DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ash1 and lin-59

DIOPT Version :9

Sequence 1:NP_001246834.1 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster
Sequence 2:NP_491206.1 Gene:lin-59 / 266825 WormBaseID:WBGene00003040 Length:1312 Species:Caenorhabditis elegans


Alignment Length:1560 Identity:342/1560 - (21%)
Similarity:546/1560 - (35%) Gaps:495/1560 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   703 PLVDFAMLSASASGTPNGSGSSNGNTKRRHKKSQSN-----DSSSPDDHKLPLKKRHYLLTPGER 762
            |....|..|.|:||..|.||.|.|:      :.|.|     :|....|:.|             .
 Worm    53 PTTTSAAASTSSSGGSNSSGGSGGH------RQQGNILRIGNSIKIGDNIL-------------E 98

  Fly   763 PPAEVAFANGKLNAEAWAAAAAAAKSTASTKSQAQFNARSVKSALTP-------KKRHLLEQPTS 820
            |...:.|:  :.:...|    ...:...:..:.|...|.......||       .:...:.||  
 Worm    99 PAGTLVFS--QADGTPW----TGQRIVVNGSTHAVVKANLFPIGTTPPVLNMQSNQNWYMNQP-- 155

  Fly   821 VSGAGSSASNSPLRIVVDNNSI---SGGKLLDISPSSLCSL-----------KQQRRGGAAK--- 868
             ||....:||:|    ...:|.   ||.:.:..||.|....           .::...|.|.   
 Worm   156 -SGTVPMSSNAP----ATTSSATPDSGIQSVPTSPPSPSYAMMNDVDIGDHDDEEDDDGPADFTD 215

  Fly   869 ----QKVSAAKDLVQLQSPAGSY-PPPGVFEPSVELEIQIPLSKLNESVITKAEVESPLLSALDI 928
                :.|....|...:  |..|. |||....|::        :.:..|..|.|..:..|.:.:::
 Worm   216 MPLLKPVDEDDDCYDV--PCTSEGPPPNNSNPAI--------TTIPSSCSTPAPPKESLPTGMNV 270

  Fly   929 KEDTKKEVGQRVVETLLHKTGGNLLL--KRKRKKINRTGFPTVRR--------------KKRKVS 977
            :|                  .|:.|:  ...|::|       |||              :.|::|
 Worm   271 EE------------------WGSFLIASNMDREEI-------VRRLMAHDPEMAKAIAMRIRELS 310

  Fly   978 VEQQTTAVIDEHEPEFDPDDEPLQSLRETRSSNNVNVQAAPNPPLDCERVPQAGEARETFVARTN 1042
            .|:....  .:.|.|...........|.||:.|....::..:|.:....:|:             
 Worm   311 AEESKKK--KDMEAEVSSTTPTTPRARGTRTRNKCATRSTNSPDVTTSNLPE------------- 360

  Fly  1043 QKAPRLSVVALERLQRPQTPARGRPRGRKPKNR-----EQAEAAPQPPPKSEPEIR----PAKKR 1098
              .|..|.:.|.:.........|:.||||||.|     |..|.......||:.|..    |....
 Worm   361 --EPSTSTMGLVKENEDVEKVEGKRRGRKPKKRRGFHKESFEDLESDAKKSKAEQHEDHLPEASC 423

  Fly  1099 GRQPKQPVLEEPPPTPPPQQKKNKMEPNIRLPDGIDPNTNFSCKIRLKRRKNLEAGTQPKKEKPV 1163
            ..:|:..:   |||..|.|                     |..|:|....:.||..|| |..:.:
 Worm   424 SSRPESVI---PPPVDPIQ---------------------FRLKVREMMERKLEQLTQ-KMSEDM 463

  Fly  1164 QPVTVEEIPPEIPVSQE----------EIDAEAE---------AKRLDSIPTEHDPLPASESHNP 1209
            ..:.:..:.....|:.|          :::.:::         .|||....||.|.|        
 Worm   464 TELRLSHLTSSKMVNGERGKRRESFLRQLNEQSKKLRKGGMLGRKRLRMFMTESDIL-------- 520

  Fly  1210 GPQDYASCSESSEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQSLMPPPAKVNKKPGLEEQVGPA 1274
                     |.::|           .:||          ..|:...|||.|:..:........|:
 Worm   521 ---------EENKD-----------NIKK----------EVKEESTPPPTKLRGRLPSRRTREPS 555

  Fly  1275 SLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSWNYRKIRTNVYAESVRPNLAGF 1339
            .::.|.|        .|..|...|   :..|.|...:.:::|.|             :.|:|   
 Worm   556 EIVNPEP--------VEKKFNGEY---FEITKSVPSSDDIIPLW-------------MAPSL--- 593

  Fly  1340 DHPTCNCKNQGEKSCLDNCLNRMVYTECSPSNCPAGEKCRNQKIQRH--------AVAPGVERFM 1396
               ||.|......|.:| ||||.:..:|| |:|.. ..|.|::..:.        :..|..:|.:
 Worm   594 ---TCGCTKGACTSDMD-CLNRALRVQCS-SDCSV-PYCSNRRFWKEDCGNKLCVSNGPRSKRVL 652

  Fly  1397 TADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHHYCLHLDGGLVIDGQRMGS 1461
                    :||:....|.::.||.|||:|.::.:::.|    .|.....:.:...|.:|..:..:
 Worm   653 --------KTKIARRAGEFLCEYAGEVITREQAQEKFA----QDRDPRIIAIAAHLFVDATKRSN 705

  Fly  1462 DCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCR 1526
            ..||:.|||:||..::.|||||..|..:||...:....|:|.|.:..|  |.: ..|.|...:|:
 Worm   706 IARFIKHSCKPNSRLEVWSVNGFYRAGVFALSDLNPNAEITVDKSDLL--PFD-MACNCGATECK 767

  Fly  1527 GVIGGKSQRVKPLPAVEAKPSGEGLSGRNGRQRKQKAKKHAQRQAGKDISSAVAVAKLQPLSEKE 1591
            .||.|...|.       |.|:                                           |
 Worm   768 RVIRGVRWRC-------ADPN-------------------------------------------E 782

  Fly  1592 KKLVRQFNTFLVRNFEKIRRCKAKRASDAAATASSPALGTTNGDIPGRRPSTPSSPSLAAQISAL 1656
            |.:.|:   |::||    ||...:|:|.:..    ||:..|..|                     
 Worm   783 KIVTRR---FVIRN----RRKTIERSSHSGL----PAILQTPMD--------------------- 815

  Fly  1657 CSPRNIKTRGLTQAVHDPELEKMAKMAVVLRDICSAMETLKMSDLLTTVSSKKKKPIKTTLSGKL 1721
               .|...|                              |||..:|...:.:.:|     :.|.:
 Worm   816 ---ENSSIR------------------------------LKMKQVLAAFAFRVRK-----IDGSM 842

  Fly  1722 GSTAA---TSKVEFRSIQAQVEQGHYKTPQEFDDHMQQLFVEAKQQHGDDEGKEKALQSLKDSYE 1783
            ..|..   |..::|..     .:|:...|.||....:: ::||.    ||:..|:|..:::..|.
 Worm   843 SRTMLPHYTLIIKFLK-----TKGNNPNPVEFVSLFRK-WLEAI----DDDDLERAFVAIESHYM 897

  Fly  1784 QQKIASYVQLVEILGDSESLQSFKPKEVLSSEEEPGKIAVKKS-PG---AKERDSPIVPLKVTPP 1844
            ...|.           |.||||.|.|     :..|...|:..| |.   :|..|:.:..|:    
 Worm   898 SSSIL-----------SSSLQSKKAK-----DNAPRARALSTSCPSPVPSKRGDADLSYLE---- 942

  Fly  1845 PLLPIEA-SPDE-----------DVIRCICGLYKDEGLMIQCSKCMVWQHTECTKADI------- 1890
            .|.||.: .||:           :.:|||||...:||.|:||..|..|.|.:|.:..:       
 Worm   943 SLYPIGSYDPDDAWESYSTNKKGNAVRCICGALDEEGTMVQCDTCHFWLHVDCCQYVVRSNEKAQ 1007

  Fly  1891 -------DADNYQCERCEPRE----VDREIPLEEFTE---EGHRYYLSLM-RGDLQVRQGDAVYV 1940
                   |...|.|:.|..::    ...::.|.|..:   |...||.||: |..:||...:.|||
 Worm  1008 KSKNPPSDDGEYICDFCTNKQNGLRPSADVKLTEQPDVRFENCDYYRSLINRRGIQVVLNETVYV 1072

  Fly  1941 LRDIP---------IKDE--SGKVLPTKKHTYE-------TIGAIDYQECDIFRVEHLWKNELGK 1987
            .|.:|         :::|  ..|...|.|:.:.       .|..:|.:...|||||.|:......
 Worm  1073 NRVLPEDHKAMLRNLREEKKGSKQKDTNKYRFPKAATSPLPIEKVDRKNARIFRVERLFVCPGNN 1137

  Fly  1988 RFIFGHHFLRPHETFHEPSRRFYPNEVVRVSLYEVVPIELVIGRCWVLDRTTFCKGRP-MECNDE 2051
            ||:||..:..||||:.:..|.|...||.....||.:|::.|||||.|||..|:||||| :....|
 Worm  1138 RFVFGSFYAWPHETYADAGRVFSKKEVFATPYYETLPLDEVIGRCLVLDTATWCKGRPKVPKFKE 1202

  Fly  2052 DHCYICELRVDKTARFFSKA--KANHPACTKSYAFRKFPEKIKISKSYAPHDVDPSLLKTRKQKT 2114
            |..::||:::.||.|.|.|.  |..:|..|.||.|.:|....|:.:.:.|:  |||....:..||
 Worm  1203 DDVFLCEMQIGKTQRVFEKVPPKNRYPINTNSYVFTEFTHPKKVVRDFRPY--DPSNPSPKPPKT 1265

  Fly  2115  2114
             Worm  1266  1265

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ash1NP_001246834.1 AWS 1340..1388 CDD:197795 15/55 (27%)
SET 1392..1512 CDD:214614 33/119 (28%)
Bromo_ASH1 1680..1787 CDD:99955 20/109 (18%)
PHD_ASH1L 1858..1900 CDD:277023 17/55 (31%)
BAH_polybromo 1929..2073 CDD:240068 57/164 (35%)
lin-59NP_491206.1 AWS 591..636 CDD:197795 17/53 (32%)
SET 638..748 CDD:214614 32/121 (26%)
PHD 970..1027 CDD:279022 17/56 (30%)
BAH_polybromo 1118..1222 CDD:240068 44/103 (43%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 91 1.000 Domainoid score I4909
eggNOG 1 0.900 - - E2759_KOG1083
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0.721928 Normalized mean entropy S5577
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0007422
OrthoInspector 1 1.000 - - oto18402
orthoMCL 1 0.900 - - OOG6_106446
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 1 1.000 - - X5557
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
98.690

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