DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ash1 and Ash1l

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	XP_008759376.1	Gene:	Ash1l / 310638	RGDID:	1306350	Length:	2958	Species:	Rattus norvegicus

Alignment Length:	2680	Identity:	704/2680 - (26%)
Similarity:	1104/2680 - (41%)	Gaps:	721/2680 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 QESGSENE----ETDSITDQ-----SSQSKSIKSATQFSVQRSDTDGL-RMRISAIRPTLGV-VA 73
            |:|.|.||    ||.....|     :|....|..|:..|..:|....: ...:.:..||:.| ..
  Rat   502 QDSFSSNERGAFETSKHEKQPPVYCTSPDFQIGGASDASTAKSPFGAVGESNLPSSSPTVSVNPL 566

  Fly    74 TKKPPKSRKM---------STQDTESGCSEA--KN-------------RAVSKKVKV-------- 106
            |:.||::...         ||.:.....||:  ||             |::...:.:
  Rat   567 TRNPPETSSQLVPNPLLLNSTAEQMEEISESIGKNQFTAESTHLNVGHRSLGHSISIECKGIDKE 631

  Fly   107 -------------------KRKKLASSSGISK------------SDK--------VSKSKKSQIS 132
                               |:..|||.|||..            |:|        .:..|..|::
  Rat   632 LNESKSTHLDISRISSSLGKKPSLASDSGIHTITPSVVNFTSLFSNKPFLKLGAVAAPDKHCQVA 696

  Fly   133 AFSSDSEDDLPLKVHQQRAPRVLLSAIIQAAQSASKPTLDIGISS-----SDNELPNLVQAAIKR 192
            ...|.|....|||..:.|..|  .:.::..:...|...||:..|.     |.:.|.|..:.| |.
  Rat   697 ESLSTSFQSKPLKKRKGRKAR--WTKVVARSTCRSPKGLDLERSELFKNVSCSSLSNSSEPA-KF 758

  Fly   193 VESDTEDTTVEGSFRKAAKDKNLPQYQSTLLQDFMEKTQMLGQTVNAKLAEEKVAKAK------- 250
            :::....:.|:..|.|    :.||:...:.....            |.||:.:.|..|
  Rat   759 MKTIGASSFVDHDFLK----RRLPKLSKSSAPSL------------ALLADSEKASHKSFITHKL 807

  Fly   251 EETLVQTA-----VPRKRRGRPK-KVVPTVPAPGNSGPAINESADSGVISTTSTTQSTTPSPKMQ 309
            ..::..|:     :.:.:||||| |.:|.:..|    |.......:..:.:..:.:...| |.:|
  Rat   808 SSSMCVTSDLLSDIYKPKRGRPKSKEMPQLEGP----PKRTLKIPASKVFSLQSKEEQEP-PILQ 867

  Fly   310 NENAVPTGSLPIASSSKPKIDMAYLDKRMYATERVLYPPPRS--------------KRRQNNKKT 360
            .|..:|:....::.|..||  .....||...:...:.||..|              ...:|::.:
  Rat   868 PEIEIPSFKQSLSVSPFPK--KRGRPKRQMRSPVKMKPPVLSVAPFVATESPSKLESESENHRSS 930

  Fly   361 ACSSSNKEELQ----LDPLWR---------EIDVNKKFRLRSMSVGAASGTGASTTICS----KV 408
            :....::::||    |:...|         |::.:||...|:      :|....|.|..    |.
  Rat   931 SDFFESEDQLQDTDDLEDSHRQSVCSVSDLEMEPDKKISKRN------NGQLMKTIIRKINKMKT 989

  Fly   409 LAAKSGYVSDYGSVRHQRSSHNHNSGYKSDASCKSRYSTKSCMSRRSRAKSCGYRSDCKESGKSG 473
            |..|        .:.:|..|.:..|..|.....| .::|.|.::....:| .|.:.:..:.|...
  Rat   990 LKRK--------KLLNQILSSSVESSNKGKVQSK-LHNTVSSLAATFGSK-LGQQINVSKKGTIY 1044

  Fly   474 LRMRRKRRASMLLK-----SSADDTVEDQDILQLAGLSLGQ-------SSEESNEYISKPSLKSL 526
            :..||.|:...:|.     |.|...|.:|...|.||.:|||       |...|:|.:..|.....
  Rat  1045 IGKRRGRKPKTVLNGLLSGSPASLAVLEQTAQQAAGSALGQILPPLLPSPASSSEILPSPICSQS 1109

  Fly   527 PTTS---------------ASKKYGEINRYVTTGQYFGRGGSLSAT------------------- 557
            ..||               :|..|..::         .|.||:..|
  Rat  1110 SGTSGGQSPVSSDAGFVEPSSVPYLHVH---------SRQGSMIQTLAMKKAAKGRRRLSPPTLL 1165

  Fly   558 -NPDNFISKMMNQRKETPAPSKSS--------------------------CKIKSRRSS------ 589
             |..:.:|::.:.::.||:|...|                          |..|.||.|
  Rat  1166 PNSPSHLSELTSLKEATPSPVSESHSDETIPSDSGIGTDNNSTSDRAEKFCGQKKRRHSFEHISL 1230

  Fly   590 ----AASMCSS---------------YVSGVSRMRRRHRRKSFSHNKSLN-IDSKLLTEIEIITS 634
                .:::.:|               |:| ..:|:|:.|::...:.:..| .|...:.|:|.:.|
  Rat  1231 IPPETSTVLNSLKEKHKHKCKRRSHDYLS-YDKMKRQKRKRKKKYPQLRNRQDPDFIAELEELIS 1294

  Fly   635 TFNSRCRIQDDRLTGSSG---KEKLLADANKLQATLAAPSPAQQLTLNGGGPASTLSKPLKRGLK 696
                  |:.:.|:|..|.   ...||....::........|:..|     .|...:.||   .||
  Rat  1295 ------RLSEIRITHRSHHFIPRDLLPTIFRINFNSFYTHPSFPL-----DPLHYIRKP---DLK 1345

  Fly   697 KRKLSEPLVDFAM--------LSASASGT------------------PNGSGSSNG--------- 726
            |::...|.:..||        ||...|.|                  |.|.|....
  Rat  1346 KKRGRPPKMREAMAEMPFMHSLSFPLSSTGFYPSYGMPYSPSPLTAAPIGLGYYGRYPPTLYPPP 1410

  Fly   727 ----------------------NTKRRHKKSQSNDSSSPDDHKLPLKKRHYLLTPGERP------ 763
                                  |..:.|||.          ||  |.::...||....|
  Rat  1411 PSPSFTTPLPPPSYMHAGHLLLNPTKYHKKK----------HK--LLRQEAFLTTSRTPLLSMST 1463

  Fly   764 ----PAEVAFA--------NGKLNAEAWAAAAAAAKSTASTKS------QAQFNARSVKSA---- 806
                |.|:|:.        :...:.|..:.....:..|.|::|      :.:|...:|...
  Rat  1464 YPSVPPEMAYGWMVEHKHRHRHKHREHRSEQPQVSMDTGSSRSVLESLKRYRFGKDTVGDRYKHK 1528

  Fly   807 -----------LTPKKRHLLEQPTSVSGAGSSASN------SPLRIVVDNNSIS---GG------ 845
                       |:|.|..:..:...||...|.:|:      :||:|....:|.|   ||
  Rat  1529 EKHRCHMSCPHLSPSKSLINREEQWVSREPSESSSLALGLQTPLQIDCSESSPSLSLGGFTPNSE 1593

  Fly   846 -----KLLDISPSSLCSLKQQRRGGAAKQKVSAAKDLVQLQSPAGSYPPPGVFEPSVELEIQIPL 905
                 :.:::..|::.|.:......:.::|::.:..|..:|..|.|.|......||.|..||
  Rat  1594 PASSDEHMNLFTSAIGSCRVSNPNSSCRKKLTDSPGLFPVQDTALSRPHRKEPLPSTERAIQ--- 1655

  Fly   906 SKLNESVITKAEVESPLLSALDIKEDTKKEVGQRVVETLLHKTGGNLLLKRKRKKINRT-----G 965
                               :|...:....:..||..|:.      |....|||.....|     |
  Rat  1656 -------------------SLAGSQSASDKPSQRSSEST------NCSPTRKRSSSESTSSTVNG 1695

  Fly   966 FPTVRRKKRKVSVEQQTTAVI------DEHEPEFDPDDEPLQSL---------------RETRSS 1009
            .|: |..:...|::.....::      ||.|......|.|:.::               |....|
  Rat  1696 IPS-RSPRLVASLDDSVDCLLQRIVQHDEQESVEKNGDAPITTVSAPPSSSPGHSYSKERTLGKS 1759

  Fly  1010 NNVNVQAAPNPPLDCERVPQAGEARETFVARTNQKAPRLSVVALERLQRPQTPARGRPRGRKPKN 1074
            :::.|.|.|:.  .|..:|...   |...:|.:....:.|||  |.:||         :.||..|
  Rat  1760 DSLLVPAVPSD--SCNSIPLLS---EKLASRCSPHHIKRSVV--EAMQR---------QARKMCN 1808

  Fly  1075 REQAEAAPQPPPKSEPEIRPAKKRGRQPKQP---VLEEP-PPTPPPQQKKNKMEP-------NIR 1128
            .::..|..:...... :|..|||..||.:..   |...| .|...|.|....|:.       |..
  Rat  1809 YDKILATKKNLDHVN-KILKAKKLQRQARTGNNFVKRRPGRPRKCPLQAVVSMQAFQAAQFVNPE 1872

  Fly  1129 LPDG------IDPNT------------NFSCKIRLK-RRKN--LEAGTQPKKEKPVQPVTVE--- 1169
            |.:|      :.|:|            |.:.:.:.. :|||  ||..|: ||:|.| |...|
  Rat  1873 LNEGEEVSLHLSPDTVTDVIEAVVQSVNLNSEHKKGWKRKNWLLEEQTR-KKQKTV-PEEEEQEN 1935

  Fly  1170 -----EIPPEIPVSQEEIDAEAEAKRLDSIPTEHD----PLPA---SESHNPGPQDYASCSESSE 1222
                 |.|.||| |..|..||         |:|.:    |:.|   .|...|.|.
  Rat  1936 NKSFIEKPVEIP-SPLETPAE---------PSEPESNLQPVLALIPREKKAPRPP---------- 1980

  Fly  1223 DKASTTSLRKLSKVKKTYLVAGLFSNHYKQS------LMPPPAKVNKKPGLEEQVGPASLLPPPP 1281
                          ||.|..|||:|:.||.:      :.....|:...|| |.:.|   |.|.|.
  Rat  1981 --------------KKKYQRAGLYSDVYKTTDPKSRLIQLKKEKLEYTPG-EHEYG---LFPAPI 2027

  Fly  1282 YCEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSWNYRKIRTNVYAESVRPNLAGFDHPTCNC 1346
            :..||||:..:||:|||||.|.:.:::|..:..||.  |:|||:|||.: |:| |:|::..||||
  Rat  2028 HVGKYLRQKRIDFQLPYDILWQWKHNQLYKKPDVPL--YKKIRSNVYVD-VKP-LSGYEATTCNC 2088

  Fly  1347 KNQGE---KSCLDNCLNRMVYTECSPSNCPAGEKCRNQKIQRHAVAPGVERFMTADKGWGVRTKL 1408
            |...:   |.|.|:|||||::.||||:.||.||:|.||:||||.....:|||...:||||:|||.
  Rat  2089 KKPDDDTRKGCGDDCLNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQCLERFRAEEKGWGIRTKE 2153

  Fly  1409 PIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPN 1473
            |:..|.:|:||:||||:|:||:.||...|.|.:.||||:||.|:|||..|||::.||:||||:||
  Rat  2154 PLKAGQFIIEYLGEVVSEQEFRNRMIEQYHNHSDHYCLNLDSGMVIDSYRMGNEARFINHSCDPN 2218

  Fly  1474 CEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCRGVIGGKSQRVKP 1538
            ||||||||||:.|:.|:|.:.:..|.||||||||..||..:.|.|:|...:|||:|||||||:..
  Rat  2219 CEMQKWSVNGVYRIGLYALKDVPAGTELTYDYNFHSFNVEKQQLCKCGFEKCRGIIGGKSQRMNG 2283

  Fly  1539 LPAVE-AKPSG---EGLSGRNGRQRKQKAKK---HAQRQAGKDISSAVAVA---KLQPLSEKEKK 1593
            ||:.: ::|:.   :....:..|:.|.|.||   |...:..::|::...:.   :::|:|.:|:.
  Rat  2284 LPSHKGSQPASTHRKSARSKEKRKSKHKLKKRRGHPSEEPSENINTPTRLTPQLQMKPMSNRERN 2348

  Fly  1594 LVRQFNTFLVRNFEKI--RRCKAKRASDAAATASSPALGTT-NGDIPGRRPSTPSSPSLAAQISA 1655
            .|.:.:.|||||:|||  ::.:.|.:.|..:|    :|.|. ||..  |......|.....|.||
  Rat  2349 FVLKHHVFLVRNWEKIHQKQEEVKHSRDIHST----SLYTRWNGIC--RDDGNIKSDVFMTQFSA 2407

  Fly  1656 LCSPRNIKTRGLTQAVHDPELEKMAKMAVVLRDICSAMETLKMSD-------LLTTVSSKKKKPI 1713
            |.:.|:::||.|..|..:.|:.:.|::|.:.::||..:.:.|.|.       ||.....||....
  Rat  2408 LQTARSVRTRRLAAAEENLEVARAARLAQIFKEICDGIISYKDSSQQALAAPLLNLPPKKKNADY 2472

  Fly  1714 KTTLSGKLGSTAATSKVEFRSIQAQVEQGHYKTPQEFDDHMQQLFVEAKQQHGDDEGKEKALQSL 1778
            ...:|..|         :..:|:.|:..|:|||.:.||..|.::|..|::.:|......:.:..|
  Rat  2473 YEKISDPL---------DLSTIEKQILTGYYKTVEAFDADMLKVFRNAEKYYGRKSPIGRDVCRL 2528

  Fly  1779 KDSYEQQKIASYVQLVEILGDSESLQSFKPKEVLSSEEEPGKIAVKKSPGAKERDSPIVPLKVTP 1843
            :.:|...:..:..|:.||:|::            :||.:..:.:|.:...:.|:
  Rat  2529 RKAYYSARHEASAQIDEIVGET------------ASEADSSETSVSEKENSHEK----------- 2570

  Fly  1844 PPLLPIEASPDEDVIRCICGLYKDEGLMIQCSKCMVWQHTECTKADIDADNYQCERCEPREVDRE 1908
                      |:|||||||||||||||||||.|||||||.:|...:.|.::|.||:|:||.||||
  Rat  2571 ----------DDDVIRCICGLYKDEGLMIQCDKCMVWQHCDCMGVNTDVEHYLCEQCDPRPVDRE 2625

  Fly  1909 IPL---EEFTEEGHRYYLSLMRGDLQVRQGDAVYVLRDIPIKDESGKVLPTKKHTYETIGAIDYQ 1970
            :|:   ..:.:.|..|::.|:|.||.:||||.||::||.....:...|    :.:|..:..|:..
  Rat  2626 VPMIPRPHYAQPGCVYFICLLRDDLLLRQGDCVYLMRDSRRTPDGHPV----RQSYRLLSHINRD 2686

  Fly  1971 ECDIFRVEHLWKNELGKRFIFGHHFLRPHETFHEPSRRFYPNEVVRVSLYEVVPIELVIGRCWVL 2035
            :.||||:|.|||||..:||.||||:.|||||.|.||||||.||:.||.|||::|:|.|:|.|.||
  Rat  2687 KLDIFRIEKLWKNEKEERFAFGHHYFRPHETHHSPSRRFYHNELFRVPLYEIIPLEAVVGTCCVL 2751

  Fly  2036 DRTTFCKGRPMECNDEDHCYICELRVDKTARFFSKAKAN-HPACTKSYAFRKFPEKIKISKSYAP 2099
            |..|:|||||....::| .|||:.|:||:|..|.|...| :|.|||.|||..||:|:...:.::|
  Rat  2752 DLYTYCKGRPKGVKEQD-VYICDYRLDKSAHLFYKIHRNRYPVCTKPYAFDHFPKKLTPKRDFSP 2815

  Fly  2100 HDVDP--------SLLKTRKQKTEL-DVGAGPTTM---HKVSGRQEQ-----------HQAKMVG 2141
            |.|..        |..|:.:.|..| |:|.....:   .:|...|||           .|.::.|
  Rat  2816 HYVPDNYKRNGGRSSWKSERSKPLLKDLGQDDDALPLIEEVLASQEQAANEMPSPEEPDQERVTG 2880

  Fly  2142 ------RKPRGISAPADATAVHVVTPVAPNKQMLKKRKSRLENVLITMKLKCLDAQTAQEQPIDL 2200
                  :||...|......:    ||    ::....::.||..:|:.: |:.:..:.|    ||:
  Rat  2881 DVSDAEKKPEESSQEPQLAS----TP----EERRHSQRERLNQILLNL-LEKIPGKNA----IDV 2932

  Fly  2201 SYLL---SGRGARQR 2212
            :|||   |||..|:|
  Rat  2933 TYLLEEGSGRKLRRR 2947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795	28/50 (56%)
		SET	1392..1512	CDD:214614	70/119 (59%)
		Bromo_ASH1	1680..1787	CDD:99955	26/113 (23%)
		PHD_ASH1L	1858..1900	CDD:277023	29/41 (71%)
		BAH_polybromo	1929..2073	CDD:240068	72/143 (50%)
Ash1l	XP_008759376.1	AWS	2082..2133	CDD:197795	28/50 (56%)
		SET_ASH1L	2136..2276	CDD:380951	78/139 (56%)
		Bromo_ASH1	2432..2537	CDD:99955	26/113 (23%)
		PHD_ASH1L	2575..2617	CDD:277023	29/41 (71%)
		BAH_polybromo	2654..2788	CDD:240068	69/138 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351984
Domainoid	1	1.000	149	1.000	Domainoid score	I4298
eggNOG	1	0.900	-	-		E2759_KOG1083
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D507784at2759
OrthoFinder	1	1.000	-	-		FOG0007422
OrthoInspector	1	1.000	-	-		oto98516
orthoMCL	1	0.900	-	-		OOG6_106446
Panther	1	1.100	-	-	LDO	PTHR46147
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5557
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.710