Protein Alignment ash1 and Kmt2d

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: XP_017172163.1
• Gene: Kmt2d / 381022
• MGIID: 2682319
• Length: 5608
• Species: Mus musculus
• Alignment Length: 1906
• Identity: 352/1906 - (18%)
• Similarity: 631/1906 - (33%)
• Gaps: 558/1906 - (29%)

  Fly    15 ETQRAQESGSENEETDSITDQSSQSKSIKSATQFSVQRSDTDGLRMRISAIRPTLGVVATKKPPK 79
            :.|:.|:...:.::......|..|..|:...:|.. |...:.|.:.::||  ..||.:..::...
Mouse  3863 QQQQQQQQQQQQQQQQQQQQQQQQQGSMTGLSQLQ-QGMMSHGGQPKMSA--QALGSLQQQQQQL 3924

  Fly    80 SRKMSTQDTESGCSEAKNRAVSKKVKVKRKKLASSSGISKSDKVSKSKKSQISAFSSDSEDDLPL 144
            .::...|              .::::.::::|...   .:..::.:.::.|:.......:....|
Mouse  3925 QQQQMLQ--------------QQQLQQQQQQLQQQ---QQQQQLQQQQQQQLQLQQQQQQQQQHL 3972

  Fly   145 KVHQQRAPRVLLSAIIQAAQSASKPTLDIGISSSDNELPNLVQAAIKRVESD--TEDTTVEGSFR 207
            : |||:..:.|...  |..|...:..|.:     ..:|....|..:::.:..  .::.|:....:
Mouse  3973 Q-HQQQQQQQLQQQ--QQLQQQQQQQLHL-----QQQLHQQQQLQLQQQQMGLLNQNRTLLSPQQ 4029

  Fly   208 KAAKDKNLPQYQSTLLQDFMEKTQM-LGQTVNAK----------LAEEKVAKAKEETLVQTAVPR 261
            :..:.:...|.|....|...::.|: ||..:..|          |....:...||:...:||:|.
Mouse  4030 QQQQQQQQQQQQQQQQQQQQQQQQVTLGPGLPVKPLQHFSSSGALGPTLLLTGKEQNNAETALPS 4094

  Fly   262 K-------RRGRPKKVVPTVP-----APGNSGPAINESADSGVISTTSTTQSTTPSPKMQNENAV 314
            :       .:|.| ..|.|.|     .||...|:|  |.||.::...|..||...|.::|
Mouse  4095 EVTEGPSTHQGGP-PAVGTAPEPMSVEPGEVKPSI--SGDSQLLLVQSQAQSQATSVQLQ----- 4151

  Fly   315 PTGSLPIASSSKPKIDMAYL--------------DKRMYATERVLYPPPRSKRRQNNKKTACSSS 365
            |...||  ...:|::::.:.              .....|...:|..|..|...|..........
Mouse  4152 PPLRLP--GQPQPQVNLLHTAGGGSHGQQLGSGSSSESPAVPHLLAQPSVSLGEQPGPMAQNLLG 4214

  Fly   366 NKEELQLDPLWREIDVN-----KKFRLRSMSVGAASGTGASTTICSKVLAAKSGYVSDYGSVRHQ 425
            :::.|.||   |.|..|     .|......|.....|.|...|: .::.|...|.::....:||
Mouse  4215 SQQPLGLD---RPIQNNTGSQPPKSGPAPQSGQGPPGAGVMPTV-GQLRAQLQGVLAKNPQLRH- 4274

  Fly   426 RSSHNHNSGYKSDASCKSRYSTKSCMSRRSRAKSCGYRS-------DCKESGKSGLRMRRKRRAS 483
                         .|.:.:...::.:.:|...:|...|.       ..:.|...||...:.:...
Mouse  4275 -------------LSPQQQQQLQALLMQRQLQQSQAVRQTPPFQEPGTQPSPLQGLLGCQPQPGG 4326

  Fly   484 MLLKSSADDTVEDQDI-------------LQLAGLSLG------------QSSEESN--EYISKP 521
            .    |...|...|::             :....||.|            .|.:|..  ..:..|
Mouse  4327 F----SVSQTGPLQELGAGSRPQGPPRLPVPQGALSTGPVLGPAHPTPPPSSPQEPKRPSQLPSP 4387

  Fly   522 SLKSLPTTSASKK---------YGEINRYVT--TGQYFGRGGSLSATNPDNFISKMM--NQRKET 573
            |.:..||...:.|         .|.::....  ...:||:|  |...:|.:.:::..  .|....
Mouse  4388 SAQLTPTHPGTPKPQGPALELPPGRVSPAAAQLADTFFGKG--LGPWDPSDNLTEAQKPEQSSLV 4450

  Fly   574 PA------------PSKSSCKIKSRRSSAASMCSSYVSGVSRMRR-------------RHRRKSF 613
            |.            ||:.|.|.:.|....|       .|...::|             .|...:.
Mouse  4451 PGHLDQVNGQVVHEPSQLSIKQEPREEPCA-------LGAQTVKREANGEPAGAPGTSNHLLLAG 4508

  Fly   614 SHNKSLN-IDSKLLTEIEI--------------ITSTFNSRCRIQDDRLTG-SSGKE------KL 656
            |.:::.: :..|||....:              |....:|:....:.:|.| ||.||      .|
Mouse  4509 SRSEAGHLLLQKLLRAKNVQLGAGRGPEGLRAEINGHIDSKLSGLEQKLQGTSSNKEDAATRKPL 4573

  Fly   657 LADANKLQATL-AAPSPAQQLTLNGGGPAS-TLSKPLKRGLKKRKLSEPLV--DFAMLSASASGT 717
            .|...::|.|. ..||..::|....|..|: .|.|.||:.|.:..|:||.:  :|::.:
Mouse  4574 PAKPKRVQKTSDRLPSSRKKLRKEDGVRANEALLKQLKQELSQLPLTEPTITANFSLFA------ 4632

  Fly   718 PNGSGS-SNGNTKRRHKKSQSNDSSSPDDHKLPLKKRHY--------LLTPGERPPAEVAFANGK 773
            |.|||. .:|.::.|.........:.||.:...|.|.:.        .|.|...|..:....||.
Mouse  4633 PFGSGCLVSGQSQLRGAFGSGALHTGPDYYSQLLTKNNLSNPPTPPSSLPPTPPPSVQQKMVNGV 4697

  Fly   774 LNAEAWAAAAAAAKSTASTKSQ--AQFNARSVKS----ALTPKKRHLLEQPTSVSGAGSSASNSP 832
            ..::   ......|.|||.:..  |..:|..|||    |..|...|  .|...|.......|:||
Mouse  4698 TPSD---ELGERPKDTASAQDSEGALRDAAEVKSLDLLAALPTPPH--NQTEDVRMESDEDSDSP 4757

  Fly   833 LRIVVDNNSISGGKLLDISPSSLCSLKQQR----RGGAAKQKVSAAKDLVQLQSPAG--SYP--- 888
            ..||..:           ||.|:...:..|    ..|..:|...|...::.:....|  .:|
Mouse  4758 DSIVPAS-----------SPESILGEEAPRFPQLGSGRWEQDNRALSPVIPIIPRTGIPVFPDTK 4811

  Fly   889 PPGVFEPSV---------------ELEIQIPLS-----KLNESVITKAEV--------------E 919
            |.||.:..|               |:.:.:.:|     .||..::..||:              :
Mouse  4812 PYGVLDLEVPGKLPATAWEKGKGSEVSVMLTVSAAAAKNLNGVMVAVAELLSMKIPNSYEVLFPD 4876

  Fly   920 SPLLSALDIKEDTKKEVGQRVVETLLHK---TGGNLLLKRKRKKINRTGFPTVRRKKRKVSVEQQ 981
            .|..:.|:.|:...:..|.: .:.|..|   ||.:.|   |:......|: |::.:...:|:.:|
Mouse  4877 GPARAGLEPKKGEAEGPGGK-EKGLSGKGPDTGPDWL---KQFDAVLPGY-TLKSQLDILSLLKQ 4936

  Fly   982 TTAVIDEHEPEFDPDDEPLQSLRETRSSNNVNVQAAPNPPLDCERVPQAGEARETFVARTNQKAP 1046
            .:           |..||......|.:.:|::|:....||      |:......:.:|.:....|
Mouse  4937 ES-----------PAPEPSIQHSYTYNVSNLDVRQLSAPP------PEEPSPPPSPLAPSPASPP 4984

  Fly  1047 RLSVVALERLQRPQTP--------------ARGRPRGRKPKNREQAEAAPQPPPKSEPEIRPAKK 1097
            ...:|.|: .:||..|              ||.:||.|.|   |::|.:..|..|....:|..:.
Mouse  4985 AEPMVELQ-AERPAEPPIPSPLPLASSPESARPKPRARPP---EESEDSRPPRLKKWKGVRWKRL 5045

  Fly  1098 R---------GRQPKQPVLEE--------PPPTPPPQQKKN------------------------ 1121
            |         |.|..:..:.|        ..|:..|:..:.
Mouse  5046 RLLLTIQKGSGHQEDEREVAEFMEQFGTALRPSKVPRDNRRCCFCHEEGDGATDGPARLLNLDLD 5110

  Fly  1122 ---------------------KMEPNIRLPDGI--------------------DPNT-NFSCKIR 1144
                                 .|...:.|..|:                    .||. :|:|.||
Mouse  5111 LWVHLNCALWSTEVYETQGGALMNVEVALHRGLLTKCSLCQRTGATSSCNRMRCPNVYHFACAIR 5175

  Fly  1145 LK----RRKNLEAGTQPKKEKPVQPVTVEEIPPEIPVSQEEIDAEAEAKRLDSIPTEHD------ 1199
            .|    :.|.:.......|....|.::...:...:.:.::|:      |::.||....:
Mouse  5176 AKCMFFKDKTMLCPVHKIKGPCEQELSSFAVFRRVYIERDEV------KQIASIIQRGERLHMFR 5234

  Fly  1200 -------------PLPASESHNPG---PQDYAS-----------------CSESSEDKASTTSLR 1231
                         |...::.|:..   |..|.:                 ||.|..:......:
Mouse  5235 VGGLVFHAIGQLLPHQMADFHSATALYPVGYEATRIYWSLRTNNRRCCYRCSISENNGRPEFVI- 5298

  Fly  1232 KLSKVKKTYLVAGLFSNHYKQS----LMPPPAKVNKKPGL----------EEQVG--------PA 1274
               ||.:..|...:|::...|:    ::.|.|.:.|:..:          ||..|        .|
Mouse  5299 ---KVIEQGLEDLVFTDASPQAVWNRIIEPVAAMRKEADMLRLFPEYLKGEELFGLTVHAVLRIA 5360

  Fly  1275 SLLPPPPYCEKYLRRTEMD--FELPYDI---WWAYTNSKLPTRNVVPSWNYRKIRTNVYAESVRP 1334
            ..||....|:.||.|....  .|||..|   ..|.:..|:.|       :|:::.|::.:.....
Mouse  5361 ESLPGVESCQNYLFRYGRHPLMELPLMINPTGCARSEPKILT-------HYKRVFTSIISFDPHN 5418

  Fly  1335 NLAGFDHP-TCNCKNQGEKSCLDNCLNRMVY--TECSPSNCPAGEKCRNQKIQRHAVAPGVERFM 1396
            ||.   .| |.|..:..:           .|  |....:|.|..::..:.|..::      .|..
Mouse  5419 NLM---RPHTLNSTSMSK-----------AYQSTFTGETNTPYSKQFVHSKSSQY------RRLR 5463

  Fly  1397 TADK-----------GWGVRTKLPIAKGTYILEYVGEVV-------TEKEFKQRMASIY---LND 1440
            |..|           |.|:.....:.|.|.::||:|.::       .||.::::...||   :|:
Mouse  5464 TEWKNNVYLARSRIQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIYEEQNRGIYMFRINN 5528

  Fly  1441 THHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDY 1505
            .|          |||....|...|::||||.|||..:..:.:...::::.:.|.|.:||||||||
Mouse  5529 EH----------VIDATLTGGPARYINHSCAPNCVAEVVTFDKEDKIIIISSRRIPKGEELTYDY 5583

  Fly  1506 NFSLFNPSEGQPCRCNTPQCR 1526
            .|...:.....||.|....||
Mouse  5584 QFDFEDDQHKIPCHCGAWNCR 5604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	65/424 (15%)
		AWS	1340..1388	CDD:197795	8/50 (16%)
		SET_ASH1L	1391..1531	CDD:380951	44/157 (28%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
Kmt2d	XP_017172163.1	ePHD1_KMT2D	134..217	CDD:277165
		PHD1_KMT2C_like	228..273	CDD:276984
		PHD_SF	275..320	CDD:473978
		PHA03247	<492..883	CDD:223021
		PHD3_KMT2D	1335..1385	CDD:277072
		PHD5_KMT2C_like	1386..1432	CDD:276988
		PHD5_KMT2D	1463..1513	CDD:277074
		HMG-box_KMT2D	1956..2039	CDD:438836
		PHA03247	<2071..2637	CDD:223021
		Med15	<4104..>4407	CDD:312941	61/334 (18%)
		ePHD2_KMT2D	5087..5193	CDD:277168	11/105 (10%)
		FYRN	5236..5287	CDD:461787	5/50 (10%)
		FYRC	5295..5382	CDD:197781	18/90 (20%)
		SET_KMT2D	5453..5607	CDD:380986	45/168 (27%)