Protein Alignment ash1 and ehmt1b

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: XP_021324462.1
• Gene: ehmt1b / 402830
• ZFINID: ZDB-GENE-080515-3
• Length: 1295
• Species: Danio rerio
• Alignment Length: 1527
• Identity: 285/1527 - (18%)
• Similarity: 461/1527 - (30%)
• Gaps: 574/1527 - (37%)

  Fly   456 RAKSCGYRSDCKESGKSGLRMRRKRRASMLLKS----SADDTVED------QDILQLAGLSLGQS 510
            :.:.|.::.....:|.||.|...|...:...:|    ..||..:|      ::.::..|......
Zfish     9 QVQPCCWKPSSLANGNSGKRETMKSEGTKESRSDQEEGGDDDHQDGRTGPLREAIEQNGTYENMD 73

  Fly   511 SEESNEYISKPSLKSLPTTSASKKYGEINRYVTTGQYFGRGGSLSATNPDN---------FISKM 566
            ::.:.:.:|.....:.|:|..:                    .||.|.|.:         .:||:
Zfish    74 TKRNEQNLSTQGSPARPSTMEN--------------------GLSETEPPHGSKVGSNGYILSKV 118

  Fly   567 MNQRKETP-----APSKSSCKIKSRRSSAASMCSSY-----VSGVSRMRRRHRRKSFSHNKSLNI 621
            .......|     :|:..:......:||..|:..|.     .||.|:......|::.:..|:..|
Zfish   119 KEDTVSAPHRTNWSPTGGTTLGHGTKSSPPSVLQSLDQGSSNSGASQGPSLTERRAETETKNGII 183

  Fly   622 DSKLLTEIEIITSTFNSRCRIQDDRLTGSSGKEKLLA---DANKLQATLAAPSPAQQLTLNGGGP 683
            .......:.....|.:.....|..:|.....||.::.   .|.|.:|....||..|.........
Zfish   184 SKTPPPTVHRARKTMSRPASNQTLKLLNRENKEPVVVKDDSAGKPEAVQPQPSLIQNQLPQSQTD 248

  Fly   684 ASTL--SKPLKRGLKKRKLSEPLVDFAMLSASASGTPNGSGSSNGNTKRRHKKSQSNDSSSPDDH 746
            |:::  :.|.|          |.::|::.:::..  |.....|.....|:.|:.....|..|...
Zfish   249 ATSVPNTTPAK----------PQIEFSLYASTVE--PRPVSPSVAAVSRKKKRKMGTYSLVPKKK 301

  Fly   747 KLPLKKRHYL-------LTPGERPPAEVAFANG-KLNAEAWAAAAAAAKSTASTKSQAQFNARSV 803
            ...||:|..|       .:|....|.|:...|| |::.|:....:...:.|.
Zfish   302 NKVLKQRTVLEMFQQISQSPPNPKPKEIVRVNGEKMDNESDEEESEEGEDTE------------- 353

  Fly   804 KSALTPKKRHLLEQPTSVSGAGSSASNSPLRIVVDNNSIS-----------------GGKLLDIS 851
                        ::...|:..|:.||:...||    .|||                 .|...|:|
Zfish   354 ------------DEEELVTEDGAKASHEEPRI----PSISQPLEEESEESQDCEGEEEGDESDLS 402

  Fly   852 PSSLC-----------------SLKQQRRGGAAKQKVSAAKDLVQLQSPAGSYPPPGVFEPSVEL 899
            ..|..                 |.|::|:..|...||||  .:.::||...|...|.|.....:.
Zfish   403 SESSLKKKWKKKAKGDHAWLRPSRKRKRKWKAKTDKVSA--PVTEIQSRPESQSAPSVPTAHRKE 465

  Fly   900 EIQIPLSKLN----ESVITKAEV---------------ESPLLSALDIKEDTKKEVGQRVVETLL 945
            ..::||..||    |:::|....               |.||.|.   :.:|.|   .|.:.||.
Zfish   466 YKEVPLDSLNLAAQEALLTSQNTAASGSLQSTDADMVQELPLCSC---RMETPK---SREILTLA 524

  Fly   946 HKTGGNLLLKRKRKKINRTGFPTVRRKKRKVSVEQQTT---AVIDEHEPEFDPDDEPLQSLRETR 1007
            .                       |:.....|::.|.:   :.:.:||.....:...|..|.|..
Zfish   525 D-----------------------RKCMATESIDGQLSRCQSAVLKHEMMRPSNSVQLLVLCEDH 566

  Fly  1008 SSNNVNVQAAP--------------NPPLD--------CERV-------PQAGE----ARETFVA 1039
            .:..|..|..|              .|.::        |..|       |..||    |:|..:|
Zfish   567 RTGMVKHQCCPGCGFFCRAGTFMECQPEVNISHRFHRTCASVLNGQSFCPHCGEEVSKAKEVTIA 631

  Fly  1040 RTNQKAPRLSVVALERLQ--------RPQTPARGRPR----GRKPKNREQAEAAPQPPPKSEPEI 1092
                ||...|.|.:....        :..|...|..|    |....|    ...|:|....:..:
Zfish   632 ----KADTTSTVPITHSSCIPSTSEGKADTTTGGSTRLSVLGEGKAN----STLPKPSESQDTSL 688

  Fly  1093 RPAKKRGRQ------PKQPVLEEPPPTPPPQ-------------QKKNKMEPN------------ 1126
            .....:.|.      |..|:    ||.||.:             .||.:..|.
Zfish   689 SLVGSKARSVAMAAAPGLPL----PPGPPKETLQSVLLALDAEKPKKLRFHPKQLYISAKQGELQ 749

  Fly  1127 ---IRLPDGIDPNTNFSCKIRLKR---RKNLEAGTQPKKEKPVQPVTVEEIPPEIPVSQEEIDAE 1185
               :.|.|||||  ||..:.:.||   ....|||.|                   .|....:.|.
Zfish   750 KVLLMLVDGIDP--NFKMESQNKRTPLHVAAEAGHQ-------------------DVCHMLVQAG 793

  Fly  1186 AEAKRLDSIPTEHDPL-PASESHNPGPQDY---ASCSESSEDKASTTSLRKLSK-----VKKTYL 1241
            |.....|.  .:..|| .|.|:::.....|   |....|.:|...:|.|...:|     :.:..|
Zfish   794 ANLDMCDE--DQRTPLMEACENNHLETVRYLLRAGAIVSHKDVEGSTCLHLAAKNGHFSIVQHLL 856

  Fly  1242 VAGL---------------FSNHYK-----QSLMPPPAKVNKKPGLEEQV--------------- 1271
            .|||               ::..||     :.|:...|.:|.: ..||.:
Zfish   857 SAGLVDINCQDDGGWTAMIWATEYKHVDQVKLLLSKGADINIR-DKEENICLHWAAFSGCVEIAE 920

  Fly  1272 ---------------GPASL-----------------------------LPPPPYC--------- 1283
                           |.:.|                             ..|...|
Zfish   921 IFLTAKCDLNTMNIHGDSPLHIASREGRLDCVNLFLSRGADVNLKNKEGETPMECCSHSSKVWNA 985

  Fly  1284 -----------------EKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSW----NYRKIRTNV 1327
                             ||.|.:         ||...|....:|..|.|.|.    ||:.:..:.
Zfish   986 LQANKKQREANRKAGATEKLLNK---------DIARGYEKVPVPCVNAVDSEPCPDNYKYVPDSC 1041

  Fly  1328 YAE--SVRPNLAGFDHPTCNCKNQ-GEKSCLDNCLN-RMVYT------------------ECSPS 1370
            ...  ::..|:....:  |.||:. ...||:...|: |..|.                  ||:.:
Zfish  1042 VTSPLNIDKNITHLQY--CVCKDDCSSASCMCGQLSLRCWYDKESRLLPEFSNEEPPLIFECNHA 1104

  Fly  1371 NCPAGEKCRNQKIQRHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMAS 1435
             |.....|:|:.:| :.:...::.|.|...||||:|...|.:||::.|||||::::.|     |.
Zfish  1105 -CSCWRTCKNRVVQ-NGLRTRLQLFKTQMMGWGVKTLQDIPQGTFVCEYVGEIISDAE-----AD 1162

  Fly  1436 IYLNDTHHYCLHLDGG--LVIDGQRMGSDCRFVNHSCEPN---CEMQKWSVNGL--SRMVLFAKR 1493
            :..||::.:.|....|  ..:|.:..|:..||:||.||||   |.:.. |...|  ..:..||.:
Zfish  1163 VRENDSYLFSLDSKVGDMYCVDARFYGNISRFINHHCEPNLLPCRVFT-SHQDLRFPHIAFFACK 1226

  Fly  1494 AIEEGEELTYDY--NF-----SLFNPSEGQPCRCNTPQCRGVIGGKSQRVKPLPAVEAKPSGEGL 1551
            .|..|:||.:||  :|     .|||      |:|.:.:|
Zfish  1227 NISAGDELGFDYGDHFWDVKGKLFN------CKCGSSKC-------------------------- 1259

  Fly  1552 SGRNGRQRKQKAKKHAQRQAGKDISSAVAVAKLQPLSEKEKKLVRQFNTFLVRNFEKIRRCKAKR 1616
                         ||          ||.|:|:.|
Zfish  1260 -------------KH----------SAAAIAQTQ------------------------------- 1270

  Fly  1617 ASDAAATASSPALGTTNGDIPGRRPSTPSSPS 1648
             :|:......|:.      :|....|||||||
Zfish  1271 -ADSTPGDQQPSA------LPDTSSSTPSSPS 1295

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	74/432 (17%)
		AWS	1340..1388	CDD:197795	14/67 (21%)
		SET_ASH1L	1391..1531	CDD:380951	49/153 (32%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
ehmt1b	XP_021324462.1	EHMT_ZBD	503..632	CDD:411018	29/161 (18%)
		ANKYR	720..973	CDD:440430	45/276 (16%)
		ANK repeat	739..765	CDD:293786	8/27 (30%)
		ANK repeat	767..800	CDD:293786	9/51 (18%)
		ANK repeat	802..833	CDD:293786	7/30 (23%)
		ANK repeat	835..867	CDD:293786	7/31 (23%)
		ANK repeat	869..900	CDD:293786	5/31 (16%)
		ANK repeat	902..933	CDD:293786	2/30 (7%)
		ANK repeat	935..966	CDD:293786	2/30 (7%)
		SET	1033..1262	CDD:394802	68/293 (23%)