Protein Alignment ash1 and Ehmt1

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: XP_006233681.2
• Gene: Ehmt1 / 362078
• RGDID: 1307588
• Length: 1309
• Species: Rattus norvegicus
• Alignment Length: 1528
• Identity: 300/1528 - (19%)
• Similarity: 473/1528 - (30%)
• Gaps: 541/1528 - (35%)

  Fly   354 RQNNKKTACSSSNKEELQLDPLWREIDVNKKFRLRSMSVGAASGTGASTTICSKVLAAKSGYVSD 418
            :|..|:..|..:  |.|:.|.|....:.:.:.:.....:.|...|..|   |.     |||.:|.
  Rat    26 KQETKQDCCMKT--ELLREDTLMAADEGSTEKQAGETPMAADGETNGS---CE-----KSGDISH 80

  Fly   419 YGSVRHQRSSHNHNSGYKSDASCKSRYSTKSCMSRRSRAKSCGYRSDCKESGKSGLRMRRKRRAS 483
            ..:.:|.:.:              :|.|.:...:|.||....|......|.||..
  Rat    81 PNAPKHTQEN--------------TRASPQEGTNRVSRVAENGVSERDTEVGKQN---------- 121

  Fly   484 MLLKSSADDTVEDQDILQLAGLSLGQSSEESNEY-ISKPSLKS----LPTTSASKKYGEINRYVT 543
               ..:|||.::...|             .||.| ::||:|:.    .|.|..|...|...:.:.
  Rat   122 ---HVTADDFMQTSVI-------------GSNGYFLNKPALQGQPLRTPNTLNSSLPGHAAKTLP 170

  Fly   544 TGQYFGRGGSLSATNPDNFISKMMNQRKETP-----APSKSSCKIKSRRSSAASMCSSYVSGVSR 603
                   ||:.....|        :...:||     .|.:.|...:.|:.:|        ||...
  Rat   171 -------GGASKCRTP--------SALPQTPTTAPTVPGEGSADTEDRKPTA--------SGTDV 212

  Fly   604 MRRRHRRKSFSHNKSLNIDSKLLTEIEIITSTFNSRCRIQD--------DRLTGSSGKEKLLADA 660
            ...|.|:........|:..||             ....:||        :|.....|:::||...
  Rat   213 RVHRARKTMPKSILGLHAASK-------------DHREVQDHKEPKEDINRNISECGRQQLLPTF 264

  Fly   661 NKLQATL------AAPSPAQQLTLNGGGP---ASTLSKPLKRGL--------KKRKLSEPLVDFA 708
            ..|..:|      .|.:.:|...|    |   |:.:|:..||.:        ||.|:.:......
  Rat   265 PALHQSLPQNQCYMATTKSQTACL----PFVLAAAVSRKKKRRMGTYSLVPKKKTKVLKQRTVIE 325

  Fly   709 MLSASASGTPNGSGSSNGNTKRRHKKSQS--NDSSSPDDHKLPLKKRHYLLTPGERPPAEVAFAN 771
            |..:....|....|....:....|...:|  .||...|..:|.
  Rat   326 MFKSITHSTVGAKGEKVLDDSALHVNGESLEMDSEEEDSEELE---------------------- 368

  Fly   772 GKLNAEAWAAAAAAAKSTASTKSQAQFNARSVKSALTPKKRHLLEQPTSVSGAGSSASNSPLRIV 836
               :.|...|..|||..|..:::..:..:.:.::|             .:.|.......||
  Rat   369 ---DEEDRGAEQAAAFPTEDSRTSKESMSETDRAA-------------KMDGDSEEEQESP---- 413

  Fly   837 VDNNSISGGKLLDISPSSLCSLKQ---QRRG--------GAAKQKVSAAKDLVQLQSPAGSYPPP 890
            .......||...|:|..|  |:|:   :|||        .|.|::..:.|....:.........|
  Rat   414 DTGEDEDGGDESDLSSES--SIKKKFLKRRGKTDSPWIKPARKRRRRSRKKPSSMLGSEACKSSP 476

  Fly   891 GVFE---------------PSVELEIQIPLSKL--NESVITKAEV-------ESPLLSALDIKED 931
            |..|               .|::|.::..||..  ||.:....:|       |.||.|.   :.:
  Rat   477 GSMEQAALGDSAGYMEVSLDSLDLRVRGILSSQTENEGLANGPDVLETDGLHEVPLCSC---RME 538

  Fly   932 TKKEVGQRVVETLLHKTGGNLLLKRKRKKINRTGFPTVRRKKRKVSVEQQ----TTAVIDEHEPE 992
            |.|   .|.:.||    ..|..:..:                   ||:.:    |.:|: ::|..
  Rat   539 TPK---SREISTL----ANNQCMATE-------------------SVDHELGRCTNSVV-KYELM 576

  Fly   993 FDPDDEPLQSLRETRSSNNVNVQAAPNPP--------LDCE---------------RV------P 1028
            ...:..||..|.|......|..|..|...        ::|:               ||      |
  Rat   577 RPSNKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNFMECQPESSISHRFHKDCASRVNNASYCP 641

  Fly  1029 QAGE----ARETFVARTNQKAPRLSVVALERLQRPQTPARGRPR------GRKPKNREQAEAAPQ 1083
            ..||    |:|..:|    ||...|.|.|...|.....|.||..      ...|::.:......|
  Rat   642 HCGEETSKAKEVTIA----KADTTSTVTLAPGQEKSLAAEGRADTTTGSIAGAPEDEKSQSTVTQ 702

  Fly  1084 PPPKSEPE-----IRPAKKRGRQPKQPVLE--------EPPPTPPPQQKKNKMEPN--------- 1126
            .|...:|.     :||.....:.|.:..||        |.|       ||.:..|.
  Rat   703 APECFDPAGPAGFVRPTSGFSQGPGKETLESALIALDSEKP-------KKLRFHPKQLYFSARQG 760

  Fly  1127 ------IRLPDGIDPNTNFS-------------------CKIRLKRRKNLEAGTQPKKEKPVQPV 1166
                  :.|.||||||....                   |.:.::...|::..::.::
  Rat   761 ELQKVLLMLVDGIDPNFKMEHQSKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQR------- 818

  Fly  1167 TVEEIPPEIPVSQEEIDAEAEAKRLDSIP------TEHDP----------LPASESH-------- 1207
                    .|:.:     .||...||::.      .:.||          |.|.:.|
  Rat   819 --------TPLME-----AAENNHLDAVKYLIKAGAQVDPKDAEGSTCLHLAAKKGHYDVVQYLL 870

  Fly  1208 NPGPQDYASCSESSEDKASTTSLRKLSKVKKTYLVAGLFS------------------------- 1247
            :.|..| .:|    :|....|.:...::.|...||..|.|
  Rat   871 SNGQMD-VNC----QDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCV 930

  Fly  1248 ----------------NHYKQSLMPPPAKVNK------------------KPG--------LEEQ 1270
                            |.:..|.:...|:.|:                  |.|        |..|
  Rat   931 DIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQ 995

  Fly  1271 VGPA---------SLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPS----WNYRK 1322
            |..|         |....|...||.:.|         ||...|....:|..|.|.|    .||:.
  Rat   996 VWSALQMSKALQDSAPDKPVAVEKTVSR---------DIARGYERIPIPCVNAVDSELCPTNYKY 1051

  Fly  1323 IRTNVYAE--SVRPNLAGFDH---------PTCNCKNQGEKSCLD---------NCLNRMVYTEC 1367
            :..|....  ::..|:....:         .||.|.....:...|         |.....:..||
  Rat  1052 VSQNCVTSPMNIDRNITHLQYCVCVDDCSSSTCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFEC 1116

  Fly  1368 SPSNCPAGEKCRNQKIQRHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQR 1432
            :.: |.....|||:.:| :.:...::.:.|.|.|||||:...|..||::.|||||::::.|...|
  Rat  1117 NHA-CSCWRNCRNRVVQ-NGLRARLQLYRTQDMGWGVRSLQDIPLGTFVCEYVGELISDSEADVR 1179

  Fly  1433 MASIYLNDTHH-----YCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVN----GLSRMV 1488
            ....||.|..:     ||        ||.:..|:..||:||.||||....:..::    ...|:.
  Rat  1180 EEDSYLFDLDNKDGEVYC--------IDARFYGNVSRFINHHCEPNLVPVRVFMSHQDLRFPRIA 1236

  Fly  1489 LFAKRAIEEGEELTYDYNFSLFNPSEGQ--PCRCNTPQCRGVIGGKSQRVKPLPAVEAKPSGEGL 1551
            .|:.|.|:.||:|.:||. ..|...:|:  .|||.:|:||                   .|...|
  Rat  1237 FFSTRLIQAGEQLGFDYG-ERFWDVKGKLFSCRCGSPKCR-------------------HSSAAL 1281

  Fly  1552 SGRNGRQRKQKAKKHAQRQAGKDISSAVAVAKL 1584
            :     ||:..|.:.||.....|.|||.|...|
  Rat  1282 A-----QRQASAAQEAQENGLPDTSSAAAADPL 1309

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	73/448 (16%)
		AWS	1340..1388	CDD:197795	12/65 (18%)
		SET_ASH1L	1391..1531	CDD:380951	50/150 (33%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
Ehmt1	XP_006233681.2	EHMT_ZBD	527..657	CDD:411018	31/163 (19%)
		ANKYR	731..987	CDD:440430	42/287 (15%)
		ANK repeat	785..814	CDD:293786	2/28 (7%)
		ANK repeat	816..847	CDD:293786	7/50 (14%)
		ANK repeat	849..881	CDD:293786	6/36 (17%)
		ANK repeat	883..914	CDD:293786	6/30 (20%)
		ANK repeat	916..947	CDD:293786	0/30 (0%)
		ANK repeat	949..980	CDD:293786	3/30 (10%)
		SET_EHMT1	1047..1277	CDD:380933	66/259 (25%)