Protein Alignment ash1 and ezh2

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: XP_012820250.1
• Gene: ezh2 / 550047
• XenbaseID: XB-GENE-956215
• Length: 769
• Species: Xenopus tropicalis
• Alignment Length: 871
• Identity: 185/871 - (21%)
• Similarity: 287/871 - (32%)
• Gaps: 314/871 - (36%)

  Fly   826 SSASNSPLRIVVDNNSISGGKLLDISP-----------SSLCSLKQQRRGGAAK-------QKVS 872
            ||||.   ||::...    ||..:..|           ..|..||:.||....|       ||:.
 Frog     8 SSASR---RIIMGQT----GKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFNTNRQKIM 65

  Fly   873 AAKDLVQLQSPAGSYPP----------PGVFEPSVELEIQIPLSKLNESVITK-AEVE-----SP 921
            ...:::..:.......|          .|..|.||..::..|...:....:|. |.|.     ||
 Frog    66 ERTEILNQEWKQRRIQPVHIMTTVSSLRGTRECSVTSDLDFPKQVIPLKTLTAVASVPIMYSWSP 130

  Fly   922 LLSALDIKEDTKKE----VGQRV-------VETLLHKTGGNLLLKRKRKKINRTGFPTVRRKKRK 975
            |.....::::|...    :|..|       :|.|:....|.:...|....|...||     ...:
 Frog   131 LQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRGICCIAECGF-----INDE 190

  Fly   976 VSVE-QQTTAVIDEHEPEFDPDDEPLQSLRETRSSNNVNVQAAPNPPL---DCERV--------P 1028
            :.|| ....|...::|.:.|.||.......:|....:.|::.....||   ..:::        |
 Frog   191 IFVELVNALAQYSDYEDDEDGDDNQDDERDDTAKDQDDNMEDQETQPLRKFPSDKIFEAISSMFP 255

  Fly  1029 QAG---EARETFVARTNQK---------APRLSVVALERLQRPQT-------------------- 1061
            ..|   |.:|.:...|.|:         .|.:.....:.:||.|:
 Frog   256 DKGTLEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLH 320

  Fly  1062 PARGRPRGRKPKNREQA-EAAP------------------------QPPPKSEPEIRPA-KKRGR 1100
            |....|...|.||.|.| :..|                        :.|||     ||: ::|||
 Frog   321 PFHATPNTYKRKNNEAANDGKPCGPHCYQLLEGAREFAAALTAERIKTPPK-----RPSGRRRGR 380

  Fly  1101 QPKQPVLEEPPPTPPPQ-------------------QKKNKMEPNIRLPDGIDPNTNFSCKIRLK 1146
            .|..   ...|.||...                   :..:|.|...:.........|..|:..:|
 Frog   381 LPNN---TSRPSTPTVNVLEAKDTDSDREAGTETGGESNDKEEEEKKDETSSSSEANSRCQTPIK 442

  Fly  1147 RRKNLEAGTQPKKEKPVQPVTVEEIPPEIPVSQEEIDAEAEAKRLDSIPTEHDPLPASESHNPGP 1211
            .:.|:|                   |||   :.|...|||...|: .|.|.:|..
 Frog   443 MKPNIE-------------------PPE---NVEWSGAEASLFRV-LIGTYYDNF---------- 474

  Fly  1212 QDYASCSESSEDKASTTSLRKL--SKVKKTYLVAGLFSNHYKQSLMPPPAKVNKKPGLEEQVGPA 1274
                 |:.:.  ...|.:.|::  .:||::.::|.:.:    :.:..||.|..:|
 Frog   475 -----CAIAR--LIGTKTCRQVYEFRVKESSIIAPVIA----EDVDTPPRKKKRK---------- 518

  Fly  1275 SLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSWNYRKIR-------TNVYAESV 1332
                                   :.:|.|:.               |||:       .:||
 Frog   519 -----------------------HRLWAAHC---------------RKIQLKKDGSSNHVY---- 541

  Fly  1333 RPNLAGFDHP------TCNC---KNQGEK--SCLDNCLNR------------------MVYTECS 1368
              |....|||      :|.|   :|..||  .|...|.||                  :...||.
 Frog   542 --NYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECD 604

  Fly  1369 PS---NCPAGE-------KCRNQKIQRHA-----VAPGVERFMTAD-KGWGVRTKLPIAKGTYIL 1417
            |.   .|.|.:       .|:|..|||.:     :||       :| .|||:..|.|:.|..:|.
 Frog   605 PDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAP-------SDVAGWGIFIKDPVQKNEFIS 662

  Fly  1418 EYVGEVVTEKEFKQRMASIYLNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVN 1482
            ||.||::::.| ..|...:|......:..:|:...|:|..|.|:..||.|||..|||..:...||
 Frog   663 EYCGEIISQDE-ADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVN 726

  Fly  1483 GLSRMVLFAKRAIEEGEELTYDYNFS 1508
            |..|:.:||||||:.||||.:||.:|
 Frog   727 GDHRIGIFAKRAIQTGEELFFDYRYS 752

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	60/352 (17%)
		AWS	1340..1388	CDD:197795	22/91 (24%)
		SET_ASH1L	1391..1531	CDD:380951	45/119 (38%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
ezh2	XP_012820250.1	EZH2_WD-Binding	54..83	CDD:463308	3/28 (11%)
		PRC2_HTH_1	173..272	CDD:436286	19/103 (18%)
		preSET_CXC	582..613	CDD:408079	4/30 (13%)
		SET_EZH2	632..751	CDD:380995	46/126 (37%)