DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ash1 and KMT2A

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	XP_011541131.1	Gene:	KMT2A / 4297	HGNCID:	7132	Length:	4005	Species:	Homo sapiens

Alignment Length:	1961	Identity:	386/1961 - (19%)
Similarity:	625/1961 - (31%)	Gaps:	649/1961 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KVLETQRAQESGSEN-----EETDSITDQSSQSK-------SIKSATQFSVQRSDTDGLRMRISA 64
            :::...|...:.|.|     ..|.:.||..|.:|       .:.|:|......|.:..|:.
Human  2244 RIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQR---- 2304

  Fly    65 IRPTLGVVATKKPPKSRKMSTQDTESGCSEAKNRAVS---KKVKVKRKKLASSS-------GI-- 117
               |:..|..|........|::..:|..|:..:::.|   :|.||...|.:..|       ||
Human  2305 ---TVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPK 2366

  Fly   118 ---------SKSDKVSK----SKKSQISAFSSDSEDDLP-LKVHQQRAPRVLLSAIIQAAQSA-- 166
                     |:...|||    ::.|.:| |||......| |.:..||..|...:...|:|.|:
Human  2367 LAPQVHNTTSRELNVSKIGSFAEPSSVS-FSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPD 2430

  Fly   167 ---SKPTLDIGISSSDNELPNLVQAAIKRVESDTEDTTVEG--SFRKAAKDKNLPQ--------- 217
               ...||.:...|:.:.:.|      :.:.|.:.|...:|  |.::..|:|:..:
Human  2431 EDTEVKTLKLSGMSNRSSIIN------EHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVT 2489

  Fly   218 --YQSTLLQDFMEKT---QMLGQTVNAKLAEEK----------VAKAK----EETLVQTAVPRKR 263
              .:..|..:||::.   :.:||.....::.:|          |.||.    |.:..:...||||
Human  2490 TGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKR 2554

  Fly   264 RGRPKKVVPTVPAPGNSGPAINESADSG--VISTTSTTQSTT------------PSPK------M 308
            ..:.......:.....|..|:.||:.:.  .|.:||.|:..:            |||.      .
Human  2555 TVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDS 2619

  Fly   309 QNEN----AVPTGSLPIASSSKPKIDMAYLDK----------------------RMYATERV-LY 346
            |:.|    .|...:|.:....||:.|.::..:                      |.|..|.: .|
Human  2620 QSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFY 2684

  Fly   347 PPPRSKRR-------------------------QNNKKTACSSSNKEELQLDPLWRE---IDVNK 383
            .....|:|                         .|..:|..||..:|.|....|:||   .|:.|
Human  2685 SSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPK 2749

  Fly   384 KFRLRSMSVGAASGTG-ASTTICSKVLAAKSGYVS-----------DYGSVRH-QRSSHNHNSGY 435
            ..:|..:..|..|.|. .:||..|..:..::|..:           |.|...| .:||..|.:..
Human  2750 ISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEP 2814

  Fly   436 KSDASCKSRYSTKSCMSRRSRAKSCGYRSDCKESGKSGLRMRRKRRASMLLKSSADDTVEDQDIL 500
            |.| :|.|          .||.|:.|  .|..|:..|.|...|:...|         |..|:::|
Human  2815 KMD-NCHS----------VSRVKTQG--QDSLEAQLSSLESSRRVHTS---------TPSDKNLL 2857

  Fly   501 QLAGLSLGQSSEESN--------------EYISK--PSLKSL---PTTSASKKYGEINRYVTTGQ 546
            ......|.:|..::|              :::.|  ||:::|   |.:|:|:...
Human  2858 DTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLN---------- 2912

  Fly   547 YFGRG-GSLSATNPDNFISKMMNQRKETPAPSKSSCKIKSRRSSAASMCSSYVSGVSRMRRRHRR 610
             .|.| |..|....|..:.::.:|:..|..|..||..
Human  2913 -LGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVS---------------------------- 2948

  Fly   611 KSFSHNKSLNIDSKLLTEIEIITSTFNSRCRIQDDRLTGSSGKEKLLADANKLQATLAAPSPAQQ 675
            .|.|..:...:..:|.:::.::|:                  :...:...|..:..:.:.|..::
Human  2949 SSISAEEQFELPLELPSDLSVLTT------------------RSPTVPSQNPSRLAVISDSGEKR 2995

  Fly   676 LTLNGGGPASTLSKPLKRGLKKRKLSEPLVDFAMLSASASGTPNG-----------------SGS 723
            :|:.....||:.|.|                 |:||.....||.|                 |..
Human  2996 VTITEKSVASSESDP-----------------ALLSPGVDPTPEGHMTPDHFIQGHMDADHISSP 3043

  Fly   724 SNGNTKRRHKKSQ--SNDSSSPD-----DHKLPLKKRHYLLTPGERP-PAEVAFA---------- 770
            ..|:.::.|..:|  :.:||:|.     ...:|::.:.|:....:.| |::::.|
Human  3044 PCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLK 3108

  Fly   771 -----------------------NGKLNAEAWAAAAAAAKSTASTK------------------- 793
                                   ||........::.::..|...|.
Human  3109 PATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNP 3173

  Fly   794 ----SQAQFNARSVKSALTPKK--RHLLEQPTSV-SGAGSSASNSPLRIVVDNNSISGGKLLDI- 850
                ||:.|  .|....|.|..  :||...|.:. |....:.||.|           .|.|:.:
Human  3174 SLPTSQSLF--PSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPP-----------SGLLIGVQ 3225

  Fly   851 ---SPSSLCSLKQQR----------RGGAAKQKVSAA-----KDLVQLQSPAGSYPPPGV----- 892
               .|..|.|...||          ..|..|:.:|..     |.|....:|:...|...|
Human  3226 PPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTL 3290

  Fly   893 --FEPSVELEIQIP-------LSKLNES-------VITKAEVE------SPLL------------ 923
              |.||     |:|       |..||.|       :|.:::..      :|||
Human  3291 INFTPS-----QLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAA 3350

  Fly   924 SALDIKEDTKKEVGQRVVETLLHKTGGNLL-LKRKRKKINRTGFPTVRRKKRKVSVEQQTTAVID 987
            ....|.:||.            |.|.|::. |......:|.....|........||....|..
Human  3351 GTSTISQDTS------------HLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLT-- 3401

  Fly   988 EHEPEF--DPDDEPLQSLRETRSSNNVNVQAAP---------NPPLDCERVPQ------------ 1029
              .|..  .||...:.:|....|..::.:|..|         .|.|...:.|.
Human  3402 --NPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICV 3464

  Fly  1030 --------------AGEARETF-VARTNQKAPRLSVVALERLQRPQTPARG-----------RPR 1068
                          :|||.|.: :...||..  .|...:...||....|.|           .|.
Human  3465 LPSTQTTGITAASPSGEADEHYQLQHVNQLL--ASKTGIHSSQRDLDSASGPQVSNFTQTVDAPN 3527

  Fly  1069 GRKPKNREQAEAAPQPPPKS---EPEIRPAKKRGRQPKQPVLEEPPPTPPPQQKKNKMEPNIRLP 1130
            ....:..:...:|.|..|.|   .|....:.:|...|..|    .|..|.|:.|:      .:||
Human  3528 SMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVP----GPTKPKPKTKR------FQLP 3582

  Fly  1131 DGIDPNTNFSCKIRLKRRKNLEA--------------GT--------------QPKKEKPVQPVT 1167
              :|.......|:...|..:.||              ||              |..:::..||..
Human  3583 --LDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAG 3645

  Fly  1168 VEEIPPEIPVSQ----EEIDAE--------------------AEAKRLDSIPTEHDPLPASESHN 1208
            ...:.||:.|:|    |:..||                    .|.||.:|| ||..|........
Human  3646 QVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESI-TEKKPKKGLVFEI 3709

  Fly  1209 PGPQDYASCSESSED-----------KASTTSLRKLSKVKKTYLVAGLFSNHYKQSLMPPPAKVN 1262
            .....:..|:||.||           ..|...|::||       .||:  |..:...:...|.|
Human  3710 SSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLS-------FAGV--NGLRMLGILHDAVV- 3764

  Fly  1263 KKPGLEEQVGPASLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSWNYRKIRTNV 1327
               .|.||:..|.      :|..|..|    |..|.:            .|..|...:...|..|
Human  3765 ---FLIEQLSGAK------HCRNYKFR----FHKPEE------------ANEPPLNPHGSARAEV 3804

  Fly  1328 YAESVRPNLAGF------DHPTCNCKNQGEKSCLDNCLNRMVYTECSPSNCPAGEKCRN-QKIQR 1385
            :......::..|      ..|..|..::.|:........|     .:..:.|...:.|: :|..:
Human  3805 HLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARR-----ATSMDLPMPMRFRHLKKTSK 3864

  Fly  1386 HAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHHYCLHLDG 1450
            .||  ||.|  :...|.|:..|..|..|..::||.|.|:...:..:|...........|...:|.
Human  3865 EAV--GVYR--SPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDD 3925

  Fly  1451 GLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEG 1515
            ..|:|....|:..||:||||||||..:..:::|...:|:||.|.|..||||||||.|.:.:.|..
Human  3926 SEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNK 3990

  Fly  1516 QPCRCNTPQCR 1526
            .||.|...:||
Human  3991 LPCNCGAKKCR 4001

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795	7/48 (15%)
		SET	1392..1512	CDD:214614	42/119 (35%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
KMT2A	XP_011541131.1	zf-CXXC	1180..1227	CDD:251032
		PHD1_KMT2A	1466..1512	CDD:277063
		PHD2_KMT2A	1514..1563	CDD:277065
		PHD3_KMT2A	1601..1660	CDD:277067
		Bromo_ALL-1	1683..1813	CDD:99925
		ePHD_KMT2A	1907..2019	CDD:277163
		FYRN	2061..2107	CDD:283589
		FYRC	3705..3788	CDD:197781	23/105 (22%)
		SET	<3861..4005	CDD:225491	52/145 (36%)
		SET	3867..3987	CDD:214614	44/123 (36%)
		PostSET	3989..4005	CDD:214703	5/13 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158009
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840