Protein Alignment ash1 and Ezh1

DIOPT Version :9

• Sequence 1: NP_001246834.1
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: NP_001100521.1
• Gene: Ezh1 / 303547
• RGDID: 1305028
• Length: 747
• Species: Rattus norvegicus
• Alignment Length: 568
• Identity: 143/568 - (25%)
• Similarity: 197/568 - (34%)
• Gaps: 203/568 - (35%)

  Fly  1062 PARGRPRGRKPKNREQAEAA-PQP-PPKSEPEIRPAKKRGRQPKQPV-----------------L 1107
            |..|.|...|.:.||..|.: |.. ||:..|.|.....:..|.:|.:                 |
  Rat   245 PENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFL 309

  Fly  1108 EEPPPTPPPQQKKN---KMEPNIRLPDGID--------------PNTNFSCKIRLKRRKNLEAGT 1155
            .....||...::||   |:||.   |.|.|              .|....|..|.:||
  Rat   310 HPFHATPNVYKRKNREIKIEPE---PCGADCFLWLEGAKEYAMLHNPRSKCSGRRRRR------- 364

  Fly  1156 QPKKEKPVQPVTVEEIPPEIPVSQEEIDAEAEAKRLDSIPTEHDPLPASESHNPGPQDYASCSES 1220
                    .||.      ....|.....|.||.|..||            ..:.| .|:||.|..
  Rat   365 --------HPVV------SASCSNTSASAMAETKEGDS------------DRDTG-NDWASSSSE 402

  Fly  1221 SEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQSLMPPPAKVNKKP-------GLEEQV------- 1271
            :..:..|.:.:|.|..                   ||...|.:.|       |.||.:
  Rat   403 ANSRCQTPTKQKASPA-------------------PPQLCVVEAPSEPVEWTGAEESLFRVFHGT 448

  Fly  1272 ------GPASLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNS---KLPTRNVV-PS--------- 1317
                  ..|.||.... |::..:             :|...|   ||||..:: ||
  Rat   449 YFNNFCSIARLLGTKT-CKQVFQ-------------FAVKESLILKLPTDELMNPSQKKKRKHRL 499

  Fly  1318 W--NYRKIR-------TNVYAESVRPNLAGFDHP------TCNC---KNQGEK--SCLDNCLNRM 1362
            |  :.|||:       |.||      |....|||      ||.|   :|..||  .|..:|.||.
  Rat   500 WAAHCRKIQLKKDNNSTQVY------NYQPCDHPDRPCDSTCPCIMTQNFCEKFCQCSPDCQNRF 558

  Fly  1363 ----VYTECSPSNCP-----------------AGE-------KCRNQKIQRHAVAPGVERFM--- 1396
                ..|:|:...||                 |.|       .|:|..|||     |:::.:
  Rat   559 PGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVVSCKNCSIQR-----GLKKHLLLA 618

  Fly  1397 TAD-KGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHHYCLHLDGGLVIDGQRMG 1460
            .:| .|||...|..:.|..:|.||.||::::.| ..|...:|......:..:|:...|:|..|.|
  Rat   619 PSDVAGWGTFIKESVQKNEFISEYCGELISQDE-ADRRGKVYDKYMSSFLFNLNNDFVVDATRKG 682

  Fly  1461 SDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFS 1508
            :..||.|||..|||..:...|||..|:.:||||||:.||||.:||.:|
  Rat   683 NKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAGEELFFDYRYS 730

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795	24/86 (28%)
		SET	1392..1512	CDD:214614	44/121 (36%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
Ezh1	NP_001100521.1	EZH2_WD-Binding	39..68	CDD:402972
		PRC2_HTH_1	159..262	CDD:407952	6/16 (38%)
		SANT	433..474	CDD:238096	8/54 (15%)
		SET	<463..727	CDD:225491	83/289 (29%)
		SET_EZH1	608..743	CDD:380994	47/129 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352041
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840