DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ash1 and setd1a

DIOPT Version :9

Sequence 1:NP_001246834.1 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster
Sequence 2:XP_001920852.4 Gene:setd1a / 556535 ZFINID:ZDB-GENE-080521-4 Length:2253 Species:Danio rerio


Alignment Length:1790 Identity:340/1790 - (18%)
Similarity:579/1790 - (32%) Gaps:533/1790 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 VLETQRAQ----ESGSENEETDSITDQSSQSKSIKSATQF--------------------SVQRS 53
            :|:.|:|:    .|..|::|.|.:.::.....|.....:.                    ..:|.
Zfish   723 LLKEQKAKFSFLASDDEDDEKDEVRERGKSENSKDGGNKLREHGGERPSHKRQGEMEAGQQRRRG 787

  Fly    54 DTDGLRMRISAIRPTLGVVATKKPPKSRKMSTQDTESGCSEAKNRAVSKKVKVKRKKLASSSGIS 118
            :.||.|.|  ..|...||...:|.|.....||....|..||:....:...   :.:...|.:..:
Zfish   788 EKDGRRSR--GKRQVSGVGEGRKTPPEVASSTPTVHSLVSESLQGQIPPP---QEEHTTSDTHRA 847

  Fly   119 KSDKVSKSKKSQISAFSSDSEDDLPLKVHQQRAPRVLLSAIIQAAQSASKPTLDIGISSSDNELP 183
            .....:.:.::|.|..|| .||   :::..:....:..:....||.|:|.|.     :||...||
Zfish   848 PHTPPTYNGEAQPSPRSS-GED---MEISDEDDNTITTATSHPAASSSSSPA-----ASSQTVLP 903

  Fly   184 NLVQAAIKRVESDTEDTTVEGS------FRKAAKDKNLPQYQSTL-------------------- 222
                       |.|.|.:...:      |........:|.|...|                    
Zfish   904 -----------SQTTDPSASPAPDTSQHFSATMPPPPIPSYPPHLPPPPLPGFSLQPPPPPGIPP 957

  Fly   223 ------------------LQDFMEKTQMLGQTVN-------------AKLAEEKVAKAKEETLVQ 256
                              :.|:....:::.|...             ::|.:.::|.:.......
Zfish   958 PLPHMELHPEYPPPLPHHMYDYASSMELMSQYCGGAPMSFQMQTHMLSRLHQMRMASSNSTAAPP 1022

  Fly   257 TAVPRKRRGRPKKVVPTVPAP-----GNSGPAINESADSGVISTTSTTQSTTPSP---------- 306
            ..||......|...:.::|.|     ....|.:::  |..|.|.........|.|          
Zfish  1023 AEVPPASEYPPSYHLHSIPPPHAPPHHPHHPYMDQ--DGNVASHYDQDHRYIPPPLPYAYPDPHA 1085

  Fly   307 -KMQNENAVPTGSLPIASSSKPKIDMAYLDKRMYATERVLYPPP---------------RSKRRQ 355
             ::.:.:.:|....|......|:...::            ||||               ...:..
Zfish  1086 AQLPHHHTIPPPHTPWPPHLLPQQFPSH------------YPPPGFGAVPGVDGELYGAAGDQMA 1138

  Fly   356 NNKKTACSSSNKEELQLDPLWREI------DVNKKFRLRSMSVGAASGTGASTTICSKVLAAKSG 414
            ......|.:..::.|.  .|..|:      |:|:|     |....|.||                
Zfish  1139 IMGHNPCEAVVQQVLA--ALIEEMKNIMQRDLNRK-----MVENVAFGT---------------- 1180

  Fly   415 YVSDYGSVRHQRSSHNHNSGYKSDASCK------SRYSTKSCMSRRSRAKSCGYRSDCKESGKSG 473
              .|....|.:|.:....:..:..|..:      .:.:|....|.|.|..........|..|..|
Zfish  1181 --FDEWWDRKERKAKPFQTAMRGVAVVREEEKKEEKTTTTMTTSNRPREPLMSLVDWAKSGGMEG 1243

  Fly   474 LRMR-----------RKRRASML----LKSSADDT---VEDQDILQLAGLSLGQSSEESNEYISK 520
            ..:|           ||....::    ||.:...|   .||:|..|...........|......:
Zfish  1244 FSLRGALRLPSFKVKRKEPQELVEGDELKRARPSTPPDEEDEDSYQGKSADAAAGRTEERRVAER 1308

  Fly   521 PSLKSLPTTSASKKYGEINRYVTTGQYFGRGGSLSATNPDNFISKMMNQRKETPAPSKSSCKIKS 585
            .:.:......|.|.| |::   :.|:....|.|....:.|   |..:::.::....:.|..:..|
Zfish  1309 GAARRRSRAKARKPY-ELD---SEGEETSDGSSSEKEDED---SDKVDESEDEALSADSDDESVS 1366

  Fly   586 RRSSAASMCSSYVSGVSRMRRRHRRKSFSHNKSLN-IDSKLLTEIEIITSTFNSRCRIQDDRLTG 649
            ..||.:|..||..|..|........:..:.::||: :|...:..:..:.:..:.|.:...|:.:.
Zfish  1367 SSSSESSSSSSASSSSSDEEDEEEGEQAAESESLDTMDESTMDSVAAVDTEKDERDKASLDQPSV 1431

  Fly   650 SSGKEKLLADANKLQATLAAPSPAQQLTLNGGGPAS--TLSKPLKRGLKKRKLSEPLVDFAMLSA 712
            ::.::|...:.:......::|.|.         |:|  .|..|||   |:||    .|.|:|..:
Zfish  1432 TTPEDKQEEEKSATPVPPSSPYPR---------PSSPILLLPPLK---KRRK----TVSFSMEES 1480

  Fly   713 SASGTPNGSGSSNGNTKRRHKKSQSNDSSSPDDHKLPLKKRHYLLTPGERPPAEVAFANGKLNAE 777
            ....:...|.:|:.:.....:.|....|.||.....|                            
Zfish  1481 EVKPSVQSSTASSPSPSPVSQASDVPPSVSPVSTPTP---------------------------- 1517

  Fly   778 AWAAAAAAAK--------STASTKSQAQFNARSVKSALT--PKKRHLL-EQPTSVSGAGSSASNS 831
              ||.:|::|        ::..::|.|..:..|..:.||  |..|.|. ::|....|...|....
Zfish  1518 --AAPSASSKPVPMLLPFASRPSESSALTSPASPSAILTVPPPVRSLRPDEPKKSPGPPPSPQTP 1580

  Fly   832 PLRIVVDNNSISGGKLLD---ISPSSLCSLKQQRRGGAAKQKVSAAKDLVQL------------- 880
            |     ..||...||  |   ..|:.:|...|......|.....|.:|.|.|             
Zfish  1581 P-----PKNSTKRGK--DSPRTPPAPVCLTVQNLPLDHASMVKMAYEDPVPLPTTQKGRARGRPR 1638

  Fly   881 ---QSPAGSYPPPGV---FEPSVELEIQIPLSKLNE-----SVITKAEVESPLLSAL---DIKED 931
               ||.:.|:..|.:   .|...|||.::   ||.|     |::..|....|.||.|   .:|.|
Zfish  1639 TLSQSASASHLHPALEEEDEDEEELEQRL---KLREQLGVSSLLQLASAPKPDLSVLADVALKMD 1700

  Fly   932 TKKEVGQRVVET-------LLHKTGGNLLLKRKRKKINRTGFPTVRRKKRKVSVEQQTTAVIDEH 989
            .:.::.....||       .|.:..|:......|:.:                ::.:...|:.||
Zfish  1701 PEADIDSEETETSDEAEEHKLEEEEGDFFAPHPRQPL----------------LDPEGLFVMQEH 1749

  Fly   990 EPEFDPDDE---PLQSLRETRSSNNV---------NVQAAPNPPLDCERVPQAGEARETFVARTN 1042
            .....|..:   |.|  ::|:..:.|         .||.||...:        |||   ..||. 
Zfish  1750 NYSKTPAPQHITPPQ--KKTKQDSTVLLPADLNQHGVQEAPEEVI--------GEA---LAARA- 1800

  Fly  1043 QKAPRLSVVALERLQRPQTPARGRPRGRKPKNREQAEAAPQPPPKSEPEIRPAKKRGRQPKQPVL 1107
             :||.| ...|:.|               ...||.||.      :::....|.|:.|...|:..|
Zfish  1801 -EAPEL-YGDLDLL---------------CDGREAAET------QTKTLSSPYKRTGSISKEVEL 1842

  Fly  1108 EEPPPTPPPQQKKNKMEPNIRLPDGIDPNTNFSCKIRLKRRKNLEAGTQPK-KEKPVQPVTVEEI 1171
            ||      ..:.|||                   |...|.::|.|..|..| |||.|:.....::
Zfish  1843 EE------RGKGKNK-------------------KRSRKDKENEELQTSKKQKEKQVKKQKKRKL 1882

  Fly  1172 PPEIPVSQEEIDAEAEAKRLDSIPTEHDPLPASESHNPGPQDYASCSESSEDKASTTSLRKLSKV 1236
                    ||.:.:.:.::|:|     ..|.:|.| :.|..|:..      :::......::.|.
Zfish  1883 --------EEFEEDVDVEQLES-----GELSSSTS-DSGDSDFGL------ERSLEFEKEEVRKS 1927

  Fly  1237 KKTYL-VAGLFSNHYKQSLMPPPAKVNKKPGLEEQVGPASLLPPPPYCEKYLRRTEMD-FELPYD 1299
            ::.:| .|||            .....::|    :..|.||..|.|   .|..|:|.: ..:.||
Zfish  1928 ERLFLQEAGL------------TPSTQRRP----KHTPESLPIPRP---SYKNRSEFEQMTILYD 1973

  Fly  1300 IWWAYTNSKLPTRNV-VPSWNYRKIRTNVYAESVRPNLAGFDHPTCNCKN-QGEKSCLDNCL--- 1359
            ||    ||.|...:: :....|.|:..:.:......:.....|...|..| :.:|...|..|   
Zfish  1974 IW----NSGLDQEDMRLLKSTYEKLLQDDHGTDWLNDTHWVPHTITNIPNPRRKKKTADGQLREH 2034

  Fly  1360 ----------------NRMVYTE--------------CSPSNCPAGEKCRNQKIQRHAVAPGVER 1394
                            .:.||.|              .:.||....|:...|:  |...|.|...
Zfish  2035 VTGCARSEGYYAISRKEKDVYLELDQPVTLREIGDYDTAGSNRVLSERRSEQR--RLLSAIGTPA 2097

  Fly  1395 FMTAD---------------------KGWGVRTKLPIAKGTYILEYVGEVV-------TEKEFKQ 1431
            .|.:|                     ..||:....|||....::||||:.:       .||.:.|
Zfish  2098 VMDSDLLKLNQLKFRKKKLRFGRSRIHEWGLFAMEPIAADEMVIEYVGQSIRQMVADNREKRYAQ 2162

  Fly  1432 R-MASIYLNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAI 1495
            . :.|.||       ..:|...:||..:.|:..||:||.|.|||..:..::....::|:::|:.|
Zfish  2163 EGIGSSYL-------FRVDHDTIIDATKCGNLARFINHCCTPNCYAKVITIESQKKIVIYSKQPI 2220

  Fly  1496 EEGEELTYDYNFSLFNPSEGQ-PCRCNTPQCRGVI 1529
            ...||:||||.|.:   .|.: ||.|.|..|||.:
Zfish  2221 GVNEEITYDYKFPI---EENKIPCLCGTESCRGTL 2252

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ash1NP_001246834.1 AWS 1340..1388 CDD:197795 14/81 (17%)
SET 1392..1512 CDD:214614 39/148 (26%)
Bromo_ASH1 1680..1787 CDD:99955
PHD_ASH1L 1858..1900 CDD:277023
BAH_polybromo 1929..2073 CDD:240068
setd1aXP_001920852.4 RRM_Set1A 89..183 CDD:240992
DUF3729 <1504..1563 CDD:315239 15/88 (17%)
N-SET 1969..2108 CDD:314603 27/144 (19%)
SET 2114..2237 CDD:214614 37/132 (28%)
PostSET 2237..2253 CDD:214703 7/16 (44%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170593922
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.840

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