DRSC/TRiP Functional Genomics Resources

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Protein Alignment ash1 and Set2

DIOPT Version :9

Sequence 1:NP_001246834.1 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster
Sequence 2:NP_572888.2 Gene:Set2 / 32301 FlyBaseID:FBgn0030486 Length:2362 Species:Drosophila melanogaster


Alignment Length:1983 Identity:405/1983 - (20%)
Similarity:665/1983 - (33%) Gaps:705/1983 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 QNETAAAKVLETQRAQESGSE----NEETDSITDQSSQSKSIKSATQFSVQRSDTDGLRMRISAI 65
            :.|...:::::.:...:|.|:    ..||:|...:..|    :......|:..|...:.|.::..
  Fly   301 KQEQNLSRMVDAEENSDSDSQIIFIEIETESPKGEEEQ----EEGRPVEVEPQDLIDIDMELAKQ 361

  Fly    66 RPT---------LGVVATKKPP------------------KSRKMSTQDTESGCSEAKNRAVSKK 103
            .||         :.|.....||                  ::.....:.....||.|..|:    
  Fly   362 EPTPDPEEDLDEIMVEVLSGPPSLWSADDEAEEEEDATVQRATPPGKEPAADSCSSAPRRS---- 422

  Fly   104 VKVKRKKLASSSGISKSDKVSKSKKSQISAFSSDSEDDLPLKVHQQRAPRVLLSAIIQAAQSASK 168
                 ::.|..||.|:..|..:...::|:|.|  |:..|..:..|.:..:.:|..:|:...|.|:
  Fly   423 -----RRSAPLSGSSRQGKTLEETFAEIAAES--SKQILEAEESQDQEEQHILIDLIEDTLSESE 480

  Fly   169 PTLDIG------------------ISSSDNELPNLVQAAIKRVESDTE-----------DTTVEG 204
            .|..:.                  :..:|..|.:..:..||:|.|:::           :..|| 
  Fly   481 VTSSVSPTIEHMVVEEVVVEENQLVDEADEILDSKQEFVIKKVFSESDNIAASLNKDIFEPKVE- 544

  Fly   205 SFRKAAKDKNLPQ--------YQSTLLQDFMEKTQMLGQTVNAKLAEEKVAKAKEETLVQTAVPR 261
              .||...:.:|:        |.:..:...:||:.::.:.....:||.|::   :|.:::.  |.
  Fly   545 --TKATCGEVVPRPEMVTEDVYITEGIAATLEKSAVVTKPTTEMIAETKLS---DEVVIEP--PL 602

  Fly   262 KRRGRPKKVVPTVPAPGNSGPAIN----ESADSGVISTTST------------------TQSTTP 304
            |....||:....:|   .|.||:|    |...|..:.|||:                  .:::..
  Fly   603 KDESDPKQTEVELP---ESKPAVNIPKSERILSAEVETTSSPLVPPECCTLESVSGPVLLETSLS 664

  Fly   305 SPKMQNEN---------AVPTGSLPIA-------SSSKPKI---------DMAYLDKRMYA-TER 343
            :.:..|||         |....|.|.|       ||.:|..         :....|:.|.. .::
  Fly   665 TEEKSNENVETTPLKTEAAKEDSPPAAPEEEASNSSEEPNFLLEDYESNQEQVAEDEMMKCNNQK 729

  Fly   344 VLYPPPRSKRRQNNKKTACSSSNKEELQLDPLWRE-IDVNKKFRLRSMSVGAASGTGASTTICSK 407
            .....|..:.::..|..|.:.|.||:...:|.... ..|:||.|...|.              .|
  Fly   730 GQKQTPLPEMKEPEKPVAETVSKKEKAMENPARSSPAIVDKKVRAGEME--------------KK 780

  Fly   408 VLAAKSGYVSDYGSVRHQRSSHNHNSGYKSDASCKSRYSTKSCMSRRSRAKSCGYRSDCKESGKS 472
            |:.:..|.|.:                       |...|.||| :..:.||.       ||||||
  Fly   781 VVKSTKGTVPE-----------------------KKMDSKKSC-AAVTPAKQ-------KESGKS 814

  Fly   473 G-----LRMRRKRRASMLLKSSADDTVEDQDILQLAGLSLGQSSEESNEYISKPSLKSLPTTSAS 532
            .     .:...|.::|..|.||:.:|::.:      |....|.|         |.|::||.    
  Fly   815 AKEAILKKETEKEKSSAKLDSSSPNTLDKK------GKDTAQWS---------PQLQTLPK---- 860

  Fly   533 KKYGEINRYVTTGQYFGRGGSLSATNP-----DNFISKMMNQRKETPAPSKSSCKIKSRRS---- 588
                                  |:|.|     .:.|||..:.:   |||.:.....|...|    
  Fly   861 ----------------------SSTKPPQESAPSVISKTTSNQ---PAPKEEQHAAKKGLSDNSP 900

  Fly   589 -SAASMCSSYVSGVSRMRRRHRRKSFSHNKSLNIDSKLLTEIEIITSTFNSRCRIQDDRLTGSSG 652
             |........|||........:....: |..|.:|.|                           .
  Fly   901 PSVLKAKEKAVSGFVECDAMFKAMDLA-NAQLRLDEK---------------------------N 937

  Fly   653 KEKLLADANKLQA------TLAAPSPAQQLTLNGGGPASTLSKPLKRGLKKRKLSEPLVDFAMLS 711
            |:||.....|::|      ..|.|.|.|:.:|:|           |..|::..:.|         
  Fly   938 KKKLKKVPTKVEAPPKVEPPTAVPVPGQKKSLSG-----------KTSLRRNTVYE--------- 982

  Fly   712 ASASGTPNGSGSSNGNTKRRHKKSQSNDSSSPDDHKLPLKKRHYLLTPGERPPAEVAFANGKLNA 776
                .:||...:|          |.|:||:..:            .:.|:..|::|   ..|:|.
  Fly   983 ----DSPNLERNS----------SPSSDSAQAN------------TSAGKLKPSKV---KKKINP 1018

  Fly   777 EAWAAAAAAAKSTASTKSQAQFNARSVKSALTPKKRHLLEQPTSVSGAGSSASNSPLRIVVDNNS 841
            .            .||..:|..:.||..|:.||.:......|.|.|...||..|...|...|   
  Fly  1019 R------------RSTICEAAKDLRSSSSSSTPTREVAASSPVSTSSDSSSKRNGSKRTTSD--- 1068

  Fly   842 ISGGKLLDISPSSLCSLKQQRRGGAAKQKVSAAKDLVQLQSPAGSYPPPGVFEPSVELEIQIPLS 906
            :.||..||....::|..:|.                                    |..|.:||:
  Fly  1069 LDGGSKLDQRRYTICEDRQP------------------------------------ETAIPVPLT 1097

  Fly   907 KLNESVITKAEVESPLLSALDIKEDTKKEVGQRVVETLLHKTGGNLLLKRKRKKINRTGFPTVRR 971
            |...|:..||.. :||                  .:|||...|      :||           .|
  Fly  1098 KRRFSMHPKASA-NPL------------------HDTLLQTAG------KKR-----------GR 1126

  Fly   972 KKRKVSVEQQTTAVIDEHEPEFDPDDEPLQS-------LRETRSSNNVNVQAAPNPPLDCERVPQ 1029
            |:.|.|:.:|.:........:..|..:.|:|       |.||.||.:.:                
  Fly  1127 KEGKESLSRQNSLDSSSSASQGAPKKKALKSAEILSAALLETESSESTS---------------- 1175

  Fly  1030 AGEARETFVARTNQKAPRLSVVALERLQRPQTPARGRPRGRKPKNREQAEAAPQPPPKSEPEIRP 1094
                       :..|..|..|                                    ::.||:..
  Fly  1176 -----------SGSKMSRWDV------------------------------------QTSPELEA 1193

  Fly  1095 AKKRGRQPKQPVLEEPPPTPPPQQKKNKMEPNIRLPDGIDPNTNFSCKIRLKRRKNLEAGTQPKK 1159
            |...|...|                        .:.||::         .|||.|   .....:|
  Fly  1194 ANPFGDIAK------------------------FIEDGVN---------LLKRDK---VDEDQRK 1222

  Fly  1160 EKPVQPVTVEEIPPEIPVSQEEIDAEAE------AKRLDSIPT-EHDPLPASESHNPGPQDYASC 1217
            |                 .|:|:..||:      |:|:.::.| ...|.|:....||        
  Fly  1223 E-----------------GQDEVKREADPEEDEFAQRVANMETPATTPTPSPTQSNP-------- 1262

  Fly  1218 SESSEDKASTTSLRKLSKVKKTYLVAGLFSNH-YKQSLMPP-------PAKVNKKP-GLEEQVGP 1273
                ||.||||::     :|:.....|:..:| .||....|       .|.|...| .::||:  
  Fly  1263 ----EDSASTTTV-----LKELETGGGVRRSHRIKQKPQGPRASQGRGVASVALAPISMDEQL-- 1316

  Fly  1274 ASLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSWNYRKIRTNVY--AESVRPNL 1336
            |.|.......|::||...::                         .::.::.|.|  |..|....
  Fly  1317 AELANIEAINEQFLRSEGLN-------------------------TFQLLKENFYRCARQVSQEN 1356

  Fly  1337 AGFDHPTCNC------KNQGEKSCLDNCLNRMVYTECSPSNCPAGEKCRNQKIQRHAVAPGVERF 1395
            |...   |:|      :.||..||...|:|||:..||.|. |..|.:|.|::.|:|...| ...|
  Fly  1357 AEMQ---CDCFLTGDEEAQGHLSCGAGCINRMLMIECGPL-CSNGARCTNKRFQQHQCWP-CRVF 1416

  Fly  1396 MTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLND--THHYCLHLDGGLVIDGQR 1458
            .|..||.|:..:|.|..|.:|:||||||:..:||::|. .:|..|  .|:|.:.|.|..|||...
  Fly  1417 RTEKKGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQ-HLYSKDRNRHYYFMALRGEAVIDATS 1480

  Fly  1459 MGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTP 1523
            .|:..|::||||:||.|.|||:|||..|:..|:.:.|:.|||:|:||.:..:. .:.|.|.|...
  Fly  1481 KGNISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQYLRYG-RDAQRCYCEAA 1544

  Fly  1524 QCRGVIGGKSQRVKPLPAVEAKPSGEGLSGRNGRQRKQKAKK-HAQRQAGKDISSAVAVAKLQ-- 1585
            .|||.|||:..          ...||.|...:....:...:: .|:.:.|:...||.|.||.:  
  Fly  1545 NCRGWIGGEPD----------SDEGEQLDEESDSDAEMDEEELEAEPEEGQPRKSAKAKAKSKLK 1599

  Fly  1586 ---PLS--EKEKKLVRQFNTFLVRNFEKIRRCKAKRASDAAATASSPALGTTNGDIPGRRPSTPS 1645
               ||:  .|.|:..:          .|.|..||.|....:||.||               |:..
  Fly  1600 AKLPLATGRKRKEQTK----------PKDREYKAGRWLKPSATGSS---------------SSAE 1639

  Fly  1646 SPSLAAQISALCSPRNIKTRGLTQAVHDPELEKMAKMAVVLR-DICSAMETLKMSDLLTTVSSKK 1709
            .|           |:..|.......:.||::  :.:::::.| .:.:..:||:.|..|.     :
  Fly  1640 KP-----------PKKPKVNKFQAMLEDPDV--VEELSLLRRGGLKNQQDTLRFSRCLV-----R 1686

  Fly  1710 KKPIKTTLSGKLGSTAATSKVEFRSIQAQVEQGHYKTPQEFDDH--MQQLFVEAKQQHGDDEGKE 1772
            .|.:||.|                ::...:..|.....:.|.|:  ::.|.....:...||:.:|
  Fly  1687 AKLLKTRL----------------ALLRVLTHGELPCRRLFLDYHGLRLLHAWISENGNDDQLRE 1735

  Fly  1773 KALQSLKDSYEQQKIASYVQLVEILGDSESLQS 1805
                :|.|:.|...|.:..    :|.||...||
  Fly  1736 ----ALLDTLESLPIPNRT----MLSDSRVYQS 1760

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ash1NP_001246834.1 AWS 1340..1388 CDD:197795 19/53 (36%)
SET 1392..1512 CDD:214614 51/121 (42%)
Bromo_ASH1 1680..1787 CDD:99955 19/109 (17%)
PHD_ASH1L 1858..1900 CDD:277023
BAH_polybromo 1929..2073 CDD:240068
Set2NP_572888.2 AWS 1358..1410 CDD:197795 19/55 (35%)
SET 1414..1533 CDD:214614 51/119 (43%)
PostSET 1535..1551 CDD:214703 6/15 (40%)
WW 2014..2043 CDD:278809
SRI 2270..2348 CDD:285448
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45467629
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D507784at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
43.880

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