DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ash1 and KMT2E

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	NP_061152.3	Gene:	KMT2E / 55904	HGNCID:	18541	Length:	1858	Species:	Homo sapiens

Alignment Length:	1464	Identity:	275/1464 - (18%)
Similarity:	470/1464 - (32%)	Gaps:	518/1464 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 KMSTQDTESGCSEAKNRAVSKKVKVKRKKLASSSGISKSDK-VSKSKKSQISAFSSDSEDDLPLK 145
            |.|::..|:         ::...:.:|||       .|.|| :||.|.:|....:.|.|.    .
Human   472 KRSSESMEN---------INSGYETRRKK-------GKKDKDISKEKDTQNQNITLDCEG----T 516

  Fly   146 VHQQRAPRVLLSAIIQAAQSASKPTLDIGISSSDNELPNLVQAAIKR------VESDTEDTTVEG 204
            .::.::|        :..|....|   :.:|.|:|:.|:.:....::      ||.::|:...|.
Human   517 TNKMKSP--------ETKQRKLSP---LRLSVSNNQEPDFIDDIEEKTPISNEVEMESEEQIAER 570

  Fly   205 SFRKAAKDKNLPQYQSTLLQDF--MEKTQMLGQTVNAKLAEEKVAKAKEET--------LVQTAV 259
            ..:...:::.:    ..:||.|  :||.:.     ..:.|.|:::.||.|.        :|..|.
Human   571 KRKMTREERKM----EAILQAFARLEKREK-----RREQALERISTAKTEVKTECKDTQIVSDAE 626

  Fly   260 PRKRRGRPKKVVPTVPAPGNSGPAINESADS-----------GVISTTSTTQSTTPSPKM-QNEN 312
            ..:.:.:.:......||..|........:.|           ..:|..|..|.::|..:: ..:|
Human   627 VIQEQAKEENASKPTPAKVNRTKQRKSFSRSRTHIGQQRRRHRTVSMCSDIQPSSPDIEVTSQQN 691

  Fly   313 AVPTGSLPIASSSKPKIDMAYLDKRMYATERVLYPPPRSKRR-------QNNKKTACSSSNKEEL 370
            .:....|.|...::..:.....:..:.|..:.....|::|:.       :.|:||...|....|
Human   692 DIENTVLTIEPETETALAEIITETEVPALNKCPTKYPKTKKHLVNEWLSEKNEKTGKPSDGLSE- 755

  Fly   371 QLDPLWREIDVNKKFRLRSMSVGAASGTGASTTICSKVLAAKSGYV---SDYGSVRHQRSSHNHN 432
                  |.:.:.....:.:..:.:..|    .|....|.:....|:   |.:.|.:.:|.....|
Human   756 ------RPLRITTDPEVLATQLNSLPG----LTYSPHVYSTPKHYIRFTSPFLSEKRRRKEPTEN 810

  Fly   433 -SGYKSDASCKSRYSTKSCMSRRSRAKSCGYRSDCKE---------SGKSGLRMR---------- 477
             ||     |||.|: .|..:...:.|....:.|.|:|         ..||.|.:.
Human   811 ISG-----SCKKRW-LKQALEEENSAILHRFNSPCQERSRSPAVNGENKSPLLLNDSCSLPDLTT 869

  Fly   478 --RKRRASMLLKS-----------------------------------SADDTVED--------- 496
              :|||...||.|                                   |.|:|..:
Human   870 PLKKRRFYQLLDSVYSETSTPTPSPYATPTHTDITPMDPSFATPPRIKSDDETCRNGYKPIYSPV 934

  Fly   497 --------QDILQLAGLSLGQSSEE-----------------------SNEYISKPSLKSLPTT- 529
                    .:.:....:|..:||.|                       .|..:::..|:.:.|.
Human   935 TPVTPGTPGNTMHFENISSPESSPEIKRRTYSQEGYDRSSTMLTLGPFRNSNLTELGLQEIKTIG 999

  Fly   530 -SASKKYGEINRY-------VTTGQYFGRGGSLSATNPDNFISKMMNQRKETPAPSKS--SCKIK 584
             ::.:...|:||.       |:..|.     .|.|..|     ..:::..||||..::  :.::.
Human  1000 YTSPRSRTEVNRQCPGEKEPVSDLQL-----GLDAVEP-----TALHKTLETPAHDRAEPNSQLD 1054

  Fly   585 SRRSSAASMCSSYVSGVSRMRRRHRRKSFSHNKSLNIDSKLLT---EIEI-----ITSTFNSRCR 641
            |..|...:|.||:|....|.         ..|.|:|.:.:.||   ::|:     |:   .|:|.
Human  1055 STHSGRGTMYSSWVKSPDRT---------GVNFSVNSNLRDLTPSHQLEVGGGFRIS---ESKCL 1107

  Fly   642 IQDDR----------------LTGSSGKEKLLADANKLQATLAAPSPAQQLTLNGGGPASTLSKP 690
            :|||.                |....|:   ..:.|.:.......:|.|:..:       :|.:.
Human  1108 MQDDTRGMFMETTVFCTSEDGLVSGFGR---TVNDNLIDGNCTPQNPPQKKKV-------SLLEY 1162

  Fly   691 LKRGLKKRKLSEPLVDFAMLSASASGTPNGSG--SSNGNTKRRHKKSQSNDSSSPDDH----KLP 749
            .||..:.||......:|.::|.|    |:.||  |:||:     ..:.|||:....||    .||
Human  1163 RKRQREARKSGSKTENFPLISVS----PHASGSLSNNGD-----GCASSNDNGEQVDHTASLPLP 1218

  Fly   750 LKKRHYLLTPGERP---PAEVAFANGKLNAEA-WAAAAAAAKSTASTKSQAQFNARSVKSALTPK 810
            .....|..|..|..   |.:.|.|:.|...|. |         |||| |..|...||.:.||
Human  1219 TPATVYNATSEETSNNCPVKDATASEKNEPEVQW---------TAST-SVEQVRERSYQRAL--- 1270

  Fly   811 KRHLLEQPTSVSGAGSSASNSPLRIVVDN--NSISGGKLLDISPSSLCSLKQQRRGGAAKQKVSA 873
                                    ::.|:  :..|||:    ||...||....:...:     |.
Human  1271 ------------------------LLSDHRKDKDSGGE----SPCVSCSPSHVQSSPS-----SH 1302

  Fly   874 AKDLVQLQSPAGSYPPPGVFE----PSVELEIQIPLSKLNESVITKAEVESPLLSALDIKEDTKK 934
            :..:.|||:..   |.|...|    |..|          |....|..|..||     |..::|.|
Human  1303 SNHIPQLQAKG---PVPSFSELMEDPDPE----------NPEPTTTNECPSP-----DTSQNTCK 1349

  Fly   935 EVGQRVVETLLHKTGGNLLLKRKRKKINRTGFPTVRRKKRKVSVEQQTTAVIDEHEPEFDPDDEP 999
                                  ...|:::.|.|      ..|...|....:..:.:|::|
Human  1350 ----------------------SPPKMSKPGSP------GSVIPAQAHGKIFTKPDPQWD----- 1381

  Fly  1000 LQSLRETRSSNNVNVQAAPNPPLDCERVPQAGEARETFVARTNQKAPRLSVVALERLQRPQTPAR 1064
             .::..:.:.|.|:::.               |.::..::..||        ||.:...|||..|
Human  1382 -STVSASEAENGVHLKT---------------ELQQKQLSNNNQ--------ALSKNHPPQTHVR 1422

  Fly  1065 GRPRGRKPKNREQAEAAPQPPPKSEPEIRPAKKRGRQPKQPVLEEPP---------------PTP 1114
            .       .:.:.::..|..|.|.           ..|..|.||.||               |.|
Human  1423 N-------SSEQLSQKLPSVPTKL-----------HCPPSPHLENPPKSSTPHTPVQHGYLSPKP 1469

  Fly  1115 PPQQ------KKNKMEPNIRLPDGIDPNTNFSCKIRLKRRKNLEAGTQPKKEKPVQPVTVEEIPP 1173
            |.||      ..:...|.:..|.. :|..||     ....:||.|.|        |..|...:..
Human  1470 PSQQLGSPYRPHHSQSPQVGTPQR-EPQRNF-----YPAAQNLPANT--------QQATSGTLFT 1520

  Fly  1174 EIPVSQEEID-AEAEAKRLDS-IPTEHDPLPASESHNPGPQDYASCSESSEDKAS---------- 1226
            :.|..|.... ::...:.|:| .|....|.|.|.|:....|..|:....::.|.|
Human  1521 QTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSG 1585

  Fly  1227 -------TTSLRKLSKVKKTYLVAGLF------SNHYK--QSLMPPPAKVNKKPG--LEEQ---- 1270
                   |||.:   .|...::..|.|      :.|::  .:::|||......||  |.:|
Human  1586 PNQALPGTTSQQ---TVPGHHVTPGHFLPSQNPTIHHQTAAAVVPPPPPPPPAPGPHLVQQPNSH 1647

  Fly  1271 --------VGPASL---------------LPPPP 1281
                    |||...               |||||
Human  1648 QQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPP 1681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795
		SET	1392..1512	CDD:214614
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
KMT2E	NP_061152.3	HCFC1-binding motif (HBM). /evidence=ECO:0000269\|PubMed:23629655	63..66
		PHD_MLL5	120..163	CDD:277025
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	217..269
		SET	343..452	CDD:214614
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..530		15/82 (18%)
		ARGLU	550..>605	CDD:330370	11/63 (17%)
		ERM	<561..>669	CDD:330563	18/116 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	630..687		8/56 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	887..960		6/72 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1039..1068		9/28 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1164..1561		116/558 (21%)
		DUF4045	<1310..>1502	CDD:330572	51/290 (18%)
		Med15	1442..>1829	CDD:312941	57/257 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1581..1835		22/104 (21%)
		Atrophin-1	<1741..1846	CDD:331285
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030