Protein Alignment ash1 and nsd1a

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: XP_683890.5
• Gene: nsd1a / 556086
• ZFINID: ZDB-GENE-080519-3
• Length: 2053
• Species: Danio rerio
• Alignment Length: 2239
• Identity: 461/2239 - (20%)
• Similarity: 720/2239 - (32%)
• Gaps: 799/2239 - (35%)

  Fly    21 ESGSENEETDSI---------TDQSSQSKSI-KSATQFSVQRSDTDGLRMRISAIRPTLGVVATK 75
            :||...:..:.:         |.:..|.::: |:.||.|          .|:.|.:.:....|..
Zfish   162 DSGDSKDNDEDVKGEVATFKDTSKKCQKRNVAKTKTQSS----------HRLDANKHSSKNTAKS 216

  Fly    76 KPPKS---------RKMSTQD--TESGCSEAKNRAVSKKVKVKRKKLASSSGISKSDKVSKSKKS 129
            .||.|         ....:.|  ::|.|........:....:.::  |.|...|.|:..|..||.
Zfish   217 DPPASPFHVPFTMMEDFDSMDDYSDSDCDLPSTENCASIFNLSKR--AHSPSDSHSNPSSSPKKK 279

  Fly   130 QISA----------------------FSSDSEDDLPLKVH--QQRAPRV----LLSAIIQAAQSA 166
            |:.:                      .::|.:.|:..|:.  .:|..|:    :...|:..|...
Zfish   280 QLLSVKYSIGDVVWAKFNRRPWWPCHVTTDPQIDVHTKMKDPSRRPCRLYFVRMFGEIVDQAWVP 344

  Fly   167 SKPTLDIGISSSDNELPNLVQAAIKRVESDTEDTTVEGSFRKAAKDKNLPQYQSTLLQDFMEKTQ 231
            :|.|..........:||.|.:...::          |..::.....:.:|.:::::|:.....|:
Zfish   345 AKATFPFEGGDQFEKLPVLRRRGRQK----------EKDYKYTVPKRLIPSWKASVLEAEASLTK 399

  Fly   232 MLG--------QTVNAKLAEEKVAKAKEETLVQTAVPRKRRGRPKKVVPTVPAPGNS-------- 280
            .|.        |.|...:.|:|..|             |....||..  |:..|.:|
Zfish   400 QLNSEPPLTLIQDVCVPITEDKAHK-------------KNPACPKST--TLSTPSSSLLSNGLNA 449

  Fly   281 --------GPAINESADSGVISTTSTTQSTTPSPKMQNENAVPTGSLPIASSSKPKI-----DMA 332
                    |.|..:.|...:|.:.|...|.|||......|         .||.||.|     |..
Zfish   450 SVKNRLKPGTASKKKATKKMIQSQSIKLSETPSLFKSKSN---------PSSDKPSIATDPLDSP 505

  Fly   333 YLDKRMYATERVLYPPPRSKRRQNNKKTACSSSNKEELQLDPLWREIDVNKKFRLRSMSVGAASG 397
            |.|  :.:..|:|                ||....|.||:: |.:|:
Zfish   506 YSD--IDSVPRIL----------------CSKRIDESLQVE-LEKEL------------------ 533

  Fly   398 TGASTTICSKVLAAKSGYVSDYGSVRHQRSSHN--HNSGYKSDASCKSRYSTKSCMSRRSRAKSC 460
                :|..:||.|.|             ::|.|  ...|.|:|..|......|....:....|:.
Zfish   534 ----STKTTKVQACK-------------KTSKNSVDKPGKKTDVKCLKNSKLKKSTPKDKTLKAT 581

  Fly   461 GYRSDCKESGKSGLRMRRKRRASMLLKSS---------ADDTVEDQDILQLAGLSLGQSSEESNE 516
            ..|  .|||...|.........|..|.:|         |.:..:::|:           |.|.|.
Zfish   582 SSR--LKESSSPGSSDGSFAMHSHYLPASSGLIVRALAAGEETKEKDL-----------SHEPNS 633

  Fly   517 YISKPSLKSLPTT-SASKKYGEINRYVTTGQYFGRGGSLSATNPDNFISKMMNQR-------KET 573
            : |..|..|.||. ..||:..|:.....:.:. ....|.|..||.:.  |.:.:|       |:.
Zfish   634 H-SPSSEHSSPTNHELSKQNWEVKNKSESSEE-SADASDSPPNPTSI--KRIKKRPQKNGIHKDP 694

  Fly   574 PAPS--KSSCKIKSRRSSAASMCSSYVS-GVSRMRRRHRRKSFSHNKSLNIDSKLLTEIEIITST 635
            |..|  :|..|:.:....:.:..||..| .:|.|      .:|...|.|:..|.:..|
Zfish   695 PPKSHEESESKVNNESMFSDTSSSSIPSPSISPM------DAFQDIKELSFRSLVKEE------- 746

  Fly   636 FNSRCRIQDDRLTGSSGKEKLLADANKLQATL---------AAPSPAQQLTLNGGGPASTLSK-- 689
                |         |||:..|.||:|...:|.         :.....:.|||....|:|.:.:
Zfish   747 ----C---------SSGESPLRADSNYKFSTFLMLLKDLHDSREKEGKPLTLPPTSPSSLIKEEP 798

  Fly   690 ---PLKRGLKKRKLSEPLVDFAMLSA--SASGTPNGSGSSNGNTKRRHKKSQSNDSSSPD---DH 746
               |:........|.|.  :||..|:  ..:.|||.|..|....|...||    :|..||   |.
Zfish   799 SLIPVGEEPPNEVLCEK--EFAEQSSLPGKTSTPNNSKQSKAKLKSTVKK----ESQKPDIVIDS 857

  Fly   747 KLPLKKRHYLLTP-------------GERPPAEVAFANGKLNAEAWAAAAAAAKSTASTKSQAQF 798
            ..||||.   ::|             |:.|.:....|         |.....||.|.
Zfish   858 VSPLKKP---ISPVGLDVLDKSLPLLGDLPKSSDVSA---------AVTDVCAKGTI-------- 902

  Fly   799 NARSVKSALTPKKRHLLEQPTSVSGAGSSASNSPLRIVVDNNSISGGKLLDISPSSLCSLKQQRR 863
                  |.:.||||    ..|..|..|.|                      |.|.|
Zfish   903 ------SKVAPKKR----WKTFESELGKS----------------------IKPKS--------- 926

  Fly   864 GGAAKQKVSAAKDLVQLQSPAGSYPPPGVFEPSVELEIQIPLSKLNESVITKAEVESPLLSALDI 928
                 .:|.:..|.|:    :.|..|.|||:..           |.||    |..:.|
Zfish   927 -----DQVDSTLDEVK----SVSTEPNGVFKDG-----------LQES----AHSDVP------- 960

  Fly   929 KEDTKKEVGQRVVETLLHKTGGNLLLKRKRKKINRTG------FPTVRRKKRKVSVEQ-QTTAVI 986
               .||:..:            |..|::..|::...|      ||:  :||.|.|.|. :|.:.|
Zfish   961 ---NKKDASE------------NKRLRKPSKRLIECGEEYEQIFPS--KKKTKKSTESCKTGSCI 1008

  Fly   987 DEHEPEFDPDDEPLQSLRETRSSNNV------NVQAAPNPPLDCERVPQA-----------GEAR 1034
            ....||....|   |...:..||::.      :|.....||.|....|.|           .|..
Zfish  1009 SNTTPEQPASD---QITPDAVSSSSAEKPLDHDVAEEQKPPADVLVPPSAPKSPSCATSLETEPC 1070

  Fly  1035 ETFVARTNQKAPRLSV-----VALERLQRPQTPARGRPRGRKPKNRE--------QAEAAPQP-- 1084
            |...|...:|.||.||     .|:|. :..:.|.:|..|..|....|        |.||.|.|
Zfish  1071 EKKSAPLERKRPRKSVHKVLDCAIEG-ESVKIPKKGESRQHKTNPEESGVRDLEKQEEAGPPPSS 1134

  Fly  1085 ----PPKSEPEIRPAKKRGRQPKQPVLEEPP-------PTPPPQQKKNKMEPNIRLPDGIDPNTN 1138
                ..:||.|:|.:..  .||..|.:.:.|       |:.|....::.:     :.:|.....|
Zfish  1135 PCAVSAQSEGELRTSSP--IQPDVPSVSQIPVEGEQSSPSKPQMNNEDSL-----ISEGFGAGLN 1192

  Fly  1139 ---FSCKIRLK--------RRKNLEAGTQPKKEKPV-----------------------QPVTVE 1169
               ||.:..|.        .::::|.|.....::.|                       |.:.:.
Zfish  1193 DSAFSSRDSLSGDLSGLSTNKRSVERGGGASLKENVCQVCEKTGELLLCEGQCCGAFHLQCIGLT 1257

  Fly  1170 EIP---------------------PEIPVSQEEIDAEAEAKRLDSIPTEHDPLPA---------- 1203
            |.|                     |:..|.:..|....:...:|.| .::.|..|
Zfish  1258 ETPKGRFICQECKMGVHTCFVCKKPDKEVRRCMIPVCGKFYHMDCI-LKYSPTVAQNRGFRCSIH 1321

  Fly  1204 -------SESHNPG-----------------PQDYASCSESSEDKASTTSL-------RKLSKVK 1237
                   :..:|||                 ..||...: .|...|:.:.|       ||..|..
Zfish  1322 VCLSCYITNPNNPGISKGRLTRCVRCPVAYHANDYCMAA-GSVPLANNSFLCPNHFTPRKGCKNH 1385

  Fly  1238 KTYLVAGLF---------------SNHYKQSL---MPP------PAKVNKKPGLEE----QVG-- 1272
            :...|:..|               :..:::.|   ||.      ..:..|||..::    :||
Zfish  1386 EHINVSWCFVCSEGGSLLCCESCPAAFHRECLNIEMPQGSWFCNDCRAGKKPHYKDILWVKVGRY 1450

  Fly  1273 ---PASLLPPPPYCEKYLRRTEMDFELPY------DIWWAY------------------------ 1304
               ||.:..|....|...|......|.|.      |..|.|
Zfish  1451 RWWPAEVTQPKSVPENISRMKHEVGEFPVHFFGSKDYVWTYQARCFPYMEGDANNKEKMGKGADA 1515

  Fly  1305 -----------------------------TNSKLPTRNVVPSWNYRKIRTNVYAESVRPNLAGFD 1340
                                         .|.|.|.       .|:.|:.|.....|....|...
Zfish  1516 VYKKALNEAADRFRELLKEKEMRQLQEDRKNDKKPP-------PYKHIKVNKQIGKVLIITADLS 1573

  Fly  1341 H-PTCNCKNQGEKSC-LDN-CLNRMVYTECSPSNCPAGEKCRNQKIQRHAVAPGVERFMTADKGW 1402
            . |.||||...|..| :|: |:|||:..||....|||||:|:||...:..... ||.|.|..:||
Zfish  1574 EIPRCNCKATDENPCGIDSECINRMLLYECHSQVCPAGERCQNQSFTKRQYTE-VEIFRTLSRGW 1637

  Fly  1403 GVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLND-THHYCLHLDGGLVIDGQRMGSDCRFV 1466
            |:|:...|.||.::.||||||:.|:|.:.|:.:...|| .:.|.|.||...:||....|::.||:
Zfish  1638 GLRSISDIKKGAFVNEYVGEVIDEEECRSRIKNAQDNDICNFYMLTLDKDRIIDAGPKGNESRFM 1702

  Fly  1467 NHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCRGVIGG 1531
            ||||:||||.|||:|||.:|:.|||...|.:|.|||::||.......: ..|:|..|.|.|.:|
Zfish  1703 NHSCQPNCETQKWTVNGDTRVGLFALEDIPKGVELTFNYNLECLGNGK-TVCKCGAPNCSGFLG- 1765

  Fly  1532 KSQRVKPLPAVEAKPSGEGLSGRNGRQRKQKAKKHAQRQAGKDISSAVAVAKLQPLSEKEKKLVR 1596
                |:|               :|......|.:|..::.:||..|.          ||..|:  |
Zfish  1766 ----VRP---------------KNQPPSDDKTRKLRRKVSGKRKSQ----------SEVTKE--R 1799

  Fly  1597 QFNTFLVRNFEKIRRCKAKRA-----SDAAATASSPALGTTNGDIP-------GRRPSTPSSPSL 1649
            :...|...:..:|..||....     :|....:..||   ...:.|       ||.
Zfish  1800 EDECFYCGDGGQIVSCKKPGCPKVYHADCLNLSKRPA---GRWECPWHQCNECGRE--------- 1852

  Fly  1650 AAQISALCSPRNI------------KTRG-LTQAVHDPELEKMAKMAVVLRDICSAMETLKMSDL 1701
            ||....:| |.:.            |..| |:.:.|||               |.. :.|:..::
Zfish  1853 AASYCEMC-PNSYCEQHREGMLFISKLDGKLSCSEHDP---------------CGP-DPLEPGEI 1900

  Fly  1702 LTTVSSKKKKPIKTTLSGKLGSTAATSKVEFRSIQAQVEQGHYKTPQEFDDHMQQLFVEAKQQHG 1766
            ...|.|       |::.|:..:.:|:.::...::....                .||:.|:.:
Zfish  1901 REYVPS-------TSIVGQAPNMSASGRITQPALPPAA----------------PLFIPAQNR-- 1940

  Fly  1767 DDEGKEKALQSLKDSYEQQKIASYVQLVEILGDSESLQSFKPKEVLSSEEEPGKIAVKKSPGAKE 1831
                  .|.||.:|.|..:.:            ...|.|..||::...:...|::..::    :|
Zfish  1941 ------PAFQSQRDPYGDEVV------------DNILPSSSPKDIKEEDMSDGEVVFEE----EE 1983

  Fly  1832 RDSPIVPLKVTPPPLLPIEASPDEDVIRC 1860
            .|..:|            :...||:.|.|
Zfish  1984 EDLELV------------DDEEDEEEIDC 2000

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	77/428 (18%)
		AWS	1340..1388	CDD:197795	22/50 (44%)
		SET_ASH1L	1391..1531	CDD:380951	61/140 (44%)
		Bromo_ASH1	1680..1787	CDD:99955	15/106 (14%)
		PHD_ASH1L	1858..1900	CDD:277023	2/3 (67%)
		BAH_polybromo	1929..2073	CDD:240068
nsd1a	XP_683890.5	None