DRSC/TRiP Functional Genomics Resources

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Protein Alignment ash1 and kmt2ca

DIOPT Version :9

Sequence 1:NP_001246834.1 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster
Sequence 2:XP_005162602.1 Gene:kmt2ca / 560793 ZFINID:ZDB-GENE-080520-3 Length:4958 Species:Danio rerio


Alignment Length:2140 Identity:378/2140 - (17%)
Similarity:603/2140 - (28%) Gaps:894/2140 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 QNETAAAKVLETQRAQESGSENEETDSITDQSSQSK--SIKSATQFSVQRS-------------- 53
            |.:....:.:..||:.:....|.:.|:|||...::|  ::|...:..||.|              
Zfish  3091 QQQQRDMQAMIRQRSSDPFFPNIDFDAITDPIMKAKMVALKGINKVMVQNSMGMPPMVMNRMQQV 3155

  Fly    54 ------DT----------DGLRMRISAIRPTLGVVATKKPPKSRKMSTQDTESGCSEAKNRAVSK 102
                  ||          || ::.....|||        ||........:::....|...:...:
Zfish  3156 PASHAPDTPAFSQPFFGPDG-KLPPQIARPT--------PPNFGPGFVNESQKKQYEEWLQETQQ 3211

  Fly   103 KVKVKRKKLASSSGISKSDKVSKSKKSQISAFSSDSEDDLPLKVHQQRAPRVLLSAIIQAAQSAS 167
            .:::::|.|....|..:     ||||:                          |||..:.|:.|.
Zfish  3212 LLQMQQKFLEDQIGAHR-----KSKKA--------------------------LSAKQRTAKKAG 3245

  Fly   168 KPTLDIGISSSDNELPNLVQAAIKRVESDTEDTTVEGSFRKAAKDKNLPQYQSTLLQDFMEKTQM 232
            :            |.|          |.|.|..            ||:.:.|| ::|..:|:.:.
Zfish  3246 R------------EFP----------EEDAEQL------------KNVTEQQS-VVQKQLEQIRK 3275

  Fly   233 LGQTVNAKLAEE-KVAKAKEETLVQTAV--PRK----RRGRPKKVVPTVPA-------------- 276
             .|..:|:|.|| :|.:.:::..:||.:  |.|    .:|:|..::|..|.              
Zfish  3276 -QQKEHAELIEEYRVKQQQQQQRLQTGMMGPMKTMPVMQGQPPGMMPVGPPMAQPMMGSMLPMQH 3339

  Fly   277 ----------------PGNSGPAINESADSG------------VISTTSTTQSTTPSP-----KM 308
                            ||.:||.      ||            :.:.....|:..|:|     |.
Zfish  3340 PHFGKPSRMPSMPGWHPGTTGPI------SGPRMPPHLPPQMALPNPAQPLQAQPPAPIAPGGKP 3398

  Fly   309 QNENAVPTGSLPIASSSKPKIDMAYLDKRMYA---TERVLYPPPRSKRRQNNKKTACSSSNKEEL 370
            .....|..|:...||||.|.:  .:.|...::   .||        :||:..::       ::|.
Zfish  3399 GQSGTVAGGNGGGASSSAPHV--KFDDNNPFSEGFQER--------ERRERLRE-------QQEK 3446

  Fly   371 QLDPLWREIDVNK---KFRLRSMSVGAASGTGASTTICSKVLAAKSGYVSD-------------- 418
            |...|.:|::..:   :..|...|:|........:      ||....|.||              
Zfish  3447 QRVQLMQEVERQRALQRLELEQQSLGLGPDNNGDS------LAQMPFYNSDLSQEFMQTPRPQQQ 3505

  Fly   419 --------------------YGSVRHQRSSH---------------------------------- 429
                                .||...|...|                                  
Zfish  3506 QQQLGPLFPQQGNVPCDFVGQGSAFMQGGEHRPIPGNGSFGPEMGPNFQPKNPMMPGFSAGRPRP 3570

  Fly   430 ---------NHNSGYKSDASCKSR-----------------YST----KSCMSRRSRAKSCGYRS 464
                     :|..|..|.....|.                 ||.    :....:|||.|.   |.
Zfish  3571 PGFGGTRMPHHGGGEPSSFGMNSTTPLPPNFPGSGQSLIQLYSNIIPEEKGKKKRSRKKK---RD 3632

  Fly   465 DCKESGKSGLRMRRKRRASMLLKSSADDT----------VEDQDILQ-------LAGLSLGQ--- 509
            |..:|.|:.........|.  |.....||          :.|||..:       :.||...:   
Zfish  3633 DDADSVKTPSTPHSDITAP--LTPCVSDTSSTPTRSVAIMGDQDTSEFSNPLGSMTGLPSSELEI 3695

  Fly   510 --------------SSEESNEYISKPSLKSLPTTSASKKYG-----------------EINRYVT 543
                          |||..:..:....|:.|.::...|..|                 |:|..::
Zfish  3696 SLSGSTPLRRQTSVSSEAEHGLLHDIKLEKLESSVCQKAEGEAPVGHSAEETGIIKTEEVNEIIS 3760

  Fly   544 TGQYFGRGGSLSATNPDNFISKMMNQRKETPAPSKSSCKIKSRRSSAASMCSSYVSGVSRMRRRH 608
            ..:........:...|.|.:.|.:.:.|.||.|           .||..|              |
Zfish  3761 HNRTSQSPAQSTKGEPGNELLKHLLKNKNTPPP-----------PSAPLM--------------H 3800

  Fly   609 RRKSFSHNKSLNIDSKLLTEIEIITSTFNSRCRIQDDRLTGSSGKEKLLADANKLQATLAAPSPA 673
            :..    |:||..:.:.|.:         |:..::.|.....||....|.|   |:.:|  |...
Zfish  3801 QMS----NESLRSEDEGLND---------SKGYLRQDSTDSMSGINSRLTD---LEPSL--PEQC 3847

  Fly   674 QQLTLNGGGPASTLSKPLKRGLKKRK---------------------------LSEPL--VDFAM 709
            ::...|...|.:.:.||..|..|::|                           |.|||  |:||.
Zfish  3848 KKKQRNKRTPKNGVDKPPSRWKKRKKDEDERQAIYTNTDTLMTQLKQQLSMLPLMEPLIGVNFAH 3912

  Fly   710 LSASASGTPNGSGSSNGNTKRRHKKSQSNDSSSPDDHKLPLKKRHYL---------LTPGERPPA 765
            .      .|.|||..||..:.......::.....|.:...:.|::.|         |.|...|.|
Zfish  3913 F------PPYGSGQLNGENRLSGSFGSASLDGVSDYYSQLIYKQNNLSNPPTPPASLPPTPPPVA 3971

  Fly   766 EVAFANGKLNAEAWA--AAAAAAKSTASTKSQAQFNARSVKSALTPKKRHLLEQPTSVSGAGSSA 828
            .....||...||..|  |....:||....:..|.|.|..          .||         |.:.
Zfish  3972 RQKLLNGFATAEELARKAEVMVSKSLGQKQLTASFKAED----------DLL---------GHTI 4017

  Fly   829 SNSPLRIVVDNNSISGGKLLDISPSSLCSLKQQRRGGAAKQKVSAAKDLVQLQSPAGSYPPPGVF 893
            :..|             |.:|: |:||.:.....     ::.:...:..:...:| .|:.|....
Zfish  4018 TQGP-------------KTVDV-PASLPTPPHNN-----QEDLRGQEHCIDRDTP-DSFVPSSSP 4062

  Fly   894 EPSVELEI-QIP-LSKLNESVITKAEVESPLLSALDIK--EDTKKEVGQRVVETLLHKTGGNL-- 952
            |..|.:|| :.| ||::.|...:.|  .||::..||.|  |..:.||.............|.|  
Zfish  4063 ESVVGMEISRYPDLSRVKEEPPSPA--VSPVIPILDCKGSEARRWEVKTEPPSNFFASQFGQLST 4125

  Fly   953 LLKRKRKKINRTGFPTVRRKKRKVSVEQQTTAVIDEHEPEFDPDDEPLQSLRETRSSNNVNVQAA 1017
            .|:.....::.|..|..     .::::...:|               |.::.......|..|..:
Zfish  4126 CLRTDLVPVSITLNPVA-----AMNIQGVVSA---------------LANMLCVSIPGNYEVTRS 4170

  Fly  1018 PNPPLDCERVPQAGEARETFVARTNQKAPRLSVVALE----RLQRPQTP---------------- 1062
            |.|           |.|.:....:..|.|..:.:..:    ||.||..|                
Zfish  4171 PGP-----------EHRSSIDMLSGLKVPHPTSLFHQQPGMRLHRPPLPHQTFSDGTAMVRRDYG 4224

  Fly  1063 -ARGRPRGRKPK-------------NREQAEAAPQ------------------------------ 1083
             ..|...|.||:             .|:..:..|.                              
Zfish  4225 QMHGSSLGSKPQWCSHCRVVVLGNGVRKSTKELPMNKLGHGGAVESLVFCSNNCLVLYSASMQSK 4289

  Fly  1084 ---------PPPKSEPEIRPAKKRGR----------------QPKQPVLEEPPPTPPPQQKKNKM 1123
                     ||.:|..:..|.|...:                ||||    .||||          
Zfish  4290 LLDGKPNFPPPSESGDKQNPTKVLHQYNNNISDLDVHCLAQLQPKQ----SPPPT---------- 4340

  Fly  1124 EPNIRLPDGIDPNTNFSCK-------IRLKRRKNL--EAGTQP-----KKEKPV--QPVTVEEIP 1172
             |.|..|..........||       ::||.|...  ..|.:|     |:.|.:  :..:|:.|.
Zfish  4341 -PIISFPSITSEMLRGDCKPDTLKVTVKLKPRPRAVHNGGDEPRYLSGKRWKALRWRRWSVQIIV 4404

  Fly  1173 PE----IPVSQEEIDAEAEAKRLDSIPTEHDPLPASESHNPGPQDYASC---------------- 1217
            |:    :|| :|||||     .|..:.|...|       .|.|:|...|                
Zfish  4405 PKGNYHLPV-EEEIDA-----LLKKLGTSLRP-------EPMPKDMRRCCFCHEEGDGLTDGPAR 4456

  Fly  1218 ------------------SESSEDKAST------------------------------------- 1227
                              :|..|.:|..                                     
Zfish  4457 LLNLDLDLWVHLNCALWSTEVYETQAGALINVELALRRGLSVRCAYCQQTGATSGCHRLRCTNAY 4521

  Fly  1228 ----------------TSLRKLSKVKKTYLVAG-------------LFSNHYKQ----------- 1252
                            |.|..|.:.:.|.|:.|             :|...|.|           
Zfish  4522 HFTCALKAQCTFFKDKTMLCHLHRPRGTSLIGGGLLGTEHELRCFAVFRRVYVQRDESRQIASII 4586

  Fly  1253 --------------------SLMPPP----------------------------------AKVNK 1263
                                .|:|..                                  ..:|:
Zfish  4587 QRGEREHTFRVGSLVLHAVGQLLPQQMLAFHSMTAIFPVGYEASRIYWSMRHGNRRCHYVCSINE 4651

  Fly  1264 KPGLEEQV------GPASLL----PPPPYCEKYL-----RRTEMDFELPYDIWW----------- 1302
            ..|..|.|      |...|:    .|....:|.|     ||.|..|...:.::.           
Zfish  4652 NDGSPEFVIRVVEQGYDDLILTGSSPKGVWDKVLEPVAERRNETGFLRLFPVYLKGEDLFGLTVS 4716

  Fly  1303 AYTN--SKLPTRNVVPSWNYRKIRTNVYAESVRPNLAGFDHPTCNCKNQGEKSCLDNCLNRMV-- 1363
            |.|.  ..||.......:.:|..|..:....:..|.:|       |.....|:|..  :.|.|  
Zfish  4717 AVTRIVESLPGVEACERYTFRYGRNPLMQLPLAINPSG-------CARSEPKACTH--IKRFVLR 4772

  Fly  1364 -YTECSPSNC-------------PAGEKCRNQKIQRHAVAPGVERFMTAD------------KGW 1402
             :|..|.|..             |..:...:.|..::       |.|.|:            :|.
Zfish  4773 PHTLTSTSKALQSPGNPAEIGVPPYSKHFVHSKSAQY-------RRMNAEWKSNVYLARSRIQGL 4830

  Fly  1403 GVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIY-LNDTHHYCLHLDGGLVIDGQRMGSDCRFV 1466
            |:.....|.|.|.::||:|.:: ..|...|...:| ..:...|...:|...|||....|...|::
Zfish  4831 GLYAARDIEKYTMVIEYIGTII-RSEVANRKEKMYEAQNRGVYMFRIDSEHVIDATITGGPARYI 4894

  Fly  1467 NHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCR 1526
            ||||.|||..:..::....::::.:.|.|:.||||.|||.|.|.:.....||.|....||
Zfish  4895 NHSCAPNCITEVVALERGHKIIISSNRRIQRGEELCYDYKFDLEDDQHKIPCHCGAVNCR 4954

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ash1NP_001246834.1 AWS 1340..1388 CDD:197795 10/63 (16%)
SET 1392..1512 CDD:214614 39/132 (30%)
Bromo_ASH1 1680..1787 CDD:99955
PHD_ASH1L 1858..1900 CDD:277023
BAH_polybromo 1929..2073 CDD:240068
kmt2caXP_005162602.1 PHD_SF 263..346 CDD:304600
PHD1_KMT2C_like 360..404 CDD:276984
PHD2_KMT2C 406..451 CDD:277069
PHD_SF 484..535 CDD:304600
PHD4_KMT2C 973..1029 CDD:277071
PHD5_KMT2C_like 1030..1076 CDD:276988
PHD_SF 1108..1157 CDD:304600
HMG 1707..1760 CDD:197700
CITED 2586..>2683 CDD:282356
ePHD2_KMT2C 4440..4544 CDD:277167 6/103 (6%)
FYRN 4599..4649 CDD:283589 2/49 (4%)
FYRC 4656..4736 CDD:283590 15/79 (19%)
SET 4819..4940 CDD:214614 36/121 (30%)
SET <4820..4958 CDD:225491 41/136 (30%)
PostSET 4942..4958 CDD:214703 5/13 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170593920
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.960

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