Protein Alignment ash1 and trr

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: NP_726773.2
• Gene: trr / 31149
• FlyBaseID: FBgn0023518
• Length: 2431
• Species: Drosophila melanogaster
• Alignment Length: 2119
• Identity: 379/2119 - (17%)
• Similarity: 627/2119 - (29%)
• Gaps: 803/2119 - (37%)

  Fly    12 KVLETQRAQESGSENEETDSIT--------------------------DQSSQSKSIKSA----- 45
            |:|...::|||....||..:|.                          .|::||:||.:.
  Fly   508 KILNKSKSQESTGGPEEFTNINSVVIKPLDKNTLNCPPSFNIFKQQQHSQAAQSQSISAVGSGAG 572

  Fly    46 --TQFSVQRSDTDGLRMRISAIRPTLGVVATKKPPKSRK--MSTQDTESGCSEAKNRAVSKKVK- 105
              ..|::...:...| ...|.:..:.|.:....|....:  :|.|:.......:|.....:|.|
  Fly   573 TPVTFTMASGNASDL-ATTSTVSVSAGTICINSPMMGTRPIISIQNKNISLVLSKTTMAQQKPKM 636

  Fly   106 VKRKKLASSSGI---------SKSDKVSKSKKSQISAFSSDSED------DLPLKVHQQRAPRVL 155
            :....|:|.:.:         |.:||...|..|. ||.|..|..      :.|.|:....||.|:
  Fly   637 ITTTTLSSQAALQMHHALIQDSSADKAGSSANSG-SATSGASMQLKLTTANTPTKLSVSLAPDVV 700

  Fly   156 ----------------LSAIIQAAQSASKPTL-----DIG--------------ISSSDNELPNL 185
                            ..|:::  .|...||.     :||              |:...|:..|.
  Fly   701 KLEEVGSESKAKLLVKQEAVVK--DSTGTPTSEERAEEIGTPEKRLNANATMTAINQVQNQSANQ 763

  Fly   186 VQAAIK-------RVESDTEDTTVEGSFRKAAKD----KNLPQYQS---TLLQDFMEKTQMLGQT 236
            :|.|..       ...:.|.:.|...:.|.||:|    |.|.|..|   :|.|..:....:...:
  Fly   764 IQMATSTSTASNPSTPNPTVNATPMNNQRSAAEDNALLKQLLQNNSSSHSLNQISITSAHVGSAS 828

  Fly   237 VNAKLAEEKVAKAKEETLVQTAVPRKRRGRPKKVVPTVPAPGNSGPAINESADSGVISTTSTTQS 301
            .:|.|:..||...:..::.:......:..||  |:|.||   .:..|...|:.||.::|::||.:
  Fly   829 ASAPLSARKVINVRAPSMGKVRSLEDQLARP--VIPPVP---TATQAAGSSSSSGSVATSTTTTT 888

  Fly   302 TTPSPKMQNENAVPTGSLPIASSS------------KPKIDMAYLDKRMYATERVLYPPPRSKRR 354
            .......|........:||:::.:            :.|.|......:..:..:...|||..:::
  Fly   889 VASGGSSQQVATASATALPVSAVAITTPGVGGEAKLEQKSDQPAAIMQNQSQNQAPPPPPPPQQQ 953

  Fly   355 QNNKKTACSSSNKEELQLDPLWREIDVNKKFRLRSMSVGAASGTGASTTICSKVLAAKSGYVSDY 419
            |..:     ....::||..|    ..|.:..::.|......||..|:.|:.::..:..:..:..
  Fly   954 QQQQ-----LHQPQQLQPSP----HQVKQTVQIVSKETSFISGPVAAKTLVTEATSKPAELLPP- 1008

  Fly   420 GSVRHQRSSHNHNSGYKSDASCKSRYSTKSCMSRRSRAKSCGYRSDCKESGKSGLRMRRKRRASM 484
                         ..|:. |:......|.|..::::..|.              |:|:.|..|..
  Fly  1009 -------------PPYEM-ATAPISNVTISISTKQAAPKE--------------LQMKPKAVAMS 1045

  Fly   485 LLKSSADDTVEDQDILQL--------AGLSLGQ-----SSEESNEYISK---------------- 520
            |.....|:::.:|....|        ||::...     |::.:|.::..
  Fly  1046 LPMEQGDESLPEQAEPPLHSEQGATAAGVAPHSGGPLVSAQWTNNHLEGGVATTKIPFKPGEPQK 1110

  Fly   521 --------------------PSLKSLPTTSASKKYGEINRYVTTGQYFGRGGSLSATNPD----- 560
                                |...|||||             .|||          ..||
  Fly  1111 RKLPMHPQLDEKQIQQQAEIPISTSLPTT-------------PTGQ----------GTPDKVQLI 1152

  Fly   561 ----NFISKMMNQRKETPAPSKSSCKIKSRRSSAASM-------CSSYVSGVS--------RMRR 606
                .::.|.....:..|..::|..:::.:....|:|       .|..:||.:        .::.
  Fly  1153 SAIATYVKKSGVPNEAQPIQNQSQGQVQMQAQMQATMQGHLSGQMSGQISGHAAGQIPAQMHLQV 1217

  Fly   607 RH----------RRKSFSHNKSLNIDSKLLT----EIEIITSTFNSRC---------RIQDDRLT 648
            :|          :::....|:..|....|..    .:.|...|..|:.         .:|..|.|
  Fly  1218 QHQLHMAVHPQQQQQQLHQNQPQNATIPLPVTGQGAVPIPVPTMESKAGDQRKRRKREVQKPRRT 1282

  Fly   649 GSSGKEKLLADANKLQATLAAPSPAQQLTLNGGGPASTLSKPLKRGLKKRKLSEPLVDFAMLSAS 713
            ..:.     ..|......|..|.||..:....|.|..|                     ..:..:
  Fly  1283 NLNA-----GQAGGALKDLTGPLPAGAMVQLAGMPPGT---------------------QYIQGA 1321

  Fly   714 ASGTPN------------GSGSSNGNT------KRRHKKSQSNDSSSPDDHKL--------PL-- 750
            ||||.:            |.|:|.|.:      ||..|.|:..:.......||        ||
  Fly  1322 ASGTGHVITSTGQGVTLGGVGASTGASSSPMLKKRVRKFSKVEEDHDAFTEKLLTHIRQMQPLQV 1386

  Fly   751 ------KKRHYLL----TPGERPPAEVAFANGKLNAEAWAAAAAAAKSTASTKSQAQFNARSVKS 805
                  :..|:|:    |.|...||.::.|     |.|.:::|...|....::.
  Fly  1387 LEPHLNRNFHFLIGSNETSGGGSPASMSSA-----ASAGSSSAGGGKLKGGSRG----------- 1435

  Fly   806 ALTPKKRHL--LEQ-----------------PT------------SVSGAGSSASNSPLRIVVDN 839
              .|..|||  ||.                 |:            .|.|:..:.|.||.
  Fly  1436 --WPLSRHLEGLEDCDGTVLGRYGRVNLPGIPSLYDSERFGGSRGLVGGSARTRSPSPA------ 1492

  Fly   840 NSISGGKLLDISPSSLCSLKQQ--------------RRGGAAKQKVSAAKDLVQLQSPAG----- 885
            .|....|:|.:|........|:              |..||.|.......|||:.:..|.
  Fly  1493 ESPGAEKMLPMSSIQNDFYDQEFSTHMERNPRERLVRHIGAVKDCNLETVDLVESEGVAAWATLP 1557

  Fly   886 ---SYPPPGVFEPSVELEIQIPLSKLNESVITKAEVESPLLSAL--DIKEDTKKEVG-------- 937
               .||...:...:.....::....|.|..:|.....||||.:.  ::::..:.|:|
  Fly  1558 RLTRYPGLILLNGNSRCHGRMSPVALPEDPLTMRFPVSPLLRSCGEELRKTQQMELGMGPLGNNN 1622

  Fly   938 --------QRVVETLLHKTGGNL--LLKRKRKKINRTGFPTVRRKKRKV--SVEQQTTAVIDEHE 990
                    |.|:..|......|:  :|:.....::.....|.:..:.|:  .:|.|.....||..
  Fly  1623 NNNYQQKNQNVILALPASASENIAGVLRDLANLLHLAPALTCKIIEDKIGNKLEDQFMNQDDEKH 1687

  Fly   991 PEFDPDDEPLQS-----LRE--------TRSSNNVNVQAAPNPPLDCERVPQAGEARETFVARTN 1042
            .:|   ..||..     ||:        .||..||                         |..|.
  Fly  1688 VDF---KRPLSQVSHGHLRKILNGRRKLCRSCGNV-------------------------VHATG 1724

  Fly  1043 QKAPRLSVVALER-----------LQRPQTP------------ARGRPRGRKPKNREQAEAAP-- 1082
            .:.||.||.|||.           |.|...|            ||.:..|:.    .|||||.
  Fly  1725 LRVPRHSVPALEEQLPRLAQLMDMLPRKSVPPPFVYFCDRACFARFKWNGKD----GQAEAASLL 1785

  Fly  1083 -QPPPKSEPEIRPAKKRG------RQPKQPVLEEPP-------------PTPPPQQKK------- 1120
             ||...|..:.......|      ..|.:.|:::.|             ||..|.|:|
  Fly  1786 LQPAGGSAVKSSNGDSPGSFCASSTAPAEMVVKQEPEDEDEKTPSVPGNPTNIPAQRKCIVKCFS 1850

  Fly  1121 ----------NKME-----------------------------------------------PNIR 1128
                      :.:|                                               |:..
  Fly  1851 ADCFTTDSAPSGLELDGTAGAGTGAGPVNNTVWETETSGLQLEDTRQCVFCNQRGDGQADGPSRL 1915

  Fly  1129 LPDGIDPNTNFSCKI------------RLKRRKNLEAGTQPKKEKPVQP-VTVE----------E 1170
            |...:|...:.:|.:            .:..:..|:||.........|| .|::          .
  Fly  1916 LNFDVDKWVHLNCALWSNGVYETVSGALMNFQTALQAGLSQACSACHQPGATIKCFKSRCNSLYH 1980

  Fly  1171 IPPEI----------------------------------------PVSQEEIDAEAEAKR----- 1190
            :|..|                                        .|:..|:.:....:|
  Fly  1981 LPCAIREECVFYKNKSVHCSVHGHAHAGITMGAGAGATTGAGLGGSVADNELSSLVVHRRVFVDR 2045

  Fly  1191 ------------------------------------LDSIPTEHDPLP----------------- 1202
                                                |::..|.|...|
  Fly  2046 DENRQVATVMHYSELSNLLRVGNMTFLNVGQLLPHQLEAFHTPHYIYPIGYKVSRYYWCVRRPNR 2110

  Fly  1203 --------ASESHNP----GPQDYASCSESSEDKASTTS------LRKLSKVKKTYLVAGLFSNH 1249
                    |.....|    ..||........|.:.|:.|      |:.:::::|.:....||..|
  Fly  2111 RCRYICSIAEAGCKPEFRIQVQDAGDKEPEREFRGSSPSAVWQQILQPITRLRKVHKWLQLFPQH 2175

  Fly  1250 YK-QSL--MPPPAKV---NKKPGLEEQVGPASLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSK 1308
            .. :.|  :..||.|   ...||:|...         .|..||.|...::|.|..:...|....
  Fly  2176 ISGEDLFGLTEPAIVRILESLPGIETLT---------DYRFKYGRNPLLEFPLAINPSGAARTE- 2230

  Fly  1309 LPTRNVVPSWNYRKIRTNVYAESVRPNLAGFDHPTCNCKNQ---------GEKSCLDNCLNRMVY 1364
             |.:..:..|  ||..|...|.|              |..|         ||.:|..:  .:.|:
  Fly  2231 -PKQRQLLVW--RKPHTQRTAGS--------------CSTQRMANSAAIAGEVACPYS--KQFVH 2276

  Fly  1365 TECSPSNCPAGEKCRNQKIQRHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEV------ 1423
            ::.|.......|...|..:.|..:           :|.|:.....|.|.|.|:||:|||
  Fly  2277 SKSSQYKKMKQEWRNNVYLARSKI-----------QGLGLYAARDIEKHTMIIEYIGEVIRTEVS 2330

  Fly  1424 -VTEKEFKQRMASIYLNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSRM 1487
             :.||:::.:...||:       ..||...|:|....|...|::||||.|||..:...|:...|:
  Fly  2331 EIREKQYESKNRGIYM-------FRLDEDRVVDATLSGGLARYINHSCNPNCVTEIVEVDRDVRI 2388

  Fly  1488 VLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCR 1526
            ::||||.|..||||:|||.|.:.:.|...||.|..|.||
  Fly  2389 IIFAKRKIYRGEELSYDYKFDIEDESHKIPCACGAPNCR 2427

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	71/516 (14%)
		AWS	1340..1388	CDD:197795	10/56 (18%)
		SET_ASH1L	1391..1531	CDD:380951	50/143 (35%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
trr	NP_726773.2	PHA03255	184..>320	CDD:165513
		PRK13914	<623..>851	CDD:237555	46/230 (20%)
		ePHD2_KMT2C_like	1898..2002	CDD:277136	12/103 (12%)
		FYRN	2067..2118	CDD:461787	4/50 (8%)
		FYRC	2126..2215	CDD:197781	21/97 (22%)
		SET_KMT2C_2D	2278..2430	CDD:380948	54/168 (32%)