DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ash1 and phf3

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	XP_005157087.1	Gene:	phf3 / 553518	ZFINID:	ZDB-GENE-090313-207	Length:	1691	Species:	Danio rerio

Alignment Length:	1866	Identity:	332/1866 - (17%)
Similarity:	561/1866 - (30%)	Gaps:	617/1866 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 DFMEKTQMLGQTVNAKLAEEKVAKAKEETLVQTAVPRK-------------RRGRPKKVVPTVPA 276
            |.::.:.:|||.:..:.::|  .:||.|..::..:..|             ......|:..:..|
Zfish    15 DQLDDSLLLGQNLECEASDE--FEAKPEDSLKNMLSDKDPMFGSASTQFHLLENEDFKLGSSADA 77

  Fly   277 PGN-SGPAINESADSGVISTTSTTQSTTPSPKMQNENAVPTGSLPIASSSKPKIDMAYLDKRMYA 340
            ... :|..:.:|...|..:.:...|....:.:||.......|.:              ..:|:
Zfish    78 DHEMTGAGVRQSPSDGEHNQSGFLQDRRQAGQMQRRQTASRGRV--------------RGRRL-- 126

  Fly   341 TERVLYPPPRSKRRQNNKKTACSSSNKEELQLDPLWREIDVNKKFRLRSMSVGAASGTGASTTIC 405
                  .|.|......|:::.||..:..:...|.. ||..::::|.:..:.      :..:..:.
Zfish   127 ------GPARKAAESYNRESTCSEEHDRDNSPDEK-REALLSRRFGVHEVD------SSMNPVVV 178

  Fly   406 SKVLAAKSGYVSDYGSVRHQRSSHNHNSGYKSD-----ASCKSRYSTKSCMSRRSRAKSCGYRSD 465
            .:.|....|                   |||.:     :.....:||       |..:|.|::.|
Zfish   179 LRRLTVTVG-------------------GYKIELLPGPSQSFGSFST-------SALQSLGFQDD 217

  Fly   466 CKESGKSGLRMRRKRRASMLLKSSADDTVEDQDILQLAG-LSLGQSS------------------ 511
            ...:...||.          |..:.|:.|.|....:..| :|:.||:
Zfish   218 GIIADGLGLD----------LGQNQDEQVVDNSTPEAVGEVSIDQSTSHDVPMDFGPYVNPNEVQ 272

  Fly   512 EESNEYISKPSLKSLPTTSASKKYGEINRYVTTGQYFGRGGSLSATNPDNFISKMMNQRKETPAP 576
            :.::..:.||.:::..:..|.||..:|           :...|||..|.|     .|.....||.
Zfish   273 DTNSTMVLKPKVENATSEDAKKKNNQI-----------KTQKLSAQKPGN-----KNGTAARPAV 321

  Fly   577 SKSSCKIKSRRSSAASMCSSYVSGVSRMRRRHRRKSFSHNKSLNIDSKLLTEIEIITSTFNSRCR 641
            .|   .:|:::|.:|                      :.||
Zfish   322 KK---LLKNKQSLSA----------------------AKNK------------------------ 337

  Fly   642 IQDDRLTGSSGKEKLLADANKLQATLAAPSPAQQLTLNGGGPASTLSKPLKRGLKKRKLSEPLVD 706
                  ..|..|..||...:|         ..|...::.|.|.....||:|.|||:
Zfish   338 ------PSSPTKPGLLQKESK---------HPQDKKIHTGQPEVHKGKPIKVGLKR--------- 378

  Fly   707 FAMLSASASGTPNGSGSSNGNTKRRHKKSQSNDSSSPDDHKLPLKKRHYLLTPGERPPAEVAFAN 771
                ..:|.|..:||         :.:|.|...|:|                       :.|..:
Zfish   379 ----PGAALGPKDGS---------KIQKIQDGHSAS-----------------------KTASPS 407

  Fly   772 GKLNAEAWAAAAAAAKSTASTKSQAQFNARSVKSALTPKKRHLLEQPTSVSGAGSSASNSPLRIV 836
            |.|      :.....||::.:...:..|:|...|...|.......:|::.....|:.|..|
Zfish   408 GPL------SPTITKKSSSESGPLSPTNSRKPSSDSVPLSPTNSRKPSNSVPLSSTNSRKP---- 462

  Fly   837 VDNNSISGGKLLDISPSSLCSLKQQRRGGAAKQKVSAAKDLVQLQSPAGSYPPPGVFEPSVELEI 901
             .:||:      .:|||:      .|:..:....:|..... :|.|.:|...|....:||.:
Zfish   463 -SSNSV------PLSPSN------SRKPSSNLVPLSPTNSR-KLSSDSGPLSPTNSRKPSSD--- 510

  Fly   902 QIPLSKLN------ESVITKAEVESPLLSALDIKEDTKKEVGQRVVETLLHKTGGNLLLKRKRKK 960
            .:|||..|      ||......|:||....   |.......|.:....:.:..|.....|.|.||
Zfish   511 SVPLSPTNSRRPSSESGPGVKSVQSPHPPK---KPQNPPTSGNKTNPPVANSQGDEEQDKVKAKK 572

  Fly   961 INRTGFPTVRRKKRKVSVEQQTTAVIDEHEPE-FDPDDEPL-------QSLRETRS----SNNVN 1013
            |.:|......|..|.:|:|          ||: |.||:.|:       .:|.|:.:    :.|..
Zfish   573 IEKTQQRHKSRNSRSISIE----------EPQLFIPDNAPVVKKEAEGDALAESETVWDPTKNCV 627

  Fly  1014 VQAAPN-------------------PPLDCERVPQAGEARETFV-----ARTNQK--APRLS--V 1050
            :...|:                   ..||..:|.|..:..:.:|     |:.::|  |..||  .
Zfish   628 LCKKPHNNRFMVGCGRCDDWFHGDCVGLDLAKVQQMEKEDQEYVCLKCCAQEDEKTQASELSDDK 692

  Fly  1051 VALERLQRPQ---TPARGRPRGRKPKNREQAEAAPQPPPKSEPEIRPAKKRGRQPKQPVLEEPPP 1112
            .|.::.||||   |....||..:....|..:|.:.|..|..:.|.:..|      ..||..:.|.
Zfish   693 SAAKQKQRPQQSLTAGGIRPFRKDAGERRPSEDSAQKGPNVKHETKKVK------ISPVSSKKPS 751

  Fly  1113 TPPPQQK----------KNKMEPNIRLP-------------------DGID---PNTNFSCKIRL 1145
            |...::.          |...|.::::.                   .|:|   .|...|....|
Zfish   752 TGHIRRSVRDSLEEILLKRSKESDLKISSDRPAEVARRTEKELFALFQGVDSKYKNKYRSLTFNL 816

  Fly  1146 KRRKN-------LEAGTQP------------KKE-----KPVQPVTVEEIPPEIPVSQEEIDAEA 1186
            |..||       |:....|            .||     |.....|:|.|..|    |.|::...
Zfish   817 KDAKNNVLFKRVLKGEVSPADLVRMTAEELASKELAAWRKRENRHTIEMIEKE----QREVERRP 877

  Fly  1187 EAK--RLDSIPTEH-DPLPASESHNPGPQDYASCSESSEDKASTTSLRKLSKVKKTYLVAGLFSN 1248
            ..|  ....|..|: :|..|.|:....|:......|..|:|
Zfish   878 ITKITHKGEIEIENQEPAKAPEAIEVEPEPVLKVVEVPEEK------------------------ 918

  Fly  1249 HYKQSLMPPPAKVNKKPGLEEQVGPASLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRN 1313
                   ||..||...                   :|.:..|.:.....:|:     |.|:.|..
Zfish   919 -------PPEIKVESP-------------------KKSIDTTNLHKSHLFDL-----NCKICTGR 952

  Fly  1314 VVP-----SWNYRKIRTNV-----------YAESVRPNLAGFDHPTCNCKNQGEKSCLDNCLNRM 1362
            :.|     |....|:.|.|           ...:..|..|..|..|.....:|       .||.:
Zfish   953 MAPPTEEASTKVVKVATTVVRRQSSATEESQPSTTTPTSALMDDLTLRAMEEG-------LLNFL 1010

  Fly  1363 VYTECSPSNCPAGEKCRNQKIQR-----------HAVAPGVERFMTADKGWGVRTKLPIAKGTYI 1416
                  |.:..|...|..:....           :...|.|.||:         ||..:..||
Zfish  1011 ------PESSRADSLCSKEDTATFLSSLESLWGGYVDMPAVARFL---------TKSYLVSGT-- 1058

  Fly  1417 LEYVGEVVTEKEFKQRMASIYLNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNC---EMQK 1478
                                    ..|....|...:.:.|:            ..|..   .::|
Zfish  1059 ------------------------LDHLTQDLPDNIQVGGR------------ISPQIVWDYVEK 1087

  Fly  1479 WSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCRGVIGGKSQRVK-----P 1538
            ...:|...:.:.......|.:|::|...::.|          ::.:..||:....::||     |
Zfish  1088 IRASGTKEICVIRFSPDTEEDEISYTLLYAYF----------SSRRRYGVVANNRKQVKDMYLIP 1142

  Fly  1539 LPAVEAKP------SGEGLSGRN-----GRQRKQKAKKHAQRQAGKDISSAVA-VAKLQPLSEKE 1591
            |.:.|..|      .|.||....     |...:|:.|:........|:|.|.: :|:.:|..:..
Zfish  1143 LGSTEKIPHQIVPFDGPGLETNRPNLLLGLIIRQRPKRDFGVILPSDVSEAPSFLAESKPQVDYP 1207

  Fly  1592 KKLVRQFNTFLVRNF-EKIRRCKAKRASD-AAATASSPALGTTNGDIPGRR--PSTPSSPSLAAQ 1652
            :|.....:|  .::| ..:...:.|..:| ..:....|.|.|...:....|  |.....|..||.
Zfish  1208 QKTPVALDT--EQSFISDLGNARKKDTTDLIKSVVEEPILDTETDENVSLRFLPGVLKLPEKAAS 1270

  Fly  1653 ISALCSPRNIKTRGLTQAVHDPELEKMAKMAVVLRDICSA-----------------METLKMSD 1700
                ||..|:|:.........|.::......|..:.|.||                 .|...:|.
Zfish  1271 ----CSNDNMKSDSTKTEAKTPSVDSGNNATVSPKPIASAPRLDRFVIKKKEPKAVKTEQAPVSV 1331

  Fly  1701 LLTTVSSKKKKPIKTTLSGKLGSTAATSKV-EFRSIQAQVEQGHYKTPQEFDDHMQQLFVEAKQQ 1764
            .|...|.||:..:..:||.|....:..|.: ...:.:.:.|.....|.........|.......:
Zfish  1332 SLEISSEKKETAVVLSLSDKPADVSTESFLSSLTNTKPKEESESCSTASPTSQETSQTTSSGTSK 1396

  Fly  1765 HGDDEGKEKALQSLKDSYEQQKIASYVQLVEILGDSESLQSFKPKEVL---SSEEEPGKIAVKKS 1826
            ...|||...|.::                 |.:....:.....|..:|   ||..||.:..:.:|
Zfish  1397 DSVDEGSSSAPKN-----------------ETISSPTATTKVSPAGILKRASSAPEPTESKLPES 1444

  Fly  1827 PGAKERDSPIVPLKVTPPPLLPIEASPDEDV--IRCICGLYKDEGL 1870
            ...|...      ||||.|... |....||:  |..|..:.|:|||
Zfish  1445 SSEKPEQ------KVTPQPSTQ-ECKAIEDIQAITTISSIGKNEGL 1483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795	8/58 (14%)
		SET	1392..1512	CDD:214614	17/122 (14%)
		Bromo_ASH1	1680..1787	CDD:99955	21/124 (17%)
		PHD_ASH1L	1858..1900	CDD:277023	6/13 (46%)
		BAH_polybromo	1929..2073	CDD:240068
phf3	XP_005157087.1	DUF4045	<341..732	CDD:330572	100/484 (21%)
		PHD_PHF3	625..675	CDD:277108	7/49 (14%)
		TFIIS_M	755..863	CDD:311443	15/107 (14%)
		SPOC	1027..1176	CDD:311609	30/205 (15%)
		Endomucin	1271..>1449	CDD:330316	34/194 (18%)
		RRM	1605..>1690	CDD:330708
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030