Protein Alignment ash1 and nsd1b

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: XP_005173940.1
• Gene: nsd1b / 564592
• ZFINID: ZDB-GENE-080519-2
• Length: 1873
• Species: Danio rerio
• Alignment Length: 1666
• Identity: 348/1666 - (20%)
• Similarity: 555/1666 - (33%)
• Gaps: 473/1666 - (28%)

  Fly   129 SQISAFSSDSED-------------DLPLKVHQQRAPRVLLSAIIQ-----------AAQSASKP 169
            |..|||.:.||:             |||      .:..::..|:||           .:::..||
Zfish   252 SPSSAFKTISEETINNTEIKVSVPVDLP------NSSFLINGAVIQNNHLNSLPHNRKSKNKKKP 310

  Fly   170 TLD-IGISSSDNELPNLVQAAIKRVESDTEDTTVEGSFRKAAKDKNLPQYQSTLLQDFMEKTQML 233
            |:. ..||...|....::..|:....||.:               ::||     ::.|.:.
Zfish   311 TISHCRISEELNCEKGMIMDALDSPYSDID---------------SVPQ-----IRRFPKS---- 351

  Fly   234 GQTVNAKLAEEKVAKAKEETLVQTAVPRKRRGRPKKVVPTVPAPGNSG---------PAINESAD 289
                |.:::...|...|:.:...|.:|.......||.|.      |.|         ..:|..:.
Zfish   352 ----NEQISNHYVINYKQSSATPTVLPSTNDKDVKKNVE------NQGGLWFSKTGKGQVNGISR 406

  Fly   290 SGVISTTST----------TQSTTPSPKMQNENAVPTGSLPIASSSKPKIDMAYLDKRMYATERV 344
            :|:.|...:          ..|.:..|| .|.|   ||...:::.:|..:|...  |.:.|:.|:
Zfish   407 AGIKSVNCSFGKVSCKIKMPDSASMKPK-DNHN---TGLEHLSTEAKKALDRRV--KCLPASSRL 465

  Fly   345 LYPPPRS-KRRQNNKKTACSSSNKEELQL-----DPLWREIDVNKKFRLRSMSVGAA------SG 397
            :   .|: |..::.:.|..|||:.|....     .|.....||:....|:.|...|.      |.
Zfish   466 M---TRALKAMEDAEWTKESSSDLETKNCVSSFDSPSLETSDVHNSILLQKMPTAAIHDLKEDSK 527

  Fly   398 TGASTTICSKVLAAKSGYVSDYGSVRHQRSSHNHNSGYKSDASCKSRYSTKSCMSRRSRAKSCGY 462
            ......:.|::|..|    .|..||:.:     ..|...|.|.|....||:         |...:
Zfish   528 ISTHAKLSSELLCCK----DDEHSVKSE-----DESSLVSQAPCAFHSSTR---------KQNSH 574

  Fly   463 RSDCKESGKSGLRMRRKRRAS--------------------------------MLLKSSADDTVE 495
            .:|...|....|.:..|...:                                |:||...|...:
Zfish   575 VNDLSSSPTPSLHLNLKDMDNMNEISFKSLANEHSGQPLSFHPDSNYKFSTFLMMLKDMHDSREK 639

  Fly   496 DQDILQLAGLSLGQSSEESNEYISKPSLKSLPTTSASKKYGEINRYVTTGQYFGRGGSLSATNPD 560
            |.::|.:..|...:...|....||  .:|....||..||.......::...       |::|
Zfish   640 DGNVLVVEPLPTTELINEEPLLIS--DVKDEKATSKQKKVKPKTNVMSENH-------LAST--- 692

  Fly   561 NFISKMMNQRKETPAPSKSSCKIKSRRSSAASMCSSYVSGVSRMRRRHR--RKSFSHNKSLNIDS 623
              |||         ...:||.||..::.:.....:.......::...||  .|....|.|.|:..
Zfish   693 --ISK---------TAQRSSKKISLKKKTTDIKANIDYKSFDKLISAHRLTSKEAETNFSANVPK 746

  Fly   624 KLLTEIEIITS----TFNSRCRIQDDRLTGSSGKEKLLADANKLQATLAAPSPAQQLTLNGGGPA 684
            |...:.:.::.    .....|..:.:|:  ||....:..|...........:.:..|..|.|...
Zfish   747 KRWQKFDQVSEKTVHIVEGNCIHKTERV--SSENCDVSMDGTNKSCFFGPETTSNALECNQGNCQ 809

  Fly   685 ST--------LSKPLKR--------------------------GLKKRKLSEPLVDFAMLSASAS 715
            :|        :.||.||                          .::.:|.|||:   |.......
Zfish   810 NTEAPTECKRIRKPSKRLIEWTEEYDQLFSAKKKAKKKPDSVTKIENQKCSEPV---AKTYDEVK 871

  Fly   716 GTPNGSGSSNGNTKRRHKKSQS-----NDSSSPDDHKLPLKKRHYLLTPGERPPAEVAFANGKLN 775
            ..|.   .:..:..||..:.|:     ...|:|..:.||.::...|......||.|:
Zfish   872 QKPQ---VTEQDVSRRLPELQTPPPEDQSQSTPLINTLPCQESQVLSAETLTPPPEI-------- 925

  Fly   776 AEAWAAAAAAAKSTASTKSQAQFNARSVKSALTPKKRHLLEQPTSVSGA---GSSASNSPLRIVV 837
                   ..:.....|.:.|.|                 .:.|.:|..:   .|.....|.:.::
Zfish   926 -------IPSPCDNISNRDQLQ-----------------RQNPVAVGDSVCLNSKRQRKPTKKIL 966

  Fly   838 DNNSISGGKLL----DISPSSLCSLKQQRRGGAAKQKVSAAKDLVQLQSPAGSYPPPGVFEPSVE 898
            : :||....:|    .:....:||.......| .:|:.|.:|:.:.::|   |.||......|.|
Zfish   967 E-SSIEAEPILIPKRKMKSMKICSSGHSTNSG-VEQQSSKSKNKLSIES---SDPPSDPMLKSTE 1026

  Fly   899 LEIQIPLSKLNESVITKAEVESPLLSALDIKEDTKKEVGQRVVETL-------LHKTGGNLLLKR 956
            :||.:     :.:|:.....||     .|...||.:..|.::.|:.       .:.....:||..
Zfish  1027 MEIDV-----SPAVLQTINTES-----ADDGSDTLRCSGSQMTESSEFYSEREENSQSDKVLLDS 1081

  Fly   957 KRKKINRTGFPTVRRKKRKVSVEQQTTAVIDEHE------PEFDPDDEPLQSLRETRSSNNVNVQ 1015
            :|....:.|..:|:.....: .|:|...::.|.:      |:....:||
Zfish  1082 RRLSEEKGGSTSVKENVCPM-CEKQGDLLLCEGQCCGAFHPQCTGLNEP---------------- 1129

  Fly  1016 AAPNPPLDCERVPQAGEARETFVA-RTNQKAPRLSVVALERLQRPQTPARGRPRGRKPKNREQAE 1079
              |.....|:.....  ....|.. |..:...|..|....:....:..|...|  ..|.||  |.
Zfish  1130 --PTGKFLCQECTSG--VHSCFACKRLGEDVRRCMVPGCGKFYHGECAASHAP--TVPLNR--AF 1186

  Fly  1080 AAPQPPPKSEPEIRPAK---KRG---RQPKQPVLEEPPPTPPPQQKKNKMEPNIRLPDGIDP--- 1135
            ..|.....|...:.||.   .:|   |..:.||.........|.......:.||..|:...|
Zfish  1187 RCPLHACLSCFILNPANPSVAKGQLTRCIRCPVAYHSSDFCIPAGSVTLTDSNIVCPNHFTPRKG 1251

  Fly  1136 -------NTNF--------------SCKIRLKRR-------------KNLEAGTQPKKEKPV--- 1163
                   |.::              ||.....|.             .:..||.:|..::.|
Zfish  1252 CRNHEHVNVSWCFVCSEGGSLLCCESCPAAFHRECLNIDMPEGSWYCNDCRAGKKPHYKEVVWVK 1316

  Fly  1164 ------QPVTVEEIPPEIPVSQEEIDAEAEAKRLDSIPTEHDPLPASESHNP----GPQDY---- 1214
                  .|..|.. |.:||   |.|           :..:||     ....|    |..||
Zfish  1317 VGRYRWWPAEVSN-PKDIP---ENI-----------LRMKHD-----VGEFPVLFFGSNDYLWTY 1361

  Fly  1215 -ASCSESSEDKASTTSLRKLSK-VKKTYLVAGLFSNHYKQSLMPPPAKVNKKPGLEEQVGPASLL 1277
             |......|..|:  |..|:.| |..||                       |..|:|    |:|.
Zfish  1362 QARVFPYMEGDAN--SKEKMGKGVDSTY-----------------------KKALDE----AALR 1397

  Fly  1278 PPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSWNYRKIRTNVYAESVRPNLAGFDH- 1341
            ......||.||:.:.|          ..|.|.|.       .|::|:.|.....|....|....
Zfish  1398 FKELQAEKELRQLQED----------RRNDKKPP-------PYKQIKVNKPFGKVLIISADLSEI 1445

  Fly  1342 PTCNCKNQGEKSC-LDN-CLNRMVYTECSPSNCPAGEKCRNQKIQRHAVAPGVERFMTADKGWGV 1404
            |.||||...|..| :|: |:|||:..||.|..|||||:|:||...:..... ||.|.|..:|||:
Zfish  1446 PRCNCKATDENPCGMDSECINRMLLYECHPQVCPAGERCQNQCFIKRQYCQ-VETFRTLSRGWGL 1509

  Fly  1405 RTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDT-HHYCLHLDGGLVIDGQRMGSDCRFVNH 1468
            |....|.||.:|.||||||:.|:|.:.|:.....|:. :.|.|.||...:||....|::.||:||
Zfish  1510 RCVHDIKKGGFISEYVGEVIDEEECRARIKHAQENNIGNFYMLTLDKDRIIDAGPKGNEARFMNH 1574

  Fly  1469 SCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCRGVIGGKS 1533
            .|:||||.|||:|||.:|:.||:...|..|.|||::||.......: ..|:|....|.|.:|
Zfish  1575 CCQPNCETQKWTVNGDTRVGLFSLTDIPAGTELTFNYNLECLGNGK-TVCKCGASNCSGFLG--- 1635

  Fly  1534 QRVKPLPAVEAKPSGEGLSGRNGRQRKQKAKKHAQRQAGKD 1574
                      .:|.....|...||:.|:|.|  :|::..|:
Zfish  1636 ----------VRPKNNPPSDDKGRKLKKKRK--SQQEVIKE 1664

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	60/325 (18%)
		AWS	1340..1388	CDD:197795	23/50 (46%)
		SET_ASH1L	1391..1531	CDD:380951	58/140 (41%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
nsd1b	XP_005173940.1	PWWP	130..244	CDD:470613
		PHD_SF	1098..1140	CDD:473978	8/60 (13%)
		PHD_SF	1145..1191	CDD:473978	11/49 (22%)
		PHD_SF	1193..1245	CDD:473978	11/51 (22%)
		PHD4_NSD1	1262..1301	CDD:277126	3/38 (8%)
		PWWP	1308..1403	CDD:470613	28/143 (20%)
		AWS	1454..1492	CDD:465559	18/37 (49%)
		SET	1494..1635	CDD:394802	58/142 (41%)
		PHD5_NSD1	1668..1710	CDD:277129
		C5HCH	1709..1758	CDD:465605