DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ash1 and NSD3

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	NP_075447.1	Gene:	NSD3 / 54904	HGNCID:	12767	Length:	1437	Species:	Homo sapiens

Alignment Length:	1590	Identity:	321/1590 - (20%)
Similarity:	534/1590 - (33%)	Gaps:	504/1590 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 PNLVQAAIKRVE------SD-TED-------TTVEGSFRKAAKDKNLPQ----YQSTL-LQDFME 228
            |.|:.:|..|.|      || .||       .|::..|:..|..::||.    |.|:: :.:...
Human    20 PQLIDSANIRQEDAFDNNSDIAEDGGQTPYEATLQQGFQYPATTEDLPPLTNGYPSSISVYETQT 84

  Fly   229 KTQMLGQTVN-------------------AKLAEEKVAKAKEE----------TLVQTAVPRKRR 264
            |.|...|..|                   :::...:..:..|:          ::.||.:| |:.
Human    85 KYQSYNQYPNGSANGFGAVRNFSPTDYYHSEIPNTRPHEILEKPSPPQPPPPPSVPQTVIP-KKT 148

  Fly   265 GRPK---KVVPTVPAPGNSGPAINESADSG-VISTTSTTQSTTPSPKMQNENAVPTGSLPIASSS 325
            |.|:   |:..|:    .:|..:.||:..| :::....::.|....:.:.|....:.....:.|.
Human   149 GSPEIKLKITKTI----QNGRELFESSLCGDLLNEVQASEHTKSKHESRKEKRKKSNKHDSSRSE 209

  Fly   326 K------PKIDMAYLDKRMYATERVLYPPPRSKRRQNNKKTACSSSN------KEELQLDPL--- 375
            :      ||::                  |..:.|.|.:....|...      |||..:.|:
Human   210 ERKSHKIPKLE------------------PEEQNRPNERVDTVSEKPREEPVLKEEAPVQPILSS 256

  Fly   376 --WREIDVNKKFRLRSMSVGAASGT----------GASTTICSKV--LAAKSGYVSDYGSVRHQR 426
              ..|:....||::..: |.:..||          .....:.:|:  ..|:..:|..:.:...:.
Human   257 VPTTEVSTGVKFQVGDL-VWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERA 320

  Fly   427 SSHNHNSGYKSDASCKSRYSTKSCMSRRSRAKSCGYRSDCKESGKSGLRMRRKRR---------- 481
            ..|.     |.....|.....:..::..::..|       ..|.|..:|..|.:|
Human   321 WVHE-----KRVREYKGHKQYEELLAEATKQAS-------NHSEKQKIRKPRPQRERAQWDIGIA 373

  Fly   482 -ASMLLKSSADDTVEDQDILQLAGLSLGQSSEESNEYISKPSLKS-------LPTTSASKKYGEI 538
             |...||.:.::.:|....:.:........|:......||..:|.       |.|.......||:
Human   374 HAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEV 438

  Fly   539 NRYVTTGQYFGRGGSLSATNPDNFISKMMNQRKETPAPSKSSCKIKSRRSSAASMCSSYVSGVSR 603
                        ..|||:|.     .:..:||:.|.|..:....:|....:||:
Human   439 ------------ASSLSSTE-----IRRHSQRRHTSAEEEEPPPVKIAWKTAAA----------- 475

  Fly   604 MRRRHRRKSF-----SHNKSLNIDSKLLTEIEIITSTFNSRCRIQDDRLTGSSGKEKLLAD---- 659
                  |||.     .|..||::....::.:..|...|         .|..::|..|.:..
Human   476 ------RKSLPASITMHKGSLDLQKCNMSPVVKIEQVF---------ALQNATGDGKFIDQFVYS 525

  Fly   660 ----ANKLQATLAAPSPAQQLTLNGGGPASTLSKPLKRGLK-KRKLSEPLVDFAMLSASASGTPN 719
                .||.:.::.            |.....:|.|.:|..| .:.:|.|           ..|..
Human   526 TKGIGNKTEISVR------------GQDRLIISTPNQRNEKPTQSVSSP-----------EATSG 567

  Fly   720 GSGSSNGNTKRRHKKSQSNDSSSPD-DHKLPLKKRHYLLTPGERPPAEVAFANGKLNAEAWAAAA 783
            .:||.....:||..:::|....|.: ..|..:||......|
Human   568 STGSVEKKQQRRSIRTRSESEKSTEVVPKKKIKKEQVETVP------------------------ 608

  Fly   784 AAAKSTASTKSQAQFNARSVKSALTPKKRHLLEQPTSVSGAGSSASNSPLRIVVDNNS------- 841
                 .|:.|:..|..|..:..:..|.|:.      |.:......::|..|...|::|
Human   609 -----QATVKTGLQKGASEISDSCKPLKKR------SRASTDVEMTSSAYRDTSDSDSRGLSDLQ 662

  Fly   842 ISGGKLLDISPS-----------SLCSLKQQRRGGAAKQKVSAAKDLV-QLQSPAGS--YPPPGV 892
            :..||.:| |||           |:.|...:|..|.:|      ||.| |:...:|.  .|..|.
Human   663 VGFGKQVD-SPSATADADVSDVQSMDSSLSRRGTGMSK------KDTVCQICESSGDSLIPCEGE 720

  Fly   893 FEPSVELEIQIPLSKLNESVITKAEVE-------SPLLSALDIKEDTKKEVGQRVVETLLHKTGG 950
            ......||. :.|:.|.:|.....|.:       |..:|..|:|..:....|:...|..:.|
Human   721 CCKHFHLEC-LGLASLPDSKFICMECKTGQHPCFSCKVSGKDVKRCSVGACGKFYHEACVRK--- 781

  Fly   951 NLLLKRKRKKINRTGFPTVRRKKRKVSVEQQTTAVI----DEHEPEFDPDDEPLQSLRETRSSNN 1011
                           |||...:.:.....|...:..    |.|
Human   782 ---------------FPTAIFESKGFRCPQHCCSACSMEKDIH---------------------- 809

  Fly  1012 VNVQAAPNPPLDCERVPQAGEARETFVARTNQKAPRLSVVALERLQRPQTP-----------ARG 1065
               :|:....:.|.|.|.|..:.:..:|..:.......::.....:|....           |||
Human   810 ---KASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHSKRSSNSSAVNVGFCFVCARG 871

  Fly  1066 -------RPRGR----------KPKNREQAEAAPQPPPKSEPEIRPAKKRGRQPKQPVL--EEPP 1111
                   .|...          ...||.:....|..|..|..: :..:|.||     :|  |..|
Human   872 LIVQDHSDPMFSSYAYKSHYLLNESNRAELMKLPMIPSSSASK-KKCEKGGR-----LLCCESCP 930

  Fly  1112 PTPPPQQKKNKMEPNIRLPDGIDPNTNFSCKIRLKRRKNLEAGTQPKKEKPVQPVTVE------- 1169
            .:..|:..      :|.:|:|.     ::|       .:.:||   ||....|.|.|:
Human   931 ASFHPECL------SIEMPEGC-----WNC-------NDCKAG---KKLHYKQIVWVKLGNYRWW 974

  Fly  1170 --EI--PPEIPVSQEEIDAEAEAKRLDSIPTEHD----PLPASESHN-------------PGPQD 1213
              ||  |..:|::.:.:              :||    |:....||:             .|.:.
Human   975 PAEICNPRSVPLNIQGL--------------KHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKS 1025

  Fly  1214 YASCSESSEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQSLMPPPAKVNKKPGLEEQVGPASLLP 1278
            :|. .::|.:|   |..:.|.:..|.:           |.|   .|:...|..||  :...|..|
Human  1026 FAE-GQTSINK---TFKKALEEAAKRF-----------QEL---KAQRESKEALE--IEKNSRKP 1070

  Fly  1279 PPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSWNYRKIRTNVYAESVRPNLAGFDH-P 1342
            ||                                       |:.|:.|.....|:..:|.... |
Human  1071 PP---------------------------------------YKHIKANKVIGKVQIQVADLSEIP 1096

  Fly  1343 TCNCKNQGEKSC-LDN-CLNRMVYTECSPSNCPAGEKCRNQKIQRHAVAPGVERFMTADKGWGVR 1405
            .||||...|..| |:: |||||:..||.|..||||::|:||...:. :.|..|...|..:|||:|
Human  1097 RCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKR-LYPDAEIIKTERRGWGLR 1160

  Fly  1406 TKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLND-THHYCLHLDGGLVIDGQRMGSDCRFVNHS 1469
            ||..|.||.::.|||||::.|:|.:.|:...:.|. |:.|.|.:....:||....|:..||:|||
Human  1161 TKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHS 1225

  Fly  1470 CEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCRGVIGGKSQ 1534
            |.||||.|||:|||..|:.|||...|..|.|||::||.........: |.|....|.|.:|
Human  1226 CNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTE-CHCGADNCSGFLG---- 1285

  Fly  1535 RVKPLPAVEAKPSGEGLSGRNGRQRKQKAK 1564
             |:|..|. |..:.|.......:|:::|.|
Human  1286 -VRPKSAC-ASTNEEKAKNAKLKQKRRKIK 1313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795	23/50 (46%)
		SET	1392..1512	CDD:214614	53/120 (44%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
NSD3	NP_075447.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..157		7/36 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	181..252		12/88 (14%)
		PWWP domain; Pfam PF00855	264..324		8/60 (13%)
		MSH6_like	267..383	CDD:99898	20/128 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..365		6/27 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	406..465		15/75 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	540..696		37/202 (18%)
		TNG2	<602..746	CDD:227367	36/186 (19%)
		PHD type zinc finger motif	697..738		12/47 (26%)
		PHD1_NSD3	703..746	CDD:277119	11/43 (26%)
		PHD type zinc finger motif	745..795		10/67 (15%)
		PHD2_NSD3	751..797	CDD:277122	10/63 (16%)
		PHD3_NSD3	798..850	CDD:277125	8/76 (11%)
		PHD type zinc finger motif	858..945		18/98 (18%)
		PHD4_NSD3	917..952	CDD:277128	11/57 (19%)
		PWWP domain; Pfam PF00855	954..1013		16/75 (21%)
		WHSC1_related	958..1051	CDD:99899	20/121 (17%)
		AWS	1094..1144	CDD:197795	23/50 (46%)
		SET	1145..1268	CDD:214614	54/122 (44%)
		SET domain	1149..1255		46/105 (44%)
		PHD type zinc finger motif	1317..1364
		PHD5_NSD3	1323..1365	CDD:277131
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D507784at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.950