DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ash1 and nsd1a

DIOPT Version :9

Sequence 1:NP_001246834.1 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster
Sequence 2:XP_683890.4 Gene:nsd1a / 556086 ZFINID:ZDB-GENE-080519-3 Length:2055 Species:Danio rerio


Alignment Length:2224 Identity:453/2224 - (20%)
Similarity:718/2224 - (32%) Gaps:766/2224 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 ESGSENEETDSITDQSSQSK-SIKSATQFSVQRSDTDGLRMRISAIRPTLGVVATKKPPKS---- 80
            :||...:..:.:..:.:..| :.|...:.:|.:::|.... |:.|.:.:....|...||.|    
Zfish   162 DSGDSKDNDEDVKGEVATFKDTSKKCQKRNVAKTETQSSH-RLDANKHSSKNTAKSDPPASPFHV 225

  Fly    81 -----RKMSTQD--TESGCSEAKNRAVSKKVKVKRKKLASSSGISKSDKVSKSKKSQISA----- 133
                 ....:.|  ::|.|........:....:.::  |.|...|.|:..|..||.|:.:     
Zfish   226 PFTMMEDFDSMDDYSDSDCDLPSTENCASIFNLSKR--AHSPSDSHSNPSSSPKKKQLLSVKYSI 288

  Fly   134 -----------------FSSDSEDDLPLKVH--QQRAPRV----LLSAIIQAAQSASKPTLDIGI 175
                             .::|.:.|:..|:.  .:|..|:    :...|:..|...:|.|.....
Zfish   289 GDVVWAKFNRRPWWPCHVTTDPQIDVHTKMKDPSRRPCRLYFVRMFGEIVDQAWVPAKATFPFEG 353

  Fly   176 SSSDNELPNLVQAAIKRVESDTEDTTVEGSFRKAAKDKNLPQYQSTLLQDFMEKTQMLG------ 234
            .....:||.|.:...::          |..::.....:.:|.:::::|:.....|:.|.      
Zfish   354 GDQFEKLPVLRRRGRQK----------EKDYKYTVPKRLIPSWKASVLEAEASLTKQLNSEPPLT 408

  Fly   235 --QTVNAKLAEEKVAKAKEETLVQTAVPRKRRGRPKKVVPTVPAPGNS----------------G 281
              |.|...:.|:|..|             |....||..  |:..|.:|                |
Zfish   409 LIQDVCVPITEDKAHK-------------KNPACPKST--TLSTPSSSLLSNGLNASVKNRLKPG 458

  Fly   282 PAINESADSGVISTTSTTQSTTPSPKMQNENAVPTGSLPIASSSKPKI-----DMAYLDKRMYAT 341
            .|..:.|...:|.:.|...|.|||......|         .||.||.|     |..|.|  :.:.
Zfish   459 TASKKKATKKMIQSQSIKLSETPSLFKSKSN---------PSSDKPSIATDPLDSPYSD--IDSV 512

  Fly   342 ERVLYPPPRSKRRQNNKKTACSSSNKEELQLDPLWREIDVNKKFRLRSMSVGAASGTGASTTICS 406
            .|:|                ||....|.||:: |.:|:                      :|..:
Zfish   513 PRIL----------------CSKRIDESLQVE-LEKEL----------------------STKTT 538

  Fly   407 KVLAAKSGYVSDYGSVRHQRSSHN--HNSGYKSDASCKSRYSTKSCMSRRSRAKSCGYRSDCKES 469
            ||.|.|             ::|.|  ...|.|:|..|......|....:....|:...|  .|||
Zfish   539 KVQACK-------------KTSKNSVDKPGKKTDVKCLKNSKLKKSTPKDKTLKATSSR--LKES 588

  Fly   470 GKSGLRMRRKRRASMLLKSS---------ADDTVEDQDILQLAGLSLGQSSEESNEYISKPSLKS 525
            ...|.........|..|.:|         |.:..:::|:           |.|.|.:.......|
Zfish   589 SSPGSSDGSFAMHSHYLPASSGLIVRALAAGEETKEKDL-----------SHEPNSHSPSSEHSS 642

  Fly   526 LPTTSASKKYGEINRYVTTGQYFGRGGSLSATNPDNFISKMMNQR-------KETPAPS--KSSC 581
            ......||:..|:.....:.:. ....|.|..||.:.  |.:.:|       |:.|..|  :|..
Zfish   643 QTNHELSKQNWEVKNNSESSEE-SVDASDSPPNPTSI--KRIKKRPQKNGIHKDPPPKSHEESES 704

  Fly   582 KIKSRRSSAASMCSSYVS-GVSRMRRRHRRKSFSHNKSLNIDSKLLTEIEIITSTFNSRCRIQDD 645
            |:.:....:.:..||..| .:|.|      .:|...|.|:..|.:..|           |     
Zfish   705 KVNNESMFSDTSSSSIPSPSISPM------DAFQDIKELSFRSLVKEE-----------C----- 747

  Fly   646 RLTGSSGKEKLLADANKLQATL---------AAPSPAQQLTLNGGGPASTLSK-----PLKRGLK 696
                |||:..|.||:|...:|.         :.....:.|||....|:|.:.:     |:.....
Zfish   748 ----SSGESPLRADSNYKFSTFLMLLKDLHDSREKEGKPLTLPPTSPSSLIKEEPSLIPVGEEPP 808

  Fly   697 KRKLSEPLVDFAMLSA--SASGTPNGSGSSNGNTKRRHKKSQSNDSSSPD---DHKLPLKKRHYL 756
            ...|.|.  :||..|:  ..:.|||.|..|....|...||    :|..||   |...||||.   
Zfish   809 NEVLCEK--EFAEQSSLPGKTSTPNNSKQSKAKLKSTVKK----ESQKPDVVIDSVSPLKKP--- 864

  Fly   757 LTP-------------GERPPAEVAFANGKLNAEAWAAAAAAAKSTASTKSQAQFNARSVKSALT 808
            ::|             |:.|.:....|         |.....||.|.              |.:.
Zfish   865 ISPVGLDVLDKSLPLLGDLPKSSDVSA---------AVTDVCAKGTI--------------SKVA 906

  Fly   809 PKKRHLLEQPTSVSGAGSSASNSPLRIVVDNNSISGGKLLDISPSSLCSLKQQRRGGAAKQKVSA 873
            ||||    ..|..|..|.|                      |.|.|              .:|.:
Zfish   907 PKKR----WKTFESELGKS----------------------IKPKS--------------DQVDS 931

  Fly   874 AKDLVQLQSPAGSYPPPGVFEPSVELEIQIPLSKLNESVITKAEVESPLLSALDIKEDTKKEVGQ 938
            ..|.|:    :.|..|.|||:..           |.||    |..:.|          .||:..:
Zfish   932 TLDEVK----SVSTEPNGVFKDG-----------LQES----AHSDVP----------NKKDASE 967

  Fly   939 RVVETLLHKTGGNLLLKRKRKKINRTG------FPTVRRKKRKVSVEQ-QTTAVIDEHEPEFDPD 996
                        |..|::..|::...|      ||:  :||.|.|.|. :|.:.|....||....
Zfish   968 ------------NKRLRKPSKRLIECGEEYEQIFPS--KKKTKKSTESCKTGSCISNTTPEQPAS 1018

  Fly   997 DE-PLQSLRETRSSNNVN--VQAAPNPPLDCERVPQA-----------GEARETFVARTNQKAPR 1047
            |: .|.::..:.:...::  |.....||.|....|.|           .|..|...|...:|.||
Zfish  1019 DQITLDAVSSSSAEKPLDHVVAEEQKPPADVLVPPSAPKSPSCATSLETEPCEKKSAPLERKRPR 1083

  Fly  1048 LSV-----VALERLQRPQTPARGRPRGRKPKNRE--------QAEAAPQP------PPKSEPEIR 1093
            .||     .|:|. :..:.|.:|..|..|....|        |.||.|.|      ..:||.|:|
Zfish  1084 KSVHKVLDCAIEG-ESVKIPKKGESRQHKTNPEESGVRDLEKQEEAGPPPSSPCAVSAQSEGELR 1147

  Fly  1094 PAKKRGRQPKQPVLEEPPPTPPPQQKKNKMEPNIR-----LPDGIDPNTN---FSCKIRLK---- 1146
            .:     .|.||.:......|...::.:..:|.|.     :.:|.....|   ||.:..|.    
Zfish  1148 TS-----SPIQPDVPSVSQIPVEGEQSSPSKPQINNEDSLISEGFAAGLNDSAFSSRDSLSGDLS 1207

  Fly  1147 ----RRKNLEAGTQPKKEKPV-----------------------QPVTVEEIP------------ 1172
                .::::|.|.....::.|                       |.:.:.|.|            
Zfish  1208 GLSTNKRSVERGGGASLKENVCQVCEKTGELLLCEGQCCGAFHLQCIGLTETPKGRFICQECKMG 1272

  Fly  1173 ---------PEIPVSQEEIDAEAEAKRLDSIPTEHDPLPA-----------------SESHNPG- 1210
                     |:..|.:..|....:...:|.| .::.|..|                 :..:||| 
Zfish  1273 VHTCFVCKKPDKEVRRCMIPVCGKFYHMDCI-LKYSPTVAQNRGFRCSIHVCLSCYITNPNNPGI 1336

  Fly  1211 ----------------PQDYASCSESSEDKASTTSL-------RKLSKVKKTYLVAGLF------ 1246
                            ..||...: .|...|:.:.|       ||..|..:...|:..|      
Zfish  1337 SKGRLTRCVRCPVAYHANDYCMAA-GSVPLANNSFLCPNHFTPRKGCKNHEHINVSWCFVCSEGG 1400

  Fly  1247 ---------SNHYKQSL---MPP------PAKVNKKPGLEE----QVG-----PASLLPPPPYCE 1284
                     :..:::.|   ||.      ..:..|||..::    :||     ||.:..|....|
Zfish  1401 SLLCCESCPAAFHRECLNIEMPQGSWFCNDCRAGKKPHYKDILWVKVGRYRWWPAEVTQPKSVPE 1465

  Fly  1285 KYLRRTEMDFELPY------DIWWAY--------------------------------------- 1304
            ...|......|.|.      |..|.|                                       
Zfish  1466 NISRMKHEVGEFPVHFFGSKDYVWTYQARCFPYMEGDANNKEKMGKGADAVYKKALNEAADRFRE 1530

  Fly  1305 --------------TNSKLPTRNVVPSWNYRKIRTNVYAESVRPNLAGFDH-PTCNCKNQGEKSC 1354
                          .|.|.|.       .|:.|:.|.....|....|.... |.||||...|..|
Zfish  1531 LLKEKEMRQLQEDRKNDKKPP-------PYKHIKVNKQIGKVLIITADLSEIPRCNCKATDENPC 1588

  Fly  1355 -LDN-CLNRMVYTECSPSNCPAGEKCRNQKIQRHAVAPGVERFMTADKGWGVRTKLPIAKGTYIL 1417
             :|: |:|||:..||....|||||:|:||...:..... ||.|.|..:|||:|:...|.||.::.
Zfish  1589 GIDSECINRMLLYECHSQVCPAGERCQNQSFTKRQYTE-VEIFRTLSRGWGLRSISDIKKGAFVN 1652

  Fly  1418 EYVGEVVTEKEFKQRMASIYLND-THHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSV 1481
            ||||||:.|:|.:.|:.:...|| .:.|.|.||...:||....|::.||:||||:||||.|||:|
Zfish  1653 EYVGEVIDEEECRSRIKNAQDNDICNFYMLTLDKDRIIDAGPKGNESRFMNHSCQPNCETQKWTV 1717

  Fly  1482 NGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCRGVIGGKSQRVKPLPAVEAKP 1546
            ||.:|:.|||...|.:|.|||::||.......: ..|:|..|.|.|.:|     |:|        
Zfish  1718 NGDTRVGLFALEDIPKGVELTFNYNLECLGNGK-TVCKCGAPNCSGFLG-----VRP-------- 1768

  Fly  1547 SGEGLSGRNGRQRKQKAKKHAQRQAGKDISSAVAVAKLQPLSEKEKKLVRQFNTFLVRNFEKIRR 1611
                   :|......|.:|..::.:||..|.          ||..|:  |:...|...:..:|..
Zfish  1769 -------KNQPPSDDKTRKLRRKVSGKRKSQ----------SEVTKE--REDECFYCGDGGQIVS 1814

  Fly  1612 CKAKRA-----SDAAATASSPALGTTNGDIP-------GRRPSTPSSPSLAAQISALCSPRNI-- 1662
            ||....     :|....:..||   ...:.|       ||.         ||....:| |.:.  
Zfish  1815 CKKPGCPKVYHADCLNLSKRPA---GRWECPWHQCNECGRE---------AASYCEMC-PNSYCE 1866

  Fly  1663 ----------KTRG-LTQAVHDPELEKMAKMAVVLRDICSAMETLKMSDLLTTVSSKKKKPIKTT 1716
                      |..| |:.:.|||               |.. :.|:..::...|.|       |:
Zfish  1867 QHREGMLFISKLDGKLSCSEHDP---------------CGP-DPLEPGEIREYVPS-------TS 1908

  Fly  1717 LSGKLGSTAATSKVEFRSIQAQVEQGHYKTPQEFDDHMQQLFVEAKQQHGDDEGKEKALQSLKDS 1781
            :.|:..:.:|:.::...::....                .||:.|:.:        .|.||.:|.
Zfish  1909 IVGQAPNMSASGRITQPALPPAA----------------PLFIPAQNR--------PAFQSQRDP 1949

  Fly  1782 YEQQKIASYVQLVEILGDSESLQSFKPKEVLSSEEEPGKIAVKKSPGAKERDSPIVPLKVTPPPL 1846
            |..:.:            ...|.|..||::...:...|::..::  |.:|.:.           |
Zfish  1950 YGDEVV------------DNILPSSSPKDIKEEDMSDGEVVFEE--GEEEEED-----------L 1989

  Fly  1847 LPIEASPDEDVIRC 1860
            ..::...||:.|.|
Zfish  1990 ELVDDEDDEEEIDC 2003

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ash1NP_001246834.1 AWS 1340..1388 CDD:197795 22/50 (44%)
SET 1392..1512 CDD:214614 56/120 (47%)
Bromo_ASH1 1680..1787 CDD:99955 15/106 (14%)
PHD_ASH1L 1858..1900 CDD:277023 2/3 (67%)
BAH_polybromo 1929..2073 CDD:240068
nsd1aXP_683890.4 PWWP 285..382 CDD:295359 13/106 (12%)
TNG2 <1108..1270 CDD:227367 29/166 (17%)
PHD1_NSD1_2 1228..1270 CDD:277118 4/41 (10%)
PHD_SF 1275..1321 CDD:304600 7/46 (15%)
PHD3_NSD1 1322..1375 CDD:277123 8/53 (15%)
PHD4_NSD1 1392..1431 CDD:277126 4/38 (11%)
WHSC1_related 1437..1531 CDD:99899 13/93 (14%)
AWS 1574..1624 CDD:197795 22/49 (45%)
SET 1626..1748 CDD:214614 56/122 (46%)
PHD5_NSD1 1802..1844 CDD:277129 8/44 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170593834
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D507784at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.850

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