DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ash1 and ash1l

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	XP_005159540.1	Gene:	ash1l / 563799	ZFINID:	ZDB-GENE-030131-6101	Length:	2988	Species:	Danio rerio

Alignment Length:	2711	Identity:	723/2711 - (26%)
Similarity:	1104/2711 - (40%)	Gaps:	717/2711 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SCSQNETAAAKVLETQRAQESGSENEETDSITDQSSQSKSIKSATQFSVQRSDTDGLRMRISAIR 66
            |.|:.|..:.|..|..|.:::.|..:.:..||...:..:..|.....|..|:|    |.:.|:
Zfish   484 SPSRIEDFSEKDKERDREKDTDSPRDLSKGITPAITGKQDAKERCSLSAPRND----RGKSSS-- 542

  Fly    67 PTLGVVATKKPPKSRKMSTQDTESGCSEAKNRAVSKKVKVKRKKLASSSGISKSDKVSKSKKSQI 131
                  ..|:.|        :.||..|...:.|.|.|..:..   :..||.|:|..........|
Zfish   543 ------PVKRSP--------NQESRVSGVPSPAESTKCTISP---SYPSGASRSPPPLCDDTGAI 590

  Fly   132 SAFSSDSEDDLPLKVHQQRAPRVLLSAIIQAAQSASK--------PT-LDIGISSSDNELPNLVQ 187
            |..|...:|..|||..:.|.|| ...|:.:..:|..:        || :..|:|.|     :.::
Zfish   591 SPASPSEQDSKPLKKRRGRRPR-WTKAVSRTHKSLHESPSNHQQIPTPMPSGLSFS-----SPIR 649

  Fly   188 AAIKRVESDT----EDTTVEGSFRKAAKDKNLPQYQSTLLQDFMEKTQM-------LGQTVNAKL 241
            .::::..||:    ||:.:   |..:.|.:..|            ||:|       .|.|.| ||
Zfish   650 ESVEQPLSDSYTSPEDSDI---FDSSPKKRGRP------------KTKMPRLDAPAHGCTPN-KL 698

  Fly   242 AEEK----VAKAKEETLVQTAVPR----------KRRGRPKKVVPTVP--------APGNSGPAI 284
            |..|    :.|:|||.......|.          ::|||||:..||:|        ||.:...::
Zfish   699 APSKSFSSLLKSKEEQDPPVLHPEVDFNPPKMMARKRGRPKRSPPTLPQETQPPTLAPESGEASV 763

  Fly   285 NE-------------SADSGVISTTSTTQSTT--------PSPKMQNE---NAVPTGSLPIASSS 325
            .|             ....|.|:...|.:...        |.|..:.|   ::.|||| |:|:..
Zfish   764 GEKPFRNKGNGQLIMKTIIGKINKMKTVKRKRLLSQILLGPKPAEEQECSRSSGPTGS-PVATKP 827

  Fly   326 K--------------PKIDMA-----YLDKRMYATERVL--------YPPPRSKRRQNNKKTACS 363
            :              |:|:::     |:.||.....:..        .|||......|.     |
Zfish   828 QSLTSLAATFGGKLGPQINVSKKGTIYMGKRRGRKPKTSTNPSPGAPTPPPEPFLSPNT-----S 887

  Fly   364 SSNKEELQ-LDPLWREIDVNKKFRLRSMSVGAASGTGASTTICSKVLAAKSGYVSDYGSVR---H 424
            |.:..::| |.....::..::.|...|:|    ..:|..:.|      :.:.:| :.|||.   |
Zfish   888 SPHHHQVQALQNQPHQLPPSEVFPSPSLS----QSSGGQSPI------SDASFV-EPGSVHFSSH 941

  Fly   425 QRSSHNHNSGYKSDASCKSRYSTKSCMSRRSRAKSCGYRSDCKES-------------------- 469
            ...||:|.. :.|.:.....:|..|..|..|.|.|..:.|..|.|
Zfish   942 PHCSHSHQV-HHSFSFPPPTFSAPSARSVASAATSTAHPSQKKSSCRGYHHHHHHYRQHYHYRKF 1005

  Fly   470 ---------GKSGLRMRRKRRASMLLKSSADDTVEDQDILQLAGLSLGQSSEESNEYISKP-SLK 524
                     ..:.|...::...|.:.:|.:::||....       .:|..:..:::...|. |..
Zfish  1006 SPPRPLLPTSPAPLSELKEATPSPVSESHSEETVPSDS-------GIGTDNNSTSDRGEKAGSAN 1063

  Fly   525 SLPTTSASK-KYGEINRYVTTGQYFGRGGSLSATNPDNFISKMMNQRKETPAPSKSSCKIKS--- 585
            .||....|: ..|.:......|...|.|..||:.......|.::.:|   |:|:.|...:::
Zfish  1064 GLPGVGVSQGMAGGLLMPGVIGPGIGTGIGLSSRGRRRHSSSVLLER---PSPTPSPLGVRASPD 1125

  Fly   586 -RRSSAASMCSSYVS-----------------GVSRMRR--RHRRKSFSHNKSLNIDSKLLTEIE 630
             |||..|:..|:.|.                 ...:::|  |.|:|.:...:|...|...|.:::
Zfish  1126 PRRSHPAAPSSALVGHKEKHKHKCKRRGHGCPSYDKLKRQKRKRKKKYLQLRSRRQDPDFLADLD 1190

  Fly   631 II---TSTFNSRCRIQDDRLTGSSGKEKLLADANKLQAT-LAAPSPAQQLTLNGGG--------- 682
            .|   .|......|....||..|.|   |.|.|...:.: |.:..|:..|   |||
Zfish  1191 EICVQLSDIRISHRTPTLRLGSSIG---LGAGAGPGRGSGLGSTRPSSSL---GGGTNPPPHHYL 1249

  Fly   683 -----------------------PASTLSKPLKRGLKKRK---------LSE----PLVDFAMLS 711
                                   |..:|....|..|||::         :||    |.:.|.:.|
Zfish  1250 HRDLLPTIFRINFSGYYSPHPAYPCDSLHYVRKPDLKKKRGRPPKLRESISEVPFVPGLGFPLSS 1314

  Fly   712 AS---------ASGTPNGSGSSNGNT-------KRRHKKSQSNDSSSPDDHKLPLKKRHYLLTPG 760
            ..         .|.||.|.|...|.|       ...|:...|..|             |::.:|.
Zfish  1315 GGFYHPSYGVPYSSTPLGLGYYRGYTPPSALYPHPHHQAPHSGPS-------------HHVHSPS 1366

  Fly   761 ERPPAEVAFANGK------LNAEAWAAAAAAAKSTASTKSQAQFNARSVKSALTPKKRHLLEQPT 819
            ..||...::.:..      ||                   .::|:          ||:|.|.:..
Zfish  1367 FPPPPPPSYVHHHHPSHLLLN-------------------PSKFH----------KKKHKLLRQE 1402

  Fly   820 SVSGAGSS----ASNSPL----------------RIVVDNNSISGGKLLDI-------------- 850
            .:.|..||    |.:|.|                |...:.....||.|..|
Zfish  1403 YLGGGRSSMLYPAMSSELSFGWHHKHKHRHKHRDRCGEEEGDDGGGVLGGIGGRGVGGEGLGAGR 1467

  Fly   851 -SPSSLCSLKQQR--RGGAA-----KQKVSAAKDLVQLQSPA----------------------- 884
             ...|:.||:..|  |.|:|     ||..||........|.|
Zfish  1468 GERGSVESLQHCRFGRDGSADSRTNKQSASANSPSSSSTSSAERYKRKEASMSCLGPSRLSLGTA 1532

  Fly   885 --GSYPPPGVFEPSVELEIQIPLSKL--NES-----VITKAEVESPLLSALDIKEDTKKEVGQRV 940
              |.:|....|...   ......|||  |:|     ..::..|::|    :|..|..:::....:
Zfish  1533 SRGHHPVDSWFRMG---SSDTDYSKLSRNQSFSGSGAFSEGHVQNP----VDCSESDEEDAASPI 1590

  Fly   941 VE-TLLHKTGGNLLLKRKRKKINRTGFPTVRRKKRKVSVEQQTTAVIDEHEPEFDPDDEPLQSLR 1004
            .| .:.|.|  ||.    ...::||.....|.||.. .:|..:.:.:|             :::|
Zfish  1591 EEPEISHHT--NLF----ASALSRTSLKGSRSKKGG-PLESPSLSRLD-------------RTVR 1635

  Fly  1005 ETRSSNNV-----NVQAAPNPPLDCERVPQAGEARETFVARTNQKAPRLSVVALE------RLQR 1058
            ..||:::.     ||.:..| .:....||...|....  ...:...|.||:....      .|.:
Zfish  1636 RDRSTSSEKREIGNVSSLQN-RVGQSSVPDVSEGLHH--RHHHHHHPPLSLSHAASCLPHCTLDQ 1697

  Fly  1059 PQTPARGRPRGRKPK------------NREQAEAAPQPPPKSE----PEIRPAKKRGRQ------ 1101
            |...|..||..|:..            :...:..:.:||||:.    .:|..|||..||
Zfish  1698 PGNTAPLRPSSRQASPSTCSSQPACCLDSPPSHLSHRPPPKNNLLHVNKILRAKKLQRQARTGNN 1762

  Fly  1102 ---------PKQPVLEEPPPTPPPQQKKNKMEPNIRLP---------------DGIDPNTNFSCK 1142
                     |::..|..||.|||||..:....|   ||               |.|:.......|
Zfish  1763 MVKKRGPGRPRKNPLPSPPATPPPQTSEQDNHP---LPERHRATALWEADTVVDAIEAVVQNQRK 1824

  Fly  1143 IRLKRRKNLEAGTQ---PKKEKPVQPVTVEEIPPEIPVSQEEIDAEAEAKRLDSIPTE------- 1197
             :.::||:.|..|:   .::|...:...||:...|....||:..|..|...:..:.||
Zfish  1825 -KGRKRKHWERETEGGDEEEEDAEEERQVEDEEEEEDEEQEQQSAAREDDVMSRVRTEGSRQWLT 1888

  Fly  1198 ----H------DPLPASESHNPGPQDYASCSESSEDKASTTSLRK--LSKVKKTYLVAGLFSNHY 1250
                |      :..|......|||    :.||.:.:.:.|:...|  ....||.:..|||:|:.|
Zfish  1889 QEEVHCFRSALEGKPDGSPERPGP----ATSEPTPNPSVTSQREKRVARPPKKKFQKAGLYSDVY 1949

  Fly  1251 K------QSLMPPPAKVNKKPGLEEQVGPASLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKL 1309
            |      |.|.....|:...|| |...|   |||.|.:..||||:..:||:|||||.|.:.:.:|
Zfish  1950 KTDDPRSQLLQLKKEKLEYTPG-EHDYG---LLPAPIHVGKYLRQKRIDFQLPYDILWLWKHDQL 2010

  Fly  1310 PTRNVVPSWNYRKIRTNVYAESVRPNLAGFDHPTCNCK---NQGEKSCLDNCLNRMVYTECSPSN 1371
            ..|..||.  |:|||:|||.: |:| |:|::..||||:   :..||.|.|:|||||:|.|||||.
Zfish  2011 YKRPDVPL--YKKIRSNVYVD-VKP-LSGYEATTCNCRLPDDSSEKGCQDDCLNRMIYAECSPST 2071

  Fly  1372 CPAGEKCRNQKIQRHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQ----- 1431
            ||..::|.||:||:|.....:|||....||||:|||.|:..|.:|:||:||||:|:||::
Zfish  2072 CPCSDQCDNQRIQKHEWVQCLERFRAEGKGWGIRTKQPLRAGQFIIEYLGEVVSEQEFRKYIASD 2136

  Fly  1432 ---------------------RMASIYLNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCE 1475
                                 ||...|.:.:.||||:||.|:|||..|||::.||||||||||||
Zfish  2137 CRLHQVKIPMLGENKKQIGVSRMMEQYFSHSGHYCLNLDSGMVIDSYRMGNEARFVNHSCEPNCE 2201

  Fly  1476 MQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCRGVIGGKSQRVKPLP 1540
            ||||||||:.|:.|||.:.|..|.||||||||..||..|.|.|:|.:..|||:|||||:|:..||
Zfish  2202 MQKWSVNGVYRIGLFALKDINSGTELTYDYNFHSFNTEEQQVCKCGSEGCRGIIGGKSKRINGLP 2266

  Fly  1541 AVEAKPSGEGLSGRN-GRQRKQKAKKHA---QRQAGKDISSAVAVAKLQPLSEKEKKLVRQFNTF 1601
               ||.:|.|...|. ||.::::..||:   :.:...|.|.......::|:|.:|:..|.:...|
Zfish  2267 ---AKGAGSGGGARRLGRLKEKRKSKHSLKKREEESSDSSKFYQHLLMKPMSNRERNFVLKHRVF 2328

  Fly  1602 LVRNFEKIRRCK--AKRASDAAATASSPALGTTNGDIPGRRPSTPSSPSLAAQISALCSPRNIKT 1664
            |:||:||:|..:  .||..:.....|..:|.|..|.:. |......|.....|.|||.:.|:::|
Zfish  2329 LLRNWEKMREKQELLKREGERERENSGLSLYTRWGGVI-RDDGNIKSDVFLTQFSALQTSRSVRT 2392

  Fly  1665 RGLTQAVHDPELEKMAKMAVVLRDICSAMETLKMSDLLTTVSSKKKKPIKTTL----SGKLGS-- 1723
            |.|..|..:.|:.:.|::|.:.::||         |::|:......:|:...|    |.|..:
Zfish  2393 RRLAAAEENTEVTRTARLAHIFKEIC---------DMITSYKDSSGQPLAAPLLNLPSRKRNTQY 2448

  Fly  1724 -TAATSKVEFRSIQAQVEQGHYKTPQEFDDHMQQLFVEAKQQHGDDEGKEKALQSLKDSYEQQKI 1787
             ...|..::..:|..|:..|||||.:.||..|.::|..|::.:|......:.:..|:.:|...:.
Zfish  2449 YEKVTDPLDLSTIDKQILSGHYKTDEAFDADMLKVFRNAEKYYGRKSAVGRDVCRLRKAYYGARH 2513

  Fly  1788 ASYVQLVEILGDSESLQSFKPKEVLSSEE-EPGKIAVKKSPGAKERDSPIVPLKVTPPPLLPIEA 1851
            .:.||:.||:|::.|       |..||:. |..........|....|.
Zfish  2514 EAAVQIDEIVGETAS-------EADSSDSLERDHAHHHHHDGGGSHDK----------------- 2554

  Fly  1852 SPDEDVIRCICGLYKDEGLMIQCSKCMVWQHTECTKADIDADNYQCERCEPREVDREIPL---EE 1913
              |:||||||||:||||||||||.|||||||.:|.:.:.|.::|.||:|:||.||||:|:   ..
Zfish  2555 --DDDVIRCICGMYKDEGLMIQCEKCMVWQHCDCMRLEADVEHYLCEQCDPRPVDREVPMVPQPS 2617

  Fly  1914 FTEEGHRYYLSLMRGDLQVRQGDAVYVLRDIPIKDESGKVLPTKKHTYETIGAIDYQECDIFRVE 1978
            :.:.|..||:.|:|.||.:.|||.||::||.....|...|    :.:|..:..|:..:.||||:|
Zfish  2618 YAQSGFIYYICLLRDDLLLHQGDCVYLMRDSRRTTEGQPV----RQSYRLLSHINRDKLDIFRIE 2678

  Fly  1979 HLWKNELGKRFIFGHHFLRPHETFHEPSRRFYPNEVVRVSLYEVVPIELVIGRCWVLDRTTFCKG 2043
            .|||||.|:||.||||:.|||||.|.||||||.||:.||.|||::|:|.|:|.|.|||..|:|||
Zfish  2679 KLWKNEKGERFAFGHHYFRPHETHHSPSRRFYHNELFRVPLYEIIPLEAVVGTCCVLDLYTYCKG 2743

  Fly  2044 RPMECNDEDHCYICELRVDKTARFFSKAKAN-HPACTKSYAFRKFPEKIKISKSYAPHDVDP--- 2104
            ||....::| .|||:.|:||:|..|.|...| :|.|||.|||..||:::...:.::||.|..
Zfish  2744 RPKGVKEQD-VYICDYRLDKSAHLFYKIHRNRYPVCTKPYAFNHFPKRLTPKRDFSPHYVPDNYK 2807

  Fly  2105 -----SLLKTRKQKTELDVGAGPTTMHKVSG---------------------------------- 2130
                 |..|:.:.|.| :..:..|:..::|.
Zfish  2808 RNGGRSAWKSERPKDE-EPSSSSTSCERLSSSFPREGDEDGGRGAEGDAEAAQEGSSTPRPQRSS 2871

  Fly  2131 ----------------------RQEQHQAKMVG-RKPRGISAPADATAVHVVTPVAPNKQMLKKR 2172
                                  |:.|.:.:..| |:..|...|.||.....::....:..:|.:|
Zfish  2872 PLESRTAGEEDEAEEEEDRERRREMQEEEEEEGCREKAGAQEPIDAQCSSSISSSPLHPAILGRR 2936

  Fly  2173 ---KSRLENVLITMKLKCLDAQTAQEQPIDLSYLL---SGRGARQR 2212
               :.||..:|:.:..:   |.|  :..||::|||   |||..|:|
Zfish  2937 EAQRERLNKILLDLLHR---APT--KNAIDVTYLLEEGSGRRLRRR 2977

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795	27/50 (54%)
		SET	1392..1512	CDD:214614	73/145 (50%)
		Bromo_ASH1	1680..1787	CDD:99955	26/113 (23%)
		PHD_ASH1L	1858..1900	CDD:277023	28/41 (68%)
		BAH_polybromo	1929..2073	CDD:240068	73/143 (51%)
ash1l	XP_005159540.1	CytochromB561_N	<529..>674	CDD:286826	39/176 (22%)
		AWS	2037..2088	CDD:197795	27/50 (54%)
		SET	2091..2238	CDD:214614	73/146 (50%)
		COG5076	2281..>2500	CDD:227408	58/228 (25%)
		Bromo_ASH1	2408..2513	CDD:99955	26/113 (23%)
		PHD_ASH1L	2559..2601	CDD:277023	28/41 (68%)
		BAH_polybromo	2633..2772	CDD:240068	73/143 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593862
Domainoid	1	1.000	151	1.000	Domainoid score	I4343
eggNOG	1	0.900	-	-		E2759_KOG1083
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	700	1.000	Inparanoid score	I649
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D507784at2759
OrthoFinder	1	1.000	-	-		FOG0007422
OrthoInspector	1	1.000	-	-		oto39574
orthoMCL	1	0.900	-	-		OOG6_106446
Panther	1	1.100	-	-	LDO	PTHR46147
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	1	1.000	-	-		X5557
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790