DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ash1 and egg

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	NP_611966.3	Gene:	egg / 37962	FlyBaseID:	FBgn0086908	Length:	1262	Species:	Drosophila melanogaster

Alignment Length:	1633	Identity:	287/1633 - (17%)
Similarity:	470/1633 - (28%)	Gaps:	661/1633 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 IQAAQSASKPTLDIGISSSDNELPNLVQAAIKRVE----SDTEDTTVEGSFRK----AAKDKNLP 216
            :|...::.:.:..:.:...:|.|.:..:.|.|.||    :.:|.....||.||    ..|..:.|
  Fly    21 VQETPASREKSYGLPVRKGENSLESPAEQAAKDVEIEELTHSEAIAATGSTRKQCPYGGKAPDEP 85

  Fly   217 QYQSTLLQDFMEKTQMLGQTVNAKLAEEKVAKAKEETLVQTAVPRKRRGRPKKVVPTVPAPGNSG 281
                                  .|||:|.               ..|:|...|.:.:.|.
  Fly    86 ----------------------GKLADES---------------EDRKGENTKAIASSPV----- 108

  Fly   282 PAINESADSGV--------ISTTSTTQSTTPSPKMQNENAVPTGSLPIASSSKPKIDMAYLDKRM 338
             .:...:||.|        .|:.:.::...|.|...||           :::|...:|
  Fly   109 -LVAVDSDSSVELIESPVKFSSANESEKDPPKPDAVNE-----------AAAKEAEEM------- 154

  Fly   339 YATERVLYPPPRSKRRQNNKKTACSSSNKEELQLDPLWREIDVNKKFRLRSMSVGAASGTGASTT 403
              |:..:..|......:.::||     |||..| :|...|:|.:.:   .|:|..|..
  Fly   155 --TDSSISSPTSESFPEKDEKT-----NKENEQ-EPPGMEVDQDVE---ESISRPAEE------- 201

  Fly   404 ICSKVLAAKSGYVSDYGSVRHQRSSHNHNSGYKSDASCKSRYSTKSCMSRRSRAKSCGYRSDCKE 468
                                           ||.:.:.|..  .:..::.....|....:.|..|
  Fly   202 -------------------------------YKIENTLKGH--KRISLTEIEEHKIVDKKDDVLE 233

  Fly   469 SGKSGLRMRRKRRASMLLKSSADDTVEDQDILQLAGLSLGQ---SSEESNEYISKPSLKSLPTTS 530
                          ..|.|.:|....||:.:..|  ||.|.   ..|..|...:|...:.:....
  Fly   234 --------------VELEKGTAPKAAEDEKLNAL--LSDGDVFYDKECVNCNCTKLHKQYVLANM 282

  Fly   531 ASKKYGEINRYVTTGQYFGRGGSLSATN-PDNFISKMMNQRKETPAPSKSSCKIKSRRSSAASMC 594
            |:..:.::.|..:..|:...|...:|.: .:.:..::|         :|....:|......|...
  Fly   283 ATLNFYQVLRKSSKQQFLCMGCHDTAMDLYEEYAGQLM---------AKQPLLLKDFHQDHADFV 338

  Fly   595 SSYVSGVSRMRRRHRRKSFSHNKSLNIDSKLLTEIEIITSTFNSRCRIQDDRLTGSSGKEKLLAD 659
            :...|......::..:..||.||...|:.:|...|:.:.:..:...::       |..|..|.|.
  Fly   339 ALDSSDEEEEEKQPEKSDFSKNKLQLIEDELDDAIKNVLNKVDFTAQL-------SWSKTILQAK 396

  Fly   660 ANKLQATLAAPSPAQQLTLNGGGPASTLSKPLKRGLKKRKLSEPLVDFAMLSASASGTPNGSGSS 724
            |:.|:...|.....                     |:|.:.:...:..|:.::....
  Fly   397 ADHLERQFALADVE---------------------LEKVQTTADKMHCALYNSCPVA-------- 432

  Fly   725 NGNTKRRHKKSQSNDSSSPDD--HKLPLKKRHYLLTPGE--RPP---AEVAFANGKLNAEAWAAA 782
                   ||...:.| ..|.|  |::|        .|||  |||   .|..:|.......:|
  Fly   433 -------HKHLPTLD-IEPSDYVHEVP--------PPGEIVRPPIQLGETYYAVKNKAIASW--- 478

  Fly   783 AAAAKSTASTKSQAQFNARSVKS--------------ALTPKKRHLLEQPTSVSGAGSSASNSPL 833
             .:.|....|:|.| .|..::||              .:|.|.....|.|             |:
  Fly   479 -VSIKVIEFTESTA-INGNTMKSYKIRYLNTPYQMIKTVTAKHIAYFEPP-------------PV 528

  Fly   834 RIVV--------DNNSISGGKLLDISPSSLC------SLKQQRR--------GG----------- 865
            |:.:        |..::|.||...:..|:..      .|||..|        .|
  Fly   529 RLTIGTRVIAYFDGTTLSRGKDKGVVQSAFYPGIIAEPLKQANRYRYLIFYDDGYTQYVPHRDVR 593

  Fly   866 ---AAKQKV-----SAAKDLVQLQSPAGSYPPPGVFEPSVELEIQIPLSKLNESVITKAEVESPL 922
               .|.:||     :|::|.:|                               ..:.|..|:.|:
  Fly   594 LVCQASEKVWEDVHAASRDFIQ-------------------------------KYVEKYSVDRPM 627

  Fly   923 LSALDIKEDTKKEVG----QRVVETLLHKTGGNLLLKRKRKKINRTGF---------PTVRRKKR 974
            :.....:..|.:..|    .||::     ...:|:|.:.....|.|.:         |..|..:.
  Fly   628 VQCTRGQSMTTESNGTWLYARVID-----IDCSLVLMQFEGDKNHTEWIYRGSLRLGPVFRETQN 687

  Fly   975 KV-SVEQQTTAVIDEHEPEFDPDDEPLQSLRETRSSNNVNVQAAPNPPLDCERVPQAGEARETFV 1038
            .: |...|...|....||.       ::..:|..||:.||.|             ....||::..
  Fly   688 NMNSSSAQQLRVPRRTEPF-------IRYTKEMESSSKVNQQ-------------MRAFARKSSA 732

  Fly  1039 ARTNQKAPRLSVVALERLQRPQTPARGRPRGRKPKNREQAEAA-----------PQPPPKSEPEI 1092
            :..|.        ||.......|||.||...........|.|.           .:..||.....
  Fly   733 SAQNN--------ALAAASSAATPAGGRTNAGGVSTSNSASAVRHLNNSTIYVDDENRPKGHVVY 789

  Fly  1093 RPAKKRGRQPKQPVLEEPPPTPPPQQKKNKMEPNIRLPDGIDPNTNFSCKIRLKRR--------K 1149
            ..||:.              .||...|.::..||              |..::..|        |
  Fly   790 FTAKRN--------------LPPKMYKCHECSPN--------------CLFKIVHRLDSYSPLAK 826

  Fly  1150 NLEAG-----TQPKKEKPVQPVTVEEIPPEIPVSQEEIDAEAEAKRLDSIPTEHDPLPASES--- 1206
            .|.:|     .:.|.:|.|    |.:.|.              .|.|.|:...|..|.|:|:
  Fly   827 PLLSGWERLVMRQKTKKSV----VYKGPC--------------GKSLRSLAEVHRYLRATENVLN 873

  Fly  1207 -----HNPGPQDYASCSESSEDKASTTSLRKLSKVKKTYLVAGL------FSNHYKQSLMPPPAK 1260
                 ..|   |....:|.|.|.         |.||.|.:..|.      ..|:|..:| |||..
  Fly   874 VDNFDFTP---DLKCLAEYSIDP---------SIVKDTDISKGQEKMAIPLVNYYDNTL-PPPCT 925

  Fly  1261 VNKKPGLEEQVGPASLLPPPPYCEKYLRRTEMDFELPYD------------IWW------AYTNS 1307
            ..|:....|.|              :|...| :|.|..|            .|.      .|.|.
  Fly   926 YAKQRIPTEGV--------------HLNLDE-EFLLCCDCEDDCSDKSKCACWQLTVAGVRYCNP 975

  Fly  1308 KLPTRNVVPSWNYRKIRTNVYAESVRPNLAGFDHPT----CN--CKNQGEKSCLDNCLNRMVYTE 1366
            |.|...:  .:.|:::..:|              ||    ||  ||      |..|||||:|
  Fly   976 KKPIEEI--GYQYKRLHEHV--------------PTGIYECNSRCK------CKKNCLNRVV--- 1015

  Fly  1367 CSPSNCPAGEKCRNQKIQRHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTE---KE 1428
                              :.::...::.|.|:::|||:|....|.||.:|..|.|.::||   .|
  Fly  1016 ------------------QFSLEMKLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTETMANE 1062

  Fly  1429 FKQRMASIYLND------------------------------------------THHYCLHL--- 1448
            ..|.....|..|                                          .:||...:
  Fly  1063 GGQDAGDEYFADLDYIEVAEQLKEGYESEVDHSDPDAEEDNGGPDAEDDDDFRPNYHYQRKIKRS 1127

  Fly  1449 ------------------------------------------------DGGLVIDGQRMGSDCRF 1465
                                                            :...::|.:..|:..|:
  Fly  1128 SRSGSTQNSSTQSSELDSQERAVINFNPNADLDETVRENSVRRLFGKDEAPYIMDAKTTGNLGRY 1192

  Fly  1466 VNHSCEPNCEMQK-----------WSVNGLSRMVLFAKRAIEEGEELTYDYNFSL-FNPSEGQPC 1518
            .||||.||..:|.           |       :..|:...|..|.|||::||:.: ..|.:...|
  Fly  1193 FNHSCSPNLFVQNVFVDTHDLRFPW-------VAFFSAAHIRSGTELTWNYNYEVGVVPGKVLYC 1250

  Fly  1519 RCNTPQCR 1526
            :|..|.||
  Fly  1251 QCGAPNCR 1258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795	13/53 (25%)
		SET	1392..1512	CDD:214614	39/227 (17%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
egg	NP_611966.3	HMT_MBD	823..879	CDD:238689	15/73 (21%)
		Pre-SET	901..1013	CDD:282838	32/149 (21%)
		SET	1022..1239	CDD:214614	39/223 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467608
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930