Protein Alignment ash1 and Setbp1

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: NP_001414555.1
• Gene: Setbp1 / 291423
• RGDID: 1306229
• Length: 1582
• Species: Rattus norvegicus
• Alignment Length: 1761
• Identity: 345/1761 - (19%)
• Similarity: 537/1761 - (30%)
• Gaps: 670/1761 - (38%)

  Fly   465 DCKESGKSGLRMRRKRRASMLLKSSADDTVEDQDI-LQLAGLSLG------QSSEESNE------ 516
            ||..:..|.             |..|.|.:|:|:. ::.|..|.|      |:::.:.:
  Rat    63 DCNSNADSE-------------KWVAGDGLEEQEFSIKEANFSEGSLKLKIQTTKRAKKPPKNLE 114

  Fly   517 -YISKPSLKSLPTTSASKKYGEINRYVTTGQYFGRGGSLSATNPDNFISKMMNQRKETPAPSKSS 580
             ||..|.:|.....|..:|....          |:.|..:.....|...|.:....:..|.....
  Rat   115 NYICPPEIKITIKQSGDQKVSRA----------GKNGKATKEEERNHSKKKLLTASDPAASDLKG 169

  Fly   581 CKIKSRRSSAASMCSSYVSGVSR------MRRRHRRKSFSHNK---SLNIDSKLLTEIEII---- 632
            .:.::...........|..|:|:      ::.:|::||.|.:.   |.|.||...|:..||
  Rat   170 FQTQAYERPQKHSTLQYDPGLSQGFTSDTLKPKHQQKSSSQSHMDWSSNSDSGPATQNCIISPES 234

  Fly   633 ----TSTFN--------SRCRIQDDR-LTG-------SSGKEKLLADANKLQATLAAP-SPAQQL 676
                |||..        |..:.|..: .||       ||.|:.||........:.::| :|:...
  Rat   235 GRDTTSTSKIPALEPVASFAKTQSKKGSTGSTWSQLSSSSKDLLLGSVVPSPGSHSSPATPSNSA 299

  Fly   677 TLNG--------GGPASTLSKP-----LKRGLKKRKLSEPL----VDFAMLSASASGTPNGSGS- 723
            ..||        ||....|.:|     .|:..||..:|:.:    :|:...:..|..|..|...
  Rat   300 ECNGLQPLGDQEGGGTKDLPEPPTISSKKKSSKKDLISQTIPNSDLDWVKSAQKAFETTEGKRET 364

  Fly   724 -SNGNTKRRHKKSQS--------NDSS-------------SPDDHKLPLKKRHYLLTPGERPPAE 766
             |..|.:......||        ||||             .|.:||  .|||..:....|:...|
  Rat   365 YSADNAQETSPTRQSISSVSNPENDSSHVRITIPIKTPSLDPTNHK--RKKRQSIKAVVEKIIPE 427

  Fly   767 VAFANGKLNAEAWAAAAAAAKSTASTKS-------------------QAQFNARSVKSALTPKKR 812
            .|.|:| :...:.......:.|..|.|.                   :...||..:......|:|
  Rat   428 KALASG-ITMSSEVVNRILSNSEGSKKDPRVPKLSKMIENESPSVGLETGANAEKIVPGGVSKQR 491

  Fly   813 HLLEQPTSVSGAGSSASNSPLRIVVDNNSISGGKLLDISPSSLCSLKQQRRGGAAKQKVSAAKDL 877
                :|..|..:.:.|.::|           .|||.:|          |....|||::.|.||
  Rat   492 ----KPPLVMTSPTRAEHAP-----------SGKLPEI----------QHPKFAAKRRCSKAK-- 529

  Fly   878 VQLQSPAGSYPPPGVFEPSVELEIQIPLSKLNESVITKAE---VE----------SPLLS---AL 926
                       ||.:               |.|:|:..||   ||          |||.:   :|
  Rat   530 -----------PPAM---------------LREAVLATAEKLMVEPPSAYPITPSSPLYTNTDSL 568

  Fly   927 DIKEDTKKEVGQ------RVVETLLHKTGGNLLLKRKRKKINRTGFPTVRRKKRKVSVEQQTTAV 985
            .:....||:.|:      ..|||:...|..:.:....|:      ||..:::||:.::.:....|
  Rat   569 TVITPVKKKRGRPKKQPLLTVETIHEGTSTSPVSPISRE------FPGTKKRKRRRNLAKLAQLV 627

  Fly   986 IDEHEPEFDP------------DDEPLQSLRETRSSNNVNVQAAPNPPLDCERVPQAGEARETFV 1038
            ..|.:|..:.            |.:.::::.:.::....|:.   |..|.|.
  Rat   628 PGEDKPMSEMKFHKKVGKLGVLDKKTIKTINKMKTLKRKNIL---NQILSCS------------- 676

  Fly  1039 ARTNQKAPRLSVVALERLQRPQT-PAR---------------------GRPRGRKPKNREQAEAA 1081
                      |.|||:....|:| |..                     |:.|||||:..
  Rat   677 ----------SSVALKAKAPPETSPGAASIESKLGKQINVSKRGTIYIGKKRGRKPRTE------ 725

  Fly  1082 PQPPPKSEPEI-----RPAKKRGRQP------KQPVLEEPPPTPPPQQKKNKMEPNIRLPDGIDP 1135
             .|||..||:.     ||...:...|      :.||...|....|...:......|:   .....
  Rat   726 -LPPPSEEPKTAIKHPRPVSSQPDVPAVPSSFQSPVASSPAAVHPLATQLGGSHGNL---SPAST 786

  Fly  1136 NTNFSCKIRLKRRKNLE--AGTQPKKEKPVQPVTVEEIPPEIPVSQEEIDAEAEAKRLDSIPTEH 1198
            .||||   .||...||:  :....|.:|.:...|.:..||.:..:......|..:.:      |.
  Rat   787 ETNFS---ELKTMPNLQPISALPTKTQKGIHSGTWKLSPPRLMANSPSHLCEIGSLK------EI 842

  Fly  1199 DPLPASESHN----PGPQDYASCSESSEDKA--STTSLRKLS----------------------K 1235
            ...|.||||:    |......:.:.|:.|:|  |:.|.|:.|                      .
  Rat   843 TLSPVSESHSEETIPSDSGIGTDNNSTSDQAEKSSESRRRYSFDFCSLDNPEAIPPDTSTKNRHG 907

  Fly  1236 VKKTYLVAGLFSNHYKQSLMPPPAKVNKK-----------PGLEEQVGPASLLP----------- 1278
            .::.:|:...|..|  :||..|..|..:|           ..|||.:....:..
  Rat   908 HRQKHLIVDTFLAH--ESLKKPKHKRKRKSLQNRDDLQFLAELEELITKFQVFRISHRGYTFYHE 970

  Fly  1279 ---------------PPPYCE----KYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSWNYRKIR 1324
                           |.||.:    .|||||                |.|.::..    ..|..:
  Rat   971 NPYPSIFRINFDHYYPVPYIQYDPLLYLRRT----------------SDLKSKKK----RGRPAK 1015

  Fly  1325 TNVYAESVRPNLAGFDHPTCNCKNQGEKSCLDNCLNRMVYTECSPSNCPAGEKCRNQKIQRHAVA 1389
            ||.....| |.|.||.:|                             .|:|.          ..|
  Rat  1016 TNDTMTKV-PFLQGFSYP-----------------------------IPSGS----------YYA 1040

  Fly  1390 PGVERFMTADKGWGV-RTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHHYCLHLDGGLV 1453
            |           :|: .|.:|:..    |.|.|         |..|.:||:.|
  Rat  1041 P-----------YGMPYTSMPMMN----LGYYG---------QYPAPLYLSHT------------ 1069

  Fly  1454 IDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEEL--TYDYNFSLFNPSEGQ 1516
                 :|:...|:..:..|    .::..:...:|....|...:.|..|  |.........||...
  Rat  1070 -----LGAASPFMRPTVPP----PQFHTSSHVKMSGATKHKAKHGVHLQGTVGMGLGDIQPSLNP 1125

  Fly  1517 PCRCNTPQCRGVIGGKSQRVKPLPAVEAKPSGEGLSGRNGRQRKQKAK-KHAQRQ---------- 1570
            |                           |..|..||.....:||.|.| ||.:.:
  Rat  1126 P---------------------------KVGGAALSSSRLHKRKHKHKHKHKEDRILGTHDNLSG 1163

  Fly  1571 --AGK--DISSAVAVAKLQ------PL-SEKEKKLVRQ------------FNTFLVRNF------ 1606
              |||  ..||.:...:|.      || |||.|...||            .|.|.|...
  Rat  1164 LFAGKATGFSSHLLSERLNSSDKELPLVSEKSKHKERQKHQHGDASHKVSKNNFEVDTLSTLSLS 1228

  Fly  1607 ----------------EKIRRCKAKRASDAAATAS-----------SPALGTTNGDIPG--RRPS 1642
                            |.:..| |||.|.:...::           :|:....:.|:.|  ||..
  Rat  1229 DAQHWTQAKDKGDLSNEPVESC-AKRYSGSGGDSTRSESLDVFSEMNPSSDKWDSDMSGSKRRGF 1292

  Fly  1643 TPSSPSLAAQISALCSPRNIKTRG-----LTQAVHDPELEKMAKMAVVLRDICSAMETLKMSDLL 1702
            ..........|.|.  ..|.|.||     :|..:..|.                    ||:..
  Rat  1293 EGFGTYREKDIQAF--KMNRKERGSYESSMTPGMPSPH--------------------LKVDQ-- 1333

  Fly  1703 TTVSSKKKKPIKTTLSGK------------------LGSTAATS------------KVEFRSIQA 1737
            |||.||.:..:.|.::.|                  |.::||||            :.|..:||.
  Rat  1334 TTVHSKSEGSVSTMMARKKPTAVDSVAIPSAPVLSLLAASAATSDAASSSLKKRFKRREIEAIQC 1398

  Fly  1738 QV-EQGHY----KTPQEFDDHMQQLFVEAKQQHGDDEG-----------KEKALQSLKDSYEQQK 1786
            :| :..||    .|.:.. ||:.::....:.|.....|           :::..|..:||.:|..
  Rat  1399 EVRKMCHYTKLLSTKKNL-DHVNKILKAKRLQRQSKTGNNFVKKRRGRPRKQPSQFDEDSRDQMP 1462

  Fly  1787 IASYVQLVEILGDSESLQSFKPK-EVLSSEEEPGKIAVKKSPGA---KERDSPIVPLKVTPPPLL 1847
            :      :|...|..|.:..||. ..|:.|...|:.||..:..|   ..|::|  ||...||||.
  Rat  1463 V------LEKCIDLPSKRGQKPSLSPLALEPASGQDAVMATIEAVIHMAREAP--PLPPPPPPLP 1519

  Fly  1848 PIEASP 1853
            |....|
  Rat  1520 PPPPPP 1525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	69/362 (19%)
		AWS	1340..1388	CDD:197795	3/47 (6%)
		SET_ASH1L	1391..1531	CDD:380951	22/142 (15%)
		Bromo_ASH1	1680..1787	CDD:99955	29/152 (19%)
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
Setbp1	NP_001414555.1	None