DRSC/TRiP Functional Genomics Resources

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Protein Alignment ash1 and Kmt2a

DIOPT Version :9

Sequence 1:NP_001246834.1 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster
Sequence 2:XP_038938273.1 Gene:Kmt2a / 315606 RGDID:1586165 Length:3986 Species:Rattus norvegicus


Alignment Length:1889 Identity:376/1889 - (19%)
Similarity:608/1889 - (32%) Gaps:573/1889 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 SGSENEETDSITDQSSQSKSIKSATQFSVQRSDTDGLRMRISAIRPTLGVVATKKPPKSRKMSTQ 86
            |||:.    ::....|::..:..::...|:||....|..:.|::             |..|..|.
  Rat  2283 SGSQR----TVVTGGSKTSHLDGSSSSGVKRSSASDLAPKGSSL-------------KGEKNRTP 2330

  Fly    87 DTESGCSEAKNRAVSKKVKVKRKKLASSSGISKSDKVSKSKKSQISAFSSDSEDDLPLKVHQQRA 151
            .::|....|.|.|.|...|:..:.|.::.|.....|:....:.....||.::.....|.:..||:
  Rat  2331 GSKSTDGSAHNTAYSGIPKLAPQVLNAAPGELNVSKIGTFAEPSTVPFSKETVSYPQLHLRGQRS 2395

  Fly   152 PRVLLSAIIQAAQSASKPTLDIGISSSDNELPNLVQAAI--------KRVESDTEDTTVEGSFRK 208
            .|   ...:.:.||. ||:     .:.|.|:..|....:        :.|.|.:.|...:|  :|
  Rat  2396 DR---DQHMDSTQSV-KPS-----PNEDGEIKTLKLPGMGHRPSILHEHVGSSSRDRRQKG--KK 2449

  Fly   209 AAKDKNLPQYQSTLLQDFMEKTQM-LGQTVNAK--LAEEKVA---------------KAKEETLV 255
            ::|:....::.|   :.|:|..|: .|:..|.|  .|:|.:.               |..::.|.
  Rat  2450 SSKETCKEKHSS---KSFLEPGQVTTGEEGNLKPEFADEVLTPGFLGQRPCNNVSSDKTGDKILP 2511

  Fly   256 QTAVPR----------KRRGRPK----KVVP-----------TVPAPGNSGPAINES-------- 287
            .:.||:          |....|:    ||.|           |....|...||..||        
  Rat  2512 LSGVPKGQSTQVEGSSKELQAPRKCSVKVTPLKMESENQSKNTQKESGPGSPAHMESACPAEPAS 2576

  Fly   288 ------ADSGVISTTSTTQSTTPS-------PKMQNENAVPTGSLPIAS----------SSKPKI 329
                  |..||..:.:.|.|..|.       |:......:|.|..|...          |::.:.
  Rat  2577 ASRSPGAGPGVQPSPNNTSSQDPQSNNYQNLPEQDRNLMIPDGPKPQEDGSFKRRYPRRSARARS 2641

  Fly   330 DMAY-----LDKRMYATERV-LYPPPRSKRR-------------------------QNNKKTACS 363
            :|.:     ...|.|..|.: .|.....|:|                         .|..:|..|
  Rat  2642 NMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVIS 2706

  Fly   364 SSNKEELQLDPLWRE---IDVNKKFRLRSMSVGAASGTGASTTICSKVLAAKSGYV--------- 416
            |...|.|....|:||   .|:.|..:|..:..|..|.|..:.|      :.||..:         
  Rat  2707 SGGDERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTAT------SRKSSQIPKRNGKENG 2765

  Fly   417 ---------SDYGSVRHQ-RSSHNHNSGYKSDASCKSRYSTKSCMSRRSRAKSCGYRSDCKESGK 471
                     .|.|...|. :|:..|.:..|.| :|.|          .||.|:.|  .|..|:..
  Rat  2766 TENLKIDRPEDAGEKEHVIKSAVGHKNEPKLD-NCHS----------VSRVKAQG--QDSLEAQL 2817

  Fly   472 SGLRMRRKRRASMLLKSSADDTVEDQDILQLAGLSLGQSSEESN--------------EYISK-- 520
            |.|...|:...|         |..|:::|......|.:|..::|              :::.|  
  Rat  2818 SSLESSRRVHTS---------TPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNT 2873

  Fly   521 PSLKSL---PTTSASK--KYGE-----INRYVTTGQYFGRGGSLSATNP-DNFISKMMN--QRKE 572
            ||:::|   |.:|:|:  ..||     .||....|.:......|.||.| |:.:|..::  ::.|
  Rat  2874 PSMQALGESPESSSSELLTLGEGLGLDSNREKDMGLFEVFSQQLPATEPVDSSVSSSISAEEQFE 2938

  Fly   573 TPAPSKSSCKIKSRRSSAASMCSSYVSGVSRMRRRHRRKSFSHNKSLNIDSKLLTEIEIITSTFN 637
            .|....|...:.:.||....                     |.|.|         .:.:|:.:..
  Rat  2939 LPLELPSDLSVLTTRSPTVP---------------------SQNSS---------RLAVISDSGE 2973

  Fly   638 SRCRIQDDRLTGSSGKEKLLADANKLQATLAAPSPAQQLT----LNGGGPASTLSKPLKRGLKKR 698
            .|..|.:..:|.:.|...||:..       ..|:|...:|    :.|...|..:|.|        
  Rat  2974 KRVTITEKSVTSTEGDPALLSPG-------VDPAPEGHMTPDHFIQGHMDADHISSP-------- 3023

  Fly   699 KLSEPLVDFAMLSASASGTPNGS-GSSNGNTKRRHKKSQSNDSSSPDDHKLPLKKRHYLLTPGER 762
                               |.|| ...:||.:...:.|.:.....|....:|::.:.|:....:.
  Rat  3024 -------------------PCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDS 3069

  Fly   763 P-PAEVAFA---------------------------------NGKLNAEAWAAAAAAAKSTASTK 793
            | |::::.|                                 ||........:..::..:...|.
  Rat  3070 PGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSPVSSTPNVMETN 3134

  Fly   794 -----------------------SQAQFNARSVKSALTPKKRHLLEQPTSVSGAGSSASNSPLRI 835
                                   ||:.|...|......|..:||...|.:...:.....:||   
  Rat  3135 TSVLGPMGSGLTLTTGLNPSLPPSQSLFPPASKGLLSMPHHQHLHSFPAAAQSSFPPNISSP--- 3196

  Fly   836 VVDNNSISGGKLLDI----SPSSLCSLKQQR----------RGGAAKQKVSAA-----KDLVQLQ 881
                   ..|.|:.:    .|..|.|...||          ..|..|:.:|..     |.|....
  Rat  3197 -------PSGLLIGVQPPPDPQLLGSEANQRTDLTTTVTTPSSGLKKRPISRLHTRKNKKLAPSS 3254

  Fly   882 SPAGSYPPPGV-------FEPSVELEIQ---IPLSKLNES-------VITKAE------VESPLL 923
            :|:...|...|       |.|| :|...   :.|..||.|       :|.:::      .::|||
  Rat  3255 APSNIAPSDVVSNMTLINFTPS-QLSNHPSLLDLGSLNPSSHRTVPNIIKRSKSGIMYFEQAPLL 3318

  Fly   924 SALDIKEDTKKEVGQRVV-ETLLHKTGGNL-LLKRKRKKINRTGFPTVRRKKRKVSVEQQTTAVI 986
            ....:...|....|...: :...|.|.|.: .|......:|.....|........||....|  :
  Rat  3319 PPQSVGGTTATGAGSSTISQDTSHLTSGPVSALASGSSVLNVVSMQTTTTPTSSTSVPGHVT--L 3381

  Fly   987 DEHEPEFDPDDEPLQSLRETRSSNNVNVQAAP---------NPPLDCERVPQAG----------- 1031
            ........||...:..|....|..::.:|..|         .|.|...:.|.|.           
  Rat  3382 ANQRLLGTPDIGSISHLLIKASHQSLGIQDQPVALPQSSGMFPQLGTSQTPSAAAMTAASSICVL 3446

  Fly  1032 ---------------EARETF-VARTNQ-KAPRLSVVALERLQRPQTPARGRPRGRKPKNREQAE 1079
                           ||.|.: :.|.|| .|.:...::|:|.:.|.:..     |.:|.|..|..
  Rat  3447 PSSQTAGMTAASPPREAEEQYKLQRVNQLLAGKTGTLSLQRDRDPDSAP-----GTQPSNFTQTA 3506

  Fly  1080 AAPQPPPKSEPEIRPAKKR------GRQPKQPVLEEPPPTPPPQQKKNKMEPNIRLPDGIDPNTN 1138
            .||......:.:..|:.|:      |..|...........|.|.:.|.|:: .|:||  :|..:.
  Rat  3507 EAPNGVRLEQNKTLPSAKQASSTSPGSSPSSGQQSGSSSVPGPTKPKPKVK-RIQLP--LDKGSG 3568

  Fly  1139 FSCKI----------------------------RLKRRKNLEAGT-QPKKEKPVQPVTVEEIPPE 1174
            ...|:                            |..|.:...||. ||.:::..||.......||
  Rat  3569 KKHKVSHLRTSSEAHIPHREANPAPQPSVKRTPRADREQQEAAGVEQPSQKECGQPAGPATALPE 3633

  Fly  1175 IPVSQ----EEIDAEAEA--------------------KRLDSIPTEHDPLPASESHNPGPQDYA 1215
            |..:|    |:.:||.:|                    ||.:|| ||..|.............:.
  Rat  3634 IQATQNPANEQENAEPKAVEEEESSFSSPLMLWLQQEQKRKESI-TERKPKKGLVFEISSDDGFQ 3697

  Fly  1216 SCSESSED-----------KASTTSLRKLSKVKKTYLVAGLFSNHYKQSLMPPPAKVNKKPGLEE 1269
            .|:||.||           ..|...|::||       .||:  |..:...:...|.|    .|.|
  Rat  3698 ICAESIEDAWKSLTDKVQEARSNARLKQLS-------FAGV--NGLRMLGILHDAVV----FLIE 3749

  Fly  1270 QVGPASLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSWNYRKIRTNVYAESVRP 1334
            |:..|.      :|..|..|    |..|.:            .|..|...:...|..|:......
  Rat  3750 QLSGAK------HCRNYKFR----FHKPEE------------ANEPPLNPHGSARAEVHLRKSAF 3792

  Fly  1335 NLAGF------DHPTCNCKNQGEKSCLDNCLNRMVYTECSPSNCPAGEKCRN-QKIQRHAVAPGV 1392
            ::..|      ..|..|..::.|:........|     .:..:.|...:.|: :|..:.||  ||
  Rat  3793 DMFNFLASKHRQPPEYNPNDEEEEEVQLKSARR-----ATSMDLPMPMRFRHLKKTSKEAV--GV 3850

  Fly  1393 ERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHHYCLHLDGGLVIDGQ 1457
            .|  :...|.|:..|..|..|..::||.|.|:...:..:|...........|...:|...|:|..
  Rat  3851 YR--SPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDAT 3913

  Fly  1458 RMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNT 1522
            ..|:..||:||||||||..:..:::|...:|:||.|.|..||||||||.|.:.:.|...||.|..
  Rat  3914 MHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGA 3978

  Fly  1523 PQCR 1526
            .:||
  Rat  3979 KKCR 3982

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ash1NP_001246834.1 AWS 1340..1388 CDD:197795 7/48 (15%)
SET 1392..1512 CDD:214614 42/119 (35%)
Bromo_ASH1 1680..1787 CDD:99955
PHD_ASH1L 1858..1900 CDD:277023
BAH_polybromo 1929..2073 CDD:240068
Kmt2aXP_038938273.1 zf-CXXC 1145..1192 CDD:366873
PHD1_KMT2A 1451..1497 CDD:277063
PHD2_KMT2A 1499..1548 CDD:277065
PHD3_KMT2A 1586..1645 CDD:277067
Bromo_ALL-1 1668..1798 CDD:99925
ePHD_KMT2A 1892..2004 CDD:277163
FYRN 2045..2092 CDD:399155
FYRC 3686..3769 CDD:197781 23/105 (22%)
SET_KMT2A_2B 3833..3986 CDD:380947 53/154 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166351994
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.840

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