DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ash1 and PHF20L1

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	XP_011515377.1	Gene:	PHF20L1 / 51105	HGNCID:	24280	Length:	1023	Species:	Homo sapiens

Alignment Length:	846	Identity:	162/846 - (19%)
Similarity:	278/846 - (32%)	Gaps:	277/846 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1489 LFAKRAI-EEGEELTYDYNFSLFNPSEGQPCRCNTPQCRGVIGGKSQRVKPLPAVEAKPSGEGLS 1552
            |.|.:|: .:|.|...|||       |..|.             ..|.:.|.|..:.|...:..|
Human   289 LLASKAVGVDGAEKKEDYN-------ETAPM-------------LEQAISPKPQSQKKNEADISS 333

  Fly  1553 GRN-------------GRQRKQKAKKHAQRQAGKDISSAVAVAKLQPLSE-----KEKKLVRQFN 1599
            ..|             |:.|.:|.|    .::| |.|..:...| .|||.     ::..||.|.:
Human   334 SANTQKPALLSSTLSSGKARSKKCK----HESG-DSSGCIKPPK-SPLSPELIQVEDLTLVSQLS 392

  Fly  1600 TFLV------------RNFE-KIRRCKAKRAS------DAAATASSPALGTTNGDI------PGR 1639
            :.::            |.|: ..||.:::|.:      |:....|||: ..|:|.:      ..:
Human   393 SSVINKTSPPQPVNPPRPFKHSERRRRSQRLATLPMPDDSVEKVSSPS-PATDGKVFSISSQNQQ 456

  Fly  1640 RPSTPSSPSLA----------------------AQISALCSPRNIKTRGL---TQAVHDPELEKM 1679
            ..|.|..|.:|                      |.:::..|.||...|..   ||.:.:|..:.:
Human   457 ESSVPEVPDVAHLPLEKLGPCLPLDLSRGSEVTAPVASDSSYRNECPRAEKEDTQMLPNPSSKAI 521

  Fly  1680 A--KMAVVLRDICSAMETLKMSDLLTTVSSKKKKPIKTTLSGKLGSTAATSKVEFRSIQAQVEQG 1742
            |  :.|.....|....:.:|:.|..:|...|:|:..|.....:       .|..:|..|.:.::.
Human   522 ADGRGAPAAAGISKTEKKVKLEDKSSTAFGKRKEKDKERREKR-------DKDHYRPKQKKKKKK 579

  Fly  1743 HYKTPQ----EFDDHMQQLFVEAKQQHGDDEGKEKALQSL----KDSYEQQKIASYVQLV-EILG 1798
            ..|:.|    :::|...:.............|...|.:|:    ..:|:..:....|.|. |.|.
Human   580 KKKSKQHDYSDYEDSSLEFLERCSSPLTRSSGSSLASRSMFTEKTTTYQYPRAILSVDLSGENLS 644

  Fly  1799 DSESLQSFKPKEVLSSEEEPGKIAVKKSPGAKERDSPIVPLKVTPPPLLPIEASPDED-----VI 1858
            |.:.|.....:.:|.|.:|..          ::.||            ...|.|.|||     ::
Human   645 DVDFLDDSSTESLLLSGDEYN----------QDFDS------------TNFEESQDEDDALNEIV 687

  Fly  1859 RCICGLYKDEGLMIQCSKCMVWQHTECTKADIDADNYQCERCEPREVDREIPLEEFTEEGHRYYL 1923
            ||||.:.::.|.||||.:|:.|||:.|...                      |||...|.:
Human   688 RCICEMDEENGFMIQCEECLCWQHSVCMGL----------------------LEESIPEQY---- 726

  Fly  1924 SLMRGDLQVRQGDAVYVLRDIPIKDESGKVLPTKKHTYETIGAIDYQECDIFRVEHLWKNELGKR 1988
                         ..|:.||.|.:..|.      |:.|:.....:.:.|.:...:..:.:...|:
Human   727 -------------ICYICRDPPGQRWSA------KYRYDKEWLNNGRMCGLSFFKENYSHLNAKK 772

  Fly  1989 FIFGHHFLRPHETFHEPSRRFYPNEVVRVSLYEVVPI----ELVIG----------RCWVLDRTT 2039
            .:..||.|                    ..:|.|..:    :|.||          ..|.
Human   773 IVSTHHLL--------------------ADVYGVTEVLHGLQLKIGILKNKHHPDLHLWA----- 812

  Fly  2040 FCKGRPMECNDEDHCYI-CELRV--DKTARFFSKAKANHPA------------CTKSYAFRKFPE 2089
             |.|:.   .|:|.... .|.::  |...|...|...||..            .|..::::| |:
Human   813 -CSGKR---KDQDQIIAGVEKKIAQDTVNREEKKYVQNHKEPPRLPLKMEGTYITSEHSYQK-PQ 872

  Fly  2090 KI-KISKSYA-PHDVDPSLLKTRKQKTELDVGAGPTTMHKVSGRQEQHQAKMVGRKPRGISAPAD 2152
            .. :..||.| |...|...:.:.:::.|         .|..|....|:.||..|...:  ..||:
Human   873 SFGQDCKSLADPGSSDDDDVSSLEEEQE---------FHMRSKNSLQYSAKEHGMPEK--KNPAE 926

  Fly  2153 ATAVHVVT-------PVAPNKQMLKKRKSRLENVL--ITMKLKCLDAQ----------TAQEQPI 2198
            ...|.|..       |...:.|......:.:|||.  :|.::..::.:          |.:.:|.
Human   927 GNTVFVYNDKKGTEDPGDSHLQWQLNLLTHIENVQNEVTSRMDLIEKEVDVLESWLDFTGELEPP 991

  Fly  2199 D 2199
            |
Human   992 D 992

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795
		SET	1392..1512	CDD:214614	8/23 (35%)
		Bromo_ASH1	1680..1787	CDD:99955	19/116 (16%)
		PHD_ASH1L	1858..1900	CDD:277023	14/41 (34%)
		BAH_polybromo	1929..2073	CDD:240068	26/160 (16%)
PHF20L1	XP_011515377.1	MBT	3..68	CDD:302657
		TUDOR	90..135	CDD:119391
		DUF3776	214..322	CDD:289391	12/52 (23%)
		PHD20L1_u1	323..388	CDD:293265	14/70 (20%)
		PHD_PHF20L1	688..733	CDD:277103	19/83 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030