Protein Alignment ash1 and Nsd1

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: NP_001388465.1
• Gene: Nsd1 / 306764
• RGDID: 1307748
• Length: 2689
• Species: Rattus norvegicus
• Alignment Length: 2364
• Identity: 500/2364 - (21%)
• Similarity: 768/2364 - (32%)
• Gaps: 749/2364 - (31%)

  Fly    78 PKSRKMSTQDTESGCSEAKNRAVSKKVKVK-RKKLASSSGISKSDKVSKSKKSQISAFSS---DS 138
            |..||...|         |.:....||..| ..|..:|.|:::...|.:..|:|....||   ||
  Rat   396 PVLRKRGKQ---------KEKGYRHKVPQKILSKWEASVGLAEQCDVPRGPKTQKCVPSSAKLDS 451

  Fly   139 EDDLPLK--------VHQQRAPRVLLSAIIQAAQSA---SKPTLDIGI-SSSDNELPNLVQAAIK 191
            |:|:|.:        .|.......|.|....:..||   .||.....: .||||.....|:..:.
  Rat   452 EEDMPFEDCANDPDSEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRVRKSSDNIKRTSVKKGLM 516

  Fly   192 RVESDTEDTTVEGSFRKAAKDKNLPQYQSTLLQDFM-------EKTQMLGQTVNAKLAE------ 243
            ..|:..|:       |:....:||.       .||:       :.:..|.:..|:....
  Rat   517 PFEAQKEE-------RRGKSPENLG-------LDFLSGGVSDKQASNELSRIANSLTGSSAAPGQ 567

  Fly   244 -------EKVAKAKEET--------LVQTAVPRKRRGRPKKVVP----------TVPAPGNSGPA 283
                   :..||...||        |.::|:..|..|..||:.|          .....|:.
  Rat   568 FLFSSCGQNTAKTDFETPNCDSLSGLSESALISKHSGEKKKLQPGQVCSSKVQLCYVGAGDE--- 629

  Fly   284 INESADSGVISTTSTTQSTTPSPKMQN-----------------ENAVPTGSLPIASSSKPKIDM 331
             .:.:||..:.|||...|:...|...|                 |||:          |..|.:.
  Rat   630 -EKRSDSVSVCTTSDDGSSDLDPTEHNSEFHKSVLEVTDALDKTENAL----------SMHKNET 683

  Fly   332 AYLDKRMYATERV------LYPPPRSKRRQNNKKTA------CSSSNKEELQL-------DPLWR 377
            .|  .|..||.||      |.....:....::.||.      .|..|..:|::       .|.:|
  Rat   684 KY--SRYPATNRVKEKQKSLITNSHTDHLMDSTKTVEPGTAEISQVNLSDLKISSPIPKPQPEFR 746

  Fly   378 EIDVNKKFR----LRSMSVGAASGTGASTTICSKVLAAKSGYVSDYGSVRHQRSSHNHNSGYKSD 438
            ...:..||.    :|:.:.....|....|.:..|....|         .|..:..|..:......
  Rat   747 NDGLTTKFNAPPGIRNENSLTKGGLANQTLLPLKCRQPK---------FRSIKCKHKESPTAAET 802

  Fly   439 ASCKSRYSTKSCMSRRSRAKSCGYRSDCKESGK-SGLR----MRRKRRASMLLKSSADDTVEDQD 498
            ::.....|.|.|.|..:.:.    .:...:||| .||:    |..|.|.|    |..:..|....
  Rat   803 SATSEDLSLKCCSSDTNGSP----MTSISKSGKGEGLKLLNNMHEKTRDS----SDIETAVVKHV 859

  Fly   499 ILQLAGLSLGQSSEESNEYISKPSLKSLPTTSASKKYGEINRYVTTGQYFGRGGSLSATNPDNFI 563
            :.:|..||....||:.::..:..|.|.|..:|||.:    |.......|  :..:|.....|...
  Rat   860 LSELKELSYRSLSEDVSDSGTSKSSKPLLFSSASSQ----NHIPIEPDY--KFSTLLMMLKDMHD 918

  Fly   564 SKMMNQRKETP-------APSKSSCKIKSRRSSAASMCSSYVSGVSRMRRRHRRKSFSHNKSLNI 621
            ||...||..|.       .|.:..|      ||.:.:.:|.|..:........:...|...|:.:
  Rat   919 SKTKEQRLMTAQNVASYRTPDRGDC------SSGSPVGTSKVLVLGGSTHNSEKPGDSTQDSVRL 977

  Fly   622 -----DSKLLTEIEIITSTFNSRCRIQDDRLTGSSGK--EKLLADANKLQATLAAPSPAQQLTLN 679
                 ||.|..|:....|...|     |.|...:.||  ...:...|..:|.|   ||..::|:
  Rat   978 SPGGGDSALSGELSSSLSVLPS-----DKRDLPACGKIRSNCIPRRNCGRAKL---SPKLRVTI- 1033

  Fly   680 GGGPASTLSKPL--KRGLK---KRKLSE-PLVDFAMLSASASGTPNGSGSSNGNTK------RRH 732
                ::.::||.  .:.||   |||||. |.|   .|:|:..|.....||.||..|      .:.
  Rat  1034 ----STQMAKPSVNPKALKTERKRKLSRLPAV---TLAANGLGNKESGGSVNGPLKGGAQDPAKE 1091

  Fly   733 KKSQSND--------------SSSPDDHKLPLKKRHYLLTPGERPPAEVAFANG----------- 772
            :..|..|              .|.||  |:..|:..:....|....:|:...|.
  Rat  1092 EPLQQMDLLRNEETHFDSKVKQSDPD--KILEKEPSFENRKGPEVGSEINIENDEPHGVDQVVPK 1154

  Fly   773 ----KLNAEAWAAAAAAAKSTASTKSQAQFNARSVKSALTPKKRHLLEQ---PTSV--------S 822
                :||.........|::......|:..|........:...:...|||   |||:        :
  Rat  1155 KRWQRLNQRRPKPGKRASRFREKENSEGAFGVLLPGDPVQKGRDDYLEQRAPPTSILEDSAADPN 1219

  Fly   823 GAGSSASNSPLRIVVDNNSISGGKLLDISPSSLCSLKQQRR---GGAAKQKVSAAKDLVQLQSPA 884
            ....|.|..|...|.|.:|:|.|.|  ...:.:.||..|.:   .....:|....|....|....
  Rat  1220 HVSHSESVGPRLNVCDKSSVSMGDL--EKETGIPSLTPQTKIPEPAVRSEKKRLRKPSKWLLEYT 1282

  Fly   885 GSYPPPGVFEP-SVELEIQIPLSKL------------------------NESVITKAE------- 917
            ..|..  :|.| ..:.::|..:.|:                        |..:.||.|
  Rat  1283 EEYDQ--IFAPKKKQKKVQEQVHKVSSRCEDESLLARCRSSAQNKQVDENSLISTKEEPPVLERE 1345

  Fly   918 ---VESPL-----------LSALDIKEDTKKEVGQRVV---ETLLHKTGGNLLLKRKRKKINRTG 965
               :|.||           |..|.:......||..|..   |.||.||.||...||:||
  Rat  1346 APFLEGPLVQSDLGVAHAELPQLTLSVPVAPEVSPRPTLESEELLVKTPGNYEGKRQRK------ 1404

  Fly   966 FPTVRRKKRKVSVEQQTTAVIDEHEPEFDPDDEPLQSLRETRSSNNVNVQAAPNPPLDCERVPQA 1030
             ||   ||...|         ::.:|.|.|....|...|:...|.::.              ...
  Rat  1405 -PT---KKLLES---------NDLDPGFMPKKGDLGLSRKCCESGHLE--------------NGV 1442

  Fly  1031 GEARETFVARTNQKAPRLSVVALERLQRPQTPARGRPRGRKP----------KNREQAEAAPQPP 1085
            |::|.|         |.     |:......|....:||.||.          |..::.::|.:.|
  Rat  1443 GDSRAT---------PH-----LKEFGGGTTRIFDKPRKRKRQRHGTARVHYKRVKKEDSARETP 1493

  Fly  1086 PKSEPEIRPAKKRGRQPKQPVLEEPPPTPPPQQKKNKME----------PNI------------- 1127
            ..:|.|:. ..:....||: :|||.....|......:::          .|:
  Rat  1494 SSAEGELM-IHRTAASPKE-ILEEGIEHDPGMSASKRLQGERGGGAALKENVCQNCEKLGELLLC 1556

  Fly  1128 ----------------RLPDG--------IDPNTNFSCKIRLKRRKNLEAGTQPKK------EKP 1162
                            .:|.|        ...:|.|.||         ::|...|:      .|.
  Rat  1557 EAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCK---------QSGEDVKRCLLPLCGKF 1612

  Fly  1163 VQPVTVEEIPPEI-------------------------------------PVSQEEID--AEAEA 1188
            .....|::.||.:                                     ||:....|  ..|.:
  Rat  1613 YHEECVQKYPPTVVQNKGFRCPLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGS 1677

  Fly  1189 KRLDS----IPTEHDPLPASESHNPGPQDYA-SCSESSE----DKASTTSLRKLSKVKKTYLVAG 1244
            |.|.|    .|....|.....:|......:. .|||...    |.......|:...:.   :..|
  Rat  1678 KILASNSIICPNHFTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNID---IPEG 1739

  Fly  1245 LFSNHYKQSLMPPPAKVNKKPGLEE----QVG-----PASLLPP---PPYCEKYLRRTEMDFELP 1297
               |.|...     .|..|||...|    :||     ||.:..|   |...:| :|....:|.:.
  Rat  1740 ---NWYCND-----CKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDK-MRHDVGEFPVL 1795

  Fly  1298 Y----DIWWAY-----------------------------------------------------T 1305
            :    |..|.:                                                     .
  Rat  1796 FFGSNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQKELRQLQEDRK 1860

  Fly  1306 NSKLPTRNVVPSWNYRKI-----RTNVYAESVRPNLAGFDHPTCNCKNQGEKSC-LDN-CLNRMV 1363
            |.|.|     |.:.:.|:     |..::...:.      :.|.||||...|..| :|: |:|||:
  Rat  1861 NDKKP-----PPYKHIKVNRPIGRVQIFTADLS------EIPRCNCKATDENPCGIDSECINRML 1914

  Fly  1364 YTECSPSNCPAGEKCRNQKIQRHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKE 1428
            ..||.|:.||||.:|:||...:... |.||.|.|..:|||:|||..|.||.::.|||||::.|:|
  Rat  1915 LYECHPTVCPAGGRCQNQCFSKRQY-PDVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEE 1978

  Fly  1429 FKQRMASIYLND-THHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAK 1492
            .:.|:.....:| |:.|.|.||...:||....|:..||:||.|:||||.|||||||.:|:.|||.
  Rat  1979 CRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFAL 2043

  Fly  1493 RAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCRGVIGGKSQRVKPLPAVEAKPSGEGLSGRNGR 1557
            ..|:.|.|||::||.......: ..|:|..|.|.|.:|   .|.|..|.|..:.|
  Rat  2044 SDIKAGTELTFNYNLECLGNGK-TVCKCGAPNCSGFLG---VRPKNQPIVTEEKS---------- 2094

  Fly  1558 QRKQKAKKHAQRQAGKDISSAVAVAKLQPLSEKEKKLVRQFNTFLVRNFEKIRRCKAKRA----- 1617
             ||.|.|.|.:|::..:::             ||    |:...|...:..::..||....
  Rat  2095 -RKFKRKPHGKRRSQGEVT-------------KE----REDECFSCGDGGQLVSCKKPGCPKVYH 2141

  Fly  1618 SDAAATASSPALGTTNG---------DIPGRRPSTPSSPSLAAQISALCSPRNIKTR-------- 1665
            :|.......||     |         |:.|:.         ||....:|.....|..
  Rat  2142 ADCLNLTKRPA-----GKWECPWHQCDVCGKE---------AASFCEMCPSSFCKQHREGMLFIS 2192

  Fly  1666 ----GLTQAVHDPELEKMAKMAVVLRDICSAMETLKMSDLLTTVSSKKKKPIKTTLSGKLGSTAA 1726
                .|:...|||               |.. ..|:..::      ::..|...|||...|:...
  Rat  2193 KLDGRLSCTEHDP---------------CGP-NPLEPGEI------REYVPPTATLSPSPGTQQT 2235

  Fly  1727 TSKVEFRSIQAQVEQGHYKTPQEFDDHMQQLFVEAKQQHGDDEGKEKALQSLKDSYEQQKIASYV 1791
            ....|..:      ||..|:.|...|..|.|.:..|...|..:      :.|......::..|..
  Rat  2236 EQSSEMGT------QGPKKSDQPPTDATQMLSLSKKAVTGTCQ------RPLLPERPPERTDSSS 2288

  Fly  1792 QLVEILGD-------SESL-QSFKPKEVLSSEEEP-GKIAVKKSPGAKERDSPIV-------PLK 1840
            .|::.:.|       |:|| .|.:|::...::|.| .:...:.||..:...||.|       ||:
  Rat  2289 HLLDRIRDLAGSGTKSQSLVSSQRPQDRPPAKEGPRPQPPDRASPVTRPSSSPSVSSLPLERPLR 2353

  Fly  1841 VTPPPL-----------LPIEASPDEDVIRCICGLYKDEGLMIQCSKCMVWQHTECTKADI---- 1890
            :|.|.|           ..:|..|....:|    |...:.|:          :|...|..|
  Rat  2354 MTEPRLDKSIGAASPKSQAVEKPPAPTGLR----LSSPDRLL----------NTNSPKPQISDRP 2404

  Fly  1891 -DADNYQ-CERCEPRE----------VDRE---IPLEEFTEEGHRYYLSLMRGDLQVRQGDAVYV 1940
             |..:.. .:|..|.|          |.:|   .|:::.|:..||..:.:...||..||.:....
  Rat  2405 PDKSHASLTQRLPPPEKVLSAVVQSLVAKEKALRPVDQNTQAKHRAAVVMDLIDLTPRQKERAAS 2469

  Fly  1941 LRDIPIK-DESGKVL-----PTKK 1958
            .:::..: ||...||     ||.:
  Rat  2470 PQEVTAQADEKTPVLESSSRPTSR 2493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	62/385 (16%)
		AWS	1340..1388	CDD:197795	22/49 (45%)
		SET_ASH1L	1391..1531	CDD:380951	62/140 (44%)
		Bromo_ASH1	1680..1787	CDD:99955	18/106 (17%)
		PHD_ASH1L	1858..1900	CDD:277023	7/47 (15%)
		BAH_polybromo	1929..2073	CDD:240068	10/36 (28%)
Nsd1	NP_001388465.1	PWWP_NSD1_rpt1	318..433	CDD:438989	11/45 (24%)
		TNG2	<1452..1585	CDD:227367	19/134 (14%)
		PHD1_NSD1_2	1543..1585	CDD:277118	2/41 (5%)
		PHD2_NSD1	1590..1636	CDD:277120	10/54 (19%)
		PHD3_NSD1	1637..1690	CDD:277123	8/52 (15%)
		PHD4_NSD1	1707..1746	CDD:277126	8/49 (16%)
		PWWP_NSD1_rpt2	1753..1848	CDD:438992	12/95 (13%)
		AWS	1899..1937	CDD:465559	17/37 (46%)
		SET_NSD1	1939..2080	CDD:380987	63/142 (44%)
		PHD5_NSD1	2118..2160	CDD:277129	7/46 (15%)
		C5HCH	2159..2208	CDD:465605	11/72 (15%)
		PHA03247	<2221..2593	CDD:223021	64/299 (21%)