DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ash1 and NSD

DIOPT Version :9

Sequence 1:NP_001246834.1 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster
Sequence 2:NP_733239.1 Gene:NSD / 43351 FlyBaseID:FBgn0039559 Length:1427 Species:Drosophila melanogaster


Alignment Length:1730 Identity:338/1730 - (19%)
Similarity:568/1730 - (32%) Gaps:612/1730 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 NETAAAKVLET--QRAQESGSENEETDSITDQSSQSKSIKSATQFSVQRSDTDGLRMRISAIRPT 68
            |.:...::|:.  |...::|::         .:::...::|..|..||:..    :.|:|.:   
  Fly    57 NNSTPVRLLDKPGQNPVQNGAQ---------PAAEESELESQRQTPVQKQQ----QQRVSMV--- 105

  Fly    69 LGVVATKKPPKSRKMSTQDTESGCSEAKNRAVSKKVKVKRKKLASSSGISKSD---KVSKSKKSQ 130
                       :||....:.:|        |:|.|. :......|.:.:|.||   :.::.:.:|
  Fly   106 -----------NRKRDLINLQS--------ALSPKY-IGYANANSPTPLSDSDDTIRTTRRRVNQ 150

  Fly   131 ISAFSSDSEDDLPLKVHQQRAPRV---------------LLSAIIQAAQSASKPTLDIGISSSDN 180
            .:|.::.|..:  ...|...:||.               |||....:  ...|..:..|.||   
  Fly   151 AAALNNSSAGE--TLAHDNASPRTPGGGGGGGGDDSANQLLSKTYMS--PIEKLLIKNGASS--- 208

  Fly   181 ELPNLVQAAIKRVESDTEDTTVEGSFRKAAKD--KNLPQYQSTLLQDFMEKTQMLGQTVNAKLAE 243
              ||..     ..|:.:||..:....||..|.  |.:|:.:.||..|  ||.|   |.|:     
  Fly   209 --PNST-----GFEAGSEDLGIRPIVRKHVKRKMKRVPKAKVTLELD--EKNQ---QEVD----- 256

  Fly   244 EKVAKAKEETLVQTAVPRKRRGRPKKVVPTVPAPGNSGPAINESADSGVISTTSTTQSTTPSPKM 308
                                    :|.|.|.|        |:|..|....:.|...|:|..|.|.
  Fly   257 ------------------------EKSVKTEP--------IDEEVDRTDEAPTQEAQTTAISIKS 289

  Fly   309 QNENAVPTGSLPIASSSKPKIDMAYLDKRMYATERVLYPPPRSKRRQNNKKTACSSSNKEELQLD 373
            :.| |....::.:....:..|.:..::..:.:|..|:...|:...:           :.|||...
  Fly   290 ETE-AEHKAAVDVHIKQEDTIRLDIVNNPVESTSIVITEEPKDLEK-----------STEELAFA 342

  Fly   374 -PLWREIDVNKKFRLRSMSVGAASGTGASTTICS----KVLAAKS-GYVSDYGSVRHQRSSHNHN 432
             ||....:|:.|      |....|.|..:|:|.|    .:.:||. ..|:|.|...:|.......
  Fly   343 LPLASSTEVDLK------SPPDLSSTALATSIKSPSSVSIDSAKGLSIVTDPGWPTYQVGDLFWG 401

  Fly   433 SGYKSDASCKSRYSTKSCMSRRSRAKSCGYRSDCKESGKSGLRMRRKRRASMLLKSSADDTVEDQ 497
            ..:.        |....||                                          |...
  Fly   402 KVFS--------YCFWPCM------------------------------------------VCPD 416

  Fly   498 DILQLAGLSLGQSSEESNEYISKPSLKSLPTTSASKKYGEINRYVTTGQYFGRGGSLSATNPDNF 562
            .:.|:.|           ...|.|...||...:.     .|..:|   ::|...|..:...|:|.
  Fly   417 PLGQIVG-----------NMPSHPQRSSLDNANV-----PIQVHV---RFFADNGRRNWIKPENL 462

  Fly   563 IS----KMMNQRKET------PAPSKSSCKIKSRR---------SSAASMC------------SS 596
            ::    |..:..:|.      |..:|....:..|.         ..|.:|.            .:
  Fly   463 LTFAGLKAFDDMREELRIKHGPKSAKYRQMVPKRTKVVIWRQAIEEAQAMTQIPYSDRLEKFYQT 527

  Fly   597 YVSGVSRMRRRHRRKSFSHNKSLNIDSKLLTEIEIITSTFNSRCRIQDDRLTGSSGKEKLLADAN 661
            |.:.|:..|::.:|..:....:.::.|.|          ::|     .|.|....|.:.|.....
  Fly   528 YENVVTLNRQKRKRTKYMMQDTSDVGSSL----------YDS-----TDNLHNKQGTQLLAVKRE 577

  Fly   662 KLQATLA-APSPAQQLTLNGGGPASTLSKPLKRGLKKRKLSEPLVDFAMLSASASGTPNGSGSSN 725
            :.::..: |.||.:             ||..||. |:||||                 ||:.:..
  Fly   578 RSESPFSPAFSPVK-------------SKNEKRA-KRRKLS-----------------NGTEADT 611

  Fly   726 GNTKRRHKKSQSN---DSS---SPDDHKLPLKKRHYLLTPGERPPAEVAFANGKLNAEAWAAAAA 784
            |:.......||:.   |||   :|:..:|......|::.  .|...:|......:.:..|     
  Fly   612 GSNSMAVTPSQTETTVDSSAYENPEFRQLLSAVMEYVMM--NRSDEKVEKVLLSVVSNIW----- 669

  Fly   785 AAKSTASTKSQAQFNARSVKSALTPKKRHLLEQP--TSVSGAGSSA------SNSPLRIVVDNNS 841
                     |..|...|.::..|...:   :|:|  :||.|.||..      ||..:.::|..:.
  Fly   670 ---------SLKQIQLRELERDLASGE---IEEPLGSSVVGRGSGVGTIKRLSNRLMTMMVRRSM 722

  Fly   842 ISGGKLLDISPSSLCSLKQQRRGGAAKQKVSAAKDLVQLQSPAGSYPPPGVFEPSVELEIQIPLS 906
            ..     .::||:                           :||.|.|.                .
  Fly   723 TP-----VVTPST---------------------------TPAPSEPD----------------R 739

  Fly   907 KLNESVITKAEVESPLLSALD--IKEDTK---KEVGQRVVETLLHKTGGNLL------------- 953
            :|:|...||..|..|:...::  ::.|:|   :.:.:..:....::.|.:|:             
  Fly   740 RLSEPPKTKKPVNRPIEEVIEDILQLDSKYLFRGLSREPICKYCYQAGSDLVRCSRTCSSWLHAD 804

  Fly   954 -LKRKRKKINRTGFPTVRRKKRKVSVEQQTTAVIDEHEPEFDPDDEPLQSLRETRSSNNVNVQAA 1017
             |:||     .||.|..:...||..|...|:                                .:
  Fly   805 CLERK-----VTGAPMPKIGSRKALVIPPTS--------------------------------KS 832

  Fly  1018 PNPPLDCERVPQAGEARETFVARTNQKAPRLSVVALERLQRPQTPARGRPRGRKPKNREQAEAAP 1082
            |:|  |.:.|  ..:|:|.....|:......:|              |.|.|....::.::.|.|
  Fly   833 PSP--DEDHV--TADAKEVVAVGTSLVCHECNV--------------GEPEGCVICHQVESPAVP 879

  Fly  1083 QPPPKSE-------------------------------PEIRPAKKRGRQPK---QPVLEEPPPT 1113
            ..|.|.:                               |:...:|...|.|:   ...:.:.|..
  Fly   880 STPRKEDSSSHTPIEDKLLTCSQPMCGKRFHTSCCKYWPQASSSKHSARCPRHVCHTCVSDDPSG 944

  Fly  1114 PPPQQKKNKMEPNIRLPDGIDPNTNFSCKIRLKRRKNLEAGTQ--------------PKKEKPVQ 1164
            ...|...:|:...:|.|....           :..|.:.||||              .|.:..|.
  Fly   945 KFQQLGSSKLAKCVRCPATYH-----------QLSKCIPAGTQMLNTTNIICPRHNIAKADAHVN 998

  Fly  1165 -------------------PVTVEEIPPEIPVSQEE--IDAEAEAKRLDSI-------------- 1194
                               |:.|......||:...|  |..|.|:.||...              
  Fly   999 VLWCYICVKGGELVCCETCPIAVHAHCRNIPIKTNESYICEECESGRLPLYGEIVWAKFNNFRWW 1063

  Fly  1195 ------PTEHDPLPASESHNPGPQDYASCSESSEDKASTTSLRKLSKVKKTYL-VAG-------- 1244
                  |||.......::|  |..|:......:.|....:.       ::.|| :.|        
  Fly  1064 PAIILPPTEVPSNILKKAH--GENDFVVRFFGTHDHGWISR-------RRVYLYIEGDTGDGHKT 1119

  Fly  1245 ---LFSNH----YKQSLMPPPAKVNK-KPGLEEQVGPASLLPPPPYCEKYLRRTEMDFELPYDIW 1301
               ||.|:    .:.|...|..|..: :..:|.|.|  :.|.||||.                  
  Fly  1120 KSQLFRNYTTGVEEASRFLPIIKARRQEQDMERQSG--NKLHPPPYV------------------ 1164

  Fly  1302 WAYTNSKLPTRNVVPSWNYRKIRTNVYAESVRPNLAGFDHPTCNCKNQGEKSC--LDNCLNRMVY 1364
                  |:.|...||...:.:            ||.  |..||||....|..|  ...|||||::
  Fly  1165 ------KIKTNKAVPPLRFSQ------------NLE--DLSTCNCLPVDEHPCGPEAGCLNRMLF 1209

  Fly  1365 TECSPSNCPAGEKCRNQKIQRHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEF 1429
            .||:|..|.||..|.|:..::.. :|.:|.....::|:|:..:.|||.|.:::||||||:...||
  Fly  1210 NECNPEYCKAGSLCENRMFEQRK-SPRLEVVYMNERGFGLVNREPIAVGDFVIEYVGEVINHAEF 1273

  Fly  1430 KQRMASIYLN-DTHHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKR 1493
            ::||.....: |.::|.|.::...:||....|:..||:|||||||||.|||:||.:.|:.:||.:
  Fly  1274 QRRMEQKQRDRDENYYFLGVEKDFIIDAGPKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIK 1338

  Fly  1494 AIEEGEELTYDYNF-SLFNPSEGQPCRCNTPQCRGVIGGK 1532
            .|....|||::|.: .|.|.|: :.|.|...:|.|.||||
  Fly  1339 DIPVNSELTFNYLWDDLMNNSK-KACFCGAKRCSGEIGGK 1377

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ash1NP_001246834.1 AWS 1340..1388 CDD:197795 20/49 (41%)
SET 1392..1512 CDD:214614 48/121 (40%)
Bromo_ASH1 1680..1787 CDD:99955
PHD_ASH1L 1858..1900 CDD:277023
BAH_polybromo 1929..2073 CDD:240068
NSDNP_733239.1 MSH6_like 391..508 CDD:99898 22/185 (12%)
PHD2_NSD 867..932 CDD:277040 8/64 (13%)
PHD3_NSD 933..988 CDD:277041 10/65 (15%)
PHD4_NSD 1001..1041 CDD:277042 6/39 (15%)
WHSC1_related 1047..1141 CDD:99899 15/102 (15%)
AWS 1183..1233 CDD:197795 20/50 (40%)
SET 1234..1354 CDD:214614 48/119 (40%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D507784at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
32.950

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