DRSC/TRiP Functional Genomics Resources

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Protein Alignment ash1 and SETD2

DIOPT Version :10

Sequence 1:NP_524160.2 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster
Sequence 2:NP_054878.5 Gene:SETD2 / 29072 HGNCID:18420 Length:2564 Species:Homo sapiens


Alignment Length:2511 Identity:521/2511 - (20%)
Similarity:857/2511 - (34%) Gaps:783/2511 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 VQRSDTDGLRMRISAIRPTLGVVATKKPPKSRKMSTQDTESGCSEAKNRAVSKKVKVKRKKLASS 114
            :|...|..::|.|.   .||.......|||||      .|.|....|...:.   ...|..||::
Human   108 LQVDSTPKMKMEIG---DTLSTAEESSPPKSR------VELGKIHFKKHLLH---VTSRPLLATT 160

  Fly   115 SG--------------ISKSDKVSKSKKS--------QISAFSSDSEDDLPLKVHQQRAPRVLLS 157
            :.              |::|..|.....|        |.:..||      |..|.:   |..|..
Human   161 TAVASPPTHAAPLPAVIAESTTVDSPPSSPPPPPPPAQATTLSS------PAPVTE---PVALPH 216

  Fly   158 AIIQAAQSASKP-TLDIGISSSDNELPNLVQAAIKRVESDTEDTTVEGSFRKAAKDKNLPQYQST 221
            ..|....:|..| .:|:.:.|. .|.|.::  ..:.:|:||:..|:..|..:             
Human   217 TPITVLMAAPVPLPVDVAVRSL-KEPPIII--VPESLEADTKQDTISNSLEE------------- 265

  Fly   222 LLQDFMEKTQMLGQTVNAKLAEEKVAKAKEETLVQT---AVPRKRRGRPKKVVPTVPAPGNSGPA 283
                  ..||:|.:..:....:|.....|:|.:..:   ::..|:.|..||      :..:.|..
Human   266 ------HVTQILNEQADISSKKEDSHIGKDEEIPDSSKISLSCKKTGSKKK------SSQSEGIF 318

  Fly   284 INESADSGVISTTSTTQS--TTPSPKMQNENAVPTGSLPIASSSKPKIDMAYLDKRMYATERVLY 346
            :...:|...:.|:|:.:|  ...|..::.|......|.|:.|....|                  
Human   319 LGSESDEDSVRTSSSQRSHDLKFSASIEKERDFKKSSAPLKSEDLGK------------------ 365

  Fly   347 PPPRSKRRQNNKKTACSSSNKEELQLDPLWREIDVNKKFRLRSMSVGAASGTGASTTICSKVLAA 411
             |.|||..:::|..:.|...::...:....|    :::.|.||.| .:.|..|:.|.: |...:.
Human   366 -PSRSKTDRDDKYFSYSKLERDTRYVSSRCR----SERERRRSRS-HSRSERGSRTNL-SYSRSE 423

  Fly   412 KSGYVSDYGSVR--HQRSSHNHNSGY-------KSDASCKSRYSTKSCMSRRSRAKSCGYRS--- 464
            :|.|   |.|.|  |:.|.:...:.|       ::..|..|....|...|||:.:.|..||.   
Human   424 RSHY---YDSDRRYHRSSPYRERTRYSRPYTDNRARESSDSEEEYKKTYSRRTSSHSSSYRDLRT 485

  Fly   465 --------DCKESGKSGLRMRRKRRASMLLKSSADDTVEDQDILQLA----------GLSLGQSS 511
                    ||| :..|.|.|.|:.:.|..|:..:..|.|::.|.:..          |.|..:..
Human   486 SSYSKSDRDCK-TETSYLEMERRGKYSSKLERESKRTSENEAIKRCCSPPNELGFRRGSSYSKHD 549

  Fly   512 EESNEY---ISKPSLKSLPTTSASKK---YGEINRYVTTGQYF------GRGGSLSATNPDNFIS 564
            ..::.|   :|||    :|.:...|.   ..|:|..:.....|      .:|..|          
Human   550 SSASRYKSTLSKP----IPKSDKFKNSFCCTELNEEIKQSHSFSLQTPCSKGSEL---------- 600

  Fly   565 KMMNQRKE-----TPAPSKSSCKIKSRRSSAASMCSSYVSGVSRMRRRHRRKSFSHNKSLNIDSK 624
            :|:|:..|     :||||       :|.:.:.::                              |
Human   601 RMINKNPEREKAGSPAPS-------NRLNDSPTL------------------------------K 628

  Fly   625 LLTEIEIITSTF------------NSRCRIQDDRL----------TGSSGKEKLLAD--ANKLQA 665
            .|.|:.|..|.|            :|..::::|:|          .||.|.|..||.  .:|..|
Human   629 KLDELPIFKSEFITHDSHDSIKELDSLSKVKNDQLRSFCPIELNINGSPGAESDLATFCTSKTDA 693

  Fly   666 TLAAPSPAQQLTLNGGGPASTLSKPLKRGLKKRKLSEPLVDFAMLSASASGTPNGSGSSN---GN 727
            .|        :|.:.....|.||              |||...||  |::|..|.|....   .:
Human   694 VL--------MTSDDSVTGSELS--------------PLVKACML--SSNGFQNISRCKEKDLDD 734

  Fly   728 TKRRHKKSQS-----NDSSSPDDHKL---PLKKRHYLLTPGERP-PAEVAFANGK---------- 773
            |...||||:|     ....||...||   |:....|..|..:.| ...|:....|          
Human   735 TCMLHKKSESPFRETEPLVSPHQDKLMSMPVMTVDYSKTVVKEPVDTRVSCCKTKDSDIYCTLND 799

  Fly   774 -----LNAEAWAAAAAAAKSTAS----------------------TKSQAQFNARSVKSALTPKK 811
                 .|:||.....:..|.:::                      :|...:...:|:.|..:...
Human   800 SNPSLCNSEAENIEPSVMKISSNSFMNVHLESKPVICDSRNLTDHSKFACEEYKQSIGSTSSASV 864

  Fly   812 RHL--LEQPTSVSGAGSSASNSPLRIVVD---------NNS------------------------ 841
            .|.  |.||...||..||..:.|..|.||         |.|                        
Human   865 NHFDDLYQPIGSSGIASSLQSLPPGIKVDSLTLLKCGENTSPVLDAVLKSKKSSEFLKHAGKETI 929

  Fly   842 ISGGKLLDISPSSLCSLKQQRRGGAAKQKVSAAKDLVQLQSPAGSYPPPGVFEPSVELEIQ---- 902
            :..|..|..|.....|.:.:|..|.      :.|.|.:.|....|..|.....|.:.|:.:    
Human   930 VEVGSDLPDSGKGFASRENRRNNGL------SGKCLQEAQEEGNSILPERRGRPEISLDERGEGG 988

  Fly   903 -IPLSKLNESVITKAEVESPLLSALD-------IKEDTKKEVGQRVVETLLHKTGGNLLLKRKRK 959
             :..|..:|.|.:..::.   |:..|       :|.|:.....: :|.|:.....|:........
Human   989 HVHTSDDSEVVFSSCDLN---LTMEDSDGVTYALKCDSSGHAPE-IVSTVHEDYSGSSESSNDES 1049

  Fly   960 KINRT-----GFPTVRRKKRKVSVEQQTTAVIDEHEP----------EFDP--DDEPLQSLRETR 1007
            ....|     ..|. .|.:..|.|.:.:|..::|..|          .:..  :||.|:|.|...
Human  1050 DSEDTDSDDSSIPR-NRLQSVVVVPKNSTLPMEETSPCSSRSSQSYRHYSDHWEDERLESRRHLY 1113

  Fly  1008 SSNNVNVQAAPNPPLDCERVPQAGEARETFVARTNQKAPRLSVVALERLQ-RPQTPARGRPR--G 1069
            .....::.:...|..|           :.|:.:..:|.|.:|.....|.| ..:.|....|:  |
Human  1114 EEKFESIASKACPQTD-----------KFFLHKGTEKNPEISFTQSSRKQIDNRLPELSHPQSDG 1167

  Fly  1070 RKPKNREQAEAAPQPPPKSEPEIRPAKKRGRQPKQ-PVLE---EPPPTPPPQQKKNKMEPNIRL- 1129
            ....:....::.|...|.||..:: ||...||.:: |:..   |..|....||...:..|:.|| 
Human  1168 VDSTSHTDVKSDPLGHPNSEETVK-AKIPSRQQEELPIYSSDFEDVPNKSWQQTTFQNRPDSRLG 1231

  Fly  1130 --------------PDGI-----------------------DPNTNFSCKIRLKRRKNLE--AGT 1155
                          .||:                       .|::::......|.::|.|  .||
Human  1232 KTELSFSSSCEIPHVDGLHSSEELRNLGWDFSQEKPSTTYQQPDSSYGACGGHKYQQNAEQYGGT 1296

  Fly  1156 Q----------PKKEKPVQP---VTVEEIPPEIPVSQEEIDAEAEAKRLDSIPTEHDPLPASESH 1207
            :          |:..:|  |   |..:....::|               ||:..:.:     |..
Human  1297 RDYWQGNGYWDPRSGRP--PGTGVVYDRTQGQVP---------------DSLTDDRE-----EEE 1339

  Fly  1208 NPGPQDYASCSESSEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQSLMPPPAKVNKKPGLEEQVG 1272
            |...||.:..|:.| ||    .|..|.|.|.:.....:.||..|.:|     .||:|....:.:.
Human  1340 NWDQQDGSHFSDQS-DK----FLLSLQKDKGSVQAPEISSNSIKDTL-----AVNEKKDFSKNLE 1394

  Fly  1273 PASLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVV-------------------PS- 1317
            ...:....| .:|..:..|.|.|         ::.:|..|..|                   || 
Human  1395 KNDIKDRGP-LKKRRQEIESDSE---------SDGELQDRKKVRVEVEQGETSVPPGSALVGPSC 1449

  Fly  1318 ----------WN-----------YRKIRTNVYAESVRPNLAGFD--HPTCNC-------KNQGEK 1352
                      |.           :..|..|||....:.|.:..|  ...|.|       :.|||.
Human  1450 VMDDFRDPQRWKECAKQGKMPCYFDLIEENVYLTERKKNKSHRDIKRMQCECTPLSKDERAQGEI 1514

  Fly  1353 SCLDNCLNRMVYTECSPSNCPAGEKCRNQKIQR--HAVAPGVERFMTADKGWGVRTKLPIAKGTY 1415
            :|.::||||::..||| |.||.|:.|.|::.||  ||   .||..:|..||||:|....:...|:
Human  1515 ACGEDCLNRLLMIECS-SRCPNGDYCSNRRFQRKQHA---DVEVILTEKKGWGLRAAKDLPSNTF 1575

  Fly  1416 ILEYVGEVVTEKEFKQRMASIYLN-DTHHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKW 1479
            :|||.|||:..||||.|:.....| :.|:|.:.|....:||..:.|:..||:|||||||||.|||
Human  1576 VLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQKW 1640

  Fly  1480 SVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCRGVIGGKSQRVKPLPAVEA 1544
            :|||..|:..|..:.:..|.|||:||.|..:. .|.|.|.|.:..|||.:||:::       |..
Human  1641 TVNGQLRVGFFTTKLVPSGSELTFDYQFQRYG-KEAQKCFCGSANCRGYLGGENR-------VSI 1697

  Fly  1545 KPSGEGLSGRNGRQRKQKAKK--------HAQRQAGKDISSAVAVAKLQPLSEKEKKLVRQFNTF 1601
            :.:|       |:.:|::::|        .|..:.|:.:|....|..|..|..:.:.|.::....
Human  1698 RAAG-------GKMKKERSRKKDSVDGELEALMENGEGLSDKNQVLSLSRLMVRIETLEQKLTCL 1755

  Fly  1602 -LVRNFEKIRRCKA--KRASDAAATASSPALGTTNGDIPGRRPSTPSSPSLAAQISALCSPRNIK 1663
             |::|.......|:  :|...:........||      .||.    |:..|..:|........|.
Human  1756 ELIQNTHSQSCLKSFLERHGLSLLWIWMAELG------DGRE----SNQKLQEEIIKTLEHLPIP 1810

  Fly  1664 TRGLTQAVHDPELEKMAKMAVVLR--DICSAMETLKMSDLLTTV-SSKKKKPIKT-TLSGKLGST 1724
            |:.:        ||:...:.::.|  ...:|:..|...|..::. :|:...|:.| ..|.||.:.
Human  1811 TKNM--------LEESKVLPIIQRWSQTKTAVPPLSEGDGYSSENTSRAHTPLNTPDPSTKLSTE 1867

  Fly  1725 AAT---SKVEFRSIQAQVEQGHYKTPQEFDDHMQQLFVEAKQQHGDDEGKEKALQSLKD--SYEQ 1784
            |.|   .|:.||.::...|           :.|.....:|..:....:|||. |..|::  ..|:
Human  1868 ADTDTPKKLMFRRLKIISE-----------NSMDSAISDATSELEGKDGKED-LDQLENVPVEEE 1920

  Fly  1785 QKIASY----VQLVEILGDSESLQSFKPKEVLSSE-EEPGKIAVKKSPGAKERDSPIVPLKVTPP 1844
            :::.|.    .||.|...|||:  :.:..::.:|| |...:|..|:|.|.|..:           
Human  1921 EELQSQQLLPQQLPECKVDSET--NIEASKLPTSEPEADAEIEPKESNGTKLEE----------- 1972

  Fly  1845 PLLPI-EASPDEDVIRCICGLYKDEGLMIQCSKCMVWQHTECTKADIDADNYQCERCEPREVDRE 1908
               || |.:|.:|         ::||:                 :|::::..|      .:.|:.
Human  1973 ---PINEETPSQD---------EEEGV-----------------SDVESERSQ------EQPDKT 2002

  Fly  1909 IPLEEFTEEGHRYYLSLMRGDLQVRQGDAVYVLRD---IPIKDESGKVLPTKKHTYETIGAIDY- 1969
            :.:                .||..:..|:...|::   ||.|.::.|...|.:...:.:|..|. 
Human  2003 VDI----------------SDLATKLLDSWKDLKEVYRIPKKSQTEKENTTTERGRDAVGFRDQT 2051

  Fly  1970 ---------QECDIFRVEHLWKNELGKR--------FIFGHHFLRPHETFHEPSRRFYPNEVVRV 2017
                     :|.|  ..:.....|..||        ..:.....||.:.:..|:.:    :.||:
Human  2052 PAPKTPNRSRERD--PDKQTQNKEKRKRRSSLSPPSSAYERGTKRPDDRYDTPTSK----KKVRI 2110

  Fly  2018 SLYEVVPIELVIGRCWVLDRTTFCKGRPMECNDEDHCYICELRVDKTARFFSKAKANHPACTKSY 2082
            .                 ||.                   :|..::..:.|.:..|...|..:..
Human  2111 K-----------------DRN-------------------KLSTEERRKLFEQEVAQREAQKQQQ 2139

  Fly  2083 AFRKFPEKIKI---SKSY-APHD--------------VDPS-------LLKTRKQKTELDVGAGP 2122
            ..:.......:   |..| |||.              ||||       ||.|    ..:|....|
Human  2140 QMQNLGMTSPLPYDSLGYNAPHHPFAGYPPGYPMQAYVDPSNPNAGKVLLPT----PSMDPVCSP 2200

  Fly  2123 TTMHKVSGRQEQHQAKMVGRKPRGISAPADATAV-HVVTPV 2162
            ...        .|...:||.....:|||.....| ||..||
Human  2201 APY--------DHAQPLVGHSTEPLSAPPPVPVVPHVAAPV 2233

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ash1NP_524160.2 PHA03247 <1018..1281 CDD:223021 61/322 (19%)
AWS 1340..1388 CDD:197795 23/58 (40%)
SET_ASH1L 1391..1531 CDD:380951 60/140 (43%)
Bromo_ASH1 1680..1787 CDD:99955 24/115 (21%)
PHD_ASH1L 1858..1900 CDD:277023 4/41 (10%)
BAH_polybromo 1929..2073 CDD:240068 25/164 (15%)
SETD2NP_054878.5 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 180..211 8/39 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 272..561 65/323 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 607..626 6/25 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 964..995 5/30 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1036..1101 9/65 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1133..1233 24/100 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1264..1352 18/109 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1393..1443 8/59 (14%)
Interaction with TUBA1A. /evidence=ECO:0000269|PubMed:27518565 1418..1714 102/314 (32%)
AWS 1495..1549 CDD:197795 21/54 (39%)
SET_SETD2 1549..1690 CDD:380949 62/144 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1831..1872 11/40 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1921..2142 52/326 (16%)
Low charge region. /evidence=ECO:0000269|PubMed:16118227 2137..2366 25/109 (23%)
WW 2391..2420 CDD:459800
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2439..2465
Interaction with POLR2A. /evidence=ECO:0000269|PubMed:16314571 2457..2564
SRI 2467..2555 CDD:462404
Blue background indicates that the domain is not in the aligned region.

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