DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ash1 and PHF20

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	NP_057520.2	Gene:	PHF20 / 51230	HGNCID:	16098	Length:	1012	Species:	Homo sapiens

Alignment Length:	887	Identity:	158/887 - (17%)
Similarity:	274/887 - (30%)	Gaps:	293/887 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1532 KSQRVKPLPAVEAKP-----------SGEGLSGRNGRQRKQKAKKHAQRQAGKDISSAVAVAKLQ 1585
            |.:..||| ..|.:|           |.:|........:.:|..|....:..::.|....|.|
Human   178 KDKEDKPL-KTEKRPKQPDKEGKLICSEKGKVSEKSLPKNEKEDKENISENDREYSGDAQVDK-- 239

  Fly  1586 PLSEKEKKLVRQFNTFLVRNFEKIRRCKAKRA-----SDAAATASSPALG-----------TTNG 1634
               :.|..:|:...       |.:|..|.||.     :..|..::|..|.           :...
Human   240 ---KPENDIVKSPQ-------ENLREPKRKRGRPPSIAPTAVDSNSQTLQPITLELRRRKISKGC 294

  Fly  1635 DIPGRRP----------STPSSPSLAAQISALCSPRNIKTRGLTQAVHDPELEKMAKMAVVLRDI 1689
            ::|.:||          |...|.:....:|...|.| :.|.| |..:.||:|        |:.|:
Human   295 EVPLKRPRLDKNSSQEKSKNYSENTDKDLSRRRSSR-LSTNG-THEILDPDL--------VVSDL 349

  Fly  1690 CSAMETLKMSDLLTTVSSKKKKPIKTTL-----------------SGKLG-------------ST 1724
               ::|..:.|.|::....::..:|:.|                 ||..|             .|
Human   350 ---VDTDPLQDTLSSTKESEEGQLKSALEAGQVSSALTCHSFGDGSGAAGLELNCPSMGENTMKT 411

  Fly  1725 AATSK-VEFRSIQAQVEQGHYKTPQEFD---------DH--------MQQLFVEAKQQHGDDE-- 1769
            ..||. ||.:.|........:|...:|.         ||        ..:.|.:||..|...:
Human   412 EPTSPLVELQEISTVEVTNTFKKTDDFGSSNAPAVDLDHKFRCKVVDCLKFFRKAKLLHYHMKYF 476

  Fly  1770 -GKEKALQ------------------------------------SLKDSYEQQKIASYVQLVEIL 1797
             |.||:|:                                    :.||. |:.|...:.:.|.:.
Human   477 HGMEKSLEPEESPGKRHVQTRGPSASDKPSQETLTRKRVSASSPTTKDK-EKNKEKKFKEFVRVK 540

  Fly  1798 GDSESLQSFKPK-------EVLSSEEEP----------------------------------GKI 1821
            ...:..:..|.|       |:..:.:||                                  ||:
Human   541 PKKKKKKKKKTKPECPCSEEISDTSQEPSPPKAFAVTRCGSSHKPGVHMSPQLHGPESGHHKGKV 605

  Fly  1822 AVKKSPGAKERDSPI-----------VPLKVTPPPLLPIEASPDEDVIRCICGLYKDEGLMIQCS 1875
            ...:.....|..|..           |.:...|...|..:...|.:|:||||.:.::...||||.
Human   606 KALEEDNLSESSSESFLWSDDEYGQDVDVTTNPDEELDGDDRYDFEVVRCICEVQEENDFMIQCE 670

  Fly  1876 KCMVWQHTEC---TKADIDADNYQCERCEPREVDREIP------LEEFTEEGHRYYLSLMR---- 1927
            :|..|||..|   .:.:: .:.|.|..|:.....|  |      .:|:...||.:.|:.:.
Human   671 ECQCWQHGVCMGLLEENV-PEKYTCYVCQDPPGQR--PGFKYWYDKEWLSRGHMHGLAFLEENYS 732

  Fly  1928 --------------GDLQVRQGDAVYVLRDIPIKDESGKVLPTKKHTYETIGAIDYQECDIFRVE 1978
                          ||:|    ..:.||..:.:|   ..:|.:::|.            |:....
Human   733 HQNAKKIVATHQLLGDVQ----RVIEVLHGLQLK---MSILQSREHP------------DLPLWC 778

  Fly  1979 HLWKNELGKRFIFGHHFLRPHETFHEPSRRFYPN-EVVRVSLYEVVPIELVIGRCWVLDRTTFCK 2042
            ..||...|:    |....|........|:...|: ..:..::.:..|:.|.:.|.......|
Human   779 QPWKQHSGE----GRSHFRNIPVTDTRSKEEAPSYRTLNGAVEKPRPLALPLPRSVEESYIT--- 836

  Fly  2043 GRPMECNDEDHCYICELRVDKTARFFSKAKANHPACTKSYAFRKFPEKIKISKSYAPHDVDPSL- 2106
                    .:|||             .|.:|.:||..:..........:..:.:....:.|.||
Human   837 --------SEHCY-------------QKPRAYYPAVEQKLVVETRGSALDDAVNPLHENGDDSLS 880

  Fly  2107 ------LKTRKQKTELDVGAG-PTTMHKVSGR---QEQHQAKMVGRKPRGISAPADATAVHVVTP 2161
                  |...:.|.:.|...| |.....||.:   :|....|::.|...|:.:.......:::|.
Human   881 PRLGWPLDQDRSKGDSDPKPGSPKVKEYVSKKALPEEAPARKLLDRGGEGLLSSQHQWQFNLLTH 945

  Fly  2162 VAPNKQMLKKRKSRLENVLITMKLKCLDAQTAQEQPIDLSYL 2203
            |...:..:..|...:|..|..:: ..||.....|.|..|:.|
Human   946 VESLQDEVTHRMDSIEKELDVLE-SWLDYTGELEPPEPLARL 986

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795
		SET	1392..1512	CDD:214614
		Bromo_ASH1	1680..1787	CDD:99955	31/193 (16%)
		PHD_ASH1L	1858..1900	CDD:277023	15/44 (34%)
		BAH_polybromo	1929..2073	CDD:240068	23/144 (16%)
PHF20	NP_057520.2	MBT	3..68	CDD:302657
		TUDOR	90..135	CDD:119391
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	142..336		33/172 (19%)
		DUF3776	176..259	CDD:289391	18/93 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..611		14/130 (11%)
		PHD_PHF20	654..697	CDD:277104	15/43 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	866..912		10/45 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030