DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ash1 and set2

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	NP_594980.1	Gene:	set2 / 2542070	PomBaseID:	SPAC29B12.02c	Length:	798	Species:	Schizosaccharomyces pombe

Alignment Length:	902	Identity:	207/902 - (22%)
Similarity:	332/902 - (36%)	Gaps:	285/902 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1176 PVSQEEIDAEAE-------AKRLDSIP---TEHDPLPASESHNPGPQDYASCSESSEDKASTTSL 1230
            |:::|.:|.::.       .:.:.|.|   :.|| ..:.|......:|.::.|.|:...:|.:|.
pombe    12 PLNEENVDRKSSWSKDTIAVQAVGSSPSSSSSHD-FESKEDAEGMNKDESAPSPSTSSPSSASSR 75

  Fly  1231 RKLSKVKKTYLVAGLFSNHYKQSLMPPPAKVNKKPGLEEQVGPASLLPPPPYCEKYLRRTEMDFE 1295
            .:...|:|..|...||  |:..|     ||                       :|.|    ..||
pombe    76 SQSKYVRKEALPPQLF--HHLDS-----AK-----------------------DKAL----TTFE 106

  Fly  1296 LPYDIWWAYTNSKLPTRNVVPSWNYRKIRTNVYAESVRPNLAGFDHPTCNCKNQ---------GE 1351
            ...:..:|..|...|..|                          :...|:|:..         |.
pombe   107 EIQECQYASANIGKPPEN--------------------------EAMICDCRPHWVDGVNVACGH 145

  Fly  1352 KSCLDNCLNRMVYTECSPSNCPAGEKCRNQKIQRHAVAPGVERFMTADKGWGVRTKLPIAKGTYI 1416
            .|   ||:|||...||:..:...|..|:||:.|||..|. |:.|:|..||:|:|....:.|.|::
pombe   146 GS---NCINRMTSIECTDEDNVCGPSCQNQRFQRHEFAK-VDVFLTEKKGFGLRADANLPKDTFV 206

  Fly  1417 LEYVGEVVTEKEFKQRMASIYLND--THHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKW 1479
            .||:|||:.|::|::||.. |.::  .|.|.:.|..|..||..:.||..||.||||.|||.:.||
pombe   207 YEYIGEVIPEQKFRKRMRQ-YDSEGIKHFYFMMLQKGEYIDATKRGSLARFCNHSCRPNCYVDKW 270

  Fly  1480 SVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCRGVIGGKSQ---------R 1535
            .|....||.:|.||.|..|||||:|||...:. ::.|||.|..|.|.|.||||:|         .
pombe   271 MVGDKLRMGIFCKRDIIRGEELTFDYNVDRYG-AQAQPCYCGEPCCVGYIGGKTQTEAQSKLPEN 334

  Fly  1536 VKPLPAVE-AKPSGEGLSGRNGRQRKQKAKKHAQRQAGKDISSAVAVAKLQP---LSEKEKKLVR 1596
            |:....:| .:.|.|.::.|  |||::|         |.|.:|.: :.::||   .||...|::
pombe   335 VREALGIEDEEDSWENITAR--RQRRKK---------GIDETSKI-IEEVQPTPLTSESATKVI- 386

  Fly  1597 QFNTFLVRNFEKIRRCKAKRASDAAATASSPALGTTNGDIPGR----RPSTPSSPSLAAQISALC 1657
                                          ..|..|..|:..|    |....|.||:...|.||.
pombe   387 ------------------------------GVLLQTKDDLLTRKLMERIFLTSDPSVCRSIIALR 421

  Fly  1658 S------------------PRNIKT-----RGLTQAVHDPELEKMAKMAVVLRDICSAMETLKMS 1699
            .                  .|:|||     |.....:.|..:|.      |:::.|. .|..::.
pombe   422 GYNIFGLMLKKFSIDIEFILRSIKTMLSWPRLTRNKIQDSNIEP------VVQEFCD-HENEEVK 479

  Fly  1700 DLLTTVSSK-----------KKKP---------------------------------IKTTLSGK 1720
            |...|:..:           ::||                                 ||:.::
pombe   480 DHAKTLLKEWESLEIAYRIPRRKPGQVAPQSTNAEPSNNQSNPPLRDQEPQRGDKGDIKSAIN-- 542

  Fly  1721 LGSTAATSKVE--FRSIQAQVEQGHYKTPQEFDDH------MQQLFVEAKQQHGDDEGKEKALQS 1777
             .||...||..  ..|.:....:...|...::..|      .:..|.:.::....|...|    :
pombe   543 -NSTEDLSKKHPALHSSRPSDSRSRSKFGNDYQSHSKHNLFRKNSFPKRRRLSNSDTPSE----T 602

  Fly  1778 LKDSYEQQKI---ASYVQLVEILGDSESLQSFKPKEVLSSE-EEPGKIAVKKSPGAKERDSPIVP 1838
            ...:.||:::   |:.|.|.:|:  |.:::|...|.||.:: ||..:||.:|.. .|.|
pombe   603 TTPNNEQEQVSNQANKVDLNKII--SAAMESVNQKNVLKAQKEEEERIAQQKRE-EKRR------ 658

  Fly  1839 LKVTPPPLLPIEASPDEDVIRCICGLYKDEGLMIQCSKCMVWQHTECTKADIDA--DNYQCERCE 1901
                                     |..:|.|.....|.    |.:.||:..||  |::......
pombe   659 -------------------------LAYEESLKRHAKKL----HEKKTKSSQDATIDHHLTSHSP 694

  Fly  1902 PREVDREIPLEEFTEEGHRYYLSLMRGDLQVRQGDAVYVLRDIPIKDESGKVLPTKK 1958
            .....:.:..:.|..:..||...|.:.:.::|    |..:.:|.:|.....||..|:
pombe   695 ESIAFKAVLAKFFANKTARYQEKLGKAEFKLR----VKKMTEIILKKHIQLVLSKKE 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795	18/56 (32%)
		SET	1392..1512	CDD:214614	53/121 (44%)
		Bromo_ASH1	1680..1787	CDD:99955	21/158 (13%)
		PHD_ASH1L	1858..1900	CDD:277023	10/43 (23%)
		BAH_polybromo	1929..2073	CDD:240068	7/30 (23%)
set2	NP_594980.1	AWS	125..179	CDD:197795	18/56 (32%)
		SET	180..303	CDD:214614	54/125 (43%)
		SET	275..791	CDD:225491	119/573 (21%)
		PostSET	304..320	CDD:214703	7/15 (47%)
		Med26	440..489	CDD:285873	12/55 (22%)
		SRI	699..771	CDD:285448	11/53 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940