Protein Alignment ash1 and set-25

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: NP_499738.3
• Gene: set-25 / 3565129
• WormBaseID: WBGene00012802
• Length: 714
• Species: Caenorhabditis elegans
• Alignment Length: 821
• Identity: 156/821 - (19%)
• Similarity: 248/821 - (30%)
• Gaps: 352/821 - (42%)

  Fly   927 DIK----EDTKKEVGQRVVETLLHKTGGNLLLKRKRKKINRTGFPTVRRKKRKVSVEQQTTAVID 987
            ||:    ||.|||....:..|.:...|.....||:|.:..||
 Worm    25 DIRAAYTEDEKKENIPPISLTSVSTNGAYPGQKRRRSESVRT----------------------- 66

  Fly   988 EHEPEFDPDDEPLQSLRE---------TRSSNNVNVQAAPNPPLDCERVPQAGEARETFVARTNQ 1043
             .:||..|  |..|.||:         |:||..:||..        :|.|:...||:      :|
 Worm    67 -LKPECPP--EETQRLRQRRRISATDATQSSRTMNVIE--------DRKPRVNRARK------SQ 114

  Fly  1044 KAPRLSVVALERLQRPQTPARGRPRGRKPKNREQAEAAPQPPPK-----------SEPEIRPAKK 1097
            .||..|....|           .|.|.|.|::   .|..|.|||           :...:..:.|
 Worm   115 DAPSTSTCGFE-----------TPVGTKRKSK---AADSQKPPKQSKLRKIDEASTSKAVDNSSK 165

  Fly  1098 RGRQPKQPVLEEPPPTPPPQQKKNKMEPNIRLPDGIDPNTNFSCKIRLKRRKNLEAGTQPKKEKP 1162
            .|::..:|.:.:                           :|       :||..|.
 Worm   166 DGKKTTKPAVTQ---------------------------SN-------RRRSGLS---------- 186

  Fly  1163 VQPVTVEEIPPEIPVSQEEIDAEAEA---KRLDSIPTEHDPLPASESHNP--------GPQDYAS 1216
            ::||.:|.|..|....:...:.||:.   :|::.|           :.||        ||.:|
 Worm   187 LRPVPIETIFSESSGRESSTEDEADVSHQQRVEKI-----------AKNPIMVVVLPLGPGNY-- 238

  Fly  1217 CSESSEDKASTTSLRKLSKVKKTYLVAGLFSNH---YKQSLMPP--PAKVNKKPGLEEQVGPASL 1276
               .:.::.:..|..| |:|.|....|.....|   .::.:..|  |.|...|..|.:....||.
 Worm   239 ---PNNERITVVSTYK-SRVNKNCNEARRAQRHGSWSRKGIAFPGIPTKKFTKSDLAKYGAHASN 299

  Fly  1277 LPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKL---------PT--------------------- 1311
            .|    .:...|..|....:.|:.|...|..:|         ||
 Worm   300 WP----AQAAFRSEEGKILIYYEGWTCLTLHRLSVEECARTAPTILEEMSIRDKFIETVKSAAAE 360

  Fly  1312 -------RN-------------------VVPS-------WNYRKIR-----------------TN 1326
                   :|                   .||.       |.|:.:.                 .:
 Worm   361 EAKLVVEKNQENGIELTLDEALKQIFIEPVPQSSPENVFWIYQDLSYFHTMDNRDLGLAPVFYIS 425

  Fly  1327 VYAESVRP--------NLAGFD-----------------------HPTCN--CKNQGEKSC---- 1354
            .|.:||||        |:...|                       .||.:  |:|..:..|
 Worm   426 SYTQSVRPPCYAYTAINIVDVDAYKRCLESRANMSFADLTGQKIWMPTRSKACENGTKCKCDARF 490

  Fly  1355 --------------------------LDNCLNRMVYTECSPSNCPAGEKCRNQKIQRHAVAPGVE 1393
                                      :||.   .:..|||.: |.....|..:.:||....|...
 Worm   491 MFLYDPHDVTNLECTPDGKVDFTDFKIDNA---RIVMECSDA-CGCSLDCPRRSLQRGQQHPLAV 551

  Fly  1394 RFMTADKGWGVRTKLPIAKGTYILEYVGEVV---------------------TEKEFKQRMASIY 1437
            .:...:||:|||....|..|..:.||.|:|.                     ...|..:|:.|.|
 Worm   552 YYEGPEKGFGVRAAANIKAGELVCEYTGDVTLLPTSDPVASSSTKTDDGEEQENPEAPERVDSSY 616

  Fly  1438 ---LNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEM-----QKWSVNGL-SRMVLFAKR 1493
               .|       .:|..::|..::.|:..||:||||:|:...     :::..:.| .|:.::|.:
 Worm   617 DAAFN-------AMDTKIIISAKKTGNISRFINHSCDPSSVFVEVYSRRFEEDPLIPRVAVYAIK 674

  Fly  1494 AIEEGEELTYDYNFSLFNPS-----EGQPCRCNTPQCRGVI 1529
            .|..|||:|..|    :.|.     ....|||.:.:|.|.:
 Worm   675 DIALGEEITIAY----YEPGIEWKRSSVKCRCKSTKCMGTL 711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	54/289 (19%)
		AWS	1340..1388	CDD:197795	15/102 (15%)
		SET_ASH1L	1391..1531	CDD:380951	41/174 (24%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
set-25	NP_499738.3	SET	<525..711	CDD:394802	49/197 (25%)