Protein Alignment ash1 and Kmt2a

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: XP_063121507.1
• Gene: Kmt2a / 315606
• RGDID: 1586165
• Length: 4017
• Species: Rattus norvegicus
• Alignment Length: 1889
• Identity: 376/1889 - (19%)
• Similarity: 608/1889 - (32%)
• Gaps: 573/1889 - (30%)

  Fly    22 SGSENEETDSITDQSSQSKSIKSATQFSVQRSDTDGLRMRISAIRPTLGVVATKKPPKSRKMSTQ 86
            |||:.    ::....|::..:..::...|:||....|..:.|::             |..|..|.
  Rat  2314 SGSQR----TVVTGGSKTSHLDGSSSSGVKRSSASDLAPKGSSL-------------KGEKNRTP 2361

  Fly    87 DTESGCSEAKNRAVSKKVKVKRKKLASSSGISKSDKVSKSKKSQISAFSSDSEDDLPLKVHQQRA 151
            .::|....|.|.|.|...|:..:.|.::.|.....|:....:.....||.::.....|.:..||:
  Rat  2362 GSKSTDGSAHNTAYSGIPKLAPQVLNAAPGELNVSKIGTFAEPSTVPFSKETVSYPQLHLRGQRS 2426

  Fly   152 PRVLLSAIIQAAQSASKPTLDIGISSSDNELPNLVQAAI--------KRVESDTEDTTVEGSFRK 208
            .|   ...:.:.||. ||:     .:.|.|:..|....:        :.|.|.:.|...:|  :|
  Rat  2427 DR---DQHMDSTQSV-KPS-----PNEDGEIKTLKLPGMGHRPSILHEHVGSSSRDRRQKG--KK 2480

  Fly   209 AAKDKNLPQYQSTLLQDFMEKTQM-LGQTVNAK--LAEEKVA---------------KAKEETLV 255
            ::|:....::.|   :.|:|..|: .|:..|.|  .|:|.:.               |..::.|.
  Rat  2481 SSKETCKEKHSS---KSFLEPGQVTTGEEGNLKPEFADEVLTPGFLGQRPCNNVSSDKTGDKILP 2542

  Fly   256 QTAVPR----------KRRGRPK----KVVP-----------TVPAPGNSGPAINES-------- 287
            .:.||:          |....|:    ||.|           |....|...||..||
  Rat  2543 LSGVPKGQSTQVEGSSKELQAPRKCSVKVTPLKMESENQSKNTQKESGPGSPAHMESACPAEPAS 2607

  Fly   288 ------ADSGVISTTSTTQSTTPS-------PKMQNENAVPTGSLPIAS----------SSKPKI 329
                  |..||..:.:.|.|..|.       |:......:|.|..|...          |::.:.
  Rat  2608 ASRSPGAGPGVQPSPNNTSSQDPQSNNYQNLPEQDRNLMIPDGPKPQEDGSFKRRYPRRSARARS 2672

  Fly   330 DMAY-----LDKRMYATERV-LYPPPRSKRR-------------------------QNNKKTACS 363
            :|.:     ...|.|..|.: .|.....|:|                         .|..:|..|
  Rat  2673 NMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVIS 2737

  Fly   364 SSNKEELQLDPLWRE---IDVNKKFRLRSMSVGAASGTGASTTICSKVLAAKSGYV--------- 416
            |...|.|....|:||   .|:.|..:|..:..|..|.|..:.|      :.||..:
  Rat  2738 SGGDERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTAT------SRKSSQIPKRNGKENG 2796

  Fly   417 ---------SDYGSVRHQ-RSSHNHNSGYKSDASCKSRYSTKSCMSRRSRAKSCGYRSDCKESGK 471
                     .|.|...|. :|:..|.:..|.| :|.|          .||.|:.|  .|..|:..
  Rat  2797 TENLKIDRPEDAGEKEHVIKSAVGHKNEPKLD-NCHS----------VSRVKAQG--QDSLEAQL 2848

  Fly   472 SGLRMRRKRRASMLLKSSADDTVEDQDILQLAGLSLGQSSEESN--------------EYISK-- 520
            |.|...|:...|         |..|:::|......|.:|..::|              :::.|
  Rat  2849 SSLESSRRVHTS---------TPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNT 2904

  Fly   521 PSLKSL---PTTSASK--KYGE-----INRYVTTGQYFGRGGSLSATNP-DNFISKMMN--QRKE 572
            ||:::|   |.:|:|:  ..||     .||....|.:......|.||.| |:.:|..::  ::.|
  Rat  2905 PSMQALGESPESSSSELLTLGEGLGLDSNREKDMGLFEVFSQQLPATEPVDSSVSSSISAEEQFE 2969

  Fly   573 TPAPSKSSCKIKSRRSSAASMCSSYVSGVSRMRRRHRRKSFSHNKSLNIDSKLLTEIEIITSTFN 637
            .|....|...:.:.||....                     |.|.|         .:.:|:.:..
  Rat  2970 LPLELPSDLSVLTTRSPTVP---------------------SQNSS---------RLAVISDSGE 3004

  Fly   638 SRCRIQDDRLTGSSGKEKLLADANKLQATLAAPSPAQQLT----LNGGGPASTLSKPLKRGLKKR 698
            .|..|.:..:|.:.|...||:..       ..|:|...:|    :.|...|..:|.|
  Rat  3005 KRVTITEKSVTSTEGDPALLSPG-------VDPAPEGHMTPDHFIQGHMDADHISSP-------- 3054

  Fly   699 KLSEPLVDFAMLSASASGTPNGS-GSSNGNTKRRHKKSQSNDSSSPDDHKLPLKKRHYLLTPGER 762
                               |.|| ...:||.:...:.|.:.....|....:|::.:.|:....:.
  Rat  3055 -------------------PCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDS 3100

  Fly   763 P-PAEVAFA---------------------------------NGKLNAEAWAAAAAAAKSTASTK 793
            | |::::.|                                 ||........:..::..:...|.
  Rat  3101 PGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSPVSSTPNVMETN 3165

  Fly   794 -----------------------SQAQFNARSVKSALTPKKRHLLEQPTSVSGAGSSASNSPLRI 835
                                   ||:.|...|......|..:||...|.:...:.....:||
  Rat  3166 TSVLGPMGSGLTLTTGLNPSLPPSQSLFPPASKGLLSMPHHQHLHSFPAAAQSSFPPNISSP--- 3227

  Fly   836 VVDNNSISGGKLLDI----SPSSLCSLKQQR----------RGGAAKQKVSAA-----KDLVQLQ 881
                   ..|.|:.:    .|..|.|...||          ..|..|:.:|..     |.|....
  Rat  3228 -------PSGLLIGVQPPPDPQLLGSEANQRTDLTTTVTTPSSGLKKRPISRLHTRKNKKLAPSS 3285

  Fly   882 SPAGSYPPPGV-------FEPSVELEIQ---IPLSKLNES-------VITKAE------VESPLL 923
            :|:...|...|       |.|| :|...   :.|..||.|       :|.:::      .::|||
  Rat  3286 APSNIAPSDVVSNMTLINFTPS-QLSNHPSLLDLGSLNPSSHRTVPNIIKRSKSGIMYFEQAPLL 3349

  Fly   924 SALDIKEDTKKEVGQRVV-ETLLHKTGGNL-LLKRKRKKINRTGFPTVRRKKRKVSVEQQTTAVI 986
            ....:...|....|...: :...|.|.|.: .|......:|.....|........||....|  :
  Rat  3350 PPQSVGGTTATGAGSSTISQDTSHLTSGPVSALASGSSVLNVVSMQTTTTPTSSTSVPGHVT--L 3412

  Fly   987 DEHEPEFDPDDEPLQSLRETRSSNNVNVQAAP---------NPPLDCERVPQAG----------- 1031
            ........||...:..|....|..::.:|..|         .|.|...:.|.|.
  Rat  3413 ANQRLLGTPDIGSISHLLIKASHQSLGIQDQPVALPQSSGMFPQLGTSQTPSAAAMTAASSICVL 3477

  Fly  1032 ---------------EARETF-VARTNQ-KAPRLSVVALERLQRPQTPARGRPRGRKPKNREQAE 1079
                           ||.|.: :.|.|| .|.:...::|:|.:.|.:..     |.:|.|..|..
  Rat  3478 PSSQTAGMTAASPPREAEEQYKLQRVNQLLAGKTGTLSLQRDRDPDSAP-----GTQPSNFTQTA 3537

  Fly  1080 AAPQPPPKSEPEIRPAKKR------GRQPKQPVLEEPPPTPPPQQKKNKMEPNIRLPDGIDPNTN 1138
            .||......:.:..|:.|:      |..|...........|.|.:.|.|:: .|:||  :|..:.
  Rat  3538 EAPNGVRLEQNKTLPSAKQASSTSPGSSPSSGQQSGSSSVPGPTKPKPKVK-RIQLP--LDKGSG 3599

  Fly  1139 FSCKI----------------------------RLKRRKNLEAGT-QPKKEKPVQPVTVEEIPPE 1174
            ...|:                            |..|.:...||. ||.:::..||.......||
  Rat  3600 KKHKVSHLRTSSEAHIPHREANPAPQPSVKRTPRADREQQEAAGVEQPSQKECGQPAGPATALPE 3664

  Fly  1175 IPVSQ----EEIDAEAEA--------------------KRLDSIPTEHDPLPASESHNPGPQDYA 1215
            |..:|    |:.:||.:|                    ||.:|| ||..|.............:.
  Rat  3665 IQATQNPANEQENAEPKAVEEEESSFSSPLMLWLQQEQKRKESI-TERKPKKGLVFEISSDDGFQ 3728

  Fly  1216 SCSESSED-----------KASTTSLRKLSKVKKTYLVAGLFSNHYKQSLMPPPAKVNKKPGLEE 1269
            .|:||.||           ..|...|::||       .||:  |..:...:...|.|    .|.|
  Rat  3729 ICAESIEDAWKSLTDKVQEARSNARLKQLS-------FAGV--NGLRMLGILHDAVV----FLIE 3780

  Fly  1270 QVGPASLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSWNYRKIRTNVYAESVRP 1334
            |:..|.      :|..|..|    |..|.:            .|..|...:...|..|:......
  Rat  3781 QLSGAK------HCRNYKFR----FHKPEE------------ANEPPLNPHGSARAEVHLRQSAF 3823

  Fly  1335 NLAGF------DHPTCNCKNQGEKSCLDNCLNRMVYTECSPSNCPAGEKCRN-QKIQRHAVAPGV 1392
            ::..|      ..|..|..::.|:........|     .:..:.|...:.|: :|..:.||  ||
  Rat  3824 DMFNFLASKHRQPPEYNPNDEEEEEVQLKSARR-----ATSMDLPMPMRFRHLKKTSKEAV--GV 3881

  Fly  1393 ERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHHYCLHLDGGLVIDGQ 1457
            .|  :...|.|:..|..|..|..::||.|.|:...:..:|...........|...:|...|:|..
  Rat  3882 YR--SPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDAT 3944

  Fly  1458 RMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNT 1522
            ..|:..||:||||||||..:..:::|...:|:||.|.|..||||||||.|.:.:.|...||.|..
  Rat  3945 MHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGA 4009

  Fly  1523 PQCR 1526
            .:||
  Rat  4010 KKCR 4013

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	75/369 (20%)
		AWS	1340..1388	CDD:197795	7/48 (15%)
		SET_ASH1L	1391..1531	CDD:380951	49/136 (36%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
Kmt2a	XP_063121507.1	None