DRSC/TRiP Functional Genomics Resources

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Protein Alignment ash1 and Setbp1

DIOPT Version :10

Sequence 1:NP_524160.2 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster
Sequence 2:NP_444329.2 Gene:Setbp1 / 240427 MGIID:1933199 Length:1582 Species:Mus musculus


Alignment Length:1792 Identity:361/1792 - (20%)
Similarity:585/1792 - (32%) Gaps:651/1792 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   439 ASCKSRYSTKSCM----SRRSRAKSC-----------GYRSDCKESGKSGLRMRRKRRASMLLKS 488
            :||:.|.|....:    ||...|..|           |.|.:.:|..:.|      ....:...|
Mouse     8 SSCRQRGSESEFLQGSSSRSPPAPGCSGEPLKGISVGGERMEPEEEDELG------SGRDVDCNS 66

  Fly   489 SAD-------DTVEDQDILQLAGLSLGQSSEESNEYISKPSLK-SLPTTSASKKYGE-INRYV-- 542
            :||       |.:|:|:.          |.:|:|  .::.||| .:.||..:||..: :..|:  
Mouse    67 NADSEKWVAGDGLEEQEF----------SIKEAN--FTEGSLKLKIQTTKRAKKPPKNLENYICP 119

  Fly   543 ---------TTGQYFGRGGSLS-ATNPDNFISKMMNQRKETPAPSKSSCKIKSRRSSA-----AS 592
                     :..|...|.|..| ||..|   .:..:::|...|...::..:|:.::.|     ..
Mouse   120 PEIKITIKQSGDQKVSRTGKNSKATKED---ERNHSKKKLLTAGDPTASDLKAFQTQAYERPQKH 181

  Fly   593 MCSSYVSGVSR------MRRRHRRKSFSHNK---SLNIDSKLLTEIEIITSTFNSRCRIQDD--R 646
            ....|..|.|:      ::.:|::||.|.:.   |.|.||...|:          .|.|..:  |
Mouse   182 STLQYDPGHSQGFTSDTLKPKHQQKSSSQSHMEWSSNSDSGPATQ----------NCFISPEAGR 236

  Fly   647 LTGSSGKEKLLADANKLQATLAAPSPAQQLTLNGGGPASTLSKPLKRGLKKRKLSEPLVDFAMLS 711
            .|.|:.|...|       ..:|:.:.||....:.||..|.||...|..|....:..|      .|
Mouse   237 DTASTSKVPAL-------EPVASFAKAQSKKGSTGGAWSQLSSSSKDLLLGSVVPSP------SS 288

  Fly   712 ASASGTPNGSGSSN----------GNTK--------RRHKKSQSNDSSSPDDHKLPLKKRHYLLT 758
            .::..||:.|...|          |:||        ...|||...|..|   ..||.....::.:
Mouse   289 HNSPATPSSSAECNGLQPLGDQDGGSTKDLPEPPTLSSKKKSSKKDMIS---QTLPNSDLDWVKS 350

  Fly   759 PGERPPAEVAFANGKLNAEAWAA----AAAAAKSTASTKSQAQFNARSVKSAL---TP------- 809
                  |:.||...:...||::|    .|:.|:.:.|:.|..:.::..|:..:   ||       
Mouse   351 ------AQKAFETTEGKREAYSADSAQEASPARQSISSVSNPENDSSHVRITIPIKTPSLDPSNH 409

  Fly   810 --KKRHLLEQ------PTSVSGAGSSASNSPLRIVVDNNSISG--------GKLLDISPSSL--- 855
              |||..::.      |.....:|.|.|:..:..::.|:..|.        ||:::....|:   
Mouse   410 KRKKRQSIKAVVEKIVPEKALASGISMSSEVVNRILSNSEGSKKDPRVPKLGKMIENETPSVGLE 474

  Fly   856 --CSLKQQRRGGAAKQKVSAAKDLVQLQSPAGS-YPPPGVFEPSVELEIQIP-------LSK--- 907
              .:.::...|||:||:    |..:.:.||..: :.|.|...     |||.|       .||   
Mouse   475 TGGNAEKIVPGGASKQR----KPPMVMTSPTRTEHAPSGKLS-----EIQHPKFAAKRRCSKAKP 530

  Fly   908 ---LNESVITKAE---VE----------SPLLS---ALDIKEDTKKEVGQ------RVVETLLHK 947
               |.|:|:..||   ||          |||.:   :|.:....||:.|:      ..|||:...
Mouse   531 PAMLREAVLATAEKLMVEPPSAYPITPSSPLYTNTDSLTVITPVKKKRGRPKKQPLLTVETIHEG 595

  Fly   948 TGGNLLLKRKRKKINRTGFPTVRRKKRKVSVEQQTTAVIDEHEPEFDP------------DDEPL 1000
            |..:.:....|:      ||..:::||:.::.:....|..|.:|..:.            |.:.:
Mouse   596 TSTSPVSPISRE------FPGTKKRKRRRNLAKLAQLVPGEDKPMSEMKFHKKVGKLGVLDKKTI 654

  Fly  1001 QSLRETRSSNNVNVQAAPNPPLDCERVPQAGEARETFVARTNQKAPRLSVVALERLQRPQT-PAR 1064
            :::.:.::....|:.   |..|.|.                       |.|||:....|:| |..
Mouse   655 KTINKMKTLKRKNIL---NQILSCS-----------------------SSVALKAKAPPETSPGA 693

  Fly  1065 ---------------------GRPRGRKPKNREQAEAAPQPPPKSEPEI-----RPAKKRGRQP- 1102
                                 |:.|||||:..       .|||..||:.     ||...:...| 
Mouse   694 ASIESKLGKQINVSKRGTIYIGKKRGRKPRTE-------LPPPSEEPKTAIKHPRPVSSQPDVPA 751

  Fly  1103 -----KQPVLEEPPPTPPPQQKKNKMEPNIRLPDGIDPNTNFSCKIRLKRRKNLE--AGTQPKKE 1160
                 :.||...|....|...:......|:   ......||||   .||...||:  :....|.:
Mouse   752 VPSSFQSPVASSPAAMHPLSTQLGGSNGNL---SPASTETNFS---ELKTMPNLQPISALPTKTQ 810

  Fly  1161 KPVQPVTVEEIPPEI--------------------PVSQ---EEIDAEAEAKRLDSIPTEHDPLP 1202
            |.:...|.:..||.:                    |||:   ||..........|:..|......
Mouse   811 KGIHGGTWKLSPPRLMANSPSHLCEIGSLKEITLSPVSESHSEETIPSDSGIGTDNNSTSDQAEK 875

  Fly  1203 ASESHNPGPQDYASCSESSEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQSLMPPPAKVNKK--- 1264
            :|||......|:.|. ::.|...|.||.:.....::.:|:...|..|  :||..|..|..:|   
Mouse   876 SSESRRRYSFDFCSL-DNPEAIPSDTSTKNRHGHRQKHLIVDTFLAH--ESLKKPKHKRKRKSLQ 937

  Fly  1265 --------PGLEEQVGPASLLP--------------------------PPPYCE----KYLRRTE 1291
                    ..|||.:....:..                          |.||.:    .||||| 
Mouse   938 NRDDLQFLAELEELITKFQVFRISHRGYTFYHENPYPSIFRINFDQYYPVPYIQYDPLLYLRRT- 1001

  Fly  1292 MDFELPYDIWWAYTNSKLPTRNVVPSWNYRKIRTNVYAESVRPNLAGFDHPTCNCKNQGEKSCLD 1356
                           |.|.::..    ..|..:||.....| |.|.||.:|              
Mouse  1002 ---------------SDLKSKKK----RGRPAKTNDTMTKV-PFLQGFSYP-------------- 1032

  Fly  1357 NCLNRMVYTECSPSNCPAGEKCRNQKIQRHAVAPGVERFMTADKGWGV-RTKLPIAKGTYILEYV 1420
                           .|:|.          ..||           :|: .|.:|:..    |.|.
Mouse  1033 ---------------IPSGS----------YYAP-----------YGMPYTSMPMMN----LGYY 1057

  Fly  1421 GEVVTEKEFKQRMASIYLNDT------------------------------H--HYCLHLDGGLV 1453
            |         |..|.:||:.|                              |  .:.:||.|.: 
Mouse  1058 G---------QYPAPLYLSHTLGAASPFMRPTVPPPQFHASSHVKISGATKHKAKHGVHLQGTV- 1112

  Fly  1454 IDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFA-----KRAIEEGEEL-TYDYNFSLFNP 1512
              |..:|        ..:|:....|.....||...|..     ||..:|...| |:| |.|    
Mouse  1113 --GMGLG--------DIQPSLNPPKVGGATLSSSRLHKRKHKHKRKHKEDRILGTHD-NLS---- 1162

  Fly  1513 SEGQPCRCNTPQCRGVIGGK---------SQRV----KPLPAVEAKPS---------GE------ 1549
                          |:..||         |:|:    |.||.|..|..         ||      
Mouse  1163 --------------GLFAGKATGFSSHLLSERLSGSDKELPLVSEKSKHKERQKHQHGEASHKVS 1213

  Fly  1550 ------------GLS-GRNGRQRKQK-----------AKKH------AQRQAGKDISSAVAVAKL 1584
                        .|| .::..|.|.|           ||::      :.|..|.|:.|     ::
Mouse  1214 KNNFEVDTLSTLSLSDAQHWTQAKDKGDLSSEPVESCAKRYSGSGGDSTRSEGLDVFS-----EM 1273

  Fly  1585 QPLSEK--------EKKLVRQFNTFLVRNFEKIRRCKAKRASDAAATASSPALGTTNGDIPGRRP 1641
            .|.|:|        :::....|.|:..::.:..:..:.:|.|  ..::.||.:.:.:..:.....
Mouse  1274 NPSSDKWDSDMGGSKRRSFEGFGTYREKDIQAFKMNRKERGS--YESSMSPGMPSPHLKVDQTAA 1336

  Fly  1642 STPSSPSLAAQISALCSPRNIKTRGLTQAVHDPELEKMAKMAVVLRDICSAMETLKMSDLLTTVS 1706
            .:.|..|::|.: |...|..:.:..:..|   |.|..:|..|..             ||   ..|
Mouse  1337 HSKSEGSISAMM-ARKKPTAVDSVAIPSA---PVLSLLAASAAT-------------SD---AAS 1381

  Fly  1707 SKKKKPIKTTLSGKLGSTAATSKVEFRSIQAQV-EQGHY----KTPQEFDDHMQQLFVEAKQQHG 1766
            |..||..|              :.|..:||.:| :..||    .|.:.. ||:.::....:.|..
Mouse  1382 SSLKKRFK--------------RREIEAIQCEVRKMCHYTKLLSTKKNL-DHVNKILKAKRLQRQ 1431

  Fly  1767 DDEG-----------KEKALQSLKDSYEQQKIASYVQLVEILGDSESLQSFKPK-EVLSSEEEPG 1819
            ...|           :::..|..:||.:|..:      :|...|..|.:..||. ..|:.|...|
Mouse  1432 SKTGNNFVKKRRGRPRKQPSQFDEDSRDQMPV------LEKCIDLPSKRGQKPSLSPLALEPASG 1490

  Fly  1820 KIAVKKSPGA---KERDSPIVPLKVTPPPLLPIEASP 1853
            :.||..:..|   ..|::|  ||...|||.||....|
Mouse  1491 QDAVMATIEAVIHMAREAP--PLPPPPPPPLPPPPPP 1525

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ash1NP_524160.2 PHA03247 <1018..1281 CDD:223021 70/357 (20%)
AWS 1340..1388 CDD:197795 3/47 (6%)
SET_ASH1L 1391..1531 CDD:380951 31/178 (17%)
Bromo_ASH1 1680..1787 CDD:99955 24/122 (20%)
PHD_ASH1L 1858..1900 CDD:277023
BAH_polybromo 1929..2073 CDD:240068
Setbp1NP_444329.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..76 15/73 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 124..246 29/134 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 278..416 33/152 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 446..513 15/75 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 595..617 5/27 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 709..787 19/87 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 845..880 9/34 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1128..1155 6/26 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1182..1215 7/32 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1236..1265 5/28 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1429..1461 5/31 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1470..1489 5/18 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1507..1582 9/21 (43%)
Blue background indicates that the domain is not in the aligned region.

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