Protein Alignment ash1 and NSD

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: NP_733239.1
• Gene: NSD / 43351
• FlyBaseID: FBgn0039559
• Length: 1427
• Species: Drosophila melanogaster
• Alignment Length: 1730
• Identity: 338/1730 - (19%)
• Similarity: 568/1730 - (32%)
• Gaps: 612/1730 - (35%)

  Fly     6 NETAAAKVLET--QRAQESGSENEETDSITDQSSQSKSIKSATQFSVQRSDTDGLRMRISAIRPT 68
            |.:...::|:.  |...::|::         .:::...::|..|..||:..    :.|:|.:
  Fly    57 NNSTPVRLLDKPGQNPVQNGAQ---------PAAEESELESQRQTPVQKQQ----QQRVSMV--- 105

  Fly    69 LGVVATKKPPKSRKMSTQDTESGCSEAKNRAVSKKVKVKRKKLASSSGISKSD---KVSKSKKSQ 130
                       :||....:.:|        |:|.|. :......|.:.:|.||   :.::.:.:|
  Fly   106 -----------NRKRDLINLQS--------ALSPKY-IGYANANSPTPLSDSDDTIRTTRRRVNQ 150

  Fly   131 ISAFSSDSEDDLPLKVHQQRAPRV---------------LLSAIIQAAQSASKPTLDIGISSSDN 180
            .:|.::.|..:  ...|...:||.               |||....:  ...|..:..|.||
  Fly   151 AAALNNSSAGE--TLAHDNASPRTPGGGGGGGGDDSANQLLSKTYMS--PIEKLLIKNGASS--- 208

  Fly   181 ELPNLVQAAIKRVESDTEDTTVEGSFRKAAKD--KNLPQYQSTLLQDFMEKTQMLGQTVNAKLAE 243
              ||..     ..|:.:||..:....||..|.  |.:|:.:.||..|  ||.|   |.|:
  Fly   209 --PNST-----GFEAGSEDLGIRPIVRKHVKRKMKRVPKAKVTLELD--EKNQ---QEVD----- 256

  Fly   244 EKVAKAKEETLVQTAVPRKRRGRPKKVVPTVPAPGNSGPAINESADSGVISTTSTTQSTTPSPKM 308
                                    :|.|.|.|        |:|..|....:.|...|:|..|.|.
  Fly   257 ------------------------EKSVKTEP--------IDEEVDRTDEAPTQEAQTTAISIKS 289

  Fly   309 QNENAVPTGSLPIASSSKPKIDMAYLDKRMYATERVLYPPPRSKRRQNNKKTACSSSNKEELQLD 373
            :.| |....::.:....:..|.:..::..:.:|..|:...|:...:           :.|||...
  Fly   290 ETE-AEHKAAVDVHIKQEDTIRLDIVNNPVESTSIVITEEPKDLEK-----------STEELAFA 342

  Fly   374 -PLWREIDVNKKFRLRSMSVGAASGTGASTTICS----KVLAAKS-GYVSDYGSVRHQRSSHNHN 432
             ||....:|:.|      |....|.|..:|:|.|    .:.:||. ..|:|.|...:|.......
  Fly   343 LPLASSTEVDLK------SPPDLSSTALATSIKSPSSVSIDSAKGLSIVTDPGWPTYQVGDLFWG 401

  Fly   433 SGYKSDASCKSRYSTKSCMSRRSRAKSCGYRSDCKESGKSGLRMRRKRRASMLLKSSADDTVEDQ 497
            ..:.        |....||                                          |...
  Fly   402 KVFS--------YCFWPCM------------------------------------------VCPD 416

  Fly   498 DILQLAGLSLGQSSEESNEYISKPSLKSLPTTSASKKYGEINRYVTTGQYFGRGGSLSATNPDNF 562
            .:.|:.|           ...|.|...||...:.     .|..:|   ::|...|..:...|:|.
  Fly   417 PLGQIVG-----------NMPSHPQRSSLDNANV-----PIQVHV---RFFADNGRRNWIKPENL 462

  Fly   563 IS----KMMNQRKET------PAPSKSSCKIKSRR---------SSAASMC------------SS 596
            ::    |..:..:|.      |..:|....:..|.         ..|.:|.            .:
  Fly   463 LTFAGLKAFDDMREELRIKHGPKSAKYRQMVPKRTKVVIWRQAIEEAQAMTQIPYSDRLEKFYQT 527

  Fly   597 YVSGVSRMRRRHRRKSFSHNKSLNIDSKLLTEIEIITSTFNSRCRIQDDRLTGSSGKEKLLADAN 661
            |.:.|:..|::.:|..:....:.::.|.|          ::|     .|.|....|.:.|.....
  Fly   528 YENVVTLNRQKRKRTKYMMQDTSDVGSSL----------YDS-----TDNLHNKQGTQLLAVKRE 577

  Fly   662 KLQATLA-APSPAQQLTLNGGGPASTLSKPLKRGLKKRKLSEPLVDFAMLSASASGTPNGSGSSN 725
            :.::..: |.||.:             ||..||. |:||||                 ||:.:..
  Fly   578 RSESPFSPAFSPVK-------------SKNEKRA-KRRKLS-----------------NGTEADT 611

  Fly   726 GNTKRRHKKSQSN---DSS---SPDDHKLPLKKRHYLLTPGERPPAEVAFANGKLNAEAWAAAAA 784
            |:.......||:.   |||   :|:..:|......|::.  .|...:|......:.:..|
  Fly   612 GSNSMAVTPSQTETTVDSSAYENPEFRQLLSAVMEYVMM--NRSDEKVEKVLLSVVSNIW----- 669

  Fly   785 AAKSTASTKSQAQFNARSVKSALTPKKRHLLEQP--TSVSGAGSSA------SNSPLRIVVDNNS 841
                     |..|...|.::..|...:   :|:|  :||.|.||..      ||..:.::|..:.
  Fly   670 ---------SLKQIQLRELERDLASGE---IEEPLGSSVVGRGSGVGTIKRLSNRLMTMMVRRSM 722

  Fly   842 ISGGKLLDISPSSLCSLKQQRRGGAAKQKVSAAKDLVQLQSPAGSYPPPGVFEPSVELEIQIPLS 906
            ..     .::||:                           :||.|.|.                .
  Fly   723 TP-----VVTPST---------------------------TPAPSEPD----------------R 739

  Fly   907 KLNESVITKAEVESPLLSALD--IKEDTK---KEVGQRVVETLLHKTGGNLL------------- 953
            :|:|...||..|..|:...::  ::.|:|   :.:.:..:....::.|.:|:
  Fly   740 RLSEPPKTKKPVNRPIEEVIEDILQLDSKYLFRGLSREPICKYCYQAGSDLVRCSRTCSSWLHAD 804

  Fly   954 -LKRKRKKINRTGFPTVRRKKRKVSVEQQTTAVIDEHEPEFDPDDEPLQSLRETRSSNNVNVQAA 1017
             |:||     .||.|..:...||..|...|:                                .:
  Fly   805 CLERK-----VTGAPMPKIGSRKALVIPPTS--------------------------------KS 832

  Fly  1018 PNPPLDCERVPQAGEARETFVARTNQKAPRLSVVALERLQRPQTPARGRPRGRKPKNREQAEAAP 1082
            |:|  |.:.|  ..:|:|.....|:......:|              |.|.|....::.::.|.|
  Fly   833 PSP--DEDHV--TADAKEVVAVGTSLVCHECNV--------------GEPEGCVICHQVESPAVP 879

  Fly  1083 QPPPKSE-------------------------------PEIRPAKKRGRQPK---QPVLEEPPPT 1113
            ..|.|.:                               |:...:|...|.|:   ...:.:.|..
  Fly   880 STPRKEDSSSHTPIEDKLLTCSQPMCGKRFHTSCCKYWPQASSSKHSARCPRHVCHTCVSDDPSG 944

  Fly  1114 PPPQQKKNKMEPNIRLPDGIDPNTNFSCKIRLKRRKNLEAGTQ--------------PKKEKPVQ 1164
            ...|...:|:...:|.|....           :..|.:.||||              .|.:..|.
  Fly   945 KFQQLGSSKLAKCVRCPATYH-----------QLSKCIPAGTQMLNTTNIICPRHNIAKADAHVN 998

  Fly  1165 -------------------PVTVEEIPPEIPVSQEE--IDAEAEAKRLDSI-------------- 1194
                               |:.|......||:...|  |..|.|:.||...
  Fly   999 VLWCYICVKGGELVCCETCPIAVHAHCRNIPIKTNESYICEECESGRLPLYGEIVWAKFNNFRWW 1063

  Fly  1195 ------PTEHDPLPASESHNPGPQDYASCSESSEDKASTTSLRKLSKVKKTYL-VAG-------- 1244
                  |||.......::|  |..|:......:.|....:.       ::.|| :.|
  Fly  1064 PAIILPPTEVPSNILKKAH--GENDFVVRFFGTHDHGWISR-------RRVYLYIEGDTGDGHKT 1119

  Fly  1245 ---LFSNH----YKQSLMPPPAKVNK-KPGLEEQVGPASLLPPPPYCEKYLRRTEMDFELPYDIW 1301
               ||.|:    .:.|...|..|..: :..:|.|.|  :.|.||||.
  Fly  1120 KSQLFRNYTTGVEEASRFLPIIKARRQEQDMERQSG--NKLHPPPYV------------------ 1164

  Fly  1302 WAYTNSKLPTRNVVPSWNYRKIRTNVYAESVRPNLAGFDHPTCNCKNQGEKSC--LDNCLNRMVY 1364
                  |:.|...||...:.:            ||.  |..||||....|..|  ...|||||::
  Fly  1165 ------KIKTNKAVPPLRFSQ------------NLE--DLSTCNCLPVDEHPCGPEAGCLNRMLF 1209

  Fly  1365 TECSPSNCPAGEKCRNQKIQRHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEF 1429
            .||:|..|.||..|.|:..::.. :|.:|.....::|:|:..:.|||.|.:::||||||:...||
  Fly  1210 NECNPEYCKAGSLCENRMFEQRK-SPRLEVVYMNERGFGLVNREPIAVGDFVIEYVGEVINHAEF 1273

  Fly  1430 KQRMASIYLN-DTHHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKR 1493
            ::||.....: |.::|.|.::...:||....|:..||:|||||||||.|||:||.:.|:.:||.:
  Fly  1274 QRRMEQKQRDRDENYYFLGVEKDFIIDAGPKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIK 1338

  Fly  1494 AIEEGEELTYDYNF-SLFNPSEGQPCRCNTPQCRGVIGGK 1532
            .|....|||::|.: .|.|.|: :.|.|...:|.|.||||
  Fly  1339 DIPVNSELTFNYLWDDLMNNSK-KACFCGAKRCSGEIGGK 1377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	62/368 (17%)
		AWS	1340..1388	CDD:197795	20/49 (41%)
		SET_ASH1L	1391..1531	CDD:380951	55/141 (39%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
NSD	NP_733239.1	PWWP_NSD_rpt1	395..514	CDD:438972	23/187 (12%)
		PHD2_NSD	867..932	CDD:277040	8/64 (13%)
		PHD3_NSD	933..988	CDD:277041	10/65 (15%)
		PHD4_NSD	1001..1041	CDD:277042	6/39 (15%)
		PWWP_NSD_rpt2	1048..1143	CDD:438963	15/103 (15%)
		AWS	1183..1233	CDD:197795	20/50 (40%)
		SET_NSD	1233..1375	CDD:380950	55/142 (39%)