DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ash1 and SETBP1

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	XP_024306917.1	Gene:	SETBP1 / 26040	HGNCID:	15573	Length:	1622	Species:	Homo sapiens

Alignment Length:	1468	Identity:	298/1468 - (20%)
Similarity:	480/1468 - (32%)	Gaps:	504/1468 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VLETQRA---QESGSENEETDSITDQSSQSKSIKSATQFSVQRSDTDGLRMRISAIRPTLGVVAT 74
            |...|:|   .|...|....||..:.|...:::.||   |...:|:..:|:.|....|:|
Human   381 VKNAQKAFDNTEGKREGYSADSAQEASPARQNVSSA---SNPENDSSHVRITIPIKAPSL----- 437

  Fly    75 KKPPKSRKMSTQDTESGCSEAKNRAVSKKVKVKRKKLASSSGISKSDKVSKSKKSQISAFSSDSE 139
             .|...::...|..         :||.:|:..::   |.:|||:.|.:|       ::...|:||
Human   438 -DPTNHKRKKRQSI---------KAVVEKIMPEK---ALASGITMSSEV-------VNRILSNSE 482

  Fly   140 DDLPLKVHQQRAPRV-LLSAIIQAAQSASKPTLDIGISSSDNE---LPNLVQAAIKRVESDTEDT 200
            .:       ::.||| .||.:|: .:|.|     :|:.:..|.   :|..|....|.....|..|
Human   483 GN-------KKDPRVPKLSKMIE-NESPS-----VGLETGGNAEKVIPGGVSKPRKPPMVMTPPT 534

  Fly   201 TVEGSFRKAAKDKNLPQYQ-----------------STLLQDFMEKTQ---MLGQTVNAKLAEEK 245
            ..:.|     ..:.||:.|                 ||:|::.:..|.   ||.......:....
Human   535 CTDHS-----PSRKLPEIQHPKFAAKRRWTCSKPKPSTMLREAVMATSDKLMLEPPSAYPITPSS 594

  Fly   246 VAKAKEETLVQTAVPRKRRGRPKKVVPTVPAPGNSGPAINESADSGVISTTSTTQSTTPSPKMQN 310
            ......::|......:|:||||||      .|..:...|:|...:..:|..|.....|...| :.
Human   595 PLYTNTDSLTVITPVKKKRGRPKK------QPLLTVETIHEGTSTSPVSPISREFPGTKKRK-RR 652

  Fly   311 ENAVPTGSLPIASSSKPKIDMAY---------LDKRMYATERVLYPPPRSKRRQN--NKKTACSS 364
            .|......| :....||..:|.:         |||:...|...:    ::.:|:|  |:..:|||
Human   653 RNLAKLAQL-VPGEDKPMSEMKFHKKVGKLGVLDKKTIKTINKM----KTLKRKNILNQILSCSS 712

  Fly   365 SNKEELQLDP------------LWREIDVNKKFRLRSMSVGAASGTGAST--------------- 402
            |...:.:..|            |.::|:|:|:   .::.:|...|.....
Human   713 SVALKAKAPPETSPGAAAIESKLGKQINVSKR---GTIYIGKKRGRKPRAELPPPSEEPKTAIKH 774

  Fly   403 --TICSK--VLAAKSGY---VSDYGSVRHQRSSH-NHNSGYKSDASCKSRYSTKSCMSRRSRAKS 459
              .:.|:  |.|..|.:   |:...:..|..|:. ..::|..|.||.::.:|....|.......:
Human   775 PRPVSSQPDVPAVPSNFQSLVASSPAAMHPLSTQLGGSNGNLSPASTETNFSELKTMPNLQPISA 839

  Fly   460 CGYRSDCKESGKSGLRMRR-KRRASMLLKSSADDTVEDQDILQLAGLSLGQSSEESNEYISKPSL 523
            ...::      :.|:.... |.....|:.:|.....|   |..|..::|...||..:|
Human   840 LPTKT------QKGIHSGTWKLSPPRLMANSPSHLCE---IGSLKEITLSPVSESHSE------- 888

  Fly   524 KSLP-----------TTSASKKYGEINRYVTTGQYFGRGGSLSATNPDNFISKMMNQRKETPAPS 577
            :::|           |:..::|..|..|..:.       ...|..||:             ..||
Human   889 ETIPSDSGIGTDNNSTSDQAEKSSESRRRYSF-------DFCSLDNPE-------------AIPS 933

  Fly   578 KSSCKIKSRRSSAASMCSSYVSGVSRMRRRHRRKSFSHNKSL--NIDSKLLTEIEIITSTFN--- 637
            .:|.|.:........:..::::..|..:.:|:||    .|||  ..|.:.|.::|.:.:.|.
Human   934 DTSTKNRHGHRQKHLIVDNFLAHESLKKPKHKRK----RKSLQNRDDLQFLADLEELITKFQVFR 994

  Fly   638 ---------------SRCRIQDD-----------------RLTGSSGKEKLLADANK-------- 662
                           |..||..|                 |.:....|:|....|..
Human   995 ISHRSYTFYHENPYPSIFRINFDHYYPVPYIQYDPLLYLRRTSDLKSKKKRGRPAKTNDTMTKVP 1059

  Fly   663 -----------------------------------------LQATLAAPSPAQQLT--------- 677
                                                     |..||.|.||..:.|
Human  1060 FLQGFSYPIPSGSYYAPYGMPYTSMPMMNLGYYGQYPAPLYLSHTLGAASPFMRPTVPPPQFHTN 1124

  Fly   678 --LNGGGPASTLSK-------PLKRGL--KKRKLSEPLVDFAMLSASASGTPNGSGSSNGNTKRR 731
              :...|.|...:|       |:..||  .:..|:.|.|..|.||         ||..: ..|.:
Human  1125 SHVKMSGAAKHKAKHGVHLQGPVSMGLGDMQPSLNPPKVGSASLS---------SGRLH-KRKHK 1179

  Fly   732 HKKSQSND--------------------SS-------SPDDHKLPL---KKRHYLLTPGERPPAE 766
            ||.....|                    ||       |..|.:|||   |.:|  ....:...:|
Human  1180 HKHKHKEDRILGTHDNLSGLFAGKATGFSSHILSERLSSADKELPLVSEKNKH--KEKQKHQHSE 1242

  Fly   767 VAFANGKLNAEAWAAAAAA---AKSTASTKSQAQFNARSVKSALTPKKRHLLEQPTSVSGAGSSA 828
            ......|.|.|....:..:   |:.....|.:...::..|.|.   .||:     :...|.|.|.
Human  1243 AGHKASKNNFEVDTLSTLSLSDAQHWTQAKEKGDLSSEPVDSC---TKRY-----SGSGGDGGST 1299

  Fly   829 SNSPLRIVVDNNSISGGKLLDISPSSLCSLKQQRRG----GAAKQK-VSAAKDLVQLQSPAGSYP 888
            .:..|.:..:.|..:.....|:|.|       :||.    |..::| :.|.|...:.:|...|..
Human  1300 RSENLDVFSEMNPSNDKWDSDVSGS-------KRRSYEGFGTYREKDIQAFKMNRKERSSYDSSM 1357

  Fly   889 PPGVFEPSVELEIQIPLSKLNESVIT------KAEVES------PLLSALDIKEDTKKEVG---- 937
            .||:..|.::::.....||...||.|      .|.|:|      |:||.|.....|...||
Human  1358 SPGMPSPHLKVDQTAVHSKNEGSVPTMMTRKKPAAVDSVTIPPAPVLSLLAASAATSDAVGSSLK 1422

  Fly   938 ----QRVVE------------TLLHKTGGNL-----LLKRKR-KKINRTGFPTVRRKKRKVSVEQ 980
                :|.:|            |.:..|..||     :||.|| ::.::||...|  |||:....:
Human  1423 KRFKRREIEAIQCEVRKMCNYTKILSTKKNLDHVNKILKAKRLQRQSKTGNNFV--KKRRGRPRK 1485

  Fly   981 QTTAVIDEHEPEFDPDDEPLQSLRETRSSNNVNVQAAPNPPLDCERVPQAGEARETFVARTNQKA 1045
            |.|        :||.|......:.|                 .|..:|          ::..||
Human  1486 QPT--------QFDEDSRDQMPVLE-----------------KCIDLP----------SKRGQK- 1514

  Fly  1046 PRLSVVALERLQRPQT----------PARGRPRGRKPKNREQAEAAPQPPPKSEPEIRPAKKRGR 1100
            |.||.:.||......|          .||              ||.|.|||...|
Human  1515 PSLSPLVLEPAASQDTIMATIEAVIHMAR--------------EAPPLPPPPPPP---------- 1555

  Fly  1101 QPKQPVLEEPPPTPPPQQKKNKMEPNIRLPDGIDPNTNFSCKIRLKRRKNLEAGTQPKKEKPVQP 1165
            .|..|    |||.|||       .|..:.|.|             .:||:       |.:.|.||
Human  1556 LPPPP----PPPLPPP-------PPLPKTPRG-------------GKRKH-------KPQAPAQP 1589

  Fly  1166 VTVEEIPPEIPVSQEEIDAEAEAKR-LDSIPTEHDPLP 1202
              .::.||:.|:.|||   |.:||| ..|..:|.:.||
Human  1590 --PQQSPPQQPLPQEE---EVKAKRQRKSRGSESEVLP 1622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795
		SET	1392..1512	CDD:214614
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
SETBP1	XP_024306917.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158056
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46147
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030