSPAGSYPPPGVFEPSVE 898
            : :||....:|    .:....:||.......| .:|:.|.:|:.:.::|   |.||......|.|
Zfish   967 E-SSIEAEPILIPKRKMKSMKICSSGHSTNSG-VEQQSSKSKNKLSIES---SDPPSDPMLKSTE 1026

  Fly   899 LEIQIPLSKLNESVITKAEVESPLLSALDIKEDTKKEVGQRVVETL-------LHKTGGNLLLKR 956
            :||.:     :.:|:.....||     .|...||.:..|.::.|:.       .:.....:||..
Zfish  1027 MEIDV-----SPAVLQTINTES-----ADDGSDTLRCSGSQMTESSEFYSEREENSQSDKVLLDS 1081

  Fly   957 KRKKINRTGFPTVRRKKRKVSVEQQTTAVIDEHE------PEFDPDDEPLQSLRETRSSNNVNVQ 1015
            :|....:.|..:|:.....: .|:|...::.|.:      |:....:||                
Zfish  1082 RRLSEEKGGSTSVKENVCPM-CEKQGDLLLCEGQCCGAFHPQCTGLNEP---------------- 1129

  Fly  1016 AAPNPPLDCERVPQAGEARETFVA-RTNQKAPRLSVVALERLQRPQTPARGRPRGRKPKNREQAE 1079
              |.....|:.....  ....|.. |..:...|..|....:....:..|...|  ..|.||  |.
Zfish  1130 --PTGKFLCQECTSG--VHSCFACKRLGEDVRRCMVPGCGKFYHGECAASHAP--TVPLNR--AF 1186

  Fly  1080 AAPQPPPKSEPEIRPAK---KRG---RQPKQPVLEEPPPTPPPQQKKNKMEPNIRLPDGIDP--- 1135
            ..|.....|...:.||.   .:|   |..:.||.........|.......:.||..|:...|   
Zfish  1187 RCPLHACLSCFILNPANPSVAKGQLTRCIRCPVAYHSSDFCIPAGSVTLTDSNIVCPNHFTPRKG 1251

  Fly  1136 -------NTNF--------------SCKIRLKRR-------------KNLEAGTQPKKEKPV--- 1163
                   |.::              ||.....|.             .:..||.:|..::.|   
Zfish  1252 CRNHEHVNVSWCFVCSEGGSLLCCESCPAAFHRECLNIDMPEGSWYCNDCRAGKKPHYKEVVWVK 1316

  Fly  1164 ------QPVTVEEIPPEIPVSQEEIDAEAEAKRLDSIPTEHDPLPASESHNP----GPQDY---- 1214
                  .|..|.. |.:||   |.|           :..:||     ....|    |..||    
Zfish  1317 VGRYRWWPAEVSN-PKDIP---ENI-----------LRMKHD-----VGEFPVLFFGSNDYLWTY 1361

  Fly  1215 -ASCSESSEDKASTTSLRKLSK-VKKTYLVAGLFSNHYKQSLMPPPAKVNKKPGLEEQVGPASLL 1277
             |......|..|:  |..|:.| |..||                       |..|:|    |:|.
Zfish  1362 QARVFPYMEGDAN--SKEKMGKGVDSTY-----------------------KKALDE----AALR 1397

  Fly  1278 PPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSWNYRKIRTNVYAESVRPNLAGFDH- 1341
            ......||.||:.:.|          ..|.|.|.       .|::|:.|.....|....|.... 
Zfish  1398 FKELQAEKELRQLQED----------RRNDKKPP-------PYKQIKVNKPFGKVLIISADLSEI 1445

  Fly  1342 PTCNCKNQGEKSC-LDN-CLNRMVYTECSPSNCPAGEKCRNQKIQRHAVAPGVERFMTADKGWGV 1404
            |.||||...|..| :|: |:|||:..||.|..|||||:|:||...:..... ||.|.|..:|||:
Zfish  1446 PRCNCKATDENPCGMDSECINRMLLYECHPQVCPAGERCQNQCFIKRQYCQ-VETFRTLSRGWGL 1509

  Fly  1405 RTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDT-HHYCLHLDGGLVIDGQRMGSDCRFVNH 1468
            |....|.||.:|.||||||:.|:|.:.|:.....|:. :.|.|.||...:||....|::.||:||
Zfish  1510 RCVHDIKKGGFISEYVGEVIDEEECRARIKHAQENNIGNFYMLTLDKDRIIDAGPKGNEARFMNH 1574

  Fly  1469 SCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCRGVIGGKS 1533
            .|:||||.|||:|||.:|:.||:...|..|.|||::||.......: ..|:|....|.|.:|   
Zfish  1575 CCQPNCETQKWTVNGDTRVGLFSLTDIPAGTELTFNYNLECLGNGK-TVCKCGASNCSGFLG--- 1635

  Fly  1534 QRVKPLPAVEAKPSGEGLSGRNGRQRKQKAKKHAQRQAGKD 1574
                      .:|.....|...||:.|:|.|  :|::..|:
Zfish  1636 ----------VRPKNNPPSDDKGRKLKKKRK--SQQEVIKE 1664

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ash1NP_001246834.1 AWS 1340..1388 CDD:197795 23/50 (46%)
SET 1392..1512 CDD:214614 54/120 (45%)
Bromo_ASH1 1680..1787 CDD:99955
PHD_ASH1L 1858..1900 CDD:277023
BAH_polybromo 1929..2073 CDD:240068
nsd1bXP_005173940.1 PWWP 132..>204 CDD:321985
TOP2c <652..1020 CDD:330395 74/435 (17%)
PHD_SF 1098..1140 CDD:328929 8/60 (13%)
PHD_SF 1145..1191 CDD:328929 11/49 (22%)
PHD_SF 1193..1245 CDD:328929 11/51 (22%)
PHD4_NSD1 1262..1301 CDD:277126 3/38 (8%)
WHSC1_related 1307..1401 CDD:99899 29/142 (20%)
AWS 1444..1494 CDD:197795 23/49 (47%)
SET 1497..1618 CDD:214614 54/120 (45%)
PHD5_NSD1 1668..1710 CDD:277129
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170593831
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D507784at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.880

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