DRSC/TRiP Functional Genomics Resources

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Protein Alignment ash1 and Set1

DIOPT Version :9

Sequence 1:NP_001246834.1 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster
Sequence 2:NP_001015221.1 Gene:Set1 / 3354971 FlyBaseID:FBgn0040022 Length:1641 Species:Drosophila melanogaster


Alignment Length:1542 Identity:295/1542 - (19%)
Similarity:522/1542 - (33%) Gaps:418/1542 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   196 DTEDTTVEGSFRKAAKDKNLPQY-QSTLLQDFMEKTQMLGQTVNAKLAEEK---VAKAKEETLVQ 256
            |:.|..:....|....|.....| :|...:.|.::          |.:.||   ..:.|.|....
  Fly   309 DSRDILIMTRERSRDSDSRPRDYCRSRERESFRDR----------KRSHEKGRDQPREKREHYYN 363

  Fly   257 TAVPRKRRGRPKKVVPTVPAPGN------SGPAINESADSGVISTTSTTQSTTPSPKMQNENAVP 315
            ::..|:.|||.:.....:.....      |..:::|..::.|..:::|..|           ...
  Fly   364 SSKDREYRGRDRDRSAEIDQRDRGSLKYCSRYSLHEYIETDVRRSSNTISS-----------YYS 417

  Fly   316 TGSLPIA-----SSSKPKID--MAYLDKRMYAT-----ERVLYPPPRSK------RRQNNKKTAC 362
            ..|||||     |.|.|.|:  ..:.|:|.:..     ..|..|||..:      ..:::|.:..
  Fly   418 ASSLPIASHGFNSCSFPSIENIKTWSDRRAWTAFQPDFHPVQPPPPPPEEIDNWDEEEHDKNSIV 482

  Fly   363 SSSNKEELQLDPLWREIDVNKKFRLRSMSVGAASGTGASTTICSKVLAAKSGYVSDYGSV---RH 424
            .:......:|.|   .:..|..|..:..||...:....:..:.:::.....|  ..:|:.   ..
  Fly   483 PTHYGCMAKLQP---PVPSNVNFATKLQSVTQPNSDPGTVDLDTRIALIFKG--KTFGNAPPFLQ 542

  Fly   425 QRSSHNHN--------SGYKSDASCKSRYSTKSCMSRRSRAKSCGYRSDCKESGKSGLRMRRKRR 481
            ..||.:..        |...||:: .|....:||.............||. .|.:..:..:.|.:
  Fly   543 MDSSDSETDQGKPEVFSDVNSDSN-NSENKKRSCEKNNKVLHQPNEASDI-SSDEELIGKKDKSK 605

  Fly   482 ASMLLKSSADDTVEDQDILQLAGLSLGQ---SSEESNEYISKPS--------------------- 522
            .|::.:...:|     |.:.|:.||..:   .::|..||.|..|                     
  Fly   606 LSLICEKEVND-----DNMSLSSLSSQEDPIQTKEGAEYKSIMSSYMYSHSNQNPFYYHASGYGH 665

  Fly   523 -LKSLPTTSASKKYGEINRYVTTGQYFGRGGSLSATNPDNFISKMMNQRKETPAPSKSSCKIKSR 586
             |..:|:.|||:.:.. ..||.: :|.   .::::.|.|:| ||..:..|...:......:.|.:
  Fly   666 YLSGIPSESASRLFSN-GAYVHS-EYL---KAVASFNFDSF-SKPYDYNKGALSDQNDGIRQKVK 724

  Fly   587 RSSAASMCSSYVSGVSRMRRRHRRK------SFSH-------------NKSL--NIDSKLLTEIE 630
            :     :....|..:.::.:|...|      :|.|             :|.|  ..||.:.|.:.
  Fly   725 Q-----VIGYIVEELKQILKRDVNKRMIEITAFKHFETWWDEHTSKARSKPLFEKADSTVNTPLN 784

  Fly   631 IITST------------FNSRCRIQDDRLTGSSGKEKLLADANKLQATLAAPSPAQQLTLNGGGP 683
            .|..|            .|:...:.|.:...|.|....:......:.....|||.          
  Fly   785 CIKDTSYNEKNPDINLLINAHREVADFQSYSSIGLRAAMPKLPSFRRIRKHPSPI---------- 839

  Fly   684 ASTLSKPLKRGLKKRKLSEPLVDFAMLSASASGTPNGSGSSNGNTKRRHKKS----QSNDSSSPD 744
                  |.||...:|.||:   ...|:..|.|...: |.....:|.|...|.    |.:||    
  Fly   840 ------PTKRNFLERDLSD---QEEMVQRSDSDKED-SNVEISDTARSKIKGPVPIQESDS---- 890

  Fly   745 DHKLPLKKRHYLLTPGERPPAEVAFANGKLNAEAWAAAAA-AAKSTASTKSQAQFNA-RSVKSAL 807
                   |.|   |.|             ||::...:|:: .:.|::||.|:|::.| ..|:.|.
  Fly   891 -------KSH---TSG-------------LNSKRKGSASSFFSSSSSSTSSEAEYEAIDCVEKAR 932

  Fly   808 TPKKRHLLEQPTSVSGAGSSASNSPLRIVVDNNSISGGKLLDISPSSLCS----LKQQRRGGAAK 868
            |       .:..|..|.|....|.....:.:.|.:  |.:..|:..:|||    .|::......|
  Fly   933 T-------SEEDSPRGYGQRNLNQRTTTIRNRNLV--GTMDVINVRNLCSGSNEFKKENVTKRTK 988

  Fly   869 QKVSAAKDLVQLQSPAGSYPPPGVFEPSVELEIQIPLSKLNESVITKAEVESPLLSALDIKEDTK 933
            :.:.:..|....::         :|....|..|...||.|.|                 |.:|:.
  Fly   989 KNIYSDTDEDNDRT---------LFPALKEKNISTILSDLEE-----------------ISKDSC 1027

  Fly   934 KEVGQRVVE-TLLHKTGGNLLLKRK------------------RKKINRTGFPTV---------- 969
            ..:.:..:| |:|.|......|..:                  :||::....|:.          
  Fly  1028 IGLDENGIEPTILRKIPNTPKLNEECRRSLTPVPPPGYNEEEIKKKVDCKQKPSFEYDRIYSDSE 1092

  Fly   970 -------RRKKRKVSVEQQTTAVIDEHEPEFDPD-DEPLQSLRETRSSNNVNVQAAPNPPLDCER 1026
                   |||:....:.|.....::|.|...:.. |:.|||......:||     :|....|..|
  Fly  1093 EEKEYQERRKRNTEYMAQMEREFLEEQEKRIEKSLDKNLQSPNNIVKNNN-----SPRNKNDETR 1152

  Fly  1027 VPQAGEARETFVARTNQKAPRLSVVALER-----------------LQRPQTPARGRPRGRKPKN 1074
            .....:.|..|.:.:......::::::|.                 ..:..|.::|:.:      
  Fly  1153 KTAISQTRSCFESASKVDTTLVNIISVENDINEFGPHEEGDVLTNGCNKMYTNSKGKTK------ 1211

  Fly  1075 REQAEAAPQPPPKSEPEIRPAKKRGRQPKQPVLEEPPPTPPPQQKKNKMEPNIRLPDGIDPNTNF 1139
                  ..|.|..||    ....:..|..|..||.....||         .::.|.|......|.
  Fly  1212 ------RTQSPVYSE----GGSSQASQASQVALEHCYSLPP---------HSVSLGDYPSGKVNE 1257

  Fly  1140 SCKIRLKRRKNLEAGTQPKKEKPVQPVTVEEIPPEIPVSQEEIDAEAEAKRLDSIPTEHDP---- 1200
            :..|..:..:|:...:|..:..|.:|   .:.|  |.:.:::.|.   |.|:.::.::..|    
  Fly  1258 TKNILKREAENIAIVSQMTRTGPGRP---RKDP--ICIQKKKRDL---APRMSNVKSKMTPNGDE 1314

  Fly  1201 ---LPASESHNPGPQDYASCSESSEDKASTTSLRK------LSKVKKTYL------VAGLFSN-- 1248
               |.....|......|.:..::.|.....|.|.|      ::.:|.:||      ...:|.|  
  Fly  1315 WPDLAHKNVHFVPCDMYKTRDQNEEMVILYTFLTKGIDAEDINFIKMSYLDHLHKEPYAMFLNNT 1379

  Fly  1249 HY------KQSLMPPPAKVNKKPG--LEEQVGPASLLPPPPYCEKYLRRTEMDFELPYDIWWAYT 1305
            |:      .::..|||:|..:|..  :..:.|.|              |||..::|  |:     
  Fly  1380 HWVDHCTTDRAFWPPPSKKRRKDDELIRHKTGCA--------------RTEGFYKL--DV----- 1423

  Fly  1306 NSKLPTRNVVPSWNYRKIRTNVYAESVRPN----LAGFDHPTCNCKNQG-EKSCLDNCLNRMVYT 1365
                 .......::|.|..|.......|.:    |....|.....|.|| .:....|  .|.:.|
  Fly  1424 -----REKAKHKYHYAKANTEDSFNEDRSDEPTALTNHHHNKLISKMQGISREARSN--QRRLLT 1481

  Fly  1366 ECSPSNCPAGE----KCRNQKIQRHAVAPGVERF-MTADKGWGVRTKLPIAKGTYILEYVGEVVT 1425
            ...    ..||    |....|.::..:     :| .:|...||:....|||....::||||::: 
  Fly  1482 AFG----SMGESELLKFNQLKFRKKQL-----KFAKSAIHDWGLFAMEPIAADEMVIEYVGQMI- 1536

  Fly  1426 EKEFKQRMASIYLNDTHH--------YCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVN 1482
                  |.....|.:|.:        |...:|...:||..:.|:..||:||||.|||..:..::.
  Fly  1537 ------RPVVADLRETKYEAIGIGSSYLFRIDMETIIDATKCGNLARFINHSCNPNCYAKVITIE 1595

  Fly  1483 GLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCRGVI 1529
            ...::|:::|:.|...||:||||.|.|  ..|..||.|....|||.:
  Fly  1596 SEKKIVIYSKQPIGINEEITYDYKFPL--EDEKIPCLCGAQGCRGTL 1640

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ash1NP_001246834.1 AWS 1340..1388 CDD:197795 11/52 (21%)
SET 1392..1512 CDD:214614 39/128 (30%)
Bromo_ASH1 1680..1787 CDD:99955
PHD_ASH1L 1858..1900 CDD:277023
BAH_polybromo 1929..2073 CDD:240068
Set1NP_001015221.1 RRM_Set1 99..191 CDD:240750
DUF1777 255..>380 CDD:285811 16/80 (20%)
PRP38_assoc <318..388 CDD:289628 14/79 (18%)
N-SET 1341..1492 CDD:288597 35/182 (19%)
SET <1463..1641 CDD:225491 56/198 (28%)
SET 1504..1625 CDD:214614 39/134 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45467643
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
32.870

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