DRSC/TRiP Functional Genomics Resources

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Protein Alignment ash1 and setdb1a

DIOPT Version :10

Sequence 1:NP_524160.2 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster
Sequence 2:NP_001038232.1 Gene:setdb1a / 553292 ZFINID:ZDB-GENE-030131-2421 Length:1436 Species:Danio rerio


Alignment Length:1621 Identity:288/1621 - (17%)
Similarity:478/1621 - (29%) Gaps:653/1621 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   235 QTVNAKLAEEKVAKAKEETLVQTAVPRKRRGRPKKVVPTVPAPGNSGPAINESADSGVISTTSTT 299
            :|:...|.:..||..|...|||..|        :.|..|  :.|.:.|....|:|....|::||.
Zfish   138 ETLEPMLEKVTVAIQKSSKLVQDLV--------QMVSKT--SMGATSPLSTSSSDINRPSSSSTP 192

  Fly   300 QSTTP---SPKMQNENA---VPTGSLPIASSSKPKIDMAYLDKRMYATERVLYPPPRSKRRQNNK 358
            :...|   :||::..|:   |.|.||    ||.|||...:                       |.
Zfish   193 EIVRPESVTPKLEITNSITIVKTESL----SSVPKISSLF-----------------------NS 230

  Fly   359 KTACSSSN------KEELQLDPLWREIDVNKKFRLRSMSVGAASGTGASTTICSKVLAAKSGYVS 417
            ...|.|..      |..::.:|.|..:               .....:.::...|::..:|    
Zfish   231 SEQCKSIADHDSYFKPTIKTEPEWTPL---------------TPWEDSESSPFEKLIKTES---- 276

  Fly   418 DYGSVRHQRSSHNHNSGYKSDASCKSRYSTKSCMSRRSRAKSCGYRSDCK-----ESGKSGLRMR 477
                                    :|...|.|.|:...:.:...::|..|     :|.::...:.
Zfish   277 ------------------------QSTDVTPSVMTPNKQPELLSFQSTTKIKPEPQSTQANTELS 317

  Fly   478 RKRRASMLL-------------KSSADDTVEDQDILQLAGLSLGQSSEESNEYISKPSLKSLPTT 529
            .....|.||             :|....:|.:.|:|:       ..||:|:...:|...|....|
Zfish   318 SPPSNSKLLENHNSLSIAAIKNESQLKASVSEVDLLE-------SDSEQSDNAATKTRFKPSEVT 375

  Fly   530 SASKKYGEINRYVTTGQYFGRGGSLSATNPDNFISKMMNQRKE-TPAPSKSSCKIKSRRSSAASM 593
            ::||       ..::|.:.....||:.|:|     |:...... ||.||||...:.:..|...: 
Zfish   376 ASSK-------LKSSGDHNSASASLNRTDP-----KVRPVTPSGTPPPSKSPPAVDNTASVETN- 427

  Fly   594 CSSYVSGVSRMRRRHRRKSFSHNKSLNIDSKLLTEIEIITSTFNSRCRIQDDRLTGSSGKEK-LL 657
                                      ..||:|.||..:..||.            .|:.||. ::
Zfish   428 --------------------------QTDSELPTETPVEESTL------------PSNPKEAVIM 454

  Fly   658 ADANKLQATLAAPSPAQQLTLNGGGPASTLSKPLKRGLKKRKLSEPLVDF----AMLSASASGTP 718
            :||.....|                     .||..|    :|.|:|.|..    :.|::|.|...
Zfish   455 SDAESTDKT---------------------EKPQTR----KKSSKPSVTTTSPESRLTSSKSPPV 494

  Fly   719 NGSGSSNGNTKRRHKKSQSNDSS-----SPDDHKLPLKKRHYLLTPGERPPAEVAFANGKLNA-E 777
            ..:.|:...|.|....|.|.|.|     |||:             |...|.........|... :
Zfish   495 TKTSSTQKETARAQSPSDSIDESADMEDSPDE-------------PSNSPTESPTKTPDKTTRND 546

  Fly   778 AWAAAAAAAKSTASTKSQAQFNARSVK----SALTPKKRHLLEQPTSVSGAGSSASNSPLRIVVD 838
            |.|..:.|.||:..:.|::....:.:|    :|:..||||                         
Zfish   547 APAKPSKAKKSSKHSSSESSKTLKEIKLKVGAAVLGKKRH------------------------- 586

  Fly   839 NNSISGGKLLDISPSSLCSLKQQRRGGAAKQKVSAAKDLVQLQSPAGSYPPPGVFEPSVELEIQI 903
             |..|.|.:.::        :.:..|...|.:....|.:|...:...:|.||             
Zfish   587 -NHWSRGTVQEV--------ETEDDGNTYKVEFKKGKTIVLSANHVAAYKPP------------- 629

  Fly   904 PLSKLNESVITKAEVESPLLSALDIKEDTKKEVGQRVVETLLHKTGGNL--------LLKRKRKK 960
                                |..|:      .:|.|||.:...:.|.:|        |.:||   
Zfish   630 --------------------SLKDL------YIGCRVVASAKSENGKSLYNAGVMVELPERK--- 665

  Fly   961 INRTGF--------------PTV-----RRKK--RKVSVEQQTTAVIDEHEPEFDPDDEPLQSLR 1004
             ||..|              |.:     :.||  |::..|.....|.|..:...:|....|:..:
Zfish   666 -NRMRFLVFFDDGLATYLALPDLYFVCKQTKKVWREIKDESSRKQVKDYLQVYPNPIAVVLRLGQ 729

  Fly  1005 ETRSSNNVNVQAAPNPPLDCE---------RVPQAGEARETFVARTNQKAPRLSVVALERLQ--- 1057
            ||::..|...:       ||.         ::....:.::.::.:.:.|...:..:.....|   
Zfish   730 ETKAVRNGQFE-------DCTVLQLDGSLVQICYKNDKQKEWIYKGSDKLEHILTIKNRHKQHSH 787

  Fly  1058 -RPQTPARGRPRGRKPKNREQAEAA------PQPPPKSEPEIRPAKKRGRQPKQPVLEEPPPTPP 1115
             :..:| .|:.:..:||....:::|      ....|.|...:.||:...:..|......|.....
Zfish   788 KKHHSP-EGKTQSSQPKTLHSSKSASTSTSSANVSPVSSDSVSPARVTRQSDKTKTSISPQKIMS 851

  Fly  1116 PQQKKNKMEPNIRLPDGIDP-------NTNFSCKIRLKRRKNLEAGTQPKKEKPVQ--------- 1164
            |..:...:...|.||..|.|       ||| |..|..||....|...:...|..|:         
Zfish   852 PAFQPKVVLQKISLPSSISPAARVSNSNTN-SSLISAKRPAPDEEEDEYFSEDEVEVLEQEQNKS 915

  Fly  1165 --------PVTVEEIPPEIPVSQEEIDAE-----------------AEAKRLDSIPTEH----DP 1200
                    |..:||:.|      .::|..                 ...:|:|.....|    .|
Zfish   916 VYLHQRCCPACLEEVRP------HQVDIHHGKNPLLIPLLFKFRRMTARRRIDGKLFFHIFYRSP 974

  Fly  1201 LPASESHNPGPQDYASCSESSEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQSLMPPPAKVNKKP 1265
            ...|.......|||                  |.:.:..:|...:|       .|.|...||:..
Zfish   975 CGRSLCDMQEVQDY------------------LFETRCDFLFLEMF-------CMDPFVLVNRAR 1014

  Fly  1266 GLEEQVGPASLLPP---------PPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSWNYR 1321
            ......|...|..|         |..|.     .|:|..|..::  .||..::|.|         
Zfish  1015 PPSTTTGQPHLYLPDISEGKEVMPVPCV-----NEVDNTLAPNV--TYTKDRVPAR--------- 1063

  Fly  1322 KIRTNVYAESVRPNLAGFDHPTCNCKNQGEKSC--------------------------LDNCLN 1360
                .|:..:....:.|.| .|..|:::.:.:|                          |...|.
Zfish  1064 ----GVFINTSSDFMVGCD-CTDGCRDRSKCACHKLTIEATSLCTGGPVDVSAGYTHKRLPTSLP 1123

  Fly  1361 RMVYTECSP-SNCPAGEKCRNQKIQRHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVV 1424
            ..|| ||:| ..|.. ..|.|:.:| |.:...:|.|||..||||:|.|..:.|||::..:.|::|
Zfish  1124 TGVY-ECNPLCRCDP-RMCSNRLVQ-HGMQLRLELFMTQHKGWGIRCKDDVPKGTFVCVFTGKIV 1185

  Fly  1425 TE--------------------------------------------------------------- 1426
            .|                                                               
Zfish  1186 NEDKMNEDDTMSGNEYLANLDFIEGVEKLKEGYESEAYCSDTEVESSKKTITMKTGPLLKNSLYK 1250

  Fly  1427 ---------------------------------------KEFKQRMASIYLNDTHH-----YCLH 1447
                                                   |:.:::::.:..||...     .|..
Zfish  1251 EDSSSGEEPMEVDTAKDKVKVHDKPLGERKLPNKPHETPKDTQKKISELRKNDGQESSGPKRCFA 1315

  Fly  1448 L---------------------------------DGGLVIDGQRMGSDCRFVNHSCEPNCEMQK- 1478
            :                                 |...:||.::.|:..|::||||.||..:|. 
Zfish  1316 IKSFQRRVKPLESTEAQKEKTKTPKNTRGLFNDEDACYIIDARQEGNLGRYINHSCSPNLFVQNV 1380

  Fly  1479 ----------WSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQP--CRCNTPQCRG 1527
                      |       :..||.:.|:.|.|||:|||:.: ...||:.  |.|.:.:|.|
Zfish  1381 FVDTHDLRFPW-------VAFFASKRIKAGTELTWDYNYEV-GSVEGKVLLCCCGSLRCTG 1433

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ash1NP_524160.2 PHA03247 <1018..1281 CDD:223021 54/335 (16%)
AWS 1340..1388 CDD:197795 16/74 (22%)
SET_ASH1L 1391..1531 CDD:380951 49/290 (17%)
Bromo_ASH1 1680..1787 CDD:99955
PHD_ASH1L 1858..1900 CDD:277023
BAH_polybromo 1929..2073 CDD:240068
setdb1aNP_001038232.1 Herpes_BLLF1 <129..500 CDD:282904 97/524 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 170..200 8/29 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 250..327 13/119 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 344..570 66/321 (21%)
PRK08581 351..>546 CDD:236304 59/290 (20%)
DUF5604 570..624 CDD:408109 13/87 (15%)
Tudor_SF 636..718 CDD:470623 19/85 (22%)
Tudor_4 725..773 CDD:408159 7/54 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 781..849 12/68 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 869..894 9/25 (36%)
HMT_MBD 943..1003 CDD:238689 11/84 (13%)
SET_SETDB1 1022..1436 CDD:380915 78/444 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1247..1294 1/46 (2%)
Blue background indicates that the domain is not in the aligned region.

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