DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ash1 and PR-Set7

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	NP_001247100.1	Gene:	PR-Set7 / 41743	FlyBaseID:	FBgn0011474	Length:	691	Species:	Drosophila melanogaster

Alignment Length:	823	Identity:	185/823 - (22%)
Similarity:	277/823 - (33%)	Gaps:	281/823 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   810 KKRHLLEQPTSVSGAGSSASNSPLRIVVDNNSISGGKLLD---ISPSSL-CSLKQQRRGGAAKQK 870
            ::|...|..:|.||..||.|..|:...:..| ::|..|.|   .||... |.|.:..:.|...:.
  Fly     7 RQRPAKEAASSSSGGASSGSGIPVDQALPLN-VAGNLLEDQYFASPKRKDCRLMKVTQNGQLPEA 70

  Fly   871 VSAA--KDL-------VQLQSPAGSYPPPGVF---------EPSVELEIQIPLS----------- 906
            ...|  ||.       |.|.:.:.:......|         :.::..|.|:.|.
  Fly    71 TMMAHNKDNKAGRTIGVPLATRSQTRTIENFFKANAAAKDSQKTIHTEEQLNLGNQELKLDDEEL 135

  Fly   907 ----KLNESVITKAEVE----SPLLSALDIKEDTK--KEVGQRVVETLLHKTGGNLLLKRKRKKI 961
                ||::.|:..|:.:    .|....:|.|.:.|  .|..|:|||.||....       .|...
  Fly   136 NGQIKLDDEVLKLADKQINENLPFADEVDAKAEQKLMDEELQQVVEELLFDGS-------SRASS 193

  Fly   962 NRTGFPTVRRKKRKVSVEQQTTAVIDEHEPEFDPDDEPLQ-------------SLRETRSS---- 1009
            |.   |..:.....:...|||..:     |......|||:             :||::.||
  Fly   194 NS---PFYQHDMDVMQEIQQTPEI-----PHIKKVTEPLEGLGSLADFQTHRSALRDSHSSTHSS 250

  Fly  1010 --NNVNVQAAPNPPLDCERVPQAGEARETFVARTNQKAPRL-----------------SVVAL-- 1053
              :|:.:| .|...||.:|.|.  :|....:.|:.:.|..:                 .:|:|
  Fly   251 STDNIFLQ-EPVLTLDIDRTPT--KASSIKINRSFELAGAVFSSPPSVLNACLNGRFNQIVSLNG 312

  Fly  1054 --ERLQRP------------------------QTPARGRPRGRKPKNREQAEAAPQ----PPPKS 1088
              |.|..|                        ::|| |:||.|||       |.|.    |.|
  Fly   313 QKEALDLPHFDLDQHDSSSCDSGVACGLTANTESPA-GQPRRRKP-------ATPHRILCPSP-- 367

  Fly  1089 EPEIRPA-KKRGRQPKQPVLEEPPPTPPPQQKKNKMEPNIRLPDGIDPNTN---FSCKIRLKRRK 1149
               |:.| |..|...|....:...|...|::.               |.|.   .:||.|  ||.
  Fly   368 ---IKTALKVTGGICKVGSADPLSPRKSPRKL---------------PTTTAAVAACKSR--RRL 412

  Fly  1150 NLEAGTQPKKEKPVQPVTVEEIPPEIPVSQEEIDAEAEAKRLDSIPTEHDPLPASESHNPGPQDY 1214
            |     |||.:.|.||..  :.||.....|::.|....   ||....|.|          ...|.
  Fly   413 N-----QPKPQAPYQPQL--QKPPSQQQQQQQDDIVVV---LDDDDDEGD----------DEDDV 457

  Fly  1215 ASCSESSEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQSLMPPPAKVNKKPGLEEQVGPASLLPP 1279
            .:..:::|::.:.......:...|    ||:     |..|.|.|.|...|     ..||....||
  Fly   458 RALIKAAEERENQNKAPATANSNK----AGM-----KTMLKPAPVKSKTK-----SKGPTKGQPP 508

  Fly  1280 PPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSWNYRKIRTNVYAESVRPNLAGFDHPTC 1344
            .|.......|...||              .|.|..|     ||.:|.|..|.:|    |.
  Fly   509 LPLAATNGNREMTDF--------------FPVRRSV-----RKTKTAVKEEWMR----GL----- 545

  Fly  1345 NCKNQGEKSCLDNCLNRMVYTECSPSNCPAGEKCRNQKIQRHAVAPGVERFMTADKGWGVRTKLP 1409
                  |::.|:                   |:|...:: ||        ||  .||.||....|
  Fly   546 ------EQAVLE-------------------ERCDGLQV-RH--------FM--GKGRGVVADRP 574

  Fly  1410 IAKGTYILEYVGEVVTEKEFKQR--------MASIYL----NDTHHYCLHLDGGLVIDGQRMGSD 1462
            ..:..:::||||::::..|..:|        .|..|:    :.:..||:    ...:|..::|
  Fly   575 FKRNEFVVEYVGDLISIGEAAEREKRYALDENAGCYMYYFKHKSQQYCI----DATVDTGKLG-- 633

  Fly  1463 CRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDY 1505
             |.:|||...|...:...:.....:||.||..||.||||||||
  Fly   634 -RLINHSRAGNLMTKVVLIKQRPHLVLLAKDDIEPGEELTYDY 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795	6/47 (13%)
		SET	1392..1512	CDD:214614	38/126 (30%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
PR-Set7	NP_001247100.1	SET	566..676	CDD:279228	35/117 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467640
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840