DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ash1 and kmt2e

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	XP_009298714.1	Gene:	kmt2e / 325395	ZFINID:	ZDB-GENE-030131-4120	Length:	1655	Species:	Danio rerio

Alignment Length:	1641	Identity:	307/1641 - (18%)
Similarity:	490/1641 - (29%)	Gaps:	635/1641 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 CSEAKNRAVSKKVKV---KRKKLASSSGISKSDKVSKSKKSQISAFSSDSEDDLPLKVHQ--QRA 151
            |...:.|.:.::..:   .||:...|.|               ...:::|.|::||:::.  |..
Zfish   169 CERCQPRTLDREHAILLQTRKRENMSDG---------------DTSATESGDEVPLELYTAFQHT 218

  Fly   152 PRVLLSAIIQAAQSASKPTLDIGISSSDNELPNLVQAAIKRVESDTEDTTVEGSFRKAA------ 210
            |   .|..:..|:..:|........|.:.|.|...:|.....|...:.:.|:||..:..
Zfish   219 P---TSITLTTARLGNKQADKKRKKSGEKEPPATARAKKSFREGSRKSSRVKGSAPECEPIDPPS 280

  Fly   211 ----KDKN-LPQYQSTLLQDFMEKTQML--------GQTV--NAKLA------EEKVAKAKE--- 251
                |.|: :.:|:......:.|:.::|        |:|:  |...|      |.:|.|.|.
Zfish   281 LWENKMKSWMERYEEASSNQYSEEVRLLLRVKEARDGKTLAYNTHTAAFKPPVESQVQKNKRILK 345

  Fly   252 --ETLVQTAVPRKRRGRP-------------KKVVPTV---------------PAPGNSGPAINE 286
              ..|...::..:.||:.             |:..|.|               .:.||....|..
Zfish   346 AVRDLAADSLIIEYRGKVMLRQQFEANGYFFKRPYPFVLFYSKFDGLEMCVDARSFGNEARFIRR 410

  Fly   287 SADSGVISTTSTTQSTTPSPKMQNENAVPTGSLPI---------------------ASSSKPKID 330
            |.                :|..:..:.:..|.|.:                     ..|.|.|:|
Zfish   411 SC----------------TPNAEVRHVIEEGMLHLYIYSLRSISKGSEITIGFDYDYGSCKYKVD 459

  Fly   331 MA---------YLDKRMYATE----------RVLYPPPRSKRRQNNKKTA-CSSSNKEEL----- 370
            .|         .|...:..||          |....|.|.:..||...|. |..|..:.|
Zfish   460 CACVKGNPECPVLKHNLEPTENLGSSTRRRGRKDKEPSRDESGQNQNLTMDCDGSKGKTLNDAKQ 524

  Fly   371 -QLDPLWREIDVNKKFRLRSMSVGAASGTGASTTICSKVLAAKSGYVSD----YGSVRHQRSSHN 430
             :|.||...|..|:...|       .......|::.::|.......:::    .||...:  ||.
Zfish   525 RKLSPLRLSISNNQDPEL-------IEDLEEKTSVSNEVEMESEEQIAERRRKMGSPAEE--SHR 580

  Fly   431 HNSGYKSDASC-------KSRYSTK--------SCMSRRSRAK-----------SCGYRSDCKES 469
            |::|    |||       ::|...|        :.|.:|.:.:           ..|.|||.||.
Zfish   581 HDAG----ASCCRALRNKETREERKMEAILQAFARMEKREKRREQALERIGTKGEVGGRSDIKEE 641

  Fly   470 G------------------------------------KSGLRMR-----RKRRA------SMLLK 487
            .                                    ||..|.|     ::|||      |.|..
Zfish   642 APATPEAESPAVIQPLLEVVKEEPGLKPAKVSRNKQRKSFSRNRTHIGQQRRRARTVSTCSDLPP 706

  Fly   488 SSADDTV-----EDQDI----LQLAGLSLGQSSEESNEYISKPSLKSLPTTSASKKYGEINRYVT 543
            ||..||:     |.|||    ...|.....|..|.|..:...|:    ||..:.:||.:..:::.
Zfish   707 SSPGDTLEPLMAETQDIEMPVAPEADAPPTQPPETSPPHSGSPA----PTCRSGQKYPKTKKHLV 767

  Fly   544 TGQYFGRGGSLSATNPDNFISKMMNQRKETPAP--------SKSSCKIKSRRSSAASM-CSSYV- 598
            : ::.|             :.|.......||.|        |.....:.::.:|...| |||:|
Zfish   768 S-EWMG-------------VDKQERVASRTPEPPPERPLRISSDPEVLATQLNSLPGMSCSSHVY 818

  Fly   599 ---------------------SGVSRMRRRHRRKSFSHNKSLNIDSKLLTEIEIITSTFNSRCR- 641
                                 .||...|||.|...                 |..|||.:.:.|
Zfish   819 STPKHYVRFSSPFLANRSPSTPGVPTGRRRSREMP-----------------ETPTSTGSCKKRW 866

  Fly   642 ----IQDDRLTGSSGKEK--LLADANKLQATLAAPSPAQQLTLNGGGPASTLSKPLKRGLKKRKL 700
                ::::..|...|...  |:...:.|..::...| ...|.|||......|..|    ||||:|
Zfish   867 LKQALEEEGSTSPGGGRPFLLIPSESPLSPSINGES-CSPLPLNGSCSLPELPTP----LKKRRL 926

  Fly   701 -------SEPLVDFA--------MLSASASGTPN----------GSGSSNGNTKRR---H---KK 734
                   ||....:.        ..|..|.|||:          ...|:..:|..:   |   ::
Zfish   927 CSLDPCMSETSTPYGSPCATPTRTESTEAPGTPSLLATPPRPRPEEPSTEPSTPLQMPNHPLLQE 991

  Fly   735 SQSNDSSSPDDHKLPLKKRHYLLTPGERPPAEVAFANGKLNAEAWAAAAAAAKSTASTKSQAQFN 799
            |:|:..||||..:.|..:      ..||||:.:|..:.: |..:..|...::||..|
Zfish   992 SESSMDSSPDGSRRPSTQ------DVERPPSLLASPSVR-NVSSDTAPQESSKSMGS-------- 1041

  Fly   800 ARSVKSALTPKKRHLLEQPTSV-----------------SGAGSSAS------------------ 829
                   |:|:..|...|..:|                 .|.||.||
Zfish  1042 -------LSPQPSHTEPQDAAVDEGMEVDAAAAVTSAAGGGGGSEASTSAPETPVSSYPPWMKSP 1099

  Fly   830 ----------NSPLRIVVDN----------NSISGGKLLDISPSSLC-----------SLKQQRR 863
                      ||.||.:..:          :|.|.|...:.:|...|           ||.....
Zfish  1100 ERGGISFSPVNSNLRDLTPSHTLEMGAYRPDSTSSGPFSEAAPFFSCNEESSGVTFTRSLSGDGT 1164

  Fly   864 GGAA------KQKVSAAK------------DLVQLQSPAGSYPPPGVFEPSVELEIQIPLSKLNE 910
            |..:      |:|||..:            ...:..||..:.||..||..:||:.:..|......
Zfish  1165 GEGSTAKNPQKKKVSLLEYRKRQREARRSGSKGECSSPVSTAPPVDVFPVAVEMAVDPPAPAATP 1229

  Fly   911 SVITKAEVESPLLSALDIKEDTKKEVGQRVVETLL--------HKTGGNLLLKRKRKKINRTGFP 967
            :..|....|.|     |..:..:...||....|.:        |:.   |||...||
Zfish  1230 TPRTPQPSEDP-----DAPQGERDGEGQWTSSTSVEQARERGYHRA---LLLSDHRK-------- 1278

  Fly   968 TVRRKKRKVSVEQQTTAVIDEHEPEFDPDDEPLQSLRETRSSNNVN--------VQAAPNPPLDC 1024
                               |....|.:..|..::.....:|..:.:        .||...|..|.
Zfish  1279 -------------------DTDGGESEGGDSQVKDCSSPKSCKSPSTHAPCSPAAQAVSRPSKDE 1324

  Fly  1025 ERVPQAGEARETFVA--RTNQKAPRLSVVAL--------------------ERLQRPQTPARGRP 1067
            :.....|.|:...|:  .::.|.|.....||                    ..:..|:...:|.|
Zfish  1325 DEAQTRGPAQPQAVSVQPSSAKTPSSKPAALTPSKLHCGPSGASQSHYAGPSLMHSPKAQPQGSP 1389

  Fly  1068 -RGRK------PKNREQAEA--------------APQPPPKSE---------------------P 1090
             ||::      |:|:.|.:|              ||.|||...                     |
Zfish  1390 FRGQRAFLTAQPQNQPQPQATSGPATFPQYNPQNAPPPPPPPPPAPPTSAPYFPTQPTAAAAPFP 1454

  Fly  1091 EIRPAKKRGRQP-KQPVLE----------------EPPPTPPPQQKKNKMEPNIRLPDGIDPNTN 1138
            ..:|.......| .||:|:                .|||.|.||.....:..|::.|.
Zfish  1455 AFKPTVASPFPPGSQPLLQTHHALHYQSSAAPPPPPPPPPPHPQPGPTLLHVNLQPPS------- 1512

  Fly  1139 FSCKIRLKRRKNLEAGTQPKKEKPVQPVTVEEIPPEIPVSQEEIDAEAEAKRLDSIPTEHDPL-- 1201
                  |::.:.|.:...|....|         ||:...||:..........:...|  |.||
Zfish  1513 ------LQQHQLLLSSAPPPPPPP---------PPQTQSSQQPPPNSGTLLSIKQGP--HPPLPP 1560

  Fly  1202 -PASESHNPGPQDYASCSESSEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQSLMPPPAKVNKKP 1265
             |.:.|.|..|..:.:.|     ...||.|.:.:....:     :.::.|:|:::|||      |
Zfish  1561 PPPAPSTNAPPHPFQNIS-----GFQTTLLHQSAPANPS-----VTASTYQQTVLPPP------P 1609

  Fly  1266 GLEEQVGPASLLPPPP 1281
            ....|..|.:..||.|
Zfish  1610 PPPPQQTPPTQTPPNP 1625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795
		SET	1392..1512	CDD:214614
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
kmt2e	XP_009298714.1	PHD_MLL5	129..172	CDD:277025	1/2 (50%)
		SET	344..453	CDD:214614	13/124 (10%)
		Atrophin-1	<706..1046	CDD:331285	85/401 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000