DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ash1 and phf20l1

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	XP_009290756.1	Gene:	phf20l1 / 327626	ZFINID:	ZDB-GENE-030131-5837	Length:	1116	Species:	Danio rerio

Alignment Length:	1279	Identity:	234/1279 - (18%)
Similarity:	386/1279 - (30%)	Gaps:	485/1279 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   862 RRGGAAKQKVS------AAKDLVQLQSPAGSYPPPGVFEPSVELEIQIPLSKL----NESVITK- 915
            |:.|..:::||      .|..|.:|         ||..| |.|.:..:|..:.    .|.|:.:
Zfish    74 RKEGLKEEEVSERLSEMRASRLREL---------PGSTE-STEDQKDLPQQRQELRDGEEVLARW 128

  Fly   916 -------AEVES----------------PLLSALDIK---EDTKKEVGQ-------RVVETLLHK 947
                   |::||                ..:..:.||   ||.|   ||       :........
Zfish   129 TDCRYYPAKIESINKEGTYTVQFYDGVIRCVKRIHIKSMPEDAK---GQQDWIALVKAASAAAKN 190

  Fly   948 TGGNLLLKRKRKKINRTGFPTVRRKKRKVSVEQQTTAVIDEHEPEFDPDDEPLQSLRETRSSNNV 1012
            .|||    |.|...|.......||::|  |.|::.....||.:.:.|.||...:...|...|..:
Zfish   191 KGGN----RPRTSANSNKDREDRREQR--SDEEEDDDDADEDDDDDDDDDGEEEEEEEDSESEKL 249

  Fly  1013 NVQAAPNPPLDCER---VPQAGEARETFVARTNQKAPRLSVVALERLQRPQTPARGRPRGRKPKN 1074
                   ..||.|.   .|.|.|.......|.:::......:...||        |:..|
Zfish   250 -------ADLDSEEEDSKPPAEELESAIAKRRSKRQGNQCSIKRSRL--------GKGAG----- 294

  Fly  1075 REQAEAAPQPPPKSEPEIRPAKKRGRQPKQPVLEEPPPTPPPQQKKN------KMEPNIRLPDGI 1133
                      ...:|.|::...|  ..|..|..:.|.|.|.|..:|:      |..|::..|.
Zfish   295 ----------CADTETELKAETK--ELPVTPQQKVPSPEPSPADEKSQSVSAQKTTPSLSNPP-- 345

  Fly  1134 DPNTNFSCKIRLKRRKNLEAGTQPKKEKPVQPVTVEEIPPEIPVSQEEIDAEAEAKRLDSIPT-- 1196
                  :||.|.:|.|:                                |:...|....:.|.
Zfish   346 ------ACKARSRRLKH--------------------------------DSGESASSCQNTPAAP 372

  Fly  1197 EHDPLPASESHNPGPQDYASCSESSEDKAS----TTSLRKLSKVKKTYLVAGLFSNHYKQSLMPP 1257
            |..|||:.....|.....|..|.....:.|    |||                       .|:.|
Zfish   373 ESSPLPSPTQTLPDSTHTAPSSSPQRRRRSQRLATTS-----------------------DLICP 414

  Fly  1258 PAKVNKKPGLEEQVGPASLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSWNYRK 1322
            |:...:        ..|:...|||           |..|                 :....:...
Zfish   415 PSPHTR--------DTATHPTPPP-----------DGPL-----------------IADEDSSTV 443

  Fly  1323 IRTNVYAE---SVRPNLAGFDHPTCNCKNQG---EKSCLDNCL--NRMVYTECSPSNCPAGEK-- 1377
            ::|...::   |..|:.|     |.....|.   ||..:::.|  |:......||:..||..:
Zfish   444 VKTEAISQKPVSESPSTA-----TSTASAQAPITEKEKMNDVLPSNQAALEGNSPAVVPAAIQKV 503

  Fly  1378 -CRNQKIQRHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDT 1441
             .|..|..:||..|.:....:.|         |:|....|::     :...:||
Zfish   504 PSRTPKANKHAREPIINTKRSDD---------PLAPNECIID-----LDHNKFK----------- 543

  Fly  1442 HHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYN 1506
                                 |:                |:|.|:....||         ..||:
Zfish   544 ---------------------CK----------------VSGCSKAFRKAK---------LLDYH 562

  Fly  1507 FSLFNPSEGQPCRCNTPQCRGVIGGKSQRVKPLPAVEAKPSGEGLSGRNGRQRKQKAKKHAQRQA 1571
            ...::.:|.:   .:|..|                     |.|    |.||.|.
Zfish   563 LKYYHNTEKE---MDTEVC---------------------SPE----REGRTRA----------- 588

  Fly  1572 GKDISSAVAVAKLQPLSE-KEKKLVRQFNTFLVRNF----------EKIRRCKAKRASDAAATAS 1625
               .|:::..:.|..:.: |.::.|...::...:.|          ...:.||.||:|   |:.|
Zfish   589 ---TSASMPTSTLSDVPDNKRRRTVSTSSSLSSQGFMLQMDSGGCVRPSKFCKKKRSS---ASMS 647

  Fly  1626 SPALGTTNGDIPGRRPSTPSSPSLAAQI-------SALCSPRNIKTRGLTQAVHDPELEKMAKMA 1683
            |   .:|...:|     .|:..:|..:|       ..||    |||.      ...:|:...::.
Zfish   648 S---DSTEVSLP-----PPTFDNLHDKIIKKDKHLDGLC----IKTE------RKFKLDDKCQLF 694

  Fly  1684 VVLRDICSAMETLKMSDLLTTVSSKKKKPIKTTLSGKLGSTAATSKVEFRSIQAQVEQGHYKTPQ 1748
            |..||  ......|..||......||||..|   ..||.......::....::......|..:..
Zfish   695 VKKRD--KDRRDRKEKDLFRIKQKKKKKKKK---KSKLHCYPDLDEMSLAYLERPSSPPHRSSSS 754

  Fly  1749 EFDDHMQQLFVEAKQQHGDDEGKEKALQSLKDSYEQQKIASYVQLV-EILGDSESLQSFKPKEVL 1812
            .|             :|              .:::..:....|.|. |.|.|.:.|:....:.:|
Zfish   755 AF-------------KH--------------STFQYPRAILSVDLTGENLSDIDFLEDSTTESLL 792

  Fly  1813 SSEEEPGKIAVKKSPGAKERDSPIVPLKVTPPPLLPIEASPDED------VIRCICGLYKDEGLM 1871
            .|.:|..          ::.||            :.:|...|||      ::||||.:.::.|.|
Zfish   793 FSGDEYN----------QDLDS------------ITMEDFQDEDDDGADEIVRCICEMDEENGFM 835

  Fly  1872 IQCSKCMVWQHTEC--TKADIDADNYQCERCEPREVDREIPLE----------EFTEEGHRYYLS 1924
            |||.:||.|||:.|  ...|...:.|.|..|      |:.|.:          ::.::||.|.||
Zfish   836 IQCEECMCWQHSVCMGLLEDSIPEQYICYIC------RDPPGQRWSAKYRHDKDWLQKGHMYGLS 894

  Fly  1925 LMRGDLQVRQGDAVY--------------VLRDIPIKDESGKVLPTKKHTYETIGAIDYQECD-- 1973
            .:..:...:....:.              :|..:.:|.:   :|..|.:....:.|..:...|
Zfish   895 FLAENYSHQNAKKIVSTHQLLADVYSVKNLLHGLQLKMD---ILQNKHNPSLHLWARSWVNSDED 956

  Fly  1974 ---------IFRVEHLWKNELGKRFIFGHH-FLRPHETFHEPSR 2007
                     :...|||.:|...:.:|...| :.:|..|..|.:|
Zfish   957 QPMGGVPDGLHFKEHLNQNSNPETYITSEHSYQKPPGTGAEHTR 1000

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795	13/55 (24%)
		SET	1392..1512	CDD:214614	14/119 (12%)
		Bromo_ASH1	1680..1787	CDD:99955	16/106 (15%)
		PHD_ASH1L	1858..1900	CDD:277023	18/43 (42%)
		BAH_polybromo	1929..2073	CDD:240068	16/105 (15%)
phf20l1	XP_009290756.1	MBT	3..68	CDD:327428
		TUDOR	121..165	CDD:119391	5/43 (12%)
		DUF3776	248..323	CDD:315317	18/106 (17%)
		Atrophin-1	<312..510	CDD:331285	52/301 (17%)
		PHD_PHF20L1	823..868	CDD:277103	19/50 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030