Protein Alignment ash1 and polybromo

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: NP_651288.1
• Gene: polybromo / 42954
• FlyBaseID: FBgn0039227
• Length: 1654
• Species: Drosophila melanogaster
• Alignment Length: 1758
• Identity: 318/1758 - (18%)
• Similarity: 557/1758 - (31%)
• Gaps: 629/1758 - (35%)

  Fly   476 MRRKRRASMLLKSSADDTVEDQDILQLAGLSLGQSSEESNEYISKPSLKSL-PTTSASKKYGEIN 539
            :.||||||.:      .:.:|:|.|||...:..||..:.....|....:.| ||....:.|..|.
  Fly     2 LSRKRRASSI------SSRQDEDPLQLDDSTPEQSPVQQTTTQSARKKRRLDPTELCQQLYDSIR 60

  Fly   540 RYVTTGQYFGRGGSLSATNPDNFISKMMNQRKETPAPSKSSCKIKSRRSSAASMCSSYVSGVSRM 604
            ....      ..||:..   |.||  .:.:|::.|                 |.....|:.:..:
  Fly    61 NIKK------EDGSMLC---DTFI--RVPKRRQEP-----------------SYYDVVVNPIDLL 97

  Fly   605 RRRHRRKSFSHNKSLNIDSKLLTEIEIITSTFNSRCRIQDDRLTGSSGKEKLLADANKLQATLAA 669
            :.:.:.|:.|::   ::|. |:.::|::..  |::...    :.|||..:    ||..|...:.:
  Fly    98 KVQQKLKTDSYD---DLDD-LMADLELLIG--NAKAFY----IPGSSEHQ----DAVSLWQHIHS 148

  Fly   670 PSPAQQLTLNGGGPASTLSKPLKRGLKKRKLSEPLVDFAMLSASASGTPNGSGSSNGNTKRRHKK 734
               .:|..:...|.|....:..:...:.|::            ::|..|.|.|::: :...::::
  Fly   149 ---QRQRIMEANGLAEEEPRARRMSRQVRRM------------TSSTEPGGDGATD-DEYNQYEE 197

  Fly   735 SQSNDSSSPDDHKLPLKKRHYLLTPGER----------PPAEVAFANGKLNAEAWAAAAAAAKST 789
            ..::..::.|.....|..|.:.|.|.::          .|.::.....|:...|:::.|...:..
  Fly   198 LFASVMTATDPVGDRLMHRMFQLLPSKKIYPDYYDVIEHPIDLRLIATKIQMNAYSSLAEMERDL 262

  Fly   790 AS-TKSQAQFN---------ARSVKSALTPKKRHLLEQPTSVSGAGSSASNSPLRIVVDNNSISG 844
            .. ||:...||         |:|:|...| ::|..||.     |.|..|.
  Fly   263 LQMTKNACLFNEPGSQIYKDAKSLKRIFT-QRRIELEM-----GKGKLAK--------------- 306

  Fly   845 GKLLDISPSSLCSLKQQRRGGAAKQKVSAAKD--------------LVQLQSPAGSYPPPGVFEP 895
             ::..:|.:::.:||::         |.::.|              ...|.:..|:...|||..|
  Fly   307 -RVKSLSSAAIAALKEE---------VDSSDDEETSKKGEGPMWALFDHLYNAPGTSEHPGVTGP 361

  Fly   896 SVELEI-QIPLSKLNESVITKAEVESPLLSALDIKEDTKKEVGQRVVETLLHK---------TGG 950
            .:...: ::|:.:.:....                |..|:.:....:.|.|.|         |..
  Fly   362 PLGNSLWKLPVRRFHPEYF----------------ELIKRPISMSQIHTKLKKGDYANISDLTAD 410

  Fly   951 NLLLKRKRKKINRTGFPTVRR--KKRKVSVEQQTTAVIDEH-EPEFDPDDEPLQSLRETRSSNNV 1012
            ..|:....||    .|||..|  |.....::.....:::|. |...|.|||
  Fly   411 LYLMLDNAKK----AFPTSHRTHKDALKMLKLMNAKLVEESLEEGSDLDDE-------------- 457

  Fly  1013 NVQAAPNPPLDCERVPQAGEARETFVARTNQKAPRLSVVALERLQRPQTPARGRPRGRKPKNREQ 1077
                      |.|.:.     .|.|...|                :|:....||||.....|
  Fly   458 ----------DAEEMD-----TEVFTVST----------------QPEKRKPGRPRINSNSN--- 488

  Fly  1078 AEAAPQPPPKSEPEIRPAKKRGRQPKQPVLEEPPPTPPPQQKKNKMEPNIRLPDGIDPNTNFSCK 1142
            :.|:..|...:.|                            |.|::..|..:...|.....:...
  Fly   489 SNASHTPNNSNSP----------------------------KSNRIAINAAIKKKILSIQKYLVD 525

  Fly  1143 IRLKRRKNLEAGTQPKKEKPVQPVTVEEIPPEIPVSQEEIDAEAEAKRLDSIPTEHDPLPASESH 1207
            ..|..|:.:|.    ..|||.:.:    .|....:.|..||       :::|           .|
  Fly   526 YSLGNRRPIEM----FMEKPPRKI----YPDYYDIIQNPID-------MNTI-----------EH 564

  Fly  1208 NPGPQDYASCSESSEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQSLMPPPA---KVNKKPGLEE 1269
            |.....||:..:...|      .|.:....:.|...|  ||.|:.:.:...|   |:.:.|||.|
  Fly   565 NIRTDRYAAVEDVVSD------YRLMFSNCRQYNEEG--SNIYEDANILERALNEKLKEFPGLTE 621

  Fly  1270 QVGPASLLPPPPYCEKYLR-----RTEMDFELPYDIWWAYTN-----------------SKLPTR 1312
              |..|.       :||.:     :|.:..|   .:|..|..                 :|||::
  Fly   622 --GKKSQ-------QKYSKVGRKLKTAVITE---RLWQFYETVKEYQEPKGKRQLSLIFTKLPSK 674

  Fly  1313 NVVPSWNYRKIRTNVYAESVRPNLAGFDHPTCNCKNQGEKSCLDNCL--------NRMVYTECSP 1369
            :..|.: |..||..:..:.:...|           .||....||:..        |...|.|
  Fly   675 SEYPDY-YDIIREPIDMDRIAQKL-----------KQGAYDTLDDLAADFLLMLENACKYNE--- 724

  Fly  1370 SNCPAGEKCRNQKIQRHAVAPGVERFMTADKGWGVRTK------LPIAKGTYILEYVGEVVTEKE 1428
                     .:.:|.:.|:   |.:.:|......:||:      :|:|             .::.
  Fly   725 ---------PDSQIYKDAL---VLQQLTLQLKQQLRTERDSLPDVPLA-------------VQEL 764

  Fly  1429 FKQRMASIYLNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKR 1493
            |.....:||                             ||..|
  Fly   765 FLTLFTTIY-----------------------------NHQDE---------------------- 778

  Fly  1494 AIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCRGVIGGKSQRVKPLPAVEAKPSGEGLSGRNGRQ 1558
                                ||   ||           .|..:..||..:....|..:.|.:...
  Fly   779 --------------------EG---RC-----------YSDSLAELPEYDEIGEGPKVRGISLDL 809

  Fly  1559 RKQKAKKHAQRQAG---KDISSAVAVAKLQPLSEKEKKLVR----------QFNTFLVRNFEKIR 1610
            .|::..|.|.::..   :||.:.:         |:.:||.|          :..|:.:|..:::
  Fly   810 VKRRLDKGAYKRLDVYQEDIFACL---------ERARKLSRTDSDIFQDSIELQTYFIRKRDEL- 864

  Fly  1611 RCKAKRASDAAATASSPALGTTNGDIPGRRPSTPSSPSLAAQISALCSPRNIKTRGLTQAVHDPE 1675
             ||        .|.||.||..             |...|.|.:. ||     :.:.:.|...|.|
  Fly   865 -CK--------DTLSSSALNF-------------SLERLMADVE-LC-----RQQKMQQEEQDQE 901

  Fly  1676 LEKMAKMAVVLRDICSAMETLKMS---------DLLTTVSSKKKKPIKTTLSGKLGSTAATSKVE 1731
            .:|.       :|..:|.:...|:         |.:.....:.|.|....:. :|.::....|:.
  Fly   902 QDKE-------KDEFNAAKGESMTINQQVFSPGDYVYVQMPENKIPSICCIE-RLWTSPTNEKLM 958

  Fly  1732 FRSIQAQVEQGHYKTPQEFDDHMQQLFVEAKQQHGDDEGKEKALQSLKDSYEQQKIASYVQLVEI 1796
            ..||..:..:.::.|.::|.:                  ||....||..:....|:.....::.|
  Fly   959 QASIFVRPHETYHVTTRKFLE------------------KEVFKSSLSQTISMDKVQGMCYVMNI 1005

  Fly  1797 LGDSESLQSFKPKEVLSSEEEPGKIAVKKSPGAKERDSPIVPLKVTPPPLLPIEASPDEDVIRCI 1861
                                   |..:|..|                      |..|::||..|.
  Fly  1006 -----------------------KDYIKMRP----------------------ENLPEKDVYVCE 1025

  Fly  1862 CGLYKDEGLMIQCSKCMVWQHTECTKADIDADNYQCERCEPREVDREIPLE------EFTE--EG 1918
             ..|..:|...:  |...|....             |....:.|.||.|||      .|.|  |.
  Fly  1026 -SRYNIQGRWFK--KLKSWPPVR-------------EGSSVKFVPREQPLELKRVMSVFKERLEK 1074

  Fly  1919 HRYYLSLMRGDLQVRQGDAVYVLRDIPIKDESGKVLPTKKHTYETI--GAI---DY-------QE 1971
            |:..|..::....:.:.:...|..|.|...|.|.   |....|.||  |||   |:       .:
  Fly  1075 HKGELEELKLQETLVEKEKPNVSCDPPPNAEVGS---TYYQQYNTICSGAIKTGDFVYVATQTGK 1136

  Fly  1972 CDIFRVEHLWKNELGKRFIFGHHFLRPHETFHEPSRRFYPNEVVRVSLYEVVPIELVIGRCWVLD 2036
            ..:.:|:.:|:.. ||.:..|...|.|.||.....::||..|::..::.||.|:..::|||.||:
  Fly  1137 QSVAQVQQIWEQN-GKSYFKGPWLLPPSETTPGLGKQFYRQELLLSTVEEVSPVVGIVGRCAVLE 1200

  Fly  2037 RTTFCKGRPMECNDEDHCYICELRVDKTARFFSK------AKANH-PACTKSYAFRKFPEKIKIS 2094
            .:.|...||.|.::.| .||||...|:..:...|      .|..| |:.|:...| .|...||.|
  Fly  1201 YSEFISSRPTEISESD-VYICESVYDELKKALRKLVTGNMRKFQHSPSVTEDEIF-YFKTPIKPS 1263

  Fly  2095 KSY 2097
            |.:
  Fly  1264 KDF 1266

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	48/265 (18%)
		AWS	1340..1388	CDD:197795	8/55 (15%)
		SET_ASH1L	1391..1531	CDD:380951	16/145 (11%)
		Bromo_ASH1	1680..1787	CDD:99955	16/115 (14%)
		PHD_ASH1L	1858..1900	CDD:277023	6/41 (15%)
		BAH_polybromo	1929..2073	CDD:240068	44/161 (27%)
polybromo	NP_651288.1	Bromodomain	46..158	CDD:445827	27/156 (17%)
		Bromo_polybromo_II	191..294	CDD:99948	17/103 (17%)
		Bromo_polybromo_III	335..443	CDD:99951	21/127 (17%)
		Bromo_polybromo_IV	512..613	CDD:99949	24/134 (18%)
		Bromo_polybromo_V	641..733	CDD:99946	19/118 (16%)
		Bromo_polybromo_VI	758..867	CDD:99956	30/225 (13%)
		BAH_polybromo	921..1040	CDD:240068	26/185 (14%)
		BAH_polybromo	1120..1234	CDD:240068	34/115 (30%)
		HMG-box_PB1	1319..1376	CDD:438800