Protein Alignment ash1 and Ehmt2

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: XP_006256016.3
• Gene: Ehmt2 / 361798
• RGDID: 1302972
• Length: 1394
• Species: Rattus norvegicus
• Alignment Length: 1402
• Identity: 268/1402 - (19%)
• Similarity: 435/1402 - (31%)
• Gaps: 507/1402 - (36%)

  Fly   454 RSRAKSCGYRSDCKESGKSGLRMRRKRRASMLLKSSADDTVEDQDILQLAG------LSLGQSSE 512
            |.||...|.|.    .|:.|....|.|..|:|....|..:...|....|.|      .|.|::..
  Rat   137 RGRAAPTGGRG----RGRGGAHRGRGRPRSLLSLPRAQASWAPQLPAGLTGPPVPCLPSQGEAPA 197

  Fly   513 ESNEYISKPSLKSLPTTSASKKYGEINRYVTTGQYFGRGGSLSATNPDNFISKMMNQRKETPAPS 577
            |....:    |:..|..:|.:.:|.:      |.......:|...|||:.        :.|...|
  Rat   198 EMGALL----LEKEPRGAAERVHGSL------GDTSHSEETLPKANPDSL--------EPTGPSS 244

  Fly   578 KSSCKIKSRRSSAASMCSSYVSGVSRMRRRHRRKSFSHNKSLNIDSKLLTEIEIITSTFNSRCRI 642
            .:|..:......|.:...:                          :.|:.|
  Rat   245 PASVTVTVGDEGADTPVGA--------------------------TPLIGE-------------- 269

  Fly   643 QDDRLTGSSGKEKLLADANKLQATL-----AAPSPAQQLTLNGGGPASTLSKPLKRGLKKRKLSE 702
            :.:.|.|..|: .||..|.|...:.     |.||.| ::::.|.|.    |.|..:.|..|.||.
  Rat   270 EPENLEGDGGR-ILLGHATKSFPSSPSKGGACPSRA-KMSMTGAGK----SPPSVQSLAMRLLSM 328

  Fly   703 PLVDFAMLSASASGTPNGSGSSNGNTK-RRHKKSQSNDSSS--PDDHKLPLKKRHY--------- 755
            |....| .:|.....|..:....|..| .|.:|:.|..|:.  |...|.|.:.:|:
  Rat   329 PGAQGA-ATAGPEPPPATTAGQEGQPKVHRARKTMSKPSNGQPPVPEKRPPEVQHFRMSDDMHLG 392

  Fly   756 ------------------------------LLTPGERPPAEV--------------AF------- 769
                                          :|..||..|.|.              |:
  Rat   393 KVTSDVAKRRKLTSGSLSEDLGSAGGSGEVILEKGEPRPLEEWETVVGDDFSLYYDAYSVDERVD 457

  Fly   770 ANGKLNAEAWA--------------------------------AAAAAAKSTASTKSQAQFNARS 802
            ::.|...||.|                                :...:.:|.:|.:.:|:...|.
  Rat   458 SDSKSEVEALAEQLSEEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRK 522

  Fly   803 ----VKSALTPKKRH--LLEQPTSVSGAGSSASNSPLRIVVDNNSISGGKLLDISPSSLCSLKQQ 861
                ||.:...:||.  ..::|..|:|.|||..:..:.:                  .|.||:..
  Rat   523 DSPWVKPSRKRRKREPPRAKEPRGVNGVGSSGPSEYMEV------------------PLGSLELP 569

  Fly   862 RRGGAAKQKVSAAKDLVQLQSPAGSYPPPGVFEPSVELEIQIPLSKLNESVITKAEVESPLLSAL 926
            ..|..:......:.|...|::..|       ||       ::||        ....:|:|.:..:
  Rat   570 SEGTLSPNHAGVSNDTSSLETERG-------FE-------ELPL--------CSCRMEAPKIDRI 612

  Fly   927 DIKEDTKKEVGQRVVETLLHKTGGNLL------LKRKRKKINRTGFPTVRRKKR---KVSVEQQT 982
                  .:..|.:.:.|  ....|.||      |||:          |:|...|   .|..|...
  Rat   613 ------SERAGHKCMAT--ESVDGELLGCNAAILKRE----------TMRPSSRVALMVLCEAHR 659

  Fly   983 TAVIDEH-------------EPEFDPDDEPLQSLRETRSSNNVNVQAAPNPPLDCERVPQAGEAR 1034
            ..::..|             ..|..||........:...|....:...|:...|      |.||:
  Rat   660 ARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGED------ASEAQ 718

  Fly  1035 ETFVARTNQKAPRLSVVALERLQRPQTP-----ARGRPRGRKPKNREQAEAAPQPPP-------- 1086
            |..:.|.:...|.:..||      |..|     |.||....:|..|.:....|:.||
  Rat   719 EVTIPRGDGGTPPVGTVA------PAPPPLAHDAPGRADTSQPSARMRGHGEPRRPPCDPLADTI 777

  Fly  1087 -KSEPEIR-------------PAKKRGRQPKQPVLEEPP--PTPPP---QQKKNKMEPN------ 1126
             .|.|.:.             |...|....|..|::|..  |:|||   ::||.:..|.
  Rat   778 DSSGPSLTLPNGGCLSAVGLPPGPGREALEKALVIQESESLPSPPPSPGRRKKLRFHPRQLYLSV 842

  Fly  1127 ---------IRLPDGIDPNTNFSCKIRLKRRKNLEAGTQPKKEKPVQPVTVEEIPPEIPVSQEEI 1182
                     :.|.|.:|||....   :..:|..|.|..|...      |.:..:..:...:...:
  Rat   843 KQGELQKVILMLLDNLDPNFQSD---QQSKRTPLHAAAQKGS------VEICHVLLQAGANINAV 898

  Fly  1183 DAEAEAKRLDSIPTEHDPLPASESHNPGPQDYASCSESSEDKASTTSLRKLSKVKKTYLVAGLFS 1247
            |.:.....::::...|..:........|      |..|.|:..| |.|...:|:....:|:.|.|
  Rat   899 DKQQRTPLMEAVVNNHLEVARYMVQLGG------CVYSKEEDGS-TCLHHAAKIGNLEMVSLLLS 956

  Fly  1248 N--------------------HYK-----QSLMPPPAKVNKKPGLEEQV--------GPASLL-- 1277
            .                    .:|     :.|:...|.|..... ||.:        |.|::.
  Rat   957 TGQVDVNAQDSGGWTPIIWAAEHKHIDVIRMLLTRGADVTLTDN-EENICLHWASFTGSAAIAEV 1020

  Fly  1278 ---------------PPPPYC---EKY---------------LRRTEMD--FELP---YDIWWAY 1304
                           ..|.:.   |.|               ||..|.|  ::|.   .|:|:|.
  Rat  1021 LLNAQCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFAL 1085

  Fly  1305 TNSKLPTRNVVPSWNYRKIRTNVYAESVRPN-------LAGFDHPTCNCKN--QGE------KSC 1354
            ..:             ||:|..|...:||..       ..|:::....|.|  .||      |..
  Rat  1086 QLN-------------RKLRLGVGNRAVRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYI 1137

  Fly  1355 LDNC------LNRMV--------YTECSPSNCPAGE----------------------------- 1376
            .:||      ::|.:        ..:||.|||..|:
  Rat  1138 SENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECN 1202

  Fly  1377 -------KCRNQKIQRHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMA 1434
                   .|:|:.:| ..:...::.:.||..|||||....|.:||:|.|||||::::.|...|..
  Rat  1203 QACSCWRSCKNRVVQ-SGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVRED 1266

  Fly  1435 SIYLNDTHH-----YCLHLDGGLVIDGQRMGSDCRFVNHSCEPN-CEMQKWSVN---GLSRMVLF 1490
            ..||.|..:     ||        ||.:..|:..||:||.|:|| ..::.:.::   ...|:..|
  Rat  1267 DSYLFDLDNKDGEVYC--------IDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFF 1323

  Fly  1491 AKRAIEEGEELTYDYNFSLFN-PSEGQPCRCNTPQCR 1526
            :.|.|..||||.:||....:: .|:...|:|.:.:|:
  Rat  1324 SSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCK 1360

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	65/359 (18%)
		AWS	1340..1388	CDD:197795	17/105 (16%)
		SET_ASH1L	1391..1531	CDD:380951	47/146 (32%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
Ehmt2	XP_006256016.3	None