Protein Alignment ash1 and lin-59

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: NP_491206.1
• Gene: lin-59 / 266825
• WormBaseID: WBGene00003040
• Length: 1312
• Species: Caenorhabditis elegans
• Alignment Length: 1560
• Identity: 342/1560 - (21%)
• Similarity: 546/1560 - (35%)
• Gaps: 495/1560 - (31%)

  Fly   703 PLVDFAMLSASASGTPNGSGSSNGNTKRRHKKSQSN-----DSSSPDDHKLPLKKRHYLLTPGER 762
            |....|..|.|:||..|.||.|.|:      :.|.|     :|....|:.|             .
 Worm    53 PTTTSAAASTSSSGGSNSSGGSGGH------RQQGNILRIGNSIKIGDNIL-------------E 98

  Fly   763 PPAEVAFANGKLNAEAWAAAAAAAKSTASTKSQAQFNARSVKSALTP-------KKRHLLEQPTS 820
            |...:.|:  :.:...|    ...:...:..:.|...|.......||       .:...:.||
 Worm    99 PAGTLVFS--QADGTPW----TGQRIVVNGSTHAVVKANLFPIGTTPPVLNMQSNQNWYMNQP-- 155

  Fly   821 VSGAGSSASNSPLRIVVDNNSI---SGGKLLDISPSSLCSL-----------KQQRRGGAAK--- 868
             ||....:||:|    ...:|.   ||.:.:..||.|....           .::...|.|.
 Worm   156 -SGTVPMSSNAP----ATTSSATPDSGIQSVPTSPPSPSYAMMNDVDIGDHDDEEDDDGPADFTD 215

  Fly   869 ----QKVSAAKDLVQLQSPAGSY-PPPGVFEPSVELEIQIPLSKLNESVITKAEVESPLLSALDI 928
                :.|....|...:  |..|. |||....|::        :.:..|..|.|..:..|.:.:::
 Worm   216 MPLLKPVDEDDDCYDV--PCTSEGPPPNNSNPAI--------TTIPSSCSTPAPPKESLPTGMNV 270

  Fly   929 KEDTKKEVGQRVVETLLHKTGGNLLL--KRKRKKINRTGFPTVRR--------------KKRKVS 977
            :|                  .|:.|:  ...|::|       |||              :.|::|
 Worm   271 EE------------------WGSFLIASNMDREEI-------VRRLMAHDPEMAKAIAMRIRELS 310

  Fly   978 VEQQTTAVIDEHEPEFDPDDEPLQSLRETRSSNNVNVQAAPNPPLDCERVPQAGEARETFVARTN 1042
            .|:....  .:.|.|...........|.||:.|....::..:|.:....:|:
 Worm   311 AEESKKK--KDMEAEVSSTTPTTPRARGTRTRNKCATRSTNSPDVTTSNLPE------------- 360

  Fly  1043 QKAPRLSVVALERLQRPQTPARGRPRGRKPKNR-----EQAEAAPQPPPKSEPEIR----PAKKR 1098
              .|..|.:.|.:.........|:.||||||.|     |..|.......||:.|..    |....
 Worm   361 --EPSTSTMGLVKENEDVEKVEGKRRGRKPKKRRGFHKESFEDLESDAKKSKAEQHEDHLPEASC 423

  Fly  1099 GRQPKQPVLEEPPPTPPPQQKKNKMEPNIRLPDGIDPNTNFSCKIRLKRRKNLEAGTQPKKEKPV 1163
            ..:|:..:   |||..|.|                     |..|:|....:.||..|| |..:.:
 Worm   424 SSRPESVI---PPPVDPIQ---------------------FRLKVREMMERKLEQLTQ-KMSEDM 463

  Fly  1164 QPVTVEEIPPEIPVSQE----------EIDAEAE---------AKRLDSIPTEHDPLPASESHNP 1209
            ..:.:..:.....|:.|          :::.:::         .|||....||.|.|
 Worm   464 TELRLSHLTSSKMVNGERGKRRESFLRQLNEQSKKLRKGGMLGRKRLRMFMTESDIL-------- 520

  Fly  1210 GPQDYASCSESSEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQSLMPPPAKVNKKPGLEEQVGPA 1274
                     |.::|           .:||          ..|:...|||.|:..:........|:
 Worm   521 ---------EENKD-----------NIKK----------EVKEESTPPPTKLRGRLPSRRTREPS 555

  Fly  1275 SLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSWNYRKIRTNVYAESVRPNLAGF 1339
            .::.|.|        .|..|...|   :..|.|...:.:::|.|             :.|:|
 Worm   556 EIVNPEP--------VEKKFNGEY---FEITKSVPSSDDIIPLW-------------MAPSL--- 593

  Fly  1340 DHPTCNCKNQGEKSCLDNCLNRMVYTECSPSNCPAGEKCRNQKIQRH--------AVAPGVERFM 1396
               ||.|......|.:| ||||.:..:|| |:|.. ..|.|::..:.        :..|..:|.:
 Worm   594 ---TCGCTKGACTSDMD-CLNRALRVQCS-SDCSV-PYCSNRRFWKEDCGNKLCVSNGPRSKRVL 652

  Fly  1397 TADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHHYCLHLDGGLVIDGQRMGS 1461
                    :||:....|.::.||.|||:|.::.:::.|    .|.....:.:...|.:|..:..:
 Worm   653 --------KTKIARRAGEFLCEYAGEVITREQAQEKFA----QDRDPRIIAIAAHLFVDATKRSN 705

  Fly  1462 DCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCR 1526
            ..||:.|||:||..::.|||||..|..:||...:....|:|.|.:..|  |.: ..|.|...:|:
 Worm   706 IARFIKHSCKPNSRLEVWSVNGFYRAGVFALSDLNPNAEITVDKSDLL--PFD-MACNCGATECK 767

  Fly  1527 GVIGGKSQRVKPLPAVEAKPSGEGLSGRNGRQRKQKAKKHAQRQAGKDISSAVAVAKLQPLSEKE 1591
            .||.|...|.       |.|:                                           |
 Worm   768 RVIRGVRWRC-------ADPN-------------------------------------------E 782

  Fly  1592 KKLVRQFNTFLVRNFEKIRRCKAKRASDAAATASSPALGTTNGDIPGRRPSTPSSPSLAAQISAL 1656
            |.:.|:   |::||    ||...:|:|.:..    ||:..|..|
 Worm   783 KIVTRR---FVIRN----RRKTIERSSHSGL----PAILQTPMD--------------------- 815

  Fly  1657 CSPRNIKTRGLTQAVHDPELEKMAKMAVVLRDICSAMETLKMSDLLTTVSSKKKKPIKTTLSGKL 1721
               .|...|                              |||..:|...:.:.:|     :.|.:
 Worm   816 ---ENSSIR------------------------------LKMKQVLAAFAFRVRK-----IDGSM 842

  Fly  1722 GSTAA---TSKVEFRSIQAQVEQGHYKTPQEFDDHMQQLFVEAKQQHGDDEGKEKALQSLKDSYE 1783
            ..|..   |..::|..     .:|:...|.||....:: ::||.    ||:..|:|..:::..|.
 Worm   843 SRTMLPHYTLIIKFLK-----TKGNNPNPVEFVSLFRK-WLEAI----DDDDLERAFVAIESHYM 897

  Fly  1784 QQKIASYVQLVEILGDSESLQSFKPKEVLSSEEEPGKIAVKKS-PG---AKERDSPIVPLKVTPP 1844
            ...|.           |.||||.|.|     :..|...|:..| |.   :|..|:.:..|:
 Worm   898 SSSIL-----------SSSLQSKKAK-----DNAPRARALSTSCPSPVPSKRGDADLSYLE---- 942

  Fly  1845 PLLPIEA-SPDE-----------DVIRCICGLYKDEGLMIQCSKCMVWQHTECTKADI------- 1890
            .|.||.: .||:           :.:|||||...:||.|:||..|..|.|.:|.:..:
 Worm   943 SLYPIGSYDPDDAWESYSTNKKGNAVRCICGALDEEGTMVQCDTCHFWLHVDCCQYVVRSNEKAQ 1007

  Fly  1891 -------DADNYQCERCEPRE----VDREIPLEEFTE---EGHRYYLSLM-RGDLQVRQGDAVYV 1940
                   |...|.|:.|..::    ...::.|.|..:   |...||.||: |..:||...:.|||
 Worm  1008 KSKNPPSDDGEYICDFCTNKQNGLRPSADVKLTEQPDVRFENCDYYRSLINRRGIQVVLNETVYV 1072

  Fly  1941 LRDIP---------IKDE--SGKVLPTKKHTYE-------TIGAIDYQECDIFRVEHLWKNELGK 1987
            .|.:|         :::|  ..|...|.|:.:.       .|..:|.:...|||||.|:......
 Worm  1073 NRVLPEDHKAMLRNLREEKKGSKQKDTNKYRFPKAATSPLPIEKVDRKNARIFRVERLFVCPGNN 1137

  Fly  1988 RFIFGHHFLRPHETFHEPSRRFYPNEVVRVSLYEVVPIELVIGRCWVLDRTTFCKGRP-MECNDE 2051
            ||:||..:..||||:.:..|.|...||.....||.:|::.|||||.|||..|:||||| :....|
 Worm  1138 RFVFGSFYAWPHETYADAGRVFSKKEVFATPYYETLPLDEVIGRCLVLDTATWCKGRPKVPKFKE 1202

  Fly  2052 DHCYICELRVDKTARFFSKA--KANHPACTKSYAFRKFPEKIKISKSYAPHDVDPSLLKTRKQKT 2114
            |..::||:::.||.|.|.|.  |..:|..|.||.|.:|....|:.:.:.|:  |||....:..||
 Worm  1203 DDVFLCEMQIGKTQRVFEKVPPKNRYPINTNSYVFTEFTHPKKVVRDFRPY--DPSNPSPKPPKT 1265

  Fly  2115  2114
             Worm  1266  1265

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	53/290 (18%)
		AWS	1340..1388	CDD:197795	15/55 (27%)
		SET_ASH1L	1391..1531	CDD:380951	39/139 (28%)
		Bromo_ASH1	1680..1787	CDD:99955	20/109 (18%)
		PHD_ASH1L	1858..1900	CDD:277023	17/55 (31%)
		BAH_polybromo	1929..2073	CDD:240068	57/164 (35%)
lin-59	NP_491206.1	AWS	591..636	CDD:197795	17/53 (32%)
		SET	629..772	CDD:394802	40/157 (25%)
		PHD	970..1027	CDD:425785	17/56 (30%)
		BAH_polybromo	1118..1222	CDD:240068	44/103 (43%)