DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ash1 and Nsd3

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	XP_038950324.1	Gene:	Nsd3 / 290831	RGDID:	1308980	Length:	1444	Species:	Rattus norvegicus

Alignment Length:	1589	Identity:	325/1589 - (20%)
Similarity:	534/1589 - (33%)	Gaps:	499/1589 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 YQSTLLQDFMEKTQMLGQTVNAKLAEEKVAKAKEETLVQTAVPRKRR------------GRPKKV 270
            ::|:|..|.:.:.| ..:.:.:| .|.:..|.|:.:..:::...:|:            .||.:.
  Rat   175 FESSLCGDLLNEVQ-ASEHLKSK-HESRKEKRKKSSRHESSRSEERKSHKVPKLEPEGQNRPNER 237

  Fly   271 VPTVPAPGNSGPAINESAD-SGVISTTSTTQSTTPSPKMQNENAV--PTGSL---PIASSSKPKI 329
            |...|......|.:.|:.. ..::|:..||:::| ..|.|..:.|  ..|:.   |...||.|::
  Rat   238 VDPAPEKPREEPVLKEAVPVQPILSSVPTTETST-GVKFQVGDLVWSKVGTYPWWPCMVSSDPQL 301

  Fly   330 D----MAYLDKRMYATERVLYPPPRS----KRRQNNK-------------KTACSSSNKEELQLD 373
            :    :.....|.|..:.....|.|:    ||.:..|             |.|.:.|.|::::..
  Rat   302 EVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHEQYEELLAEAAKQASNHSEKQKIRKP 366

  Fly   374 PLWRE--------------IDVNKKFRLRSMSV------GAASGTGASTTICSKVLAAKSGYVSD 418
            ...||              :.:.::.|:...:.      ...|.:.|..::.||....|.
  Rat   367 RPQRERAQWDIGIAHAEKALQMTREERVEQYTFIYIDKQPEESPSQAKKSVTSKAEVKKP----- 426

  Fly   419 YGSVRHQRSSHNHNSGYKSDASCKSRYSTKSCMSRRSRAKSCGYRSDCKESGKSGLRMRRKRRAS 483
                |..||..|......|.....|..|     |...|.:|....:..:|.|...:::..:..|:
  Rat   427 ----RRPRSVGNSQPEQTSAGEVASPQS-----STDPRRQSQRRHTSVEEDGPPPVKIAWRTAAA 482

  Fly   484 MLLKSSADDTVEDQDILQLAGLSLGQSSEESNEYISKPSLK-----SLPTTSASKKYGEINRYVT 543
            .  ||..            |.:::.:.|.:.::....|.:|     :|...:...|:  |:::|.
  Rat   483 R--KSLP------------ASITMHKGSLDLHKCNMSPVVKIEQVFALQNATGDGKF--IDQFVY 531

  Fly   544 TGQYFGRGGSLSATNPDNFISKMMNQRKETPAPSKSSCKIKSRRSSAASMCSSYVSGVSRMRRRH 608
            :.:..|....:|....|..|....:||.|...||.|..:..|             .....:.::.
  Rat   532 STKGIGNKTEISVRGQDRLIISSPSQRNEKSTPSASPPEATS-------------GSAGPVEKKQ 583

  Fly   609 RRKSFSHNKSLNIDSKLLTEIEIITSTFNSRCRIQDDRLTGSSGKEKLLADANKLQATLAAPSPA 673
            :|:|.                         |.|.:.::.|....|:|:    .|.|....:|..:
  Rat   584 QRRSI-------------------------RTRSESEKSTEVVSKKKI----KKEQQVETSPQAS 619

  Fly   674 QQLTLNGGGPASTLSKPLKRGLKKRKLSEPLVDFAMLSASASGTPNGSGSSNGNTKRRHKKSQSN 738
            .:..|..|  ||.:|...| .||||..:...|:      :||.|              ::.:..:
  Rat   620 LKTGLQKG--ASEISDSCK-PLKKRSRASTDVE------TASCT--------------YRDTSDS 661

  Fly   739 DSSSPDDHKLPLKKRHYLLTPGERPPAEVAFANGKLNAEAWAAAAAAAKSTASTKSQAQFNARSV 803
            ||..|.|                   .:|.|  || ..::.:|||.|..|          :|:||
  Rat   662 DSRGPSD-------------------GQVGF--GK-QVDSPSAAADADAS----------DAQSV 694

  Fly   804 KSALTPKKRHLLEQPTSVSGAGSSASNSPLRIVVDNNSISGGKLLDISPSSLCSLKQQRRGGAAK 868
            .|:|:.:            |.|.|..:                       ::|.:.:
  Rat   695 DSSLSRR------------GVGLSKKD-----------------------TVCQVCE-------- 716

  Fly   869 QKVSAAKDLVQLQSPAGSYPPPGVFEPSVELEIQIPLSKLNESVITKAEVE-------SPLLSAL 926
               :....||..:.....:     |.|..     :.|:.:.|...|..|.|       |..:|..
  Rat   717 ---NTGDSLVACEGECCRH-----FHPEC-----LGLAAVPEGRFTCEECETGQHPCFSCKVSGK 768

  Fly   927 DIKEDTKKEVGQRVVETLLHKTGGNLLLKRKRKKINRTGFPTVRRKKRKVSVEQQTTAVI----D 987
            |:|..:....|:...|..:.|                  |||...:.:.....|...:..    |
  Rat   769 DVKRCSVSVCGKFYHEACVRK------------------FPTAIFESKGFRCPQHCCSSCSMEKD 815

  Fly   988 EHEPEFDPDDEPLQSLRETRSSNNVNVQAAPNPPLDCERVPQAGEARETFVARTNQKAPRLSVVA 1052
            .|                         :|:....:.|.|.|.|....:..||..:.......::.
  Rat   816 IH-------------------------KASKGRMMKCLRCPIAYHFGDACVAAGSVSVSSHILIC 855

  Fly  1053 LERLQRPQTPARGR-------PRG---------------------RKPKNREQAEAAPQPPPKSE 1089
            ....:|....|...       .||                     ....||.:....|..|..|.
  Rat   856 SNHSKRSSHSAAINVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLSESNRAELMKLPMIPSSSA 920

  Fly  1090 PEIRPAKKRGRQPKQPVL--EEPPPTPPPQQKKNKMEPNIRLPDGIDPNTNFSC-------KIRL 1145
            .:.| .:|.||     :|  |..|.:..|:..      :|.:|:|.     ::|       |:..
  Rat   921 SKKR-CEKGGR-----LLCCESCPASFHPECL------SIDMPEGC-----WNCNDCKAGKKLHY 968

  Fly  1146 KRRKNLEAGTQPKKEKPVQPVTVEEIPPEIPVSQEEIDAEAEAKRLDSIPT----EHD------- 1199
            |:...::.|..  :..|.:..:...:|         ::.:.....:...|.    .||
  Rat   969 KQIVWVKLGNY--RWWPAETCSPRSVP---------LNIQGLKHGVGDFPVLFFGSHDYYWVHQG 1022

  Fly  1200 -PLPASESHNPGPQDYASCSESSEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQSLMPPPAKVNK 1263
             ..|..|    |..::|. .::|.:|   |..:.|.:..|.:           |.|   .|:...
  Rat  1023 RVFPYVE----GDTNFAE-GQTSINK---TFKKALEEAAKRF-----------QEL---KAQRES 1065

  Fly  1264 KPGLEEQVGPASLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSWNYRKIRTNVY 1328
            |..||  :...|..|||                                       |:.|:.|..
  Rat  1066 KEALE--IEKTSRKPPP---------------------------------------YKHIKANKV 1089

  Fly  1329 AESVRPNLAGFDH-PTCNCKNQGEKSC-LDN-CLNRMVYTECSPSNCPAGEKCRNQKIQRHAVAP 1390
            ...|:..:|.... |.||||...|..| |:: |||||...||.|..||||::|:||...:. :.|
  Rat  1090 IGKVQIQVADLSEIPRCNCKPGDENPCGLESECLNRMSQYECHPQVCPAGDRCQNQCFTKR-LYP 1153

  Fly  1391 GVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLND-THHYCLHLDGGLVI 1454
            ..|...|..:|||:|||..|.||.::.|||||::.|:|.:.|:...:.|. |:.|.|.:....:|
  Rat  1154 DAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRII 1218

  Fly  1455 DGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQP-C 1518
            |....|:..||:||||.||||.|||:|||..|:.|||...|..|.|||::||....  ..|:. |
  Rat  1219 DAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCL--GNGRTVC 1281

  Fly  1519 RCNTPQCRGVIGGKSQRVKP----LPAVEAKPSGEGLSGRNGRQRKQKAKK-HAQR--QAG---- 1572
            .|....|.|.:|     |:|    ..|.:.|.....|..|  |:.|.:||: |...  |.|
  Rat  1282 HCGADNCSGFLG-----VRPKSACTSAADEKTKNAKLKKR--RRGKAEAKQIHEDYCFQCGDGGE 1339

  Fly  1573 ------KDISSAVAVAKL---QPLSEKEK----------KLVRQFNTFLVRNFEKIRRCKAKRAS 1618
                  ||...|..:..|   ||...|.:          .....|..|...:|     |||....
  Rat  1340 LVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQCDECGSAAISFCEFCPHSF-----CKAHEKG 1399

  Fly  1619 DAAATASSPALGTTNGDIPGRRPSTPSSP 1647
            ....:|....|..:|.|     |::|.||
  Rat  1400 ALVPSALEGRLCCSNHD-----PASPVSP 1423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795	23/50 (46%)
		SET	1392..1512	CDD:214614	53/120 (44%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
Nsd3	XP_038950324.1	MSH6_like	274..390	CDD:99898	21/115 (18%)
		PHD1_NSD3	711..753	CDD:277119	8/62 (13%)
		PHD2_NSD3	759..805	CDD:277122	10/63 (16%)
		PHD_SF	806..858	CDD:419867	9/76 (12%)
		PHD4_NSD3	925..960	CDD:277128	11/50 (22%)
		WHSC1_related	966..1059	CDD:99899	17/122 (14%)
		AWS	1112..1150	CDD:407759	18/37 (49%)
		SET_NSD3	1152..1293	CDD:380989	59/142 (42%)
		PHD5_NSD3	1330..1372	CDD:277131	9/41 (22%)
		C5HCH	1371..1420	CDD:407828	11/58 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D507784at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920