DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ash1 and G9a

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	NP_001259088.1	Gene:	G9a / 30971	FlyBaseID:	FBgn0040372	Length:	1657	Species:	Drosophila melanogaster

Alignment Length:	1856	Identity:	351/1856 - (18%)
Similarity:	554/1856 - (29%)	Gaps:	688/1856 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QNETAAAK----VLETQRAQESGSENEETDSITDQSSQSKSIKSATQFSVQRSDTDGLRMRISAI 65
            ||:.||.|    :|...:..|:.:|...|..| :.:..|..:.|:....:....|:.:|...||.
  Fly   178 QNKKAAEKEEEPILAATQKLEANAEPLTTTRI-EVAVASPLVVSSASVKLAADATNQMRAATSAG 241

  Fly    66 RPTLGVVATKKPPKSRKMSTQ-----DTESGCSEAKNRAVSKKVKVKRKKLASSSGISKSDKVSK 125
            ..||.....:..|...:.|.:     ||.:..::       :.|:|:.||      ..||::.:.
  Fly   242 AATLADKNVQVSPGGTRRSRRTPRPIDTPTSVTD-------EHVQVENKK------FGKSEQYTD 293

  Fly   126 SKKSQISAFSSDSEDDLPLKVHQQRAPRVLLSAII--QAAQSASKPTLDIGISSSDNE--LPNLV 186
            . .|.:..|:.|..                 :||:  |......||:| ..:|..:|.  .|...
  Fly   294 C-SSHLERFTLDDN-----------------TAIVRLQLKSEPDKPSL-TALSPEENSAPAPKRG 339

  Fly   187 QAAIKRVESDTEDTTVE---------GSFRKAAKDKNLPQYQSTLLQDFMEKTQMLGQTVNAKLA 242
            :...:::..|.|..|.|         |. :|..:.:.||        |.....|.|...|..|..
  Fly   340 RGRARKIRPDAEVETSEVILPCEDSLGE-KKPGRKRKLP--------DEPIDQQQLSDLVVVKTE 395

  Fly   243 EEKVAKAKEETLVQTAVPRKRR-----------GRPKKVVPTV---PAPGNSGPAINESADSGVI 293
            :|::..|.     ...|.|.||           |.|.:.|.|.   |.|         ||:....
  Fly   396 QEELGDAP-----LGDVKRMRRSVRLGNRLHADGSPWEEVKTEALHPQP---------SAELSFA 446

  Fly   294 STTST-----------------TQSTTPSPKMQNENAVPTGSLPIASSSKPKIDMAYLDKRMYAT 341
            ..||.                 .::.||..|:::|.:.   .||.|:.:|........:.::
  Fly   447 EVTSEILPLAVLDEKTPPKKRGRKAKTPCVKLESETSC---GLPFANGNKKTNSSGGCELQL--- 505

  Fly   342 ERVLYPPPRSKRR-------QNNKKTACSSSNKEELQLDPLWREIDVNKKFRLRSMSVGAASGTG 399
                  |.|||||       ..|.:..|....| .::....|.             |..|..|..
  Fly   506 ------PKRSKRRIKPTPKILENDELRCEFETK-HIERMTQWE-------------SAAAVDGDF 550

  Fly   400 ASTTICSKVLAAKSGYVSDYGSVRHQRSSHNHNSGYK-------SDASCKSRYSTKS-------- 449
            .:.|         :|......|...|:|..:..|.::       ..::.|.|..:||
  Fly   551 ETPT---------TGGNGSNSSTSRQKSDKSDGSNFEGGPGHPAGTSAIKKRLFSKSQRDIENYG 606

  Fly   450 -CMSRRSRAKSC----GYRSDCKES-------------GKSGLRMRRKRRASML----LKSSADD 492
             .|..:|:...|    .:.:|.|.|             .|...|...|::...|    |:.:..|
  Fly   607 AAMLAKSKLPPCPDVEQFLNDIKASRINANRSPEERKLNKKQQRKLAKQKEKHLKHLGLQKNHRD 671

  Fly   493 TVEDQDILQLAGLSLGQSSEESNEY-------ISKPSL---------KSLPTTSASKKYGEINRY 541
            ...|.|           ||...||:       :.|||:         |.||||:..|  ...|..
  Fly   672 EPSDND-----------SSNTDNEFFPTTRVQVGKPSVTLRVRNSVTKELPTTATLK--SRRNPV 723

  Fly   542 VTTGQYFGRGGSLSA-------------TNPD---------------------------NFISKM 566
            |...:...|.|:.:|             :.||                           :.:||.
  Fly   724 VQAAKLTRRIGARAAGEVTEAARASVPISTPDAEQLHSLDTSIQADVTPIRDLDMRPSTSRVSKF 788

  Fly   567 M------NQRKETPAPSKSSC----KIKSRRSSAASMCSSYVSGVSRMRRR---------HRRKS 612
            :      :|.....||..|.|    .|..::....:..||.|..:.|..:|         |:::.
  Fly   789 ICLCQKPSQYYARNAPDSSYCCAIDHIDDQKIGCCNELSSEVHNLLRPSQRVSYMILCDEHKKRL 853

  Fly   613 FSHN--------------------------------------KSLNIDS----KLLTEIEII--- 632
            .|||                                      |.|..:.    |..:.:.::
  Fly   854 QSHNCCAGCGIFCTQGKFVLCKQQHFFHPDCAQRFILSTSYEKELGDEEDQGVKFSSPVLVLKCP 918

  Fly   633 ---------TSTFNSRC------------RIQDDRLTGSSGKEKL--LADANKLQATLAAPSPAQ 674
                     |||...:|            :|:..|||.||...:.  :.:||...||
  Fly   919 HCGLDTPERTSTVTMKCQSLPVFLRTQKYKIKPARLTTSSHLTQFGTVENANTPGAT-------- 975

  Fly   675 QLTLNGGG--PASTLSKPLKRGLKKRKLSEPLVDFAMLSASASGTPNG-SGSSNGNTKRRHKKSQ 736
              ..|.||  .|.|||          ..|.|       ::..:|...| :|:||.|:  ||..:.
  Fly   976 --ARNKGGLSTAVTLS----------AASSP-------ASKTNGAQRGRAGTSNSNS--RHALNS 1019

  Fly   737 SNDSSSPDDHKLPLKKRHYLLTPGERPPAE-------VAFANGKLNAEAWAAAAAAAKSTASTKS 794
            .|.:....:..:.:..|.::::...|..||       .|..|..|...|...|
  Fly  1020 INFAQLIPESVMNVVLRGHVVSASGRVTAEFTPRDMYYAVQNDDLERVAEILA------------ 1072

  Fly   795 QAQFNARSVKSALTPKKRHLLEQPTSVSGAGSSASNSPLRIVVDNNSISGGKLLDISPSSLCSLK 859
             |.||      .|||.:.:|              :.:.|.:|..:.::....||      ||
  Fly  1073 -ADFN------VLTPIREYL--------------NGTCLHLVAHSGTLQMAYLL------LC--- 1107

  Fly   860 QQRRGGAAKQKVSAAKDLVQLQSPAGSYPPPGVFEPSVELEIQIPL--SKLNESVITKAEVESPL 922
                      |.:::.|.|.:                |:.|::..|  :.:||    |.::.:..
  Fly  1108 ----------KGASSPDFVNI----------------VDYELRTALMCAVMNE----KCDMLNLF 1142

  Fly   923 LSA---LDIKEDTKKEVGQRVVETLLHKTG--GNLLLKRKRKKINRTGFPTVRRKKRKVSVEQQT 982
            |..   :.||....|        |.||...  |||                           :.|
  Fly  1143 LQCGADVAIKGPDGK--------TSLHIAAQLGNL---------------------------EAT 1172

  Fly   983 TAVIDEHEPEFDPDDEPLQSLRETRSSNNVN-----------------VQAAPNPPLDCER---V 1027
            ..::|.:                 |:|.|:.                 |.||.....|..|   :
  Fly  1173 QLIVDSY-----------------RTSRNITSFLSFIDAQDEGGWTAMVWAAELGHTDIVRLASL 1220

  Fly  1028 PQAGEARETFVARTNQKAPRLSVVALERLQRPQTPARGRPRGRKPKNREQAEAAPQPPPKSEPEI 1092
            |||     .|:...|      ..:.:..|
  Fly  1221 PQA-----VFLKLIN------IFLFISFL------------------------------------ 1238

  Fly  1093 RPAKKRGRQPKQPVLEEPPPTPPPQQKKNKMEPNIRLPDGIDPNT-----NFSCKIRLKRRKNLE 1152
                         :.::..|..........:..:....||:|..|     ...|.:     :|:|
  Fly  1239 -------------LNQDADPNICDNDNNTVLHWSTLHNDGLDTITVLLQSGADCNV-----QNVE 1285

  Fly  1153 AGTQPKKEKPVQPVTVEEIPPEIPVSQEEIDAEAEAKRLDSIPTEHDPLPASESHNPGPQDYASC 1217
             |..|........||...|......:...|..:||....|.||.|.                :.|
  Fly  1286 -GDTPLHIACRHSVTRMCIALIANGADLMIKNKAEQLPFDCIPNEE----------------SEC 1333

  Fly  1218 SESSEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQSLMPPPAKVNKKPGLEEQVGPASLLPPPPY 1282
            ..:........|.|.|.  .:|::|....||                 |.|.:        |...
  Fly  1334 GRTVGFNMQMRSFRPLG--LRTFVVCADASN-----------------GREAR--------PIQV 1371

  Fly  1283 CEKYLRRTEMDFELPYDIW--WAYTNSKLPTRNVVPSWNYRKIRTNVYAESVRPNLAGFDHPTCN 1345
            ....|..:|.:.|....:|  :.|....:..:|.|      :|...|....:...|.......|.
  Fly  1372 VRNELAMSENEDEADSLMWPDFRYVTQCIIQQNSV------QIDRRVSQMRICSCLDSCSSDRCQ 1430

  Fly  1346 CKNQGEKS--CLDNCLNR-------MVYTECSPSNCPAGE-KCRNQKIQRHAVAP-GVERFMTAD 1399
            |.....::  ..::.||.       .|..||: ..|...: .|:|:.:|.....| .:.......
  Fly  1431 CNGASSQNWYTAESRLNADFNYEDPAVIFECN-DVCGCNQLSCKNRVVQNGTRTPLQIVECEDQA 1494

  Fly  1400 KGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHHYCLHLDGGLVIDGQRMGSDCR 1464
            ||||||....:.|||::..|.||::|..|..:|....|..|       ||.|..||....|:..|
  Fly  1495 KGWGVRALANVPKGTFVGSYTGEILTAMEADRRTDDSYYFD-------LDNGHCIDANYYGNVTR 1552

  Fly  1465 FVNHSCEPNC-------EMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQ--PCRC 1520
            |.|||||||.       |.|.:.   ..::..|:.|.|:.|||:.:||....:......  .|||
  Fly  1553 FFNHSCEPNVLPVRVFYEHQDYR---FPKIAFFSCRDIDAGEEICFDYGEKFWRVEHRSCVGCRC 1614

  Fly  1521 NTPQCRGVIGGKSQRVKPLPAVEAKPSGEG-LSGRN 1555
            .|..|:......|....|..|..|..:..| ||..|
  Fly  1615 LTTTCKYASQSSSTNASPTNATTAPENETGTLSSTN 1650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795	11/57 (19%)
		SET	1392..1512	CDD:214614	42/126 (33%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
G9a	NP_001259088.1	ATP-synt_B	150..248	CDD:304375	18/70 (26%)
		Ank_2	1056..1152	CDD:289560	28/167 (17%)
		ANK	1088..1217	CDD:238125	34/219 (16%)
		ANK repeat	1088..1120	CDD:293786	9/66 (14%)
		ANK repeat	1124..1153	CDD:293786	6/32 (19%)
		Ank_2	1127..1249	CDD:289560	31/237 (13%)
		ANK	1155..1306	CDD:238125	36/268 (13%)
		ANK repeat	1155..1196	CDD:293786	12/92 (13%)
		ANK repeat	1199..1249	CDD:293786	12/109 (11%)
		Ank_2	1205..1316	CDD:289560	24/176 (14%)
		ANK repeat	1251..1283	CDD:293786	5/36 (14%)
		ANK repeat	1285..1316	CDD:293786	7/31 (23%)
		PreSET	1357..1466	CDD:128744	22/140 (16%)
		SET	1495..1602	CDD:214614	42/116 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467634
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840